LOCUS       NM_001394067            8101 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens Rap guanine nucleotide exchange factor 2 (RAPGEF2),
            transcript variant 7, mRNA.
ACCESSION   NM_001394067 XM_005263360
VERSION     NM_001394067.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8101)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 8101)
  AUTHORS   Jang,Y.N., Jang,H., Kim,G.H., Noh,J.E., Chang,K.A. and Lee,K.J.
  TITLE     RAPGEF2 mediates oligomeric Abeta-induced synaptic loss and
            cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's
            disease
  JOURNAL   Neuropathol Appl Neurobiol 47 (5), 625-639 (2021)
   PUBMED   33345400
  REMARK    GeneRIF: RAPGEF2 mediates oligomeric Abeta-induced synaptic loss
            and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's
            disease.
REFERENCE   3  (bases 1 to 8101)
  AUTHORS   Zhu,B., Cao,A., Li,J., Young,J., Wong,J., Ashraf,S., Bierzynska,A.,
            Menon,M.C., Hou,S., Sawyers,C., Campbell,K.N., Saleem,M.A.,
            He,J.C., Hildebrandt,F., D'Agati,V.D., Peng,W. and Kaufman,L.
  TITLE     Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte
            dysfunction in congenital nephrotic syndrome caused by mutations in
            MAGI2
  JOURNAL   Kidney Int 96 (3), 642-655 (2019)
   PUBMED   31171376
  REMARK    GeneRIF: Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to
            podocyte dysfunction in congenital nephrotic syndrome caused by
            mutations in MAGI2.
REFERENCE   4  (bases 1 to 8101)
  AUTHORS   Kim,T.Y., Siesser,P.F., Rossman,K.L., Goldfarb,D., Mackinnon,K.,
            Yan,F., Yi,X., MacCoss,M.J., Moon,R.T., Der,C.J. and Major,M.B.
  TITLE     Substrate trapping proteomics reveals targets of the
            betaTrCP2/FBXW11 ubiquitin ligase
  JOURNAL   Mol Cell Biol 35 (1), 167-181 (2015)
   PUBMED   25332235
  REMARK    GeneRIF: SCF(FBXW11) bound, polyubiquitylated, and destabilized
            RAPGEF2, a guanine nucleotide exchange factor that activates the
            small GTPase RAP1
REFERENCE   5  (bases 1 to 8101)
  AUTHORS   Ye,T., Ip,J.P., Fu,A.K. and Ip,N.Y.
  TITLE     Cdk5-mediated phosphorylation of RapGEF2 controls neuronal
            migration in the developing cerebral cortex
  JOURNAL   Nat Commun 5, 4826 (2014)
   PUBMED   25189171
  REMARK    GeneRIF: Cdk5-mediated phosphorylation of RapGEF2 controls neuronal
            migration in the developing cerebral cortex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8101)
  AUTHORS   Rebhun,J.F., Castro,A.F. and Quilliam,L.A.
  TITLE     Identification of guanine nucleotide exchange factors (GEFs) for
            the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction
  JOURNAL   J Biol Chem 275 (45), 34901-34908 (2000)
   PUBMED   10934204
REFERENCE   7  (bases 1 to 8101)
  AUTHORS   Pham,N., Cheglakov,I., Koch,C.A., de Hoog,C.L., Moran,M.F. and
            Rotin,D.
  TITLE     The guanine nucleotide exchange factor CNrasGEF activates ras in
            response to cAMP and cGMP
  JOURNAL   Curr Biol 10 (9), 555-558 (2000)
   PUBMED   10801446
  REMARK    Erratum:[Curr Biol 2000 Jul 27-Aug 10;10(15):R577-8]
REFERENCE   8  (bases 1 to 8101)
  AUTHORS   de Rooij,J., Boenink,N.M., van Triest,M., Cool,R.H.,
            Wittinghofer,A. and Bos,J.L.
  TITLE     PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1
            and Rap2
  JOURNAL   J Biol Chem 274 (53), 38125-38130 (1999)
   PUBMED   10608883
REFERENCE   9  (bases 1 to 8101)
  AUTHORS   Liao,Y., Kariya,K., Hu,C.D., Shibatohge,M., Goshima,M., Okada,T.,
            Watari,Y., Gao,X., Jin,T.G., Yamawaki-Kataoka,Y. and Kataoka,T.
