LOCUS       XM_017003197            3816 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens Rap guanine nucleotide exchange factor 4
            (RAPGEF4), transcript variant X5, mRNA.
ACCESSION   XM_017003197
VERSION     XM_017003197.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017003197.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..3816
                     /gene="RAPGEF4"
                     /gene_synonym="CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2;
                     Nbla00496"
                     /note="Rap guanine nucleotide exchange factor 4; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 50 ESTs, 571 long SRA reads, 5 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 12 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:11069"
                     /db_xref="HGNC:HGNC:16626"
                     /db_xref="MIM:606058"
     CDS             141..2690
                     /gene="RAPGEF4"
                     /gene_synonym="CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2;
                     Nbla00496"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 4 isoform
                     X5"
                     /protein_id="XP_016858686.1"
                     /db_xref="GeneID:11069"
                     /db_xref="HGNC:HGNC:16626"
                     /db_xref="MIM:606058"
                     /translation="MLYKKYRQYMAGLLAPPYGVMETGSNNDRIPDKENVPSEKILRA
                     GKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQV
                     LLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQM
                     GPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKG
                     GTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVL
                     REDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQ
                     KYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHY
                     HAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDD
                     ARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEV
                     LFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDV
                     SVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWE
                     LFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLL
                     KKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDP
                     SRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
                     VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP"
ORIGIN      
        1 cctttctgtg gactgagagc cactcagtag tagacacgaa cagggaatga acggcaatga
       61 aggtacattt tgctgatcaa ataaaggata gatgctcact ggatgtctga gaactttgag
      121 agaccgaaaa agaaggacgt atgctctaca agaaatatcg acagtatatg gcaggacttc
      181 tggctcctcc ttatggtgtt atggaaacgg gctctaacaa tgacaggatt cctgacaagg
      241 agaacgtccc ttcagagaag atcctcagag ctggaaaaat tttacgaaat gccattctct
      301 ctcgagcacc tcacatgata agagatagaa aataccacct aaagacatac agacaatgct
      361 gtgtgggaac tgaactggtg gactggatga tgcagcagac accatgtgtt cactcccgga
      421 ctcaagctgt tggcatgtgg caagtcctgt tagaagatgg tgttctcaac cacgtggacc
      481 aggagcacca tttccaagac aaatatttat tctatcgatt tctggatgat gagcacgagg
      541 atgccccttt gcctactgag gaggagaaga aggagtgtga tgaggagctc caggacacca
      601 tgctgctgct gtcacagatg ggccccgacg cccacatgag gatgatcctt cgcaaaccac
      661 ctggccagag gactgtggat gacctagaga ttatctatga ggagcttctt catattaaag
      721 ccttatccca tctttctacc acagtgaaac gagagttagc aggtgttctc atttttgagt
      781 ctcacgccaa aggagggact gtgttgttta accaggggga agaaggtacc tcctggtaca
      841 ttattctaaa aggatcagtg aatgtagtca tttacggcaa gggtgtggtc tgcaccctgc
