LOCUS       NM_002886               8402 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens RAP2B, member of RAS oncogene family (RAP2B), mRNA.
ACCESSION   NM_002886
VERSION     NM_002886.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8402)
  AUTHORS   Zhu,J., Cao,X., Chen,Z., Lai,B., Xi,L., Zhang,J., Zhu,S., Qi,S.,
            Liang,Y., Cao,F., Zhou,B., Song,Y., Jiang,S., Wang,T., Kang,X. and
            Kong,E.
  TITLE     Inhibiting S-palmitoylation arrests metastasis by relocating Rap2b
            from plasma membrane in colorectal cancer
  JOURNAL   Cell Death Dis 15 (9), 675 (2024)
   PUBMED   39277583
  REMARK    GeneRIF: Inhibiting S-palmitoylation arrests metastasis by
            relocating Rap2b from plasma membrane in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8402)
  AUTHORS   Fu,Y., Liu,K., Jiang,X., Zhao,L. and Wang,T.
  TITLE     Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression
            through miR-1184/RAP2B Axis
  JOURNAL   Urol Int 107 (6), 632-645 (2023)
   PUBMED   36958293
  REMARK    GeneRIF: Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer
            Progression through miR-1184/RAP2B Axis.
REFERENCE   3  (bases 1 to 8402)
  AUTHORS   Dai,C., Yu,H., Bai,Q., Huang,D., Li,J. and Wang,W.
  TITLE     MicroRNA-708 suppresses the proliferation, migration, and invasion
            of human retinoblastoma cells by targeting RAP2B, a member of the
            RAS oncogene family
  JOURNAL   Acta Biochim Pol 69 (4), 719-724 (2022)
   PUBMED   36444911
  REMARK    GeneRIF: MicroRNA-708 suppresses the proliferation, migration, and
            invasion of human retinoblastoma cells by targeting RAP2B, a member
            of the RAS oncogene family.
REFERENCE   4  (bases 1 to 8402)
  AUTHORS   Pang,L., Zhang,Q., Wu,Y., Yang,Q., Zhang,J., Liu,Y. and Li,R.
  TITLE     Long non-coding RNA CCAT1 promotes non-small cell lung cancer
            progression by regulating the miR-216a-5p/RAP2B axis
  JOURNAL   Exp Biol Med (Maywood) 246 (2), 142-152 (2021)
   PUBMED   33023331
  REMARK    GeneRIF: Long non-coding RNA CCAT1 promotes non-small cell lung
            cancer progression by regulating the miR-216a-5p/RAP2B axis.
REFERENCE   5  (bases 1 to 8402)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 8402)
  AUTHORS   Torti,M., Ramaschi,G., Sinigaglia,F., Lapetina,E.G. and Balduini,C.
  TITLE     Association of the low molecular weight GTP-binding protein rap2B
            with the cytoskeleton during platelet aggregation
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7553-7557 (1993)
   PUBMED   8356055
REFERENCE   7  (bases 1 to 8402)
  AUTHORS   Mollinedo,F., Perez-Sala,D., Gajate,C., Jimenez,B., Rodriguez,P.
            and Lacal,J.C.
  TITLE     Localization of rap1 and rap2 proteins in the gelatinase-containing
            granules of human neutrophils
  JOURNAL   FEBS Lett 326 (1-3), 209-214 (1993)
   PUBMED   8391995
REFERENCE   8  (bases 1 to 8402)
  AUTHORS   Ohmstede,C.A., Farrell,F.X., Reep,B.R., Clemetson,K.J. and
            Lapetina,E.G.
  TITLE     RAP2B: a RAS-related GTP-binding protein from platelets
  JOURNAL   Proc Natl Acad Sci U S A 87 (17), 6527-6531 (1990)
   PUBMED   2118648
REFERENCE   9  (bases 1 to 8402)
  AUTHORS   Farrell,F.X., Ohmstede,C.A., Reep,B.R. and Lapetina,E.G.
