LOCUS       NM_000966               2917 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens retinoic acid receptor gamma (RARG), transcript
            variant 1, mRNA.
ACCESSION   NM_000966 XM_352902
VERSION     NM_000966.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Li,X.M., Yang,Y., Jiang,F.Q., Hu,G., Wan,S., Yan,W.Y., He,X.S.,
            Xiao,F., Yang,X.M., Guo,X., Lu,J.H., Yang,X.Q., Chen,J.J., Ye,W.L.,
            Liu,Y., He,K., Duan,H.X., Zhou,Y.J., Gan,W.J., Liu,F. and Wu,H.
  TITLE     Histone lactylation inhibits RARgamma expression in macrophages to
            promote colorectal tumorigenesis through activation of
            TRAF6-IL-6-STAT3 signaling
  JOURNAL   Cell Rep 43 (2), 113688 (2024)
   PUBMED   38245869
  REMARK    GeneRIF: Histone lactylation inhibits RARgamma expression in
            macrophages to promote colorectal tumorigenesis through activation
            of TRAF6-IL-6-STAT3 signaling.
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Gunduz,A., Duman,D., Basbinar,Y., Tasdelen,B., Kupeli,S. and
            Karpuz,D.
  TITLE     The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4
            rs17863783 Single-nucleotide Polymorphisms in the
            Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors
  JOURNAL   J Pediatr Hematol Oncol 46 (1), e65-e70 (2024)
   PUBMED   37828659
  REMARK    GeneRIF: The Role of RARG rs2229774, SLC28A3 rs7853758, and
            UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the
            Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors.
REFERENCE   3  (bases 1 to 2917)
  AUTHORS   Zhang,F.X., Xu,P., Zhang,L.J., Fan,R., Zhang,H.X., Liu,D.H., Liu,K.
            and Shen,D.Y.
  TITLE     RARgamma promotes the invasion and metastasis of thyroid carcinoma
            by activating the JAK1-STAT3-CD24/MMPs axis
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111129 (2023)
   PUBMED   37897947
  REMARK    GeneRIF: RARgamma promotes the invasion and metastasis of thyroid
            carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.
REFERENCE   4  (bases 1 to 2917)
  AUTHORS   Ji,K., Dou,W., Zhang,N., Wen,B., Zhong,M., Zhang,Q., Xu,S., Zhou,J.
            and Liu,J.
  TITLE     Retinoic acid receptor gamma is required for proliferation of
            pancreatic cancer cells
  JOURNAL   Cell Biol Int 47 (1), 144-155 (2023)
   PUBMED   36183362
  REMARK    GeneRIF: Retinoic acid receptor gamma is required for proliferation
            of pancreatic cancer cells.
REFERENCE   5  (bases 1 to 2917)
  AUTHORS   Homma,H., Watanabe,M., Inoue,N., Isono,M., Hidaka,Y. and Iwatani,Y.
  TITLE     Polymorphisms in Vitamin A-Related Genes and Their Functions in
            Autoimmune Thyroid Disease
  JOURNAL   Thyroid 31 (11), 1749-1756 (2021)
   PUBMED   34470463
  REMARK    GeneRIF: Polymorphisms in Vitamin A-Related Genes and Their
            Functions in Autoimmune Thyroid Disease.
REFERENCE   6  (bases 1 to 2917)
  AUTHORS   Lehmann,J.M., Zhang,X.K. and Pfahl,M.
  TITLE     RAR gamma 2 expression is regulated through a retinoic acid
            response element embedded in Sp1 sites
  JOURNAL   Mol Cell Biol 12 (7), 2976-2985 (1992)
   PUBMED   1320193
REFERENCE   7  (bases 1 to 2917)
  AUTHORS   Vollberg,T.M. Sr., Nervi,C., George,M.D., Fujimoto,W., Krust,A. and
            Jetten,A.M.
  TITLE     Retinoic acid receptors as regulators of human epidermal
            keratinocyte differentiation
  JOURNAL   Mol Endocrinol 6 (5), 667-676 (1992)
   PUBMED   1318502
REFERENCE   8  (bases 1 to 2917)
  AUTHORS   Leid,M., Kastner,P., Lyons,R., Nakshatri,H., Saunders,M.,
            Zacharewski,T., Chen,J.Y., Staub,A., Garnier,J.M., Mader,S. et al.
