LOCUS       NM_001271186            3972 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RAP2C, member of RAS oncogene family (RAP2C),
            transcript variant 1, mRNA.
ACCESSION   NM_001271186
VERSION     NM_001271186.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3972)
  AUTHORS   Gambi,G., Mengus,G., Davidson,G., Demesmaeker,E., Cuomo,A.,
            Bonaldi,T., Katopodi,V., Malouf,G.G., Leucci,E. and Davidson,I.
  TITLE     The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and
            Promote Resistance to MAPK Inhibition in Melanoma
  JOURNAL   Cancer Res 82 (24), 4555-4570 (2022)
   PUBMED   36214632
  REMARK    GeneRIF: The LncRNA LENOX Interacts with RAP2C to Regulate
            Metabolism and Promote Resistance to MAPK Inhibition in Melanoma.
REFERENCE   2  (bases 1 to 3972)
  AUTHORS   Cao,J., Jiang,M., Ren,H. and Xu,K.
  TITLE     MicroRNA-200c-3p suppresses intervertebral disc degeneration by
            targeting RAP2C/ERK signaling
  JOURNAL   Mol Med Rep 24 (6) (2021)
   PUBMED   34676879
  REMARK    GeneRIF: MicroRNA200c3p suppresses intervertebral disc degeneration
            by targeting RAP2C/ERK signaling.
REFERENCE   3  (bases 1 to 3972)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3972)
  AUTHORS   Tong,J., Lu,J., Yin,Y., Wang,Y. and Zhang,K.
  TITLE     microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via
            Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction
  JOURNAL   Technol Cancer Res Treat 19, 1533033820977546 (2020)
   PUBMED   33302819
  REMARK    GeneRIF: microRNA-195 Promotes Small Cell Lung Cancer Cell
            Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal
            Transduction.
REFERENCE   5  (bases 1 to 3972)
  AUTHORS   Chan,L.N., Hart,C., Guo,L., Nyberg,T., Davies,B.S., Fong,L.G.,
            Young,S.G., Agnew,B.J. and Tamanoi,F.
  TITLE     A novel approach to tag and identify geranylgeranylated proteins
  JOURNAL   Electrophoresis 30 (20), 3598-3606 (2009)
   PUBMED   19784953
REFERENCE   6  (bases 1 to 3972)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 3972)
  AUTHORS   Lilljebjorn,H., Heidenblad,M., Nilsson,B., Lassen,C., Horvat,A.,
            Heldrup,J., Behrendtz,M., Johansson,B., Andersson,A. and
            Fioretos,T.
  TITLE     Combined high-resolution array-based comparative genomic
            hybridization and expression profiling of ETV6/RUNX1-positive acute
            lymphoblastic leukemias reveal a high incidence of cryptic Xq
            duplications and identify several putative target genes within the
            commonly gained region
  JOURNAL   Leukemia 21 (10), 2137-2144 (2007)
   PUBMED   17690704
REFERENCE   8  (bases 1 to 3972)
  AUTHORS   Guo,Z., Yuan,J., Tang,W., Chen,X., Gu,X., Luo,K., Wang,Y., Wan,B.
            and Yu,L.
  TITLE     Cloning and characterization of the human gene RAP2C, a novel
            member of Ras family, which activates transcriptional activities of
            SRE
  JOURNAL   Mol Biol Rep 34 (3), 137-144 (2007)
   PUBMED   17447155
  REMARK    GeneRIF: RAP2C is a novel member of the Ras family, belonging to
            the Rap branch of small GTPase proteins and may be involved in
            SRE-mediated gene transcription.
REFERENCE   9  (bases 1 to 3972)
  AUTHORS   Greco,F., Ciana,A., Pietra,D., Balduini,C., Minetti,G. and Torti,M.
  TITLE     Rap2, but not Rap1 GTPase is expressed in human red blood cells and
            is involved in vesiculation
  JOURNAL   Biochim Biophys Acta 1763 (3), 330-335 (2006)
   PUBMED   16540189
REFERENCE   10 (bases 1 to 3972)
  AUTHORS   Paganini,S., Guidetti,G.F., Catricala,S., Trionfini,P., Panelli,S.,
            Balduini,C. and Torti,M.
  TITLE     Identification and biochemical characterization of Rap2C, a new
            member of the Rap family of small GTP-binding proteins
  JOURNAL   Biochimie 88 (3-4), 285-295 (2006)
   PUBMED   16213650
  REMARK    GeneRIF: This work demonstrates that Rap2C is a new member of the
            Rap2 subfamily of proteins, able to bind guanine nucleotides with
            peculiar properties, and differently expressed by various
            hematopoietic subsets
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX399437.2, DB252216.1,
            BC035382.1 and AY298955.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001271186.1.