  TITLE     RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing
            a Ras/Rap1A-associating domain, is conserved between nematode and
            humans
  JOURNAL   J Biol Chem 274 (53), 37815-37820 (1999)
   PUBMED   10608844
REFERENCE   10 (bases 1 to 8101)
  AUTHORS   Ohtsuka,T., Hata,Y., Ide,N., Yasuda,T., Inoue,E., Inoue,T.,
            Mizoguchi,A. and Takai,Y.
  TITLE     nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G
            protein that interacts with synaptic scaffolding molecule (S-SCAM)
  JOURNAL   Biochem Biophys Res Commun 265 (1), 38-44 (1999)
   PUBMED   10548487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC095064.3, AC105316.5 and AC074344.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2021 this sequence version replaced NM_001394067.1.
            
            Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of
            GTPases function in signal transduction as GTP/GDP-regulated
            switches that cycle between inactive GDP- and active GTP-bound
            states. Guanine nucleotide exchange factors (GEFs), such as
            RAPGEF2, serve as RAS activators by promoting acquisition of GTP to
            maintain the active GTP-bound state and are the key link between
            cell surface receptors and RAS activation (Rebhun et al., 2000
            [PubMed 10934204]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000691494.1/ ENSP00000510694.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1153              AC095064.3         33368-34520
            1154-1224           AC105316.5         30988-31058
            1225-1281           AC105316.5         37546-37602
            1282-1365           AC105316.5         54846-54929
            1366-1441           AC105316.5         83155-83230
            1442-1609           AC105316.5         85547-85714
            1610-1627           AC105316.5         88120-88137
            1628-1759           AC074344.5         2117-2248
            1760-1937           AC074344.5         12366-12543
            1938-2074           AC074344.5         20122-20258
            2075-2233           AC074344.5         21234-21392
            2234-2386           AC074344.5         27633-27785
            2387-2551           AC074344.5         28109-28273
            2552-2659           AC074344.5         29206-29313
            2660-2863           AC074344.5         29405-29608
            2864-2972           AC074344.5         29701-29809
            2973-3219           AC074344.5         30226-30472
            3220-3377           AC074344.5         36086-36243
            3378-3618           AC074344.5         36889-37129
            3619-4002           AC074344.5         39339-39722
            4003-4214           AC074344.5         40754-40965
            4215-4338           AC074344.5         41056-41179
            4339-4362           AC074344.5         41811-41834
            4363-4586           AC074344.5         42881-43104
            4587-4796           AC074344.5         44564-44773
            4797-4949           AC074344.5         47912-48064
            4950-5175           AC074344.5         50460-50685
            5176-5735           AC074344.5         51262-51821
            5736-6041           AC074344.5         53628-53933
            6042-8101           AC074344.5         55889-57948
FEATURES             Location/Qualifiers
     source          1..8101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..8101
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /note="Rap guanine nucleotide exchange factor 2"
                     /db_xref="GeneID:9693"
                     /db_xref="HGNC:HGNC:16854"
                     /db_xref="MIM:609530"
     exon            1..1153
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             1085..6067
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /note="isoform 6 is encoded by transcript variant 7; PDZ
