LOCUS       NM_001290216            3177 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens retinoic acid receptor beta (RARB), transcript variant
            3, mRNA.
ACCESSION   NM_001290216
VERSION     NM_001290216.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3177)
  AUTHORS   Petty,W.J., Li,N., Biddle,A., Bounds,R., Nitkin,C., Ma,Y.,
            Dragnev,K.H., Freemantle,S.J. and Dmitrovsky,E.
  TITLE     A novel retinoic acid receptor beta isoform and retinoid resistance
            in lung carcinogenesis
  JOURNAL   J Natl Cancer Inst 97 (22), 1645-1651 (2005)
   PUBMED   16288117
  REMARK    GeneRIF: In H358 lung cancer cells transiently transfected with
            RARbeta1', RA treatment restored target gene expression compared
            with that in vector-transfected cells and suppressed cell growth
            compared with that in untreated cells.
REFERENCE   2  (bases 1 to 3177)
  AUTHORS   Peng,X., Mehta,R.G., Tonetti,D.A. and Christov,K.
  TITLE     Identification of novel RARbeta2 transcript variants with short
            5'-UTRs in normal and cancerous breast epithelial cells
  JOURNAL   Oncogene 24 (7), 1296-1301 (2005)
   PUBMED   15558014
REFERENCE   3  (bases 1 to 3177)
  AUTHORS   Peng,X., Maruo,T., Cao,Y., Punj,V., Mehta,R., Das Gupta,T.K. and
            Christov,K.
  TITLE     A novel RARbeta isoform directed by a distinct promoter P3 and
            mediated by retinoic acid in breast cancer cells
  JOURNAL   Cancer Res 64 (24), 8911-8918 (2004)
   PUBMED   15604252
REFERENCE   4  (bases 1 to 3177)
  AUTHORS   Jin,P., Fu,G.K., Wilson,A.D., Yang,J., Chien,D., Hawkins,P.R.,
            Au-Young,J. and Stuve,L.L.
  TITLE     PCR isolation and cloning of novel splice variant mRNAs from known
            drug target genes
  JOURNAL   Genomics 83 (4), 566-571 (2004)
   PUBMED   15028279
REFERENCE   5  (bases 1 to 3177)
  AUTHORS   Chen,L.I., Sommer,K.M. and Swisshelm,K.
  TITLE     Downstream codons in the retinoic acid receptor beta -2 and beta -4
            mRNAs initiate translation of a protein isoform that disrupts
            retinoid-activated transcription
  JOURNAL   J Biol Chem 277 (38), 35411-35421 (2002)
   PUBMED   12118004
  REMARK    GeneRIF: downstream codons in mRNAs initiate translation of a
            protein isoform that disrupts retinoid-activated transcription
REFERENCE   6  (bases 1 to 3177)
  AUTHORS   Sommer,K.M., Chen,L.I., Treuting,P.M., Smith,L.T. and Swisshelm,K.
  TITLE     Elevated retinoic acid receptor beta(4) protein in human breast
            tumor cells with nuclear and cytoplasmic localization
  JOURNAL   Proc Natl Acad Sci U S A 96 (15), 8651-8656 (1999)
   PUBMED   10411930
REFERENCE   7  (bases 1 to 3177)
  AUTHORS   Houle,B., Pelletier,M., Wu,J., Goodyer,C. and Bradley,W.E.
  TITLE     Fetal isoform of human retinoic acid receptor beta expressed in
            small cell lung cancer lines
  JOURNAL   Cancer Res 54 (2), 365-369 (1994)
   PUBMED   8275470
REFERENCE   8  (bases 1 to 3177)
  AUTHORS   Bardakjian,T., Weiss,A. and Schneider,A.
  TITLE     Microphthalmia/Anophthalmia/Coloboma Spectrum - RETIRED CHAPTER,
            FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301552
REFERENCE   9  (bases 1 to 3177)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   10 (bases 1 to 3177)
  AUTHORS   Nagpal,S., Zelent,A. and Chambon,P.
  TITLE     RAR-beta 4, a retinoic acid receptor isoform is generated from
            RAR-beta 2 by alternative splicing and usage of a CUG initiator
            codon
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2718-2722 (1992)
   PUBMED   1313565
REFERENCE   11 (bases 1 to 3177)
  AUTHORS   de The,H., Marchio,A., Tiollais,P. and Dejean,A.
