LOCUS       NM_001251922           13237 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens RAP1B, member of RAS oncogene family (RAP1B),
            transcript variant 6, mRNA.
ACCESSION   NM_001251922
VERSION     NM_001251922.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13237)
  AUTHORS   Pardo,L.M., Aanicai,R., Zonic,E., Hakonen,A.H., Zielske,S.,
            Bauer,P. and Bertoli-Avella,A.M.
  TITLE     Adding to the evidence of gene-disease association of RAP1B and
            syndromic thrombocytopenia
  JOURNAL   Clin Genet 105 (2), 196-201 (2024)
   PUBMED   37850357
  REMARK    GeneRIF: Adding to the evidence of gene-disease association of
            RAP1B and syndromic thrombocytopenia.
REFERENCE   2  (bases 1 to 13237)
  AUTHORS   Zhang,B., Ding,J. and Ma,Z.
  TITLE     ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex
            Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells
  JOURNAL   Viruses 15 (7), 1457 (2023)
   PUBMED   37515145
  REMARK    GeneRIF: ICP4-Associated Activation of Rap1b Facilitates Herpes
            Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial
            Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13237)
  AUTHORS   Zhang,H., Tao,Y., Ding,X., Wang,Y. and Wang,X.
  TITLE     Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation
            and apoptosis of acute myeloid leukemia cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (3), 382-393 (2023)
   PUBMED   36951484
  REMARK    GeneRIF: Roles of the hsa_circ_0013880/USP32/Rap1b axis in the
            proliferation and apoptosis of acute myeloid leukemia cells.
REFERENCE   4  (bases 1 to 13237)
  AUTHORS   Chen,S., Li,Q.H., Chen,X., Bao,H.J., Wu,W., Shen,F., Lu,B.F.,
            Jiang,R.Q., Zong,Z.H. and Zhao,Y.
  TITLE     SNORA70E promotes the occurrence and development of ovarian cancer
            through pseudouridylation modification of RAP1B and alternative
            splicing of PARPBP
  JOURNAL   J Cell Mol Med 26 (20), 5150-5164 (2022)
   PUBMED   36056690
  REMARK    GeneRIF: SNORA70E promotes the occurrence and development of
            ovarian cancer through pseudouridylation modification of RAP1B and
            alternative splicing of PARPBP.
REFERENCE   5  (bases 1 to 13237)
  AUTHORS   Kawata,M., Farnsworth,C.C., Yoshida,Y., Gelb,M.H., Glomset,J.A. and
            Takai,Y.
  TITLE     Posttranslationally processed structure of the human platelet
            protein smg p21B: evidence for geranylgeranylation and carboxyl
            methylation of the C-terminal cysteine
  JOURNAL   Proc Natl Acad Sci U S A 87 (22), 8960-8964 (1990)
   PUBMED   2123345
REFERENCE   6  (bases 1 to 13237)
  AUTHORS   Siess,W., Winegar,D.A. and Lapetina,E.G.
  TITLE     Rap1-B is phosphorylated by protein kinase A in intact human
            platelets
  JOURNAL   Biochem Biophys Res Commun 170 (2), 944-950 (1990)
   PUBMED   1696481
REFERENCE   7  (bases 1 to 13237)
  AUTHORS   Matsui,Y., Kikuchi,A., Kawata,M., Kondo,J., Teranishi,Y. and
            Takai,Y.
  TITLE     Molecular cloning of smg p21B and identification of smg p21
            purified from bovine brain and human platelets as smg p21B
  JOURNAL   Biochem Biophys Res Commun 166 (2), 1010-1016 (1990)
   PUBMED   2105724
REFERENCE   8  (bases 1 to 13237)
  AUTHORS   Rousseau-Merck,M.F., Pizon,V., Tavitian,A. and Berger,R.
  TITLE     Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2
            genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively
  JOURNAL   Cytogenet Cell Genet 53 (1), 2-4 (1990)
   PUBMED   2108841
REFERENCE   9  (bases 1 to 13237)
  AUTHORS   Bokoch,G.M., Parkos,C.A. and Mumby,S.M.
