LOCUS       NM_015085               6663 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAP1 GTPase activating protein 2 (RAP1GAP2),
            transcript variant 1, mRNA.
ACCESSION   NM_015085 XM_371003
VERSION     NM_015085.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6663)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6663)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6663)
  AUTHORS   Myers,R.A., Scott,N.M., Gauderman,W.J., Qiu,W., Mathias,R.A.,
            Romieu,I., Levin,A.M., Pino-Yanes,M., Graves,P.E., Villarreal,A.B.,
            Beaty,T.H., Carey,V.J., Croteau-Chonka,D.C., del Rio Navarro,B.,
            Edlund,C., Hernandez-Cadena,L., Navarro-Olivos,E.,
            Padhukasahasram,B., Salam,M.T., Torgerson,D.G., Van den Berg,D.J.,
            Vora,H., Bleecker,E.R., Meyers,D.A., Williams,L.K., Martinez,F.D.,
            Burchard,E.G., Barnes,K.C., Gilliland,F.D., Weiss,S.T.,
            London,S.J., Raby,B.A., Ober,C. and Nicolae,D.L.
  CONSRTM   GRAAD
  TITLE     Genome-wide interaction studies reveal sex-specific asthma risk
            alleles
  JOURNAL   Hum Mol Genet 23 (19), 5251-5259 (2014)
   PUBMED   24824216
REFERENCE   4  (bases 1 to 6663)
  AUTHORS   Yasuda,T. and Fukuda,M.
  TITLE     Slp2-a controls renal epithelial cell size through regulation of
            Rap-ezrin signaling independently of Rab27
  JOURNAL   J Cell Sci 127 (Pt 3), 557-570 (2014)
   PUBMED   24284068
REFERENCE   5  (bases 1 to 6663)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6663)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 6663)
  AUTHORS   Neumuller,O., Hoffmeister,M., Babica,J., Prelle,C., Gegenbauer,K.
            and Smolenski,A.P.
  TITLE     Synaptotagmin-like protein 1 interacts with the GTPase-activating
            protein Rap1GAP2 and regulates dense granule secretion in platelets
  JOURNAL   Blood 114 (7), 1396-1404 (2009)
   PUBMED   19528539
  REMARK    GeneRIF: Slp1 inhibits dense granule secretion in platelets and
            that Rap1GAP2 modulates secretion by binding to Slp1.
REFERENCE   8  (bases 1 to 6663)
  AUTHORS   Hoffmeister,M., Riha,P., Neumuller,O., Danielewski,O., Schultess,J.
            and Smolenski,A.P.
  TITLE     Cyclic nucleotide-dependent protein kinases inhibit binding of
            14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets
  JOURNAL   J Biol Chem 283 (4), 2297-2306 (2008)
   PUBMED   18039662
  REMARK    GeneRIF: Platelet activation by ADP and thrombin enhances serine 9
            phosphorylation and increases 14-3-3 binding to endogenous
            Rap1GAP2.
REFERENCE   9  (bases 1 to 6663)
  AUTHORS   Stork,P.J. and Dillon,T.J.
  TITLE     Multiple roles of Rap1 in hematopoietic cells: complementary versus
            antagonistic functions
  JOURNAL   Blood 106 (9), 2952-2961 (2005)
   PUBMED   16076873
  REMARK    Review article
REFERENCE   10 (bases 1 to 6663)
  AUTHORS   Schultess,J., Danielewski,O. and Smolenski,A.P.
  TITLE     Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in
            human platelets
  JOURNAL   Blood 105 (8), 3185-3192 (2005)
   PUBMED   15632203
  REMARK    GeneRIF: Rap1GAP2 is the first GTPase-activating protein of Rap1
            found in platelets and is likely to have an important regulatory
            role in platelet aggregation
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ628446.1, AC015921.20,
            CR627427.1, BE208439.1, DN831680.1, AC097370.10 and BU629928.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015085.4.