  TITLE     Purification, cloning, and RXR identity of the HeLa cell factor
            with which RAR or TR heterodimerizes to bind target sequences
            efficiently
  JOURNAL   Cell 68 (2), 377-395 (1992)
   PUBMED   1310259
  REMARK    Erratum:[Cell. 1992 Nov 27;71(5):887.. PMID: 1330328]
REFERENCE   9  (bases 1 to 2917)
  AUTHORS   Mattei,M.G., Riviere,M., Krust,A., Ingvarsson,S., Vennstrom,B.,
            Islam,M.Q., Levan,G., Kautner,P., Zelent,A., Chambon,P. et al.
  TITLE     Chromosomal assignment of retinoic acid receptor (RAR) genes in the
            human, mouse, and rat genomes
  JOURNAL   Genomics 10 (4), 1061-1069 (1991)
   PUBMED   1655630
REFERENCE   10 (bases 1 to 2917)
  AUTHORS   Lehmann,J.M., Hoffmann,B. and Pfahl,M.
  TITLE     Genomic organization of the retinoic acid receptor gamma gene
  JOURNAL   Nucleic Acids Res 19 (3), 573-578 (1991)
   PUBMED   1849262
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA436501.1 and BC072462.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000966.5.
            
            Summary: This gene encodes a retinoic acid receptor that belongs to
            the nuclear hormone receptor family. Retinoic acid receptors (RARs)
            act as ligand-dependent transcriptional regulators. When bound to
            ligands, RARs activate transcription by binding as heterodimers to
            the retinoic acid response elements (RARE) found in the promoter
            regions of the target genes. In their unbound form, RARs repress
            transcription of their target genes. RARs are involved in various
            biological processes, including limb bud development, skeletal
            growth, and matrix homeostasis. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072462.1, SRR14038194.390989.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425354.7/ ENSP00000388510.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA436501.1         48-54
            8-2917              BC072462.1         1-2910
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2917
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="retinoic acid receptor gamma"
                     /db_xref="GeneID:5916"
                     /db_xref="HGNC:HGNC:9866"
                     /db_xref="MIM:180190"
     exon            1..236
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            237..303
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            304..629
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..1810
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RAR-gamma; nuclear receptor subfamily 1 group B member 3"
                     /codon_start=1
                     /product="retinoic acid receptor gamma isoform 1"
                     /protein_id="NP_000957.1"
                     /db_xref="CCDS:CCDS8850.1"
                     /db_xref="GeneID:5916"
                     /db_xref="HGNC:HGNC:9866"
                     /db_xref="MIM:180190"
                     /translation="MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSP
                     SFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHY
                     GVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAV
                     RNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADH
                     RVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRIC
                     TRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAI
                     CLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK
                     GAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGL
                     KSPA"
     exon            630..778
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            779..920
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1081
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1258
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1463
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1622