            
            Summary: The protein encoded by this gene is a member of the
            Ras-related protein subfamily of the Ras GTPase superfamily.
            Members of this family are small GTPases that act as molecular
            switches to regulate cellular proliferation, differentiation, and
            apoptosis. This protein has been reported to activate in vitro
            transcriptional activity of the serum response element. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2153980
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370874.2/ ENSP00000359911.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BX399437.2         34-42
            10-14               DB252216.1         39-43
            15-2347             BC035382.1         1-2333
            2348-3972           AY298955.1         2309-3933
FEATURES             Location/Qualifiers
     source          1..3972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     gene            1..3972
                     /gene="RAP2C"
                     /note="RAP2C, member of RAS oncogene family"
                     /db_xref="GeneID:57826"
                     /db_xref="HGNC:HGNC:21165"
                     /db_xref="MIM:301016"
     exon            1..78
                     /gene="RAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            79..188
                     /gene="RAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            189..285
                     /gene="RAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            286..1096
                     /gene="RAP2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             824..1375
                     /gene="RAP2C"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ras-related protein Rap-2c; small GTPase RAP2C"
                     /codon_start=1
                     /product="ras-related protein Rap-2c isoform 1 precursor"
                     /protein_id="NP_001258115.1"
                     /db_xref="CCDS:CCDS14632.1"
                     /db_xref="GeneID:57826"
                     /db_xref="HGNC:HGNC:21165"
                     /db_xref="MIM:301016"
                     /translation="MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEI
                     EVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVR
                     VKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEI
                     VRQMNYSSLPEKQDQCCTTCVVQ"
     exon            1097..1409
                     /gene="RAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..3972
                     /gene="RAP2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3665..3670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP2C"
                     /note="hexamer: AATAAA"
     polyA_site      3686
                     /gene="RAP2C"
     regulatory      3947..3952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP2C"
                     /note="hexamer: AATAAA"
     polyA_site      3972
                     /gene="RAP2C"
                     /note="major polyA site"
ORIGIN      
        1 agagctgggg acttcgctgg agagatggca ccggcctgag gtcaaggaga aattgaacta
       61 aactctcctt tgaagactgt ttccagaggc ccgttcccga agccggagtc ccgacccgaa
      121 accgtccccg gccggctcgc tcgctcagca gggcgcggct ccagcgccac ccggctcgcc
      181 ccgaagagca gcgctggggc agcggagaga cagaggagcc agcgggtggc catggccttg
      241 gcgtgacaga gcctccccgg cggccgggcg ggtgcggacg gcggggccgg acgacccccg
      301 cgggagccgg ggcccagaaa cccgcccggg cagcggtaac tggaacggag ccctcaggcc
      361 tgagccggct gggctgcgcg agcaggaagc ggggtccctg ggcccctttg tgtgaagggc
      421 gggggaggag tgccgggcag ccccgggctg cgggctcctc cgacgtccgc ctcgccgcag
      481 ggtcccctcg ccgcagcccc caccctttcc ctcccggggg cacgcgcctc ctcgccaccc
      541 tcgccgggct tttcccaggc tcgccctcct ccccacgccc cctgctcggg ctgcagttcc
      601 tataggaagg gcattaccat cccttcccca ccctccccga ctctacgctc tttcccctcc
      661 ccctcctgta acttcctctt cttccccggt tgggccctct gctcctctgc actctcctcc
      721 ccagttcgca gatttccgcc caccttccgc ctcgtctagc cgcgccacag ctagcggggt