                     domain containing guanine nucleotide exchange factor (GEF)
                     1; RA(Ras/Rap1A-associating)-GEF; cyclic nucleotide ras
                     GEF; ras/Rap1-associating GEF-1; neural RAP guanine
                     nucleotide exchange protein; PDZ domain-containing guanine
                     nucleotide exchange factor 1; Rap guanine nucleotide
                     exchange factor (GEF) 2"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 2 isoform
                     6"
                     /protein_id="NP_001380996.1"
                     /db_xref="CCDS:CCDS93662.1"
                     /db_xref="GeneID:9693"
                     /db_xref="HGNC:HGNC:16854"
                     /db_xref="MIM:609530"
                     /translation="MASYVDNSFRQAVMKNPPERTPQDLEIVYSYLHGMEALSNLREH
                     QLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGS
                     FRRGCECIVLEPSEMIVVDYMDENEEYFQRQASHRQSRRRFRKINQKGERQTIIDTVD
                     PYPMGKPPLPRGYHTECTKSQLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSS
                     SLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDP
                     IDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSW
                     SVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDY
                     CRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSV
                     VDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGD
                     PAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGS
                     EKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITV
                     KTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKK
                     SKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVS
                     GTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQA
                     IREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETET
                     LCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTS
                     CANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAII
                     SGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPL
                     FPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKK
                     WRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE
                     LEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQ
                     PPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKK
                     QAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNFSDSGHSEISSRSSIVSNSS
                     FDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEGRGLYAT
                     ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFG
                     HTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYW
                     GEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAVASSTTKGLIAR
                     KEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSS
                     VQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV"
     exon            1154..1224
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1281
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1365
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1441
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1609
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1627
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1759
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1937
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2074
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2233
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2386
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2551
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2659
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2863
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2972
