LOCUS       NM_001042728            2701 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens retinoic acid receptor gamma (RARG), transcript
            variant 2, mRNA.
ACCESSION   NM_001042728 XM_940838
VERSION     NM_001042728.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2701)
  AUTHORS   Li,X.M., Yang,Y., Jiang,F.Q., Hu,G., Wan,S., Yan,W.Y., He,X.S.,
            Xiao,F., Yang,X.M., Guo,X., Lu,J.H., Yang,X.Q., Chen,J.J., Ye,W.L.,
            Liu,Y., He,K., Duan,H.X., Zhou,Y.J., Gan,W.J., Liu,F. and Wu,H.
  TITLE     Histone lactylation inhibits RARgamma expression in macrophages to
            promote colorectal tumorigenesis through activation of
            TRAF6-IL-6-STAT3 signaling
  JOURNAL   Cell Rep 43 (2), 113688 (2024)
   PUBMED   38245869
  REMARK    GeneRIF: Histone lactylation inhibits RARgamma expression in
            macrophages to promote colorectal tumorigenesis through activation
            of TRAF6-IL-6-STAT3 signaling.
REFERENCE   2  (bases 1 to 2701)
  AUTHORS   Gunduz,A., Duman,D., Basbinar,Y., Tasdelen,B., Kupeli,S. and
            Karpuz,D.
  TITLE     The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4
            rs17863783 Single-nucleotide Polymorphisms in the
            Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors
  JOURNAL   J Pediatr Hematol Oncol 46 (1), e65-e70 (2024)
   PUBMED   37828659
  REMARK    GeneRIF: The Role of RARG rs2229774, SLC28A3 rs7853758, and
            UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the
            Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors.
REFERENCE   3  (bases 1 to 2701)
  AUTHORS   Zhang,F.X., Xu,P., Zhang,L.J., Fan,R., Zhang,H.X., Liu,D.H., Liu,K.
            and Shen,D.Y.
  TITLE     RARgamma promotes the invasion and metastasis of thyroid carcinoma
            by activating the JAK1-STAT3-CD24/MMPs axis
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111129 (2023)
   PUBMED   37897947
  REMARK    GeneRIF: RARgamma promotes the invasion and metastasis of thyroid
            carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.
REFERENCE   4  (bases 1 to 2701)
  AUTHORS   Ji,K., Dou,W., Zhang,N., Wen,B., Zhong,M., Zhang,Q., Xu,S., Zhou,J.
            and Liu,J.
  TITLE     Retinoic acid receptor gamma is required for proliferation of
            pancreatic cancer cells
  JOURNAL   Cell Biol Int 47 (1), 144-155 (2023)
   PUBMED   36183362
  REMARK    GeneRIF: Retinoic acid receptor gamma is required for proliferation
            of pancreatic cancer cells.
REFERENCE   5  (bases 1 to 2701)
  AUTHORS   Homma,H., Watanabe,M., Inoue,N., Isono,M., Hidaka,Y. and Iwatani,Y.
  TITLE     Polymorphisms in Vitamin A-Related Genes and Their Functions in
            Autoimmune Thyroid Disease
  JOURNAL   Thyroid 31 (11), 1749-1756 (2021)
   PUBMED   34470463
  REMARK    GeneRIF: Polymorphisms in Vitamin A-Related Genes and Their
            Functions in Autoimmune Thyroid Disease.
REFERENCE   6  (bases 1 to 2701)
  AUTHORS   Lehmann,J.M., Zhang,X.K. and Pfahl,M.
  TITLE     RAR gamma 2 expression is regulated through a retinoic acid
            response element embedded in Sp1 sites
  JOURNAL   Mol Cell Biol 12 (7), 2976-2985 (1992)
   PUBMED   1320193
REFERENCE   7  (bases 1 to 2701)
  AUTHORS   Vollberg,T.M. Sr., Nervi,C., George,M.D., Fujimoto,W., Krust,A. and
            Jetten,A.M.
  TITLE     Retinoic acid receptors as regulators of human epidermal
            keratinocyte differentiation
  JOURNAL   Mol Endocrinol 6 (5), 667-676 (1992)
   PUBMED   1318502
REFERENCE   8  (bases 1 to 2701)
  AUTHORS   Leid,M., Kastner,P., Lyons,R., Nakshatri,H., Saunders,M.,
            Zacharewski,T., Chen,J.Y., Staub,A., Garnier,J.M., Mader,S. et al.