      781 gatctttccc cccctctggt aggagttggt gaaggtgaga ctcatgaggg aatacaaggt
      841 agtggtgtta gggagtggag gggttggcaa atctgccctt actgtgcagt ttgtcactgg
      901 gactttcatt gagaaatatg accccaccat tgaagatttc taccgcaaag agatcgaagt
      961 ggactcttcc ccctccgtgc tggaaattct ggacaccgca ggaactgagc agtttgcctc
     1021 catgagagat ctctacatca aaaacggcca aggtttcatc ctggtttata gcctggttaa
     1081 tcaacagtct tttcaggata tcaagccaat gagagatcaa attgtcagag tgaagagata
     1141 tgaaaaagtc ccactaatcc tagtaggaaa taaagtggat ctggaaccag aaagagaggt
     1201 tatgtcttca gaaggcagag ctctggctca agaatggggc tgtcctttca tggagacatc
     1261 ggcaaaaagt aaatcaatgg tggatgaact ttttgctgag atcgtcaggc aaatgaacta
     1321 ttcatccctg ccggagaagc aagatcagtg ttgtacaact tgtgtcgtcc agtaaagaag
     1381 ataacctcaa tcatggccat accgagcaga taaaactcag aggaaatttg cacagatgct
     1441 gctttggaga actttacaac ctgggttgca gaactgagcc ttggtaaacc tgtctctatt
     1501 acagcatgtt gccatacatc tatttaagtg cataaggtct ttggccttca agatccatcg
     1561 accttaaaca ggaatgctta gcacgtttac catacgttta aaatccattc tttatcaatc
     1621 agtcctttta tagctttcta agttcttatt gatggctaat atacaagggt taatttttaa
     1681 tattttaatt gatttcttta atcagtttct cgacttgtat ttattaaata ctcaaactca
     1741 gtattaccta ctcaatgcct tttaaaagaa agttataatg gagaaaaaat tgagccttaa
     1801 acaaatggtt acttctgtat attacctcgt accagtgctt catcctattt gtaaaatctt
     1861 tctcctttaa aattattggt taatactttg agactttgtt tacgtgtggc agtgttgtaa
     1921 aaagaaacta aagatcacat tttacctgta tggatggaat atcccttttc ttcaagtgca
     1981 gtttgtgatg tgttttgttt tttttttttt ttttttgtaa ttaacatgtt ctgaaggtta
     2041 caattgatat ttgaaattga ctgtagagca tttagttgaa gagttaagca ttcagttcca
     2101 ttaggttttc acatgtgtta atctcattta cagcattgaa ttgcggcagt aacattttcc
     2161 tttctgtgaa gttctaaatt tagttatgac ctatttagca atgcctttga aaagggatat
     2221 tgtatccatg gtaaattaat tgtataccta aacagagata gctcatcttt gcctatcagg
     2281 cttgtaattg acatctagta gacttctgca catgtaaaat tgaattcaaa taaaatcata
     2341 cacactttct agttcttaat atttgtcttt ctgaataata gtttaaagca atatttgtta
     2401 aagttttctt gcactatcac aattgctttt tagttatttc tcaagaagca tgttcgtatt
     2461 agagacaaaa tctgtgtaac aggagggaga atagcgccaa gtctctgggc tattttttat
     2521 ttttgcaaat gtgctttcta atagccattg ccttccatgt tgtttaccta atcagcatat
     2581 ttttgtctga atacttgaac attttaacag taacgcaggt gtagaatcag aaaggaaact
     2641 tatgcagagt aatattttgg ttcagtttta acatcgtgac aatgagggct ttttctagca
     2701 atgattttta aattgtgtaa gtttgacagt attttattgt tgggttttta tttgatttta
     2761 gttgtgtgct tttcatttgc agaagttagt aactgcagct cacctactgc accaaagttc
     2821 tcgattttag gagcccagct ttagtcattt gaacatgctt ctaaataaaa taaaacaaaa
     2881 ccaaaactat acttttgatc tataataaga gctcaataac tttgtcaagg aaagctctaa
     2941 tatatgcagt gatggtttat gaaagggtgt ggcaatttta aatttatatt gtgtgtgatg
     3001 ttcaaataaa gtggtatcta cattcatgtg atttatgggt cagcatgacc attaattact
     3061 gagtagaaat tgactaaact ttgatttcct ttttttaaat cgtgttgcat ttgattcctg
     3121 agcaaattcc ctcaaagtga actcttgttc ttaaattttg aattttatgg tgagattgta
     3181 aagatagagg caattgaaac attgttcctt atttatgaac tgcttgaagt gaatacttaa
     3241 tttaagtttg cactttaata ccaaacttaa aaccaaacac tcatttaaaa gtaggttaag
     3301 tgatcatgga tcattgttat tagctttgtg gctttgtgaa attctaaagg aatcaaataa
     3361 ttcatcatga tttaaatttt ctagagattt tgattttttt ataatgtttc tttcctgtag
     3421 attgtgttct tgtttctctc tctctctctc tctctctctc tctctctctc tctctctctc
     3481 tctctctctc aaaattacag tgttcattgt cattgacctc agcagcaaat ttgacttgaa
     3541 ttcacttagg atcgcaggaa tcaggggaaa gtgattttaa aggtggtttc tccagcacat
     3601 tttaagaaaa gggaccaaaa gttattttag cttcctcaat agattgcatg ttgcttatta
     3661 ggataataaa ttaatattaa atgcaatata tgtcttgtct ttattatggc atctatttag
     3721 gagttgttca aatcactgca gtagggctct gcaaataaaa taatgtaacc tattatcatg
     3781 gatctaatgt actgtaactt tatcagtgaa aggtaaaatc tcaaataaca agtacaaaca
     3841 ttgaacaatt acctataaag atttgtaaaa gtaaaatttt tccaatagat ttcattcttg
     3901 tcattttgta agacgaccct gcagtccacc tgtttgtaac ttttttaata aaatagacat
     3961 ctgtattact ga
//