            
            Summary: This gene encodes a GTPase-activating protein that
            activates the small guanine-nucleotide-binding protein Rap1 in
            platelets. The protein interacts with synaptotagmin-like protein 1
            and Rab27 and regulates secretion of dense granules from platelets
            at sites of endothelial damage. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) encodes isoform 1. This
            variant is also known as variant b, as described in PMID: 15632203.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ628446.1, BC140870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254695.13/ ENSP00000254695.8
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               AJ628446.1         1-683
            684-684             AC015921.20        45833-45833         c
            685-1931            CR627427.1         609-1855
            1932-2106           BE208439.1         210-384
            2107-2458           DN831680.1         416-767
            2459-6387           AC097370.10        117426-121354       c
            6388-6663           BU629928.1         18-293              c
FEATURES             Location/Qualifiers
     source          1..6663
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..6663
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /note="RAP1 GTPase activating protein 2"
                     /db_xref="GeneID:23108"
                     /db_xref="HGNC:HGNC:29176"
                     /db_xref="MIM:618714"
     exon            1..134
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2283
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GTPase activating Rap/RanGAP domain-like 4; GTPase
                     activating RANGAP domain-like 4; rap1 GTPase-activating
                     protein 2; GTPase-activating Rap/Ran-GAP domain-like
                     protein 4"
                     /codon_start=1
                     /product="rap1 GTPase-activating protein 2 isoform 1"
                     /protein_id="NP_055900.4"
                     /db_xref="CCDS:CCDS45573.1"
                     /db_xref="GeneID:23108"
                     /db_xref="HGNC:HGNC:29176"
                     /db_xref="MIM:618714"
                     /translation="MFGRKRSVSFGGFGWIDKTMLASLKVKKQELANSSDATLPDRPL
                     SPPLTAPPTMKSSEFFEMLEKMQGIKLEEQKPGPQKNKDDYIPYPSIDEVVEKGGPYP
                     QVILPQFGGYWIEDPENVGTPTSLGSSICEEEEEDNLSPNTFGYKLECKGEARAYRRH
                     FLGKDHLNFYCTGSSLGNLILSVKCEEAEGIEYLRVILRSKLKTVHERIPLAGLSKLP
                     SVPQIAKAFCDDAVGLRFNPVLYPKASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEE
                     LFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFH
                     VSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQVETP
                     GTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREFLLTKLTNAENACCKSDKFA
                     KLEDRTRAALLDNLHDELHAHTQAMLGLGPEEDKFENGGHGGFLESFKRAIRVRSHSM
                     ETMVGGQKKSHSGGIPGSLSGGISHNSMEVTKTTFSPPVVAATVKNQSRSPIKRRSGL
                     FPRLHTGSEGQGDSRARCDSTSSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKEKPF
                     MKLKENGRAISRSSSSTSSVSSTAGEGEAMEEGDSGGSQPSTTSPFKQEVFVYSPSPS
                     SESPSLGAAATPIIMSRSPTDAKSRNSPRSNLKFRFDKLSHASSGAGH"
     exon            135..170