  TITLE     cDNA sequence of a new ras-related gene (rap2b) isolated from human
            platelets with sequence homology to rap2
  JOURNAL   Nucleic Acids Res 18 (14), 4281 (1990)
   PUBMED   2115998
REFERENCE   10 (bases 1 to 8402)
  AUTHORS   Pizon,V., Chardin,P., Lerosey,I., Olofsson,B. and Tavitian,A.
  TITLE     Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3
            encode proteins closely related to ras in the 'effector' region
  JOURNAL   Oncogene 3 (2), 201-204 (1988)
   PUBMED   3045729
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI551390.1, BU507815.1,
            BC012362.1, BQ378964.1, HY071303.1, BU860799.1, AW997098.1,
            CB116910.1, BX116683.1, AI718675.1 and AC117394.10.
            
            On May 17, 2019 this sequence version replaced NM_002886.3.
            
            Summary: This intronless gene belongs to a family of RAS-related
            genes. The proteins encoded by these genes share approximately 50%
            amino acid identity with the classical RAS proteins and have
            numerous structural features in common. The most striking
            difference between the RAP and RAS proteins resides in their 61st
            amino acid: glutamine in RAS is replaced by threonine in RAP
            proteins. Evidence suggests that this protein may be
            polyisoprenylated and palmitoylated. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR6380200.139075.9, AL713766.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323534.5/ ENSP00000319096.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BI551390.1         6-17
            13-44               BU507815.1         1-32
            45-1381             BC012362.1         1-1337
            1382-1426           BQ378964.1         149-193
            1427-1687           HY071303.1         30-290
            1688-2207           BU860799.1         26-545
            2208-2694           AW997098.1         7-493               c
            2695-3136           CB116910.1         150-591
            3137-3514           BX116683.1         38-415
            3515-3963           AI718675.1         2-450               c
            3964-8402           AC117394.10        65118-69556         c
FEATURES             Location/Qualifiers
     source          1..8402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.2"
     gene            1..8402
                     /gene="RAP2B"
                     /note="RAP2B, member of RAS oncogene family"
                     /db_xref="GeneID:5912"
                     /db_xref="HGNC:HGNC:9862"
                     /db_xref="MIM:179541"
     exon            1..8402
                     /gene="RAP2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             469..1020
                     /gene="RAP2B"
                     /EC_number="3.6.5.2"
                     /note="small GTP binding protein"
                     /codon_start=1
                     /product="ras-related protein Rap-2b"
                     /protein_id="NP_002877.2"