  TITLE     Purification and characterization of the 22,000-dalton GTP-binding
            protein substrate for ADP-ribosylation by botulinum toxin, G22K
  JOURNAL   J Biol Chem 263 (32), 16744-16749 (1988)
   PUBMED   3141412
REFERENCE   10 (bases 1 to 13237)
  AUTHORS   Pizon,V., Lerosey,I., Chardin,P. and Tavitian,A.
  TITLE     Nucleotide sequence of a human cDNA encoding a ras-related protein
            (rap1B)
  JOURNAL   Nucleic Acids Res 16 (15), 7719 (1988)
   PUBMED   3137530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB448914.1, AK301428.1,
            AC015550.19, AJ420497.1, CX868584.1 and AC090061.15.
            
            On May 31, 2019 this sequence version replaced NM_001251922.1.
            
            Summary: This gene encodes a member of the RAS-like small
            GTP-binding protein superfamily. Members of this family regulate
            multiple cellular processes including cell adhesion and growth and
            differentiation. This protein localizes to cellular membranes and
            has been shown to regulate integrin-mediated cell signaling. This
            protein also plays a role in regulating outside-in signaling in
            platelets. Alternate splicing results in multiple transcript
            variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6
            and 9. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (6) differs in the 5' UTR and
            lacks an in-frame exon in the coding region, compared to variant 1.
            The encoded isoform (4) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301428.1, SRR1803617.364740.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DB448914.1         63-92
            31-248              AK301428.1         1-218
            249-249             AC015550.19        16868-16868         c
            250-1090            AK301428.1         220-1060
            1091-1858           AJ420497.1         1229-1996
            1859-1941           CX868584.1         31-113              c
            1942-8623           AC015550.19        1-6682              c
            8624-13237          AC090061.15        16790-21403         c
FEATURES             Location/Qualifiers
     source          1..13237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..13237
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /note="RAP1B, member of RAS oncogene family"
                     /db_xref="GeneID:5908"
                     /db_xref="HGNC:HGNC:9857"
                     /db_xref="MIM:179530"
     exon            1..145
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /inference="alignment:Splign:2.1.0"
     exon            146..228
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..585
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /EC_number="3.6.5.2"
                     /note="isoform 4 is encoded by transcript variant 6;
                     RAS-related protein RAP1B; ras-related protein Rap-1b;
                     small GTP binding protein; Ras family small GTP binding
                     protein RAP1B; GTP-binding protein smg p21B"
                     /codon_start=1
                     /product="ras-related protein Rap-1b isoform 4"
                     /protein_id="NP_001238851.1"