  TITLE     A novel steroid thyroid hormone receptor-related gene
            inappropriately expressed in human hepatocellular carcinoma
  JOURNAL   Nature 330 (6149), 667-670 (1987)
   PUBMED   2825037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC133680.2, DA240288.1,
            AC092422.3, DC376623.1, AF157483.1 and BC030234.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001290216.2.
            
            Summary: This gene encodes retinoic acid receptor beta, a member of
            the thyroid-steroid hormone receptor superfamily of nuclear
            transcriptional regulators. This receptor localizes to the
            cytoplasm and to subnuclear compartments. It binds retinoic acid,
            the biologically active form of vitamin A which mediates cellular
            signalling in embryonic morphogenesis, cell growth and
            differentiation. It is thought that this protein limits growth of
            many cell types by regulating gene expression. The gene was first
            identified in a hepatocellular carcinoma where it flanks a
            hepatitis B virus integration site. Alternate promoter usage and
            differential splicing result in multiple transcript variants.
            [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (3, also known as beta-1)
            initiates from an upstream promoter and differs in the 5' UTR and
            5' coding region compared to variant 1. The resulting isoform (3)
            has a longer and different N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2985901.1,
                                           SRR14038196.470958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156670, SAMN03267770
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC133680.2         91197-91279
            84-401              DA240288.1         268-585
            402-465             AC092422.3         160907-160970
            466-991             DC376623.1         39-564
            992-1865            AF157483.1         589-1462
            1866-3177           BC030234.1         1740-3051
FEATURES             Location/Qualifiers
     source          1..3177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..3177
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /note="retinoic acid receptor beta"
                     /db_xref="GeneID:5915"
                     /db_xref="HGNC:HGNC:9865"
                     /db_xref="MIM:180220"
     exon            1..83
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..162
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            163..214
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            215..671
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             494..1861
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     retinoic acid receptor, beta polypeptide; hepatitis B
                     virus activated protein; HBV-activated protein;
                     RAR-epsilon; RAR-beta; nuclear receptor subfamily 1 group
                     B member 2"
                     /codon_start=1
                     /product="retinoic acid receptor beta isoform 3"
                     /protein_id="NP_001277145.1"
                     /db_xref="CCDS:CCDS93227.1"
                     /db_xref="GeneID:5915"
                     /db_xref="HGNC:HGNC:9865"
                     /db_xref="MIM:180220"
                     /translation="MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGL
                     HGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGV
                     SACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRN
                     DRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRV
                     RLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTR
                     YTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICL
                     ICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGA
                     ERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQ
                     SPLVQ"
     exon            672..820
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            821..962
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1123
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1300
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1505
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1664