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3219
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3377
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3618
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..4002
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4214
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4215..4338
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4339..4362
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4363..4586
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4587..4796
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4797..4949
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4950..5175
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            5176..5735
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            5736..6041
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     exon            6042..8101
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8062..8067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /note="hexamer: AATAAA"
     regulatory      8073..8078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /note="hexamer: CATAAA"
     polyA_site      8078
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
                     /note="major polyA site"
     polyA_site      8101
                     /gene="RAPGEF2"
                     /gene_synonym="CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1;
                     PDZGEF1; RA-GEF; RA-GEF-1; RAGEF; Rap-GEP"
ORIGIN      
        1 gaggagcggc tccggcggcc ggagaaggcg caggaggagg aagaggcgga ggaagaggag
       61 gggaatcgcc gcttcccaaa cactctctcc gagggggctg tgcgcggctc tcggctttcg
      121 gccctcggac gcccgcgccg ggagtccgaa cccgggctgt ccgcggcccc ctcttccccc
      181 tcctccgccc cgcgcagacg aggaacaaag ttgccgagag cgactgggcc ggagggctgc
      241 agcccgggcc gggtgctctg gccgcggcgg cgccggcgcc ggggcagctc cgctccgggc
      301 gcgctgatgg ggggaggcgg cggcggcgga gcccacagcg gcggcccgag cagcagaggc
      361 ggcggcggcg gcggctgggc ggcccgaggg gatgcagcag cagtcgggag ggacggccga
      421 gcccagtaga cagagaccag gagcggcggc cgaggcgatc gggcttcgca gcgcccggac
      481 ctgagccaga cccacctggt ccgtcctccc gaccggcggc cgaggcgccc gaggactggg
      541 gacgcggaag atccaagtga ttctcggaga cccctgggcg gcggctgcgc aagcccctga
      601 gaggaggggg cgaccctcag cgccgtgggg gaggaggctc cgcctgccca cagccctccc
      661 cactgccact cgtacctccc taaaaataac tcgggcccgc tggggccagg aggagccgcc
      721 actgtccccc gagtggagcc ggggaggcgt gtcgagccag ggccggagga agccggcgga
      781 gcggcgagga agaggaggag gaggaggaag gggagttccg cctgcgggcc gcatcgcacg
      841 gcagcctagg ggcgccgcga ccctcccggc tgcgtccagc ccctcgcgcc tgtaccgcgc
      901 tctcggccgc cgggcccagc cgagccgccc ccccgcgggc cccgcgccgc cgccgccgcg
      961 gtttggctga ttagtcgcgg gcgggcgggc gggcgcagcg cgcagggcgg aggcagcagc
     1021 ggcgctgggc cgggaggagg ccggccaggg tgcggagcgg ccccggcccg ctcccagagg
     1081 ggagatggcg tcctacgtag ataacagctt ccgccaggcg gtgatgaaga atccccccga
     1141 aaggaccccc caggatctgg aaatagtata ttcctattta catggtatgg aagccttatc
     1201 aaacttgagg gagcatcaac ttaggttaat gtgtgaaact gtgagatatg agagacacga
     1261 agcaaatgaa gttttatact accctgatga tattgggacc tgctggtata tccttctttc
     1321 tggttccgtg ttcatcaagg aatccatgtt tcttccaaga agcagttttg gcaagcgttc
     1381 tgcaggaagt tttaggcgtg gctgtgaatg cattgtttta gagccttctg aaatgattgt
     1441 ggtggactat atggatgaaa atgaagaata ttttcagcgg caagcttccc atagacagtc
     1501 tcgaaggaga tttagaaaaa tcaaccagaa aggtgaaaga caaacaatta ttgacactgt
     1561 ggatccttat cccatgggca aacctccttt gcctagaggc tatcacacgg aatgcactaa
     1621 atctcagctt cctgcagatt tcacaaaact gcatcttact gacagtctcc acccacaggt
     1681 gacccacgtt tcttctagcc attcaggatg tagtatcact agtgattctg ggagcagcag
     1741 tctttctgat atctaccagg ccacagaaag cgaggctggt gatatggacc tgagtgggtt
     1801 gccagaaaca gcagtggatt ccgaagacga cgacgatgaa gaagacattg agagagcatc
     1861 agatcctctg atgagcaggg acattgtgag agactgccta gagaaggacc caattgaccg