                     /db_xref="CCDS:CCDS58252.1"
                     /db_xref="GeneID:5908"
                     /db_xref="HGNC:HGNC:9857"
                     /db_xref="MIM:179530"
                     /translation="MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQV
                     EVDAQQCMLEILDTAGTVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAK
                     SKINVNEIFYDLVRQINRKTPVPGKARKKSSCQLL"
     exon            229..297
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /inference="alignment:Splign:2.1.0"
     exon            298..354
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /inference="alignment:Splign:2.1.0"
     exon            355..498
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /inference="alignment:Splign:2.1.0"
     exon            499..615
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /inference="alignment:Splign:2.1.0"
     exon            616..13237
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1821..1826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /note="hexamer: AATAAA"
     polyA_site      1858
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /note="major polyA site"
     regulatory      1908..1913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /note="hexamer: AATAAA"
     polyA_site      1941
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
     regulatory      2115..2120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /note="hexamer: AATAAA"
     polyA_site      2133
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
     regulatory      2216..2221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /note="hexamer: AATACA"
     polyA_site      2236
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
     regulatory      2686..2691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /note="hexamer: AATAAA"
     polyA_site      2707
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
     regulatory      6197..6202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /note="hexamer: AATAAA"
     polyA_site      6220
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
     regulatory      13210..13215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
                     /note="hexamer: AATAAA"
     polyA_site      13237
                     /gene="RAP1B"
                     /gene_synonym="K-REV; RAL1B; THC11"
ORIGIN      
        1 gacatcgcca aacctcgccc agattcaggc gtgtaaacca gccggagcgg cgcggcagcg
       61 gcaggaccgc cgtggcgcct agagtagcga cccgggggga gcgcggggcg acgctggctg
      121 cagggacccg gtgacagcgt gagaggtact aggttttgac aagcttgcat catgcgtgag
      181 tataagctag tcgttcttgg ctcaggaggc gttggaaagt ctgctttgac tgtacaattt
      241 gttcaaggaa tttttgtaga aaaatacgat cctacgatag aagattctta tagaaagcaa
      301 gttgaagtag atgcacaaca gtgtatgctt gaaatcttgg atactgcagg aacggttcca
      361 atgattcttg ttggtaataa gtgtgacttg gaagatgaaa gagttgtagg gaaggaacaa
      421 ggtcaaaatc tagcaagaca atggaacaac tgtgcattct tagaatcttc tgcaaaatca
      481 aaaataaatg ttaatgagat cttttatgac ctagtgcggc aaattaacag aaaaactcca
      541 gtgcctggga aggctcgcaa aaagtcatca tgtcagctgc tttaatatac taaatgcatt
      601 gtagctctga gccaggtctg aagaactgtt gcccaattca acagtgccag cattccaact