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..3177
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3161..3166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /note="hexamer: AATATA"
     polyA_site      3177
                     /gene="RARB"
                     /gene_synonym="HAP; MCOPS12; NR1B2; RARbeta; RARbeta1;
                     RRB2"
                     /note="major polyA site"
ORIGIN      
        1 gtctgctctc agcggcggcg gcaggggctg agggcacagc cagcgggcgg cgcgccgcgg
       61 actccaaggc agcccgccaa aagaatcctg aacatcatca taaaaagaca gtcaccagtc
      121 ctgctcatct ggaggactgt tctcacaatc ttcagcaagg agataaaaca gagtactgca
      181 gagatgaagt aacttgccct aagacccata cctgaattaa cagctctgaa atttgaaggt
      241 gctagtgtct cactggtctt aaactgcgaa gctgaacgac gaaagcatcc ttcctgtaat
      301 cagtgtagca aaatgacagg cagagaaacc atgctgggaa gaagcaaggt catcagttga
      361 accatcttga ctttggccca gaacacagct cagcctcaac tcctgcagtg catttgcctc
      421 cctcactttg gtttaagacc tggagtgatg tgttcctgct ccagagcacc tttctttctg
      481 tgaggcccga aacatgacca ccagcggcca cgcatgtccg gtcccagcag tgaacggaca
      541 catgactcac tatccagcca caccctaccc gttactcttt ccacctgtca tcggaggact
      601 ttccctgcct cccctccatg gccttcatgg acatccgcct ccgagtggat gcagcacccc
      661 gtcgccggca acaattgaaa cacagagcac cagctctgag gaactcgtcc caagcccccc
      721 atctccactt cctccccctc gagtgtacaa accctgcttc gtctgccagg acaaatcatc
      781 agggtaccac tatggggtca gcgcctgtga gggatgtaag ggctttttcc gcagaagtat
      841 tcagaagaat atgatttaca cttgtcaccg agataagaac tgtgttatta ataaagtcac
      901 caggaatcga tgccaatact gtcgactcca gaagtgcttt gaagtgggaa tgtccaaaga
      961 atctgtcagg aatgacagga acaagaaaaa gaaggagact tcgaagcaag aatgcacaga
     1021 gagctatgaa atgacagctg agttggacga tctcacagag aagatccgaa aagctcacca
     1081 ggaaactttc ccttcactct gccagctggg taaatacacc acgaattcca gtgctgacca
     1141 tcgagtccga ctggacctgg gcctctggga caaattcagt gaactggcca ccaagtgcat
     1201 tattaagatc gtggagtttg ctaaacgtct gcctggtttc actggcttga ccatcgcaga
     1261 ccaaattacc ctgctgaagg ccgcctgcct ggacatcctg attcttagaa tttgcaccag
     1321 gtatacccca gaacaagaca ccatgacttt ctcagacggc cttaccctaa atcgaactca
     1381 gatgcacaat gctggatttg gtcctctgac tgaccttgtg ttcacctttg ccaaccagct
     1441 cctgcctttg gaaatggatg acacagaaac aggccttctc agtgccatct gcttaatctg
     1501 tggagaccgc caggaccttg aggaaccgac aaaagtagat aagctacaag aaccattgct
     1561 ggaagcacta aaaatttata tcagaaaaag acgacccagc aagcctcaca tgtttccaaa
     1621 gatcttaatg aaaatcacag atctccgtag catcagtgct aaaggtgcag agcgtgtaat
     1681 taccttgaaa atggaaattc ctggatcaat gccacctctc attcaagaaa tgctggagaa
     1741 ttctgaagga catgaaccct tgaccccaag ttcaagtggg aacacagcag agcacagtcc
     1801 tagcatctca cccagctcag tggaaaacag tggggtcagt cagtcaccac tcgtgcaata
     1861 agacattttc tagctacttc aaacattccc cagtaccttc agttccagga tttaaaatgc
     1921 aagaaaaaac atttttactg ctgcttagtt tttggactga aaagatatta aaactcaaga
     1981 aggaccaaga agttttcata tgtatcaata tatatactcc tcactgtgta acttacctag
     2041 aaatacaaac ttttccaatt ttaaaaaatc agccatttca tgcaaccaga aactagttaa
     2101 aagcttctat tttcctcttt gaacactcaa gattgcatgg caaagaccca gtcaaaatga
     2161 tttacccctg gttaagtttc tgaagacttt gtacatacag aagtatggct ctgttctttc
     2221 tatactgtat gtttggtgct ttccttttgt cttgcatact caaaataacc atgacaccaa
     2281 ggttatgaaa tagactactg tacacgtcta cctaggttca aaaagataac tgtcttgctt
     2341 tcatggaata gtcaagacat caaggtaagg aaacaggact attgacagga ctattgtaca
     2401 gtatgacaag ataaggctga agatattcta ctttagttag tatggaagct tgtctttgct
     2461 ctttctgatg ctctcaaact gcatctttta tttcatgttg cccagtaaaa gtatacaaat
     2521 tccctgcact agcagaagag aattctgtat cagtgtaact gccagttcag ttaatcaaat
     2581 gtcatttgtt caattgttaa tgtcacttta aattaaaagt ggtttattac ttgtttaatg
     2641 acataactac acagttagtt aaaaaaaatt tttttacagt aatgatagcc tccaaggcag
     2701 aaacactttt cagtgttaag tttttgttta cttgttcaca agccattagg gaaatttcat
     2761 gggataatta gcaggctggt ctaccacctg gaccatgtaa ctctagtgtc cttcctgatt
     2821 catgcctgat attgggattt ttttttccag ccttcttgat gccaaggggc taattaatat
     2881 taacaactcc caaagaaaca ggcatagaat ctgcctcctt tgaccttgtt caatcactat
     2941 gaagcagagt gaaagctgtg gtagagtggt taacagatac aagtgtcagt ttcttagttc
     3001 tcatttaagc actagtggaa tttttttttt ttgatatatt agcaagtctg tgatgtactt
     3061 tcactggctc tgtttgtaca ttgagattgt ttgtttaaca atgctttcta tgttcatata
     3121 ctgtttacct ttttccatgg agtctcctgg caaagaataa aatatattta ttttaaa
//