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            171..255
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..291
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            292..336
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            337..369
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..582
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..686
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            687..765
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            766..819
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            820..903
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1004
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1134
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1290
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1362
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1449
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1584
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1722
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1841
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1955
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2070
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2197
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2274
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2313
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..6663
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6640..6645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /note="hexamer: AATAAA"
     polyA_site      6663
                     /gene="RAP1GAP2"
                     /gene_synonym="GARNL4; RAP1GA3"
                     /note="major polyA site"
ORIGIN      
        1 actgaccccg ctgtaccacg gccctcttgc ggacagcccc ggggacgtcg ttgggacatc
       61 gctgggaccc cgggctctgc agccacaacc atgtttggcc ggaagcgcag tgtctccttt
      121 gggggcttcg gatggatcga caagaccatg ctggcaagtc tgaaggtcaa gaagcaggag
      181 ctggccaaca gctcggatgc gaccctccca gaccggccgc tctcccctcc tctcacggca
      241 cctcccacca tgaagtcgtc ggagttcttt gagatgctgg agaaaatgca ggggatcaag
      301 cttgaagagc agaagccggg accccagaag aacaaggacg actatatccc ataccccagc
      361 atcgacgagg ttgtggagaa gggaggcccg taccctcagg tcatcctgcc acagtttggg
      421 ggctattgga tcgaggaccc ggagaacgtg ggcaccccaa catcgctggg gagcagcatc
      481 tgtgaggagg aggaagagga caacctcagc cccaacacat ttggctacaa gctcgagtgc
      541 aagggtgaag ccagggccta ccggaggcac ttcctgggga aggatcatct aaacttttac
      601 tgtaccggca gcagcctggg gaacttgatc ctgtccgtca agtgcgagga agcagagggg
      661 atcgagtacc tccgggtcat ccttaggtcc aaactgaaga cggtacatga gcggatcccc
      721 ttggctggac tgagcaagct tcccagtgtc cctcagattg caaaggcttt ctgtgatgat
      781 gcagtgggac tgagattcaa tcctgtcctg taccccaagg cctcccaaat gattgtgtcc
      841 tatgatgagc atgaagtcaa caacacattc aaattcggag tcatttatca aaaagccagg
      901 cagaccctgg aggaggagct atttgggaac aatgaggaga gcccagcttt taaggagttc
      961 ttggacctgc tgggggacac gatcacactg caggatttca aaggtttccg aggaggcctg
     1021 gacgtgaccc acggacagac aggggtggaa tcagtgtaca caacattccg ggacagggag
     1081 atcatgtttc acgtttccac aaagctgcca tttaccgacg gagacgccca gcagctccag
     1141 agaaagagac acattggaaa tgacatcgtg gccatcatct tccaagagga aaacacgccg
     1201 tttgtcccag acatgatagc ctccaatttc ttacatgcct acatcgtcgt gcaggtcgag
     1261 accccaggca cagagacccc atcctacaag gtctctgtca ctgcgcggga agatgtgccc