      661 ttgttaaacc taccaacatc ttaaatggac tttcctgtgg tggtaccctt taagaggcgg
      721 atgaaagcta ctatatcagt ttgcacattc taatcacttt ccagtatcac aagagagatt
      781 tttacttata taatagtcct agagtttgca gctggtaaaa ccagaggcta catccagtat
      841 tactgctaag agacattctt catccaccaa tgttgtacat gtatgaaaat ggtgtactgt
      901 atactttaac atgccccata ctttgtattg gagagtacaa taatgtaaat cctaaaagca
      961 ccactatttt agcataataa aagaaagtcc aaagagctcc tatatagact actccagata
     1021 acttcgcttc tttgatactt gtagcttatt gtaatttttt ttaagaaatt caaggtcatt
     1081 attattgtac aaaataagcg ctttgattaa cacagctata tagttttttt aatttttaaa
     1141 aaacctgtgg agacggtgat cttgtcttta aaacatgata gtcctttcag tataatgtct
     1201 tagattaaag acgttgcctt taatatctgt tgggaaggaa atgtccagac ttttcaaatc
     1261 tcttattata tgtttccttt ttttgtttac atagggaaca atgtttatag tcgtgtgtac
     1321 agtgggggtc tacaacaaga agtgtatatt ttcaaacaat tttttaatga tttaacaatt
     1381 tttgtaaatc attttcaggc ttctgcagct gtagattctc actgtgaatc ccttgcttgc
     1441 tcatgcataa gtgtatttgc aataccaaat atacaggttt agtatttttg cctgttagtg
     1501 attgtttcac atgtgtaacg ttttggttga gatgttaaat ggtggacgag tactgtggat
     1561 gtgaatgtgg gaagtaattt taatcatatg taattggtca caaggcctaa tttgcagtaa
     1621 ctattgctgt tttatttaac aatgccttgt tgctttgtat gcattaatgt ttggatgtaa
     1681 agattgtgtg tctatccaac agggagccac agtatttaaa ttgaccaacc taatgttaca
     1741 actactttga ggtggccaaa tgtaaactaa aagccttaat taaagtggtg caattttgta
     1801 taacttagca tcagtagttc aataaatttg gattgccatg caagggcttg cattataatt
     1861 acttgccact tgaatgtgtt ttgtgtaatg ttttaacagt gctagtaaat aaatacgggt
     1921 ttaccctggt tttaattgta ataggtgcat tttacacagc atggtttcat aatttaacat
     1981 ctgggcaagc cagactcatt aattacagga ataaggaagt agcgagtttt ctggtattgt
     2041 ttgaatatcc acataaccac cttttgaact tttccttgag aaataatttt gtaaatcaag
     2101 cagtattact tacgaataaa tgcctttggg taatgttcag tagctatttg atgaggtagg
     2161 taaaagagga acgatttaac atactttcat ggatgttaca ctatggattt tttaaaatac
     2221 aggattgaag ttagaatatt gtggttataa aaatctttga gtgatgtgga ttaagcactt
     2281 agagaatcga tatttttctt aaatatgcta taattgaatt ctgtaagaac tgaattctta
     2341 tagaattatt ttaaaacttt ttaaaaattg taaagctctt aaaaaacttt ttgaaagtat
     2401 ttgccagcta ctggagcaat taatcagtga taatatctaa tagaggggta tctgctaatc
     2461 ccctaaatac acgctgtttg aatgatacat ttttaaaggc tttcatgtta agaaaaagtc
     2521 tgattcttta caaaagggac ttgttttggc agaactggtt ttatttataa tcatttggga
     2581 aaaaaattaa gcccaaaaaa ctgggactgt gaaacactaa aattacttca atttactatg
     2641 tcctgttaca tccattgata ccgccattat tcaataatta cttttaataa atgtttgctg
     2701 cctaccagct atgtaccagg cccagttcta ggctcaaaca gctaaatatt cattcattgg
     2761 acaaattaag tacttaagta taaaaattgt tctaggccta aggatgtagc agcaaccaag
     2821 atcaactata aaatgctgcc ctcctagaat ttatattcta ttgaagagtt tctcagcctc
     2881 agcactattg atgttttatg tttgataatg tattctggcg actctcctgt gcattatagg
     2941 aattttaata tctgcccact agatgccagt cacaccaccc cagcccccaa gttgtggcaa
     3001 ccaaaaatgt ttccagacat tgccagatgt tccccagttg gattgttggg ggacaaggga
     3061 ggtgaacttg gagggcaaaa tcaccctggt gaagaactac tgctctggtg ggaaacaaca
     3121 cattagttac agatgagtgt tagggttaca agatggatgg tttactatat agtgaataag
     3181 aatataaagt ttggagccag acttcctggg tttttaatcc cagctcttcc agttcctact