  TITLE     Purification, cloning, and RXR identity of the HeLa cell factor
            with which RAR or TR heterodimerizes to bind target sequences
            efficiently
  JOURNAL   Cell 68 (2), 377-395 (1992)
   PUBMED   1310259
  REMARK    Erratum:[Cell. 1992 Nov 27;71(5):887.. PMID: 1330328]
REFERENCE   9  (bases 1 to 2701)
  AUTHORS   Mattei,M.G., Riviere,M., Krust,A., Ingvarsson,S., Vennstrom,B.,
            Islam,M.Q., Levan,G., Kautner,P., Zelent,A., Chambon,P. et al.
  TITLE     Chromosomal assignment of retinoic acid receptor (RAR) genes in the
            human, mouse, and rat genomes
  JOURNAL   Genomics 10 (4), 1061-1069 (1991)
   PUBMED   1655630
REFERENCE   10 (bases 1 to 2701)
  AUTHORS   Lehmann,J.M., Hoffmann,B. and Pfahl,M.
  TITLE     Genomic organization of the retinoic acid receptor gamma gene
  JOURNAL   Nucleic Acids Res 19 (3), 573-578 (1991)
   PUBMED   1849262
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK297277.1, DC294855.1,
            AK316259.1 and BC072462.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001042728.2.
            
            Summary: This gene encodes a retinoic acid receptor that belongs to
            the nuclear hormone receptor family. Retinoic acid receptors (RARs)
            act as ligand-dependent transcriptional regulators. When bound to
            ligands, RARs activate transcription by binding as heterodimers to
            the retinoic acid response elements (RARE) found in the promoter
            regions of the target genes. In their unbound form, RARs repress
            transcription of their target genes. RARs are involved in various
            biological processes, including limb bud development, skeletal
            growth, and matrix homeostasis. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon compared to variant 1. This results in translation
            initiation from an alternate start codon, and a shorter isoform (2)
            with a distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2220994.1,
                                           SRR14038191.110571.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AK297277.1         52-148
            98-225              DC294855.1         85-212
            226-1885            AK316259.1         1-1660
            1886-2701           BC072462.1         2095-2910
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2701
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="retinoic acid receptor gamma"
                     /db_xref="GeneID:5916"
                     /db_xref="HGNC:HGNC:9866"
                     /db_xref="MIM:180190"
     exon            1..413
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1594
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RAR-gamma; nuclear receptor subfamily 1 group B member 3"
                     /codon_start=1
                     /product="retinoic acid receptor gamma isoform 2"
                     /protein_id="NP_001036193.1"
                     /db_xref="CCDS:CCDS41790.1"
                     /db_xref="GeneID:5916"
                     /db_xref="HGNC:HGNC:9866"
                     /db_xref="MIM:180190"
                     /translation="MYDCMETFAPGPRRLYGAAGPGAGLLRRATGGSCFAGLESFAWP
                     QPASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGF
                     FRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEV
                     KEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDK
                     FSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMT
                     FSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLE
                     EPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKME
                     IPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA"
     exon            414..562
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            563..704
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            705..865