     1321 acctttggtc cacctctgcc cagtcccccc gttttccaga agggcccgga attcagggag
     1381 tttctgctca ccaagctcac caatgccgag aacgcctgct gcaagtcgga caagtttgca
     1441 aagctggagg accggaccag ggctgccctc ctggacaacc ttcacgatga gctccacgcc
     1501 cacacacagg ccatgctggg actgggccca gaggaggaca agtttgagaa tggaggccac
     1561 ggggggttcc tggagtcttt taagagggcc atccgcgtac gcagccactc catggagacc
     1621 atggtgggcg gccagaagaa gtcgcacagt gggggcatcc ctggcagcct cagcgggggc
     1681 atctcccaca acagcatgga ggtcaccaag accaccttct cgcctccagt ggtggcggca
     1741 acggtgaaga accagtcacg gagtcccatc aagcgacgct cggggctctt cccccgcctg
     1801 cacacgggct cagaaggcca gggcgacagc cgggcacgat gtgacagcac atccagcaca
     1861 cccaagaccc cagatggtgg acactcctct caggagataa agtctgagac ctcatccaat
     1921 cccagctctc cggaaatctg ccccaacaag gagaagccct tcatgaagtt gaaggaaaac
     1981 ggccgtgcca tctcccgctc ctcctccagc accagcagcg tcagcagcac tgcaggggag
     2041 ggcgaggcca tggaggaggg cgacagtggg ggcagccagc cgtccacgac ctcacccttc
     2101 aagcaggagg tgtttgtcta cagcccgtcc ccgagcagcg agagccccag cctgggggca
     2161 gctgccaccc cgatcatcat gagccggagt cccacagatg ccaaaagcag aaactccccg
     2221 agatcgaacc tgaaattccg ctttgacaag ctcagccatg ccagctctgg tgcgggtcac
     2281 taatgtgaaa gtggagtcct tcgcctgtcc aagggaatcc cctcttctgt cctggaaaag
     2341 gctcctgtac cagcagtttg ggagtgccgt ccacgaccct gacagtccca gccctgctgc
     2401 cccatggcca cgtgcccaca gatgtgctgt tggtccaggt gtcccagtct ggccacagcc
     2461 ctgcctccgc cctcacctac atgccctccc agcccctccc atctctggac gaggcctcct
     2521 tcctcaggtt cctcctgctc ctgacctccc agtgtgatgt ccgggtcctt tatcatccta
     2581 ttcatcctgg agaggaaaag tgtcgggcaa agggggatct ggggggagct cagcagtgac
     2641 tggggagctg gtctgcctca gagacagagt agggggtggg agcagagcct cggtgagggt
     2701 cttggccaca gggcagtgcc ttcctgaacg tggcaggctt tactaccagg aacgcactcg
     2761 gtggtggagg ccccatgttc ccaggagcca agattcgtag catccttgag gccatcctga
     2821 taaaattcgg cgctattgcc cccgtagctc tggagctcta aaccgtctat ctgcttctgt
     2881 gctgaacgcc tttcccatct gctgacgtag gcccagggct gccctgcccc tgctgccagt
     2941 gtaccgtgag cggggctcca gccagttcaa gctcagagcc agagctggac gggccagaac
     3001 tgcgctgcac acttcctgga ctgaggcggg gactttgggt cccacccggt ttctcctgat
     3061 tatggctgct gtggggtgag gggagggagg ggcagccccg aggcagtctc ttccctttga
     3121 gaagatattt tcccacaaag gggtgggaag ccaggagtga gaaggaattc agggagagca
     3181 aaggagccag tgctgagatg ctgctgtgtt ggttgaggaa aacctcgggc ctgagggcca
     3241 ggccggagcc caggtctctg ctgacaatgg gggttcaagg aagacgtcgt tatctcccct
     3301 ccccacttac tcgaggagag aggtgagggg gggatgactt gcgggttctg atcaggcccc
     3361 tgggtgggga aggggcacag tgtccctcag cagcttacgc ccctggagtc ttggggggcc
     3421 cagcctggcc ctggggcctt ttccagctac tgtgcccttg ggcagctgcg tctggggctc
     3481 aaccccccaa tcctgttccc ctctccagct gcgggtctgt aggcagctgt cacatctgaa
     3541 gggtttctgc aacctggacc ccatctgggt gtgggtcaga ccctgtgacc cacatgccac
     3601 ccccaccctc cacagagccc ccttgctggg acagccagct cacctccaag gacatcccct
     3661 cctggcttct cccccttccg agtctgcagc gccgtgggct tctctgccga tgggcccggg
     3721 ttggggttaa ggtgggcatc ctccaggtac aacgagcctg aagagcccct ttcagtgcag
     3781 acggggctgc agagtgacac tggctgggca cctgccccac gaccaatgac aaggatttcc
     3841 agctgaatgc tttattccca tagggatctg gacctgtgcc caagatataa atactacact
     3901 tttttttttt ttttttaact gacattgtga aattctccct atagcttttg ccattcaagc
     3961 aacattgtga tctttcttcc ccgccacgtg tgtgggaatg attgagtcct gtttgcaagc