                     /db_xref="CCDS:CCDS3170.1"
                     /db_xref="GeneID:5912"
                     /db_xref="HGNC:HGNC:9862"
                     /db_xref="MIM:179541"
                     /translation="MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEI
                     EVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIR
                     VKRYERVPMILVGNKVDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEI
                     VRQMNYAAQPNGDEGCCSACVIL"
     regulatory      2473..2478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP2B"
                     /note="hexamer: AATACA"
     regulatory      2492..2497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP2B"
                     /note="hexamer: AAGAAA"
     polyA_site      2501
                     /gene="RAP2B"
                     /note="major polyA site"
     polyA_site      2508
                     /gene="RAP2B"
                     /note="major polyA site"
     regulatory      4925..4930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP2B"
                     /note="hexamer: AGTAAA"
     polyA_site      4944
                     /gene="RAP2B"
     regulatory      6231..6236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP2B"
                     /note="hexamer: AATAAA"
     polyA_site      6251
                     /gene="RAP2B"
     regulatory      8375..8380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP2B"
                     /note="hexamer: AATAAA"
     polyA_site      8402
                     /gene="RAP2B"
ORIGIN      
        1 agtagaggct gtgggagaga gcgcgatggg ccgcggcggt gggcgcacgt tccgcgggga
       61 ctcatgccac gcgcgtcccg gcccgacgcg caattagcag ccacctccgc agcccgccgc
      121 caccgcctcc ctgccctccc gggctgccgc agctaggagc tccagccgtc gcctcgcgca
      181 ggctgcgggc attgtcctct cggttcgccg cccgggctgc tgctgccgcc gcggactgct
      241 gcggggcccg gacccgcacc ccagggatac gctgccgccg ccgccggccg gcccggcgcc
      301 cggcctccgt tcggtggttt ccgccctgcg ttctctgggt tgctctctcc tgggtttttc
      361 ctgcgtagct gaggaagggg aagagaagtc cagccgccaa gcccagcctt ccccggcgcg
      421 cagccccgac ggggccgcgg caggcgcggc gagagcgctg acggagccat gagagagtac
      481 aaagtggtgg tgctgggctc gggcggcgtg ggcaagtccg cgctcaccgt gcagttcgtg
      541 acgggctcct tcatcgagaa gtacgacccg accatcgaag acttttaccg caaggagatt
      601 gaggtggact cgtcgccgtc ggtgctggag atcctggata cggcgggcac cgagcagttc
      661 gcgtccatgc gggacctgta catcaagaac ggccagggct tcatcctggt ctacagcctc
      721 gtcaaccagc agagcttcca ggacatcaag cccatgcggg accagatcat ccgcgtgaag
      781 cggtacgagc gcgtgcccat gatcctggtg ggcaacaagg tggacctgga gggtgagcgc
      841 gaggtctcgt acggggaggg caaggccctg gctgaggagt ggagctgccc cttcatggag
      901 acgtcggcca aaaacaaagc ctcggtagac gagctatttg ccgagatcgt gcggcagatg
      961 aactacgcgg cgcagcccaa cggcgatgag ggctgctgct cggcctgcgt gatcctctga
     1021 ggcggccacc gcgcgccggc cgcgctctgc gcacaaaagc caaacgcatc cgactctcta
     1081 aatgtgattt atttcttgct ttgagattgg agaccacttt gcattggcca gggtgtcttg
     1141 ggagcccggc tggcctccgc ggccggcgtc ccctgcctcc accctgtgcc cgagggggtg