     3241 atatgccttt ggttgggtgc cttggtttcc tcatctgtaa aatgagaatg ataataccta
     3301 cttcatagga gagtgaaatg aatgccagtg ctatcctcta ggtctatata tatatatata
     3361 tatatatatt atatatagta catatataga gagagtatat atatatatgt agtacagtgg
     3421 aggtctatat aatactatat atataattta tttttttcaa tgctgatagg aataaggctg
     3481 tggtttggca aaaagcacca ttttctccta tacaaaatag taactgcagt ttgggagcac
     3541 aactcatgta gattgacttt tctggtgctt aatgggaaaa tactaaaata attgagtcag
     3601 aaaaggcatg aattcctttt cacgtcccca aggatacttg aagaaacttg agttttagga
     3661 gaaaatcaga gtggtctttc acttacattt ttctaaaaag tgtaaaaacc ctgtattgac
     3721 tttcttgttg attcagttgt ttcttaaacg taaatagctc atctttacca tatgtgggca
     3781 ttacaaatag aaatttttaa aattccattt ataaaatgaa gttttgccgt tttttttttt
     3841 aaatcattcc gtctttagtt gtgggacagc aaacttagaa tcgaaactca tcactacaac
     3901 ttttctttga gttaaactct tatctgtgtt ttcattgaat ttaatctcca tctattctat
     3961 ctcttcttaa atcttggaaa tgtaaaaggg agttatagtg ttttacaatt aatactctta
     4021 ctattacctt agaagcctta aaagtgcttg caggcttgtc tcataatctg tcagtgagcc
     4081 ttaacattgt gatttgtaag actaaaattt ttttttcaaa caaaacaaat ctgacagcct
     4141 gggcaacata gaccccatct ctacaaaaaa aaattttttt ttaattagct gggcatggtg
     4201 gtgcacgtct gtacctgtag tcccagctat tcagaaggat tgcttgatcc caggagatca
     4261 aggatacagt gaactgtgtt cgcgccactg cacccccacg atggcaatag agtgagaccc
     4321 tgtcttagaa aaaaaagata aataagtctg ttctatttgt tacagtgcat caacacattt
     4381 gaattttctt tttttttctt tttctttttt ttttttgaga ctgagtttcg ctcttgttgc
     4441 ccaggctggc gtacagtggt gcgatcttgg ctcaccccaa cctctgcctc ccaggttcaa
     4501 gcaattcttc tgcctcagcc tcctgaatag ctgggattac aagcatgcac caccacgcct
     4561 ggctaatttt gtattttttg gtagagatga ggtttctcca tgttggttag gctggtttcg
     4621 aactcccgac ccaggtgatc cgcctgcgtc agcctcccaa agtgctggga ttacaggtgt
     4681 gagccaccgc acccagccta atcaatacat ttgatatttc aagaatacat gagagaagag
     4741 aggtagattg agaacagaac taaactttat atatgtttcc ttaactattg ggaggaaaat
     4801 ggatgagtct gtgttgggat acctgttgaa acaagactac taaacagatt aatcaactaa
     4861 ttccataggc ttgacattag tttatctttg aaaagtaaaa gtaaagtgct tattgctaaa
     4921 taggtctgta ttctaaatgc tgccattttt taaaaaaagt attccatgtt acacacattt
     4981 taaacttgct tcttaaaaca tccctgttgg tggcctgtag gttactgacc ttaggaatta
     5041 caggctttat ccaaaattag gcatatctac ctgatttttg tatctgagaa tcaataaatg
     5101 cattcagtat tctctaccgt gtttcaggcg ctgtttacaa tatcggaggt acagcaggga
     5161 ttttctgccc acgtggggaa aacacacagc aaatgaacaa agctctattg gtaacagtct
     5221 gttaaacttt ctaagagctt tccaactttc taagagaaaa ttgtaatgat tttagaaaag
     5281 tgagctgtca tttttcatat atataaattt ttttattcat aggtaatcta atttttctca
     5341 tttctccaaa agggtacgaa gacagttttt actatgttgt tttactatga acctagttta
     5401 acctgacttt ccttacagac ccacataaat gagacaatcc aaatttagta tttgggtcaa
     5461 aatgcagggt tttttcctga aaacaaaaca gcacacacat atattacagg atttttatgt
     5521 aataatatat tcacttcagt caggtttcag tttttaaata ggcagagatc aaaagcctct
     5581 aatgtttttg tcatccgcca ttattaccca ttcaaatttc tatttatgtc tggtagttat
     5641 gtcccctgtg agcactaatt tcagaacagg aaattctatt aactgtcaaa ctctttaatg
     5701 tgcagtgcag taggtttgga gcagagggga gtaggaagga gtaaatgata taatccagtc
     5761 tggcctggca tggtggctca cacttgtaat cccaatgctt tgggaggccg agatgggtgg
