LOCUS       NP_000955                462 aa            linear   PRI 12-JUN-2025
DEFINITION  retinoic acid receptor alpha isoform 1 [Homo sapiens].
ACCESSION   NP_000955
VERSION     NP_000955.1
DBSOURCE    REFSEQ: accession NM_000964.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 462)
  AUTHORS   Xu,Q., Peng,Y., Sun,S., Zhang,Y., Shi,T., Kuang,X., Wu,Y. and
            Zhu,H.H.
  TITLE     Acute promyelocytic leukemia with TTMV::RARA fusion potentially
            responds to all-trans retinoic acid/arsenic trioxide treatment
  JOURNAL   Haematologica 110 (6), 1426-1431 (2025)
   PUBMED   39844766
REFERENCE   2  (residues 1 to 462)
  AUTHORS   Katerndahl,C.D.S., Rogers,O.R.S., Day,R.B., Xu,Z., Helton,N.M.,
            Ramakrishnan,S.M., Miller,C.A. and Ley,T.J.
  TITLE     PML::RARA and GATA2 proteins interact via DNA templates to induce
            aberrant self-renewal in mouse and human hematopoietic cells
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2317690121 (2024)
   PUBMED   38648485
  REMARK    GeneRIF: PML::RARA and GATA2 proteins interact via DNA templates to
            induce aberrant self-renewal in mouse and human hematopoietic
            cells.
REFERENCE   3  (residues 1 to 462)
  AUTHORS   Catalano,A., Dawson,M.A., Somana,K., Opat,S., Schwarer,A.,
            Campbell,L.J. and Iland,H.
  TITLE     The PRKAR1A gene is fused to RARA in a new variant acute
            promyelocytic leukemia
  JOURNAL   Blood 110 (12), 4073-4076 (2007)
   PUBMED   17712046
REFERENCE   4  (residues 1 to 462)
  AUTHORS   Wells,R.A., Catzavelos,C. and Kamel-Reid,S.
  TITLE     Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic
            apparatus protein, by a variant translocation in acute
            promyelocytic leukaemia
  JOURNAL   Nat Genet 17 (1), 109-113 (1997)
   PUBMED   9288109
REFERENCE   5  (residues 1 to 462)
  AUTHORS   Chen,Z., Guidez,F., Rousselot,P., Agadir,A., Chen,S.J., Wang,Z.Y.,
            Degos,L., Zelent,A., Waxman,S. and Chomienne,C.
  TITLE     PLZF-RAR alpha fusion proteins generated from the variant
            t(11;17)(q23;q21) translocation in acute promyelocytic leukemia
            inhibit ligand-dependent transactivation of wild-type retinoic acid
            receptors
  JOURNAL   Proc Natl Acad Sci U S A 91 (3), 1178-1182 (1994)
   PUBMED   8302850
REFERENCE   6  (residues 1 to 462)
  AUTHORS   Baniahmad,A., Kohne,A.C. and Renkawitz,R.
  TITLE     A transferable silencing domain is present in the thyroid hormone
            receptor, in the v-erbA oncogene product and in the retinoic acid
            receptor
  JOURNAL   EMBO J 11 (3), 1015-1023 (1992)
   PUBMED   1347744
REFERENCE   7  (residues 1 to 462)
  AUTHORS   Kastner,P., Perez,A., Lutz,Y., Rochette-Egly,C., Gaub,M.P.,
            Durand,B., Lanotte,M., Berger,R. and Chambon,P.
  TITLE     Structure, localization and transcriptional properties of two
            classes of retinoic acid receptor alpha fusion proteins in acute
            promyelocytic leukemia (APL): structural similarities with a new
            family of oncoproteins
  JOURNAL   EMBO J 11 (2), 629-642 (1992)
   PUBMED   1311253
REFERENCE   8  (residues 1 to 462)
  AUTHORS   Kliewer,S.A., Umesono,K., Mangelsdorf,D.J. and Evans,R.M.
  TITLE     Retinoid X receptor interacts with nuclear receptors in retinoic
            acid, thyroid hormone and vitamin D3 signalling
  JOURNAL   Nature 355 (6359), 446-449 (1992)
   PUBMED   1310351
REFERENCE   9  (residues 1 to 462)
  AUTHORS   de The,H., Lavau,C., Marchio,A., Chomienne,C., Degos,L. and
            Dejean,A.
  TITLE     The PML-RAR alpha fusion mRNA generated by the t(15;17)
            translocation in acute promyelocytic leukemia encodes a
            functionally altered RAR
  JOURNAL   Cell 66 (4), 675-684 (1991)
   PUBMED   1652369
REFERENCE   10 (residues 1 to 462)
  AUTHORS   Brand,N.J., Petkovich,M. and Chambon,P.
  TITLE     Characterization of a functional promoter for the human retinoic
            acid receptor-alpha (hRAR-alpha)
  JOURNAL   Nucleic Acids Res 18 (23), 6799-6806 (1990)
   PUBMED   2175878
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA061829.1, BC008727.2,
            X06614.1 and BM992549.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene represents a nuclear retinoic acid receptor. The
            encoded protein, retinoic acid receptor alpha, regulates
            transcription in a ligand-dependent manner. This gene has been
            implicated in regulation of development, differentiation,
            apoptosis, granulopoeisis, and transcription of clock genes.