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1042
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1247
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1406
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..2701
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2682..2687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="hexamer: AATAAA"
     polyA_site      2701
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="major polyA site"
ORIGIN      
        1 agtgctagct gccgaagcac ccagataaga gctggacgga ggctaaagcg gcagccccag
       61 cttcgcgccc cgcccagtcc ctttcccctg ctggggatcc cccctcttcc ccgcccaccc
      121 cttacccgca tgcagcccag cgccctatgc tagccctccc cctccccccc tgctggagcg
      181 gggcgccgcc gggggaggag ggggaatcgg ctgcgggtcc ttggtgtttc cagcacccag
      241 tttcccttca agccgggtcg cgatgtacga ctgtatggaa acgtttgccc cgggtccgcg
      301 acggctgtac ggggcggccg ggcccggggc cggcttgctg cgcagagcca ccggcggctc
      361 ctgtttcgcc ggacttgaat cttttgcctg gccgcaaccc gccagcctgc aatcggtgga
      421 gacacagagc accagctcag aggagatggt gcccagctcg ccctcgcccc ctccgcctcc
      481 tcgggtctac aagccatgct tcgtgtgcaa tgacaagtcc tctggctacc actatggggt
      541 cagctcttgt gaaggctgca agggcttctt tcgccgaagc atccagaaga acatggtgta
      601 cacgtgtcac cgcgacaaaa actgtatcat caacaaggtg accaggaatc gctgccagta
      661 ctgccggcta cagaagtgct tcgaagtggg catgtccaag gaagctgtgc gaaatgaccg
      721 gaacaagaag aagaaagagg tgaaggaaga agggtcacct gacagctatg agctgagccc
      781 tcagttagaa gagctcatca ccaaggtcag caaagcccat caggagactt tcccctcgct
      841 ctgccagctg ggcaagtata ccacgaactc cagtgcagac caccgcgtgc agctggatct
      901 ggggctgtgg gacaagttca gtgagctggc taccaagtgc atcatcaaga tcgtggagtt
      961 tgccaagcgg ttgcctggct ttacagggct cagcattgct gaccagatca ctctgctcaa
     1021 agctgcctgc ctagatatcc tgatgctgcg tatctgcaca aggtacaccc cagagcagga
     1081 caccatgacc ttctccgacg ggctgaccct gaaccggacc cagatgcaca atgccggctt
     1141 cgggcccctc acagaccttg tctttgcctt tgctgggcag ctcctgcccc tggagatgga
     1201 tgacaccgag acagggctgc tcagcgccat ctgcctcatc tgcggagacc gcatggacct
     1261 ggaggagccc gaaaaagtgg acaagctgca ggagccactg ctggaagccc tgaggctgta
     1321 cgcccggcgc cggcggccca gccagcccta catgttccca aggatgctaa tgaaaatcac
     1381 cgacctccgg ggcatcagca ctaagggagc tgaaagggcc attactctga agatggagat
     1441 tccaggcccg atgcctccct taatccgaga gatgctggag aaccctgaaa tgtttgagga
     1501 tgactcctcg cagcctggtc cccaccccaa tgcctctagc gaggatgagg ttcctggggg
     1561 ccagggcaaa gggggcctga agtccccagc ctgaccaggg cccctgacct ccccgctgtg
     1621 ggggttgggg cttcaggcag cagactgacc atctcccaga ccgccagtga ctgggggagg
     1681 acctgctctg ccctctcccc accccttcca atgagctcct tgtttttgcc aaagtttcta
     1741 ggggtgcctc tgtgttcatc cccttcctga tctaaccggc tccctcgcca gtcccggggg
     1801 cctgccctgc tcccaccagg agagagggca aagggatgag cctgggtttg gactctaaaa
     1861 tctcagcact gccccatggg tcctagactt cccagggcaa gaggaagacc ctgccattcc
     1921 acagcccctt cctctgccag gtgcttggct ctctgagagc aaacaggaac actagagacc
     1981 aaaaagggga caaaggagaa gggctgagcc caccttcttg ctcctaccct tggtgcctaa
     2041 tgctgtgtga tgcacctgca gggtgtgtgc tagcctctgt gccccgtcct tgtgccaggt
     2101 caaggtgggg gcaggctggg ccctgcattt ctggggcagg aacagagggt gaaagggaca
     2161 gatagatgca ggtccattct gcacctcttg gctcgggtgc agagttcacc ctgtgccctc
     2221 cgttataagt ccctccccca gccctgtcat gtgccttggg ctcctcctgc cctccatctc
     2281 agccattggg gcagggaccc tcctacacta cagaggggcc aggggatccc tctctcccta
     2341 gtgccttcca ccctttactc cccagagcag cttggcccag ggagggggga tgctgcttag
     2401 ctgatcccgc cctgacccag aggaagcctc tatttattta ttagcttttg tttacaccgt
     2461 ggaattgacc ccttcctcca ggggtcttgg gtgggggagc ccagggcccc tgtgacccct
     2521 cctttcttcc tccaatcccc agtttgtatt tagctgccaa ataagattcc cattggctcc
     2581 ctgtgttctc ttggggggtc agggtgctgt cccctcccct ctgtttacat ctcccctcta
     2641 ccccgctgta tcgcatattg ctgagttttc tatttttgca aaataaagtg atggaaactc
     2701 a
//