     1921 gacagatgat gacattgaac aactcttgga atttatgcac cagttgcctg cttttgccaa
     1981 tatgacaatg tcagtgaggc gagaactctg tgctgtgatg gtgttcgcag tggtggaaag
     2041 agcagggacc atagtgttaa atgatggtga agagctggac tcctggtcag tgattctcaa
     2101 tggatctgtg gaagtgactt atccagatgg aaaagcagaa atactgtgca tgggaaatag
     2161 ttttggtgtc tctcctacca tggacaaaga atacatgaaa ggagtgatga gaacaaaggt
     2221 ggatgactgc cagtttgtct gcatagccca gcaagattac tgccgtattc tcaatcaagt
     2281 agaaaagaac atgcaaaaag ttgaagagga aggagagatt gttatggtga aagaacaccg
     2341 agaacttgat cgaactggaa caagaaaggg acacattgtc atcaagggta cctcagaaag
     2401 gttaacaatg catttggtgg aagagcattc agtagtagat ccaacattca tagaagactt
     2461 tctgttgacc tataggactt ttctttctag cccaatggaa gtgggcaaaa agttattgga
     2521 gtggtttaat gacccgagcc tcagggataa ggttacacgg gtagtattat tgtgggtaaa
     2581 taatcacttc aatgactttg aaggagatcc tgcaatgact cgatttttag aagaatttga
     2641 aaacaatctg gaaagagaga aaatgggtgg acacctaagg ctgttgaata tcgcgtgtgc
     2701 tgctaaagca aaaagaagat tgatgacgtt aacaaaacca tcccgagaag ctcctttgcc
     2761 ttttatctta cttggaggct ctgagaaggg atttggaatc tttgttgaca gtgtagattc
     2821 aggtagcaaa gcaactgaag caggcttgaa acggggggat cagatattag aagtaaatgg
     2881 ccaaaacttt gaaaacattc agctgtcaaa agctatggaa attcttagaa ataacacaca
     2941 tttatctatc actgtgaaaa ccaatttatt tgtatttaaa gaacttctaa caagattgtc
     3001 agaagagaaa agaaatggtg ccccccacct tcctaaaatt ggtgacatta aaaaggccag
     3061 tcgctactcc attccagatc ttgctgtaga tgtagaacag gtgataggac ttgaaaaagt
     3121 gaacaaaaaa agtaaagcca acactgtggg aggaaggaac aagctgaaaa agatactcga
     3181 caagactcgg atcagtatct tgccacagaa accatacaat gatattggga ttggtcagtc
     3241 tcaagatgac agcatagtag gattaaggca gacaaagcac atcccaactg cattgcctgt
     3301 cagtggaacc ttatcatcca gtaatcctga tttattgcag tcacatcatc gcattttaga
     3361 cttcagtgct actcctgact tgccagatca agtgctaagg gtttttaagg ctgatcagca
     3421 aagccgctac atcatgatca gtaaggacac tacagcaaag gaagtggtca ttcaggctat
     3481 cagggagttt gctgttactg ccaccccgga tcaatattca ctatgtgagg tctctgtcac
     3541 acctgaggga gtaatcaaac aaagaagact tccagatcag ctttccaaac ttgcagacag
     3601 aatacaactg agtggaaggt attatctgaa aaacaacatg gaaacagaaa ctctttgttc
     3661 agatgaagat gctcaggagt tgttgagaga gagtcaaatt tccctccttc agctcagcac
     3721 tgtggaagtt gcaacacagc tctctatgcg aaattttgaa ctctttcgca acattgaacc
     3781 tactgaatat atagatgatt tatttaaact cagatcaaaa accagctgtg ccaacctgaa
     3841 gagatttgaa gaagtcatta accaggaaac attttgggta gcatctgaaa ttctcagaga
     3901 aacaaaccag ctgaagagga tgaagatcat taagcatttc atcaagatag cactgcactg
     3961 tagggaatgc aagaatttta actcaatgtt tgcaatcatc agtggcctaa acctggcacc
     4021 agtggcaaga ctgcgaacga cctgggagaa acttcccaat aaatacgaaa aactatttca
     4081 agatctccaa gacctgtttg atccttccag aaacatggca aaatatcgta atgttctcaa
     4141 tagtcaaaat ctacaacctc ccataatccc tctattccca gttatcaaaa aggatctcac
     4201 cttccttcac gaaggaaatg actcaaaagt agacgggctg gtcaattttg agaagctaag
     4261 gatgattgca aaagaaattc gtcacgttgg ccgaatggct tcagtgaaca tggaccctgc
     4321 cctcatgttc aggactcgga agaagaaatg gcggagtttg gggtctctca gccagggtag
     4381 tacaaatgca acagtgctag atgttgctca gacaggtggt cataaaaagc gggtacgtcg
     4441 tagttccttt ctcaatgcca aaaagcttta tgaagatgcc caaatggctc gaaaagtgaa
     4501 gcagtacctt tccaatttgg agctagaaat ggacgaggag agtcttcaga cattatctct
     4561 gcagtgtgag ccagcaacca acacattgcc taagaatcct ggtgacaaaa agcctgtcaa
     4621 atccgagacc tctccagtag ctccaagggc agggtcacaa cagaaagctc agtccctgcc
     4681 acagccccag cagcagccac caccagcaca taaaatcaac cagggactac aggttcccgc
     4741 cgtgtccctt tatccttcac ggaagaaagt gcccgtaaag gatctcccac cttttggcat
     4801 aaactctcca caagctttaa aaaaaattct ttctttgtct gaagaaggaa gtttggaacg
     4861 tcacaagaaa caggctgaag atacaatatc aaatgcatct tcgcagcttt cttctcctcc
     4921 tacttctcca cagagttctc caaggaaagg ctatactttg gctcccagtg gtactgtgga