      901 atgaaggaga tgacttcggc aagttagcac tagtgaatga tgccccacga gctgcctcta
      961 tcgtcttacg agaagataac tgccatttct taagagtaga caaggaggat ttcaaccgga
     1021 tcctaaggga cgtggaggcg aatacagtca gacttaaaga acatgaccaa gatgtcttgg
     1081 tgctggagaa ggtcccagca gggaacagag cttctaatca aggaaactca cagcctcagc
     1141 aaaagtatac tgtgatgtca ggaacacctg aaaaaatttt agagcatttt ctagaaacaa
     1201 tacgccttga ggcaacttta aatgaagcaa cagattctgt tttaaatgac tttattatga
     1261 tgcactgtgt ttttatgcca aatacccagc tttgcccggc actggtggcc cactaccacg
     1321 cacagccttc acaaggtaca gaacaggaga aaatggatta tgccctcaac aataagaggc
     1381 gagtcatccg cctggttcta cagtgggctg ccatgtatgg agacctcctg caagaggatg
     1441 acgtgtctat ggccttcctg gaggagtttt atgtatctgt atcagatgat gcccggatga
     1501 ttgctgccct caaggagcaa ctgccagagt tggagaagat tgtcaagcaa atctcagaag
     1561 atgcaaaggc accacaaaag aagcacaagg ttcttttgca acagttcaat acgggcgatg
     1621 agagagccca gaagcgccag cctatccgcg gctctgatga agttctgttt aaggtctatt
     1681 gcatggacca cacctacaca accattcggg tgccagtggc cacttcggtg aaggaagtca
     1741 tcagtgcagt tgccgacaag ctgggctccg gggagggcct gatcatagtc aagatgagtt
     1801 ccggaggaga aaaggtggtg ctcaaaccta atgatgtttc agtatttacg acgctcacca
     1861 ttaatggacg cctgtttgct tgcccgcgag agcaattcga ttcactgact cccttaccag
     1921 aacaggaagg cccaactgtt ggaacagtgg gaacttttga actgatgagc tccaaagatt
     1981 tagcatacca gatgacaatt tatgattggg aactcttcaa ctgcgtgcat gagctggagc
     2041 taatctatca cacatttgga aggcataatt ttaaaaagac cacagcaaac ttggatttgt
     2101 tcctgaggag atttaatgaa attcagtttt gggtcgtcac tgagatctgc ctttgttctc
     2161 agctcagcaa gcgtgttcag ctattaaaaa aatttattaa gatagcagcc cactgtaagg
     2221 agtataaaaa tctgaattcc ttttttgcca tcgtcatggg actaagtaac gttgctgtga
     2281 gccgcttggc actaacgtgg gagaaactgc caagcaagtt caagaagttc tatgcggagt
     2341 ttgaaagttt aatggaccct tcaaggaacc acagggccta caggctgaca gtagctaagc
     2401 tggaacctcc tctcatcccc ttcatgcctt tgctcattaa agatatgaca tttactcatg
     2461 aggggaacaa gacgttcatt gacaatctag taaactttga aaaaatgcgc atgattgcaa
     2521 atacggccag aacagtgaga tactacagga gccaaccctt caatcctgat gcagctcaag
     2581 ctaataagaa ccatcaggat gtccggagtt atgtacggca attaaatgtg attgacaacc
     2641 agagaacttt atcacagatg tcacacagat tagagcctcg tcgaccatag acatttcaaa
     2701 tgcccaaagc aacagtttgt ctccagtcca caatctttca aaaatgccat ttatgctact
     2761 actgactgta ttgccactag agaattctac aaaacaagca aaaacacatc ctgagacacc
     2821 tcagggctgc attcagctta ccagctacct agcaagagaa ggaattattt gacatgccta
     2881 aagcttacac actctagctt aggaatcccc agtttgtggc taccctgttt catttccact
     2941 tgtgccatct tctttgctga agtgttgaat aaggcccacg tgaagagttt ggtagaaata
     3001 gccttgtcaa gagaactagc aagcccctga catttttttc taagagtgtt tatgggatga
     3061 gatgtgctac aaatgggata gatttggata aaattttaac tcaacatctt gatttggagc
     3121 ctggggtttc gggaaggtgt tgaggaatct atagaagtcc aaattatagg ttgtattctt
     3181 ccatcttcat tgtcttacct ctgaaggaat agaacctgac cacattatta tgaaacatta
     3241 tggctgttta tgtaatttag ggaggactgg tctgtaattt ctgaatgtat atagaataat
     3301 atttatgttt acaatgtaac ttttcaaaat ttacaaatca ggattatata cataagaatt
     3361 ccactaagaa atgccaagat tcttaaattt gccagcgtta aagtagaaaa taacatttca
     3421 gaagagcaca atatgcataa aacatttttc aaaattgaaa tattttcctg ggcattaaaa
     3481 acctttacta ttggctacaa atttattgta cctgatgaaa acatattttc tggacttaaa
     3541 tgttattaca aatatcttaa ttttcagtaa ttgttttgca ctttcaaaga ttgtaaatag
     3601 ttcattcaat caatggtatg gagttattta tttgctacat aatagatact gtgccaaata
     3661 attacttttt atttatttta tttagtacgt aattttgaag tacatttttt cctgttttca
     3721 caattagact acatttaatg tgtaggaatt gtatgtatgt atatcttctg taaataacat
     3781 ctagtatctt cactaaatat aattgtcgac aagaaa
//