     1201 tccggtcctg cccatccgat actctggtgg aaatgtggct ctttgcagca tgtacgtttc
     1261 tccctgattt tggttgatgc atatttcccc gtttaagtag ccgttagggc gcagtatcgg
     1321 cagcttgaca cccaccaagc aaaagtttca gcctggaaaa aaaatggggg ggaagggtgg
     1381 atgaaaagga gggagagaag gtggaaatgg tttttttttt tttttttcta ttttctttct
     1441 tttttttttt tttttttttt ggtcaacagc cgtttttcta gttccaagtt ttaaatacat
     1501 ggaaggaagt ccgggagaac catatgaagg agcaggagga gaggaagaaa ctttttttcc
     1561 ttcttttcca ggagtagctg gaaattaaga tcgggttcct tttctgccag cttggaaggg
     1621 caaccccatg actgattgcg attctgagga tgtctatgca aagttggatt cttgttacag
     1681 tgtatccaat ctgaagtatt gcacatctga actgggactg ttaacactga tgccaataca
     1741 gtgtggggtg ccagaaagtg tctgctgata tttgtggaaa aaaaatctat tttgtttacc
     1801 tactgtatca aaggggagtc tgggggagaa tggtagtatt tttttttttt atcagctgtg
     1861 aaaaaaatgt tacagatctg cacattttcg tgtgtactat ggtgtgtgtg tgtatgtgtg
     1921 tggtgtgtgt gtgttttaag tttagccttt tgtttttgtt ttttggttgg cagtaaccga
     1981 ttttaatgac tagcttttaa aaatacagta caaagacttt gtaaatgtga ttcagggccc
     2041 ccagcacccc tgtgtctgca gagtgccttc aaaactcagc tgttccagcc ggtgccaacc
     2101 tgtgaacttc ccaccatatc ccagaatctg ctattcccca aaccacttcc cagtttcctt
     2161 tcagtaatct ttctgaagga gccaggacaa tagggcctgt tgtttagtga atttctttat
     2221 tattttcagc ctttaaaatg taatttccat ctcttgcaat gaatttgttt cccttttttt
     2281 tgcttcattt tgtttaaatt ttcaggtatt tagctcccct ttcatattat ttttaaattt
     2341 tttaattacc tgttgtaggg tgttcctcca gaagcaaaga gcaaaatttt actgttgtga
     2401 tgtaccaatt ctaactaatt gtaattttta atttcatgcg tttaatcatt gtctcttcat
     2461 tttaagactt ttaatacaaa tgtcattttt aaagaaacaa acccaaaact attgtttgtg
     2521 tttctgtgtt tcatattcag tgatttaata cagtatcatg gctgaggtgg atggggcagg
     2581 tgcatgatac tcttcagagc tatttgtgaa attttaaaga cagaagtgtc tcagtgacaa
     2641 gttggatgac actactccca actttttaaa tttggagaaa accatcaagg tcgaggaagc
     2701 cctgggtatg gccattacca tctgattaga agatgaacag gtattttgaa tctgatctga
     2761 catggaacag tttacctcat tgtaggtagg gaacaagaga acccatctat taaaattgcc
     2821 ttagatctgg gaaagtaacc atccttctgg caaagtagga tggcactttt aagtttttct
     2881 tccttttttc cctctgttta tattgcacat caagtcaaaa acatgtttgg gaaagatggt
     2941 tttcaattct gaagttatac ctagtgatgt tttttgcagt acatttgaat ggattgtaga
     3001 cactgcctca acccttttga ggttttgatt tggaaataga tttaaaagaa aacaggctaa
     3061 gataatatcc ttgttctcat ttacaccctg cagtttggac cacatttgac ctcataagtt
     3121 tttcctttta acagtaggag gcagtgtgag ctttttattt tttatttttc ttaaggtggt
     3181 cttagtaata taacatgttc atacatatca agagagtact tggtatacct taggtctatg
     3241 aagtgtagct gaaatctgaa gagtcttgac aaagggattt acacccttga caaaaccaaa
     3301 agaaattaac aggccacagg tttctttaaa gctgtgttaa catatcttgc cttaaaatgt
     3361 gtgtgtgtgt ttttgctttg cttttttttt tttgcccaag aggcatctca gtactccagc
     3421 aatggaggaa gaatagagaa ttttgcctgg caatggtcct actgccattt tttttttccc
     3481 actctgatct cacttaagtt tgatatcaaa cacaattggg aggcaatagt atcaatatcc
     3541 taaatgtaga aattaaaaga tactgtataa ttttatgcct ttgcaaagat tcgttcttgt