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..2917
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="hexamer: AATAAA"
     polyA_site      2917
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="major polyA site"
ORIGIN      
        1 cgtgtccccg cctgcagagt cagtgtgcgg tttgggagaa aatgtgtcgg atattttggg
       61 gcggtcacgt gggcgggcgg gctccgagag gccccgggac agtcccagcc tagagccgtg
      121 cccccccagg agccccccag tacggcgagc cccggacatt gcgacgctcc atccaagaga
      181 ctgcccgacg ccgggacctc ggggctccgc cgcctccctt ccccctccca ctccagcagc
      241 tacggcccag ttccctcaac ctgacccagt atgtagaagc cagtctctgc aggcggccag
      301 cgggactttt ggaggcccag tgggcaggcc aggcagggcg ggtacggagc ctcccaggct
      361 ggggcagtgg gcatgggcag gggctgtggc tgaagacctc gcccgcccac tgcagacccc
      421 aggggactct cacaccgcag ctgccatggc caccaataag gagcgactct ttgcggctgg
      481 tgccctgggg cctggatctg gctacccagg ggcaggtttc cccttcgcct tcccaggggc
      541 actcaggggg tctccgcctt tcgagatgct gagccctagc ttccggggcc tgggccagcc
      601 tgacctcccc aaggagatgg cctctctgtc ggtggagaca cagagcacca gctcagagga
      661 gatggtgccc agctcgccct cgccccctcc gcctcctcgg gtctacaagc catgcttcgt
      721 gtgcaatgac aagtcctctg gctaccacta tggggtcagc tcttgtgaag gctgcaaggg
      781 cttctttcgc cgaagcatcc agaagaacat ggtgtacacg tgtcaccgcg acaaaaactg
      841 tatcatcaac aaggtgacca ggaatcgctg ccagtactgc cggctacaga agtgcttcga
      901 agtgggcatg tccaaggaag ctgtgcgaaa tgaccggaac aagaagaaga aagaggtgaa
      961 ggaagaaggg tcacctgaca gctatgagct gagccctcag ttagaagagc tcatcaccaa
     1021 ggtcagcaaa gcccatcagg agactttccc ctcgctctgc cagctgggca agtataccac
     1081 gaactccagt gcagaccacc gcgtgcagct ggatctgggg ctgtgggaca agttcagtga
     1141 gctggctacc aagtgcatca tcaagatcgt ggagtttgcc aagcggttgc ctggctttac
     1201 agggctcagc attgctgacc agatcactct gctcaaagct gcctgcctag atatcctgat
     1261 gctgcgtatc tgcacaaggt acaccccaga gcaggacacc atgaccttct ccgacgggct
     1321 gaccctgaac cggacccaga tgcacaatgc cggcttcggg cccctcacag accttgtctt
     1381 tgcctttgct gggcagctcc tgcccctgga gatggatgac accgagacag ggctgctcag
     1441 cgccatctgc ctcatctgcg gagaccgcat ggacctggag gagcccgaaa aagtggacaa
     1501 gctgcaggag ccactgctgg aagccctgag gctgtacgcc cggcgccggc ggcccagcca
     1561 gccctacatg ttcccaagga tgctaatgaa aatcaccgac ctccggggca tcagcactaa
     1621 gggagctgaa agggccatta ctctgaagat ggagattcca ggcccgatgc ctcccttaat
     1681 ccgagagatg ctggagaacc ctgaaatgtt tgaggatgac tcctcgcagc ctggtcccca
     1741 ccccaatgcc tctagcgagg atgaggttcc tgggggccag ggcaaagggg gcctgaagtc
     1801 cccagcctga ccagggcccc tgacctcccc gctgtggggg ttggggcttc aggcagcaga
     1861 ctgaccatct cccagaccgc cagtgactgg gggaggacct gctctgccct ctccccaccc
     1921 cttccaatga gctccttgtt tttgccaaag tttctagggg tgcctctgtg ttcatcccct
     1981 tcctgatcta accggctccc tcgccagtcc cgggggcctg ccctgctccc accaggagag
     2041 agggcaaagg gatgagcctg ggtttggact ctaaaatctc agcactgccc catgggtcct
     2101 agacttccca gggcaagagg aagaccctgc cattccacag ccccttcctc tgccaggtgc
     2161 ttggctctct gagagcaaac aggaacacta gagaccaaaa aggggacaaa ggagaagggc
     2221 tgagcccacc ttcttgctcc tacccttggt gcctaatgct gtgtgatgca cctgcagggt
     2281 gtgtgctagc ctctgtgccc cgtccttgtg ccaggtcaag gtgggggcag gctgggccct
     2341 gcatttctgg ggcaggaaca gagggtgaaa gggacagata gatgcaggtc cattctgcac
     2401 ctcttggctc gggtgcagag ttcaccctgt gccctccgtt ataagtccct cccccagccc
     2461 tgtcatgtgc cttgggctcc tcctgccctc catctcagcc attggggcag ggaccctcct
     2521 acactacaga ggggccaggg gatccctctc tccctagtgc cttccaccct ttactcccca
     2581 gagcagcttg gcccagggag gggggatgct gcttagctga tcccgccctg acccagagga
     2641 agcctctatt tatttattag cttttgttta caccgtggaa ttgacccctt cctccagggg
     2701 tcttgggtgg gggagcccag ggcccctgtg acccctcctt tcttcctcca atccccagtt
     2761 tgtatttagc tgccaaataa gattcccatt ggctccctgt gttctcttgg ggggtcaggg
     2821 tgctgtcccc tcccctctgt ttacatctcc cctctacccc gctgtatcgc atattgctga
     2881 gttttctatt tttgcaaaat aaagtgatgg aaactca
//