     4981 taatttttca gattctggtc acagtgaaat ttcttcacga tccagtattg ttagcaattc
     5041 gtcttttgac tcagtgccag tctcactgca cgatgagagg cgccagaggc attctgtcag
     5101 catcgtggaa acaaacctag ggatgggcag gatggagagg cggaccatga ttgaacctga
     5161 tcagtatagc ttggggtcct atgcaccaat gtccgagggc cgaggcttat atgctacagc
     5221 tacagtaatt tcttctccaa gcacagagga actttcccag gatcaggggg atcgcgcgtc
     5281 acttgatgct gctgacagtg gccgtgggag ctggacgtca tgctcaagtg gctcccatga
     5341 taatatacag acgatccagc accagagaag ctgggagact cttccattcg ggcatactca
     5401 ctttgattat tcaggggatc ctgcaggttt atgggcatca agcagccata tggaccaaat
     5461 tatgttttct gatcatagca caaagtataa caggcaaaat caaagtagag agagccttga
     5521 acaagcccag tcccgagcaa gctgggcgtc ttccacaggt tactggggag aagactcaga
     5581 aggtgacaca ggcacaataa agcggagggg tggaaaggat gtttccattg aagccgaaag
     5641 cagtagccta acgtctgtga ctacggaaga aaccaagcct gtccccatgc ctgcccacat
     5701 agctgtggca tcaagtacta caaaggggct cattgcacga aaggagggca ggtatcgaga
     5761 gcccccgccc acccctcccg gctacattgg aattcccatt actgactttc cagaagggca
     5821 ctcccatcca gccaggaaac cgccggacta caacgtggcc cttcagagat cgcggatggt
     5881 cgcacgatcc tccgacacag ctgggccttc atccgtacag cagccacatg ggcatcccac
     5941 cagcagcagg cctgtgaaca aacctcagtg gcataaaccg aacgagtctg acccgcgcct
     6001 cgccccctat cagtcccaag ggttttccac cgaggaggat gaagatgaac aagtttctgc
     6061 tgtttgaggc acagactttt ctggaagcag agcgagccac ctgaaaggag agcacaagaa
     6121 gacgtcctga gcattggagc cttggaactc acattctgag gacggtggac cagtttgcct
     6181 ccttccctgc cttaaaagca gcatggggct tcttctcccc ttcttccttt cccctttgca
     6241 tgtgaaatac tgtgaagaaa ttgccctggc acttttcaga ctttgttgct tgaaatgcac
     6301 agtgcagcaa tcttcgagct cccactgttg ctgcctgcca catcacacag tatcattcca
     6361 aattccaaga tcatcacaac aagatgattc actctggctg cacttctcaa tgcctggaag
     6421 gatttttttt aatcttcctt ttagatttca atccagtcct agcacttgat ctcattggga
     6481 taatgagaaa agctagccat tgaactactt ggggccttta acccaccaag gaagacaaag
     6541 aaaaacaatg aaatcctttg agtacagtgc ttgtccactt gtttacaatg tcctcctttt
     6601 aaaaaaaaaa aatgagttta aagattttgt tcagagagta aatatatatc catttaatga
     6661 ttacagtatt attttaaacc ttaagtaggg ttgccagcct ggtttctgaa aaaccaaata
     6721 tgccggacag ggtgtggcca caccaagaag acgggaagac ctggcttgtg accctggctt
     6781 cccatgtcct tctggtctca cccgcgaagt gccctatcct ggaagtatga aatgttagcc
     6841 aattaatacc aagacacctc atctgctcct tccccagtgg atggggttct tctgtaaaac
     6901 tgtttgcaca tggccagggg agggaactag gacccttgtg tcctgtctga gccttatgga
     6961 ggcaggacgg tgtcattggc ggatgtgtcc tgctccattg agatggatgg caaaccccat
     7021 ttttaagtta tatttctttg atttttgtta atttagaggt gtaggttttg ttttttgttt
     7081 ttttgttttt ttttaagaga aacatttata actggatagc attgcagtga aagcagcttg
     7141 ggatgttgga gctaatgcca gctgtttata ctgctctttc aagacagcct ccctttattg
     7201 aattggcatt agggaataaa caagccttta aacgtgataa aagatcaaaa acctggttag
     7261 acatgccagc ctttgcaagg caggttagtc accaaagact aacctccaag tggctttatg
     7321 gacgctgcat atagagaagg cctaagtgta gcaaccatct gctcacagct gctattaacc
     7381 ctataatgac tgaaatgacc cctccactct atttttgtgt tgttttgcac agactccgga
     7441 aaagtgaagg ctgccaatct gagtagtact caaatgtgag gaactgctgg tcttggattt
     7501 tttttccatt aaattcagct gatcatattg atcagtagat aaacgtaaat agcttcaaat
     7561 tttaaaagtg gaattgcagt gttttttcac tgtatcaaac aatgtcagtg ctttatttaa
     7621 taattctctt ctgtatcatg gcatttgtct acttgcttat tacattgtca attatgcatt
     7681 tgtaatttta catgtaatat gcattatttg ccagttttat tatataggct atggacctca
     7741 tgtgcatata gaaagacaga aatctagctc taccacaagt tgcacaaatg ttatctaagc
     7801 attaagtaat tgtagaacat aggactgcta atctcagttc gctctgtgat gtcaagtgca
     7861 gaatgtacaa ttaactggtg atttcctcat acttttgata ctacttgtac ctgtatgtct
     7921 tttagaaaga cattggtgga gtctgtatcc cttttgtatt tttaatacaa taattgtaca
     7981 tattggttat atttttgttg aagatggtag aaatgtacta tgtttatgct tctacatcca
     8041 gtttgtacaa gctggaaaat aaataaatat aacataaagc cttgcctata ttcttaatga
     8101 a
//