     4021 tggagaggag ctctcccttt gctagtactt tctctaaagt actagtctag taaaatttat
     4081 tcttgttaga aggtcaacaa aatatctgtt tagcttttat gaagagtcac cgtagcagcc
     4141 cccacggctg gaaagaggcc tgtacgttct ggacgcgttt tgttggctgg gcttctggag
     4201 gcactggcaa ggtcaaactg catttcttta agaacagttg caggatctgg ctcgcctctg
     4261 tgggaagccg gcattacagg tgcttggtgg atgggccgtg tcacattgcc atctggggtc
     4321 ctttggggtt tccaggttgt caccatgctg tcccatttgg gaatcccata cctgcctgtc
     4381 cccactgcgc tggctgaccc ttgctgcctg ctgcctcttg ggagggcttt gtccctgcct
     4441 ctgagctggt gggcaggatg gctgggtggc ccccagagaa gcacagacct gagatggggt
     4501 ctccatgccc ggtttgctgt tggaatgatc tgaacaggac cccaaatgcc tcttccctct
     4561 ggtcatgcct cactatctct aggagctcca tcctgtggct tccagagtgt gcacttccag
     4621 cccacccggg cagtgctgag agggaggagg agaacaagga tggcccagcc tcccctccct
     4681 cccctagacc acggggcggg cagctcgggt tcctggaggg ctgtttcccc cacgctgtcc
     4741 ctacatctgc tctgatctaa aatgtctttc cttttatgct gcgcccagtc ttggggctca
     4801 aagatttgcc caaacctcat tggccctcgt gactaggctc atctagatgg tgctcacgct
     4861 ggtgtttgag gcatttccac tgtgatctcc acgaggggat gttttccggg acacatctct
     4921 ggctctggga actgcctgac tcactgaaga aactactttt caggcactgt agggtcaccc
     4981 atatgcctcc agctcagttg acgcttaaaa acaggtgcag aaaagctcgc gatggaaggt
     5041 cttaatgaga gtgtctgtct atgccaatca tgtaaaatga cgtttcttga aaaagattca
     5101 gtggttcagc tttgtcagca tcatctcaac acaagcctgc tggctctttt tagcatctca
     5161 tccaaccatg tcatcgtcca gatgagaaat cttagcccag gtgaggggag taacttgctt
     5221 gaggtcacac agctggctgt tggcaaagct gggattagaa ccctcaaccc agggtccctt
     5281 cctctgcagc gcctacatgg ttggttgaat aagtggctgc gtttcctggg gccctgggtt
     5341 ttggggaagc cagttagctg ctgctttggc actggcatgg aggtgagcag tcaaggatgc
     5401 tggtgaggct gcagtttctg ctctttttca tcagggggga tagtctctag gatttttcag
     5461 tgaggaccct tgggctttgg atgcagcttg aaccaagaaa acgaggaggg aaagggattc
     5521 agtgaactat tcctcagtgg gatcggttct tcagctcctg atgggggctg tgtaatgggg
     5581 gcagaggcca gggaaaaaga tgctgttcac ccaccctcag cttccctttt cctaaattaa
     5641 gaggaaaagt ggtcaaagaa aaactcttca tttctccctg attcttaaac gaaggtggtt
     5701 aatagaaact caggctcccg tgacaaggca ggacaagagc ctgtttcgct ttcctccctg
     5761 accctgccag gtgccaactc aaacactacc tttctcattg gtttctaagt cagtagagac
     5821 agatctgttt taagcagttg ggggttcgag tagatctcat gggtacagga ggccagcagg
     5881 gaccaggcca gtcagccatg ctcaggaccc ctcggctcct cccccagcct ctagctaccc
     5941 tgtatcgagg caaggggagg ccagtaaagt ttgccaagcc tgatcctgca gcctggtggg
     6001 gctggctggg gtattctttt accaaactct gttttaccgc cagccccttg tacaccccaa
     6061 tcccatgtct ccctcccttc agctggaccg tgtgcccctt tgggaggaag aagacaagcc
     6121 ccactagggc caagggcagc agagccctgc cgagtgagag gctgtggggc agcggctctg
     6181 tcctgtgcct taccagccct ggggaggggg gcatttggct ggaagactgg aatttaattg
     6241 ccatcgtctt tgattttgtg acatttctgc ttggaagtgt gaactacccc cccccccccg
     6301 cttcctgctc cttagcatgc gtgcagctct ctcctgtttt gggtgttccc cttggacact
     6361 ccagctcggg gactgctggc gtgtgaatgt gcagattccc ctgtgtggtc gaacctaaga
     6421 actgtggctt ggaagtgatg ctccatgtga cgacgacttt gctttctttc ctcttagtga
     6481 ggaggtgatt cgtagatccc aactgcctat gtaatgtaaa taatgtacat ttaatttatt
     6541 gctatggtag cacattgtat ttgttaatgt acaaaacaaa ttctaaaagg ttgacaaatg
     6601 tatattttgt tgcttaaatg tgtctttgca gaaattgaca ataaataaca tattttgtgt
     6661 cca
//