     3601 atttgaataa attcagttgc taaagtagat ccaaagtgtt aaaaatgctg aagtcatgtc
     3661 aagtactgtc tggagggttt ttttaagaaa aggcatttgg catttaactg tctcttgttt
     3721 tatttttaag tttttggaaa ccttttgaca taaaatgctg ccaagtatct aagaaatgta
     3781 tatactgaca gaagatattt gaaagtggaa aattggaaat gaaatatgtt gctgggtgcg
     3841 ttaatcacct ccgcccagga tttagtcact tgcaggacct ctttatagtc taggatggca
     3901 gagcagaaga ttttaatatg cttttattaa gtgatgtaaa ataaatgctt tttggattat
     3961 caatgaaagc aattttatgt gtgcctgaag caagaaaata gcgtttttgg ttttatctca
     4021 tattttcttg gcaaaattga gagaaattag gaacactgct atttttttct taaaaatgtt
     4081 tttaagaata tgttcgtttc tttgactatt aagaacccct tgtggtatta gtgtgtgaag
     4141 agataagggc atttgtttca atgaaaaagt tagtgttaaa ggaagtgagt cagggagggc
     4201 ggagtttgtt gtaaggcaat cacctgtcaa aacagaaatt gggtgggaaa ggagtcttta
     4261 tcttggggag caaaagctga cttttaaact tgacccctgc tgtttttaaa cagcttttcc
     4321 ttttggtctc tgacagtcaa tccaggtttt atgttatttc aaaagggtta tttttgtcct
     4381 ccttttttaa tagcttcagg aaagttaaag gtatcatctt aggtctaaca ctctagtctt
     4441 tgagagttac ggttctttcg tagaacaatt tccatgttgt taactgttgt agacttaatt
     4501 gaatcacatt ttgggaccag atgtatttgg ggatagaatt ctttaaatgt atgggacttc
     4561 atgcttcctg attatgtaat atttcctgtg gttgggaatc ctagaatgcc tgatctattt
     4621 tatctgttca ggtagttttg ttattgtacc ctcttttggg tcatattcta gtatttctca
     4681 cagggggtat gagaaacaga aagctatatg tagcagctgg tcttgagaag tagaagcatc
     4741 ttaactgtca taagagcata gattttttgt ttttcacaac agctggaata agttcctgca
     4801 ttataagtat aaagggaacc gagatttaat ttggagatca tcactgttaa aacgatacca
     4861 gacatttgtc acagtgtctt atttggggaa agtttgctaa tatacatttt gtctgtgaaa
     4921 atatagtaaa ttttaaaata ctaatataat gtggtattct tgattacagt attttatgca
     4981 gactattagg aatgattcag tgcatttaac tgaacacaga gctagttcta ggtgagtgag
     5041 atctttatct attaactgga ttttgaaggt ttgagaaggc tatggggatc atctggttga
     5101 aaggttctca aacttgacca tatatcaaaa tcacctggag cttaaaacat gtactgctgg
     5161 gaccctcctc cagtttctta cccagtgggt ctcgggtagg gtctcaattt tcatttctaa
     5221 caagtttcca agtgattgtg ttattgctgt tccagggacc acactttgaa aaccagtgat
     5281 ctagactgaa ctccaaatga gtactatact gacagccacc tagatattga gagacacaga
     5341 cttcagactc atgtcacaca ttttggagtg ctgtctacta cagttagaga ataatctcta
     5401 ttgaaatcta agctaaagag gacatatacc atttatacta agactaactg ttgtgtgtga
     5461 aatagaataa acattgcagg tagtttttga tcattttcac attattacag gaacattttg
     5521 actatggttt tcaatgttaa ttcagaagtt gactttaaat gaaaatgtgg ttagaataga
     5581 ggcaaagcct aagtgatcag aatcaacatt ccccttctcc ccaacctagg ggaaaaaaaa
     5641 tttgaaaagt atgtcttcaa taaaagggga cactttattt gtcttctctt caacattaaa
     5701 aaacaaagat tttaagtttt catggcaagg gttctaaaaa tcattgtgcc agagaattta
     5761 aatcttcata tcatggtaag cacatgcgta tgtctgtgac tcagtttctt agccagactt
     5821 ccaggtgtta gttaattcct tctcatttag ttctactgta atccattctg ggaaaatgca
     5881 taccacaaaa ctgtgtatct tgcagcttct ttcgttatgc atcttaattc cctcagaagg
     5941 tcccagaact ttatgttaaa gatctgggtt tttaaagaca atttgggggc cttctaaaga