            Translocations between this locus and several other loci have been
            associated with acute promyelocytic leukemia. Alternatively spliced
            transcript variants have been found for this locus.[provided by
            RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1). Variants 1 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1168678.1, BC008727.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254066.10/ ENSP00000254066.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     Protein         1..462
                     /product="retinoic acid receptor alpha isoform 1"
                     /note="retinoic acid receptor, alpha polypeptide;
                     nucleophosmin-retinoic acid receptor alpha fusion protein
                     NPM-RAR long form; PML-DDX5-RARA fusion; TTMV/RARA fusion;
                     TTMV/RARA fusion protein; PML-DDX5-RARA fusion protein;
                     RAR-alpha; nuclear receptor subfamily 1 group B member 1"
                     /calculated_mol_wt=50640
     Region          1..87
                     /region_name="Modulating"
                     /note="propagated from UniProtKB/Swiss-Prot (P10276.2)"
     Region          52..77
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10276.2)"
     Site            60..61
                     /site_type="other"
                     /note="Breakpoint for translocation to form
                     PLZF-RAR-alpha, RAR-alpha1-PLZF and PML-RAR-alpha
                     oncogenes; propagated from UniProtKB/Swiss-Prot
                     (P10276.2)"
     Site            77
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK7.
                     /evidence=ECO:0000250|UniProtKB:P11416; propagated from
                     UniProtKB/Swiss-Prot (P10276.2)"
     Region          82..166
                     /region_name="NR_DBD_RAR"
                     /note="DNA-binding domain of retinoic acid receptor (RAR)
                     is composed of two C4-type zinc fingers; cd06964"
                     /db_xref="CDD:143522"
     Site            order(88,91,105,108,124,130,140,143)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143522"
     Site            96
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1.
                     /evidence=ECO:0000269|PubMed:16417524; propagated from
                     UniProtKB/Swiss-Prot (P10276.2)"
     Site            order(98..100,106..107,109,111,113..114,117,137..138,141,
                     144,157..159)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143522"
     Site            order(135,138..141)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:143522"
     Region          154..182
                     /region_name="Hinge"
                     /note="propagated from UniProtKB/Swiss-Prot (P10276.2)"
     Region          186..416
                     /region_name="NR_LBD_RAR"
                     /note="The ligand binding domain (LBD) of retinoic acid
                     receptor (RAR), a members of the nuclear receptor
                     superfamily; cd06937"
                     /db_xref="CDD:132735"
     Site            219
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000269|PubMed:20215566; propagated from
                     UniProtKB/Swiss-Prot (P10276.2)"
     Site            order(228,231..232,235,266,269..270,273,276,286..287,302,
                     394..395,398,414)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132735"
     Site            order(240,244,254,257..258,261..262,408..409,412..413)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132735"
     Region          254..258
                     /region_name="UBR5-degron.
                     /evidence=ECO:0000269|PubMed:37478846"
                     /note="propagated from UniProtKB/Swiss-Prot (P10276.2)"
     Site            order(315,337..338,349,352..353,356..357,360,364,375..376,
                     378..379,382,385..386)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:132735"
     Site            369
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000269|PubMed:20215566; propagated from
                     UniProtKB/Swiss-Prot (P10276.2)"
     Region          404..419
                     /region_name="Required for binding corepressor NCOR1"
                     /note="propagated from UniProtKB/Swiss-Prot (P10276.2)"
     Region          408..416
                     /region_name="9aaTAD.
                     /evidence=ECO:0000269|PubMed:30468856"
                     /note="propagated from UniProtKB/Swiss-Prot (P10276.2)"
     Region          419..462
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10276.2)"
     CDS             1..462
                     /gene="RARA"
                     /gene_synonym="NR1B1; RAR; RARalpha"
                     /coded_by="NM_000964.4:470..1858"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS11366.1"
                     /db_xref="GeneID:5914"
                     /db_xref="HGNC:HGNC:9864"
                     /db_xref="MIM:180240"
ORIGIN      
        1 masnssscpt pggghlngyp vppyafffpp mlgglsppga lttlqhqlpv sgystpspat
       61 ietqssssee ivpsppsppp lpriykpcfv cqdkssgyhy gvsacegckg ffrrsiqknm
      121 vytchrdknc iinkvtrnrc qycrlqkcfe vgmskesvrn drnkkkkevp kpecsesytl
      181 tpevgeliek vrkahqetfp alcqlgkytt nnsseqrvsl didlwdkfse lstkciiktv
      241 efakqlpgft tltiadqitl lkaacldili lrictrytpe qdtmtfsdgl tlnrtqmhna
      301 gfgpltdlvf afanqllple mddaetglls aiclicgdrq dleqpdrvdm lqepllealk
      361 vyvrkrrpsr phmfpkmlmk itdlrsisak gaervitlkm eipgsmppli qemlensegl
      421 dtlsgqpggg grdggglapp pgscspslsp ssnrsspath sp
//