     6001 aacaatagta gatctaatta caagtagtgg attgcttact tcaaatttct cttttacaat
     6061 ttagaaagtt tagtaccagt ttatagactg agggagtagt agctactatt tagatgctga
     6121 gaataatatt atcatgcttg ggtggggaag aaaggccctt actcaaatct ccattttcat
     6181 ttttaatgct tcctggactt cagttatttt cttgcttttg cctcaagaat aataaatatt
     6241 tttggttaaa attttttttg ttcaaccctg ttgttgttac tgttattttc atagcacagt
     6301 agtctacagc tctctatagt agcttaatag ctatttgctg aatgaatgga acatggagtg
     6361 ttacatctga aactattcta ttagaaggtg aaaagtgttg attgaagaat ggtaggattt
     6421 tatcttccct acccatgata gatttattaa gattgtcttt ggagctatgt cttccattcc
     6481 aactatacag aaataaactt ttttaaagtt tagtttgccc atctgataaa ggaacattcc
     6541 tgtatgctat tctaaggttc attttcaaca aaagttacag acatttatgg ttgatagttt
     6601 gagatctatg acagttttag ggagctccat attcaaaagg ctattgctgg tgatagtaca
     6661 atgaaacact gacttcagta tatttttatc ttggctttca ttttacggtt atttctacta
     6721 ctgttaatat ggactaatac ttgattttgt gaacctgttt taattttagg gttatattta
     6781 tgttggaata atatatttta aaagtgtcct atactatgaa tttatttgcc atatataaga
     6841 caatcagaat tatctggtag tttattctaa tcctggttaa taatcattag gactaaacta
     6901 tttacattaa agaaggaaaa aacaatgaga tgataatttt ttttttcttt gagacggagt
     6961 cttgctctgt cggccaggct ggagtgcaat ggcgcgatct cggctcactg caacttccgc
     7021 ttcctgggtt caagcaattc tcctgcctca gcctttccag tagctgggac tacgggcgcc
     7081 ctccaccact cccggctaat ttttgtattt ttcatagaga cagcatttca ccatactggc
     7141 caggctggtc gtgaactcct gaccttgtga tctgcccacc ttggcttccc aaagtgctgg
     7201 gattacaggt gtgagccacc gcacccagcc ttttttttga aatggagtct ggctctgtcg
     7261 cccaggctgg agtgcaatgg cgcgatctcg gctcactgca acctctgcct cccaggttca
     7321 agcgattagc ctgcctcatc ctcctgagta gctgggatta caggcgtgca ccaccacgcc
     7381 cgcctaattt ttgtattttt agtagagatg gggtttcact acgttggtca ggatggtctt
     7441 gaacttctga ccttgtgctc cacccacctc agcctcccaa gagttgggat tacaggcgtg
     7501 agccactgca cccggctgag atgataattt tatttaaaaa aaaaattgta gagatagggt
     7561 cttgccgtgt tgcccaggct ggtctcaaat tcctgggctc aggagatctt ccctcctcag
     7621 cccctcaaag tgctgggatt acaggcctga gccactgcat ccagccagga gtgacaattt
     7681 ctaaagcctt aattagtgaa atggtttgtt ttgagaagca gaaatgacta agtggtatag
     7741 acatgcagga aaagcaaaat gggccttatg gctattgaaa ttatgagtgt tgatctgttc
     7801 tataaattgg aggagacagc tatttgcatt ctttcttatc cagttgacta aacttactca
     7861 ttttaaaatg aattatcttg caaaattatg tgaggttaag tttgtcagag gattgaaaac
     7921 gtggttggtt tatttgtggt aattgtgaaa aattgcaaag gtagcaaaat tttttaaaaa
     7981 atggaaaaga gaaagattat tgatgccttg tgaatacagg tgtccccaaa aggcctgaga
     8041 ccaaccttaa ttatcaagaa tatggttgca gtggaaattg gtaaacagct gaaattgatt
     8101 cattgattat tcaacactta ttgagcacat actactatta ttaatagctg tactgcgagc
     8161 gctaatactt aaaagaggaa gtcaggtgaa ggcgcaacag ctttatgctc tttttcacta
     8221 taatctgtga aatagtgtat attaaacaat aatagtatat ggaaaagcac atctacatgt
     8281 gtcatcagtt ataatactgt ggggctgttt ggcagacaat agagtagata aatttattga
     8341 acattgggcc tttgaaaggt atgtggaaat tgtaaataaa aatggattcc atgaatttca
     8401 aa
//