     5821 atcactggaa gccaggagtt tgagacaagc ctggccaaca tggtgaaacc ccgtctctac
     5881 taaaaataac aaaaattaga cgggcacggt ggtgtgtgcc tgtaatccca gctactcagg
     5941 aggctgaggc aggagaatca cttgaacctg ggaggccgag gttgcagtga gctgagatca
     6001 caccactgca cttcagcatg ggcaacagag tgagactgca aaaaaaagaa aaagaaaaaa
     6061 aaatccagtc tctgctggca aggtgtttaa caagtcaatg atgggaaaga ccagtcaaat
     6121 aaactatcag atctaataac ttttctaacc ataggtgatt cttcttccat tatccatact
     6181 aaagcaagtg actcataata aaaattgtta ttttgtaaaa tatatggact gtttgcttta
     6241 tattcccaac tattacatct ggttgactat taacaggtca atgtcagatt tcctgagcaa
     6301 atcaaccaat aatgaaaaac tatgtggctg gcagaaaaaa ataagtgcgt gtggtggtgc
     6361 ttgcctgtaa tcccagctgc ttgggaggct gaggtaggag gaactcttga gctccggtgg
     6421 tttgaggcca gcatggataa catagggaga ccctgtcact tgacaaaagt atctttccct
     6481 actggaaatg gaatagaatc ggatgggtat ggtacagcag gtagttatgg ggagacctct
     6541 actgttctaa atgagactaa tagtaaatgt tacataacta aagcaacaga tttgccagct
     6601 gtgtgaaaga taacccagag aggggtaatg gtagagccag aattaacaca gccagcttgt
     6661 cagctacctt tgaacatgta ttttctgtgc agtcagattt gaagggttgg accttggagt
     6721 tactgacatt ggaggcaact gaaaccatga gtgtgaatga aattattttc gtaagaatta
     6781 cttggggtta aaaatagtaa taaaaaggaa agcctggcct aaacagtctt gggatgggga
     6841 gaagggttgg agtacaaagg attgctatta caaagacatg ggcagagaac aaggcaaata
     6901 gctgagcagc aattgagaat acagcatctt ttatggcaaa gagcaaaata ctattgttcc
     6961 tcttctagta tgctatagac cagcagtaat tttgtgctct aaaatgctta tttttatctc
     7021 tctgtatata cttggtggtg aatttgctac aaatgtaagg agatgatggg atagtttttg
     7081 gaaataccat cctctaatta gtaccaggtc tatgtatatc tgcagcaact ataaagtctg
     7141 tttcagagtc agtattggca aacttatatt taaattcagc tgtaacaaga catctttttt
     7201 tttttttttg agagagtctg gctctgtcac ccaggctggt gtgcagtggc gcgatctcgg
     7261 ctcactgcaa cctccgcctc ccaggttcaa gcagttctct gcctcagcct cccgagcagc
     7321 tgggattaca ggcatctgcc accaagccct gctaattttt ctatttttag tagagacggg
     7381 gtttcgccat cttggccagg ctggtcttga actcctgacc tcgtgatcca tctgcttcag
     7441 cctcccaaag tgctgggatt actggcatga gccactgcgc ccggcaagtt gtctttcaaa
     7501 tatatgcctt tgcagtattt ctctacttcc ccagtaatgt aaactttatt ttctctcaat
     7561 tttcgtaagt ggtattttgg tgctttaccc aaaatattag ggagaaaatt cttcttttta
     7621 attggattct cgtatgttga tctatttcta ttgttttcta aaaaaaagtt agtgtcctag
     7681 tttaaaagta tatattagtt tcctagggct gctgtaacaa attatcacaa atttggtggc
     7741 ttaaagcaac agaaatgtac tctttcacag ttctgaaggt cgaagtccaa aatcaaagtg
     7801 ttaggatgta ctcctagagg ctctcggaga gaacctgttc ccatggcatt atgccacatc
     7861 acatgtgcct ctatctttgt atctcctcct ctctataatc tttcttttaa aaggacaatt
     7921 gttttgacat ttagggctta cccacatact tcaggataat ctcatctcaa aatgcttaat
     7981 cacatctgca aagacacttt tttcaaataa agttaacaga cagaagtttg ggggttggga
     8041 tgtggacatg cctttgggag ccattaacaa cctaccaaaa cattttaaca atttttcagt
     8101 accaaagact agtatgggtc tgctccaaga taactcaaaa cattctgaac tgaatcagca
     8161 gaccctcagg tctccctaga gagatcctga gcacctagga aagccccaga attaagctac
     8221 tctacaagga ttctgaggga agtctgggat taggtgagac tttaatgagt ccatcagagg
     8281 tttagtatgg actagttcta cagttccaga agcaacatac tgggtatgga atattgttaa
     8341 ccattgtcat cccacagaat taccttctac ttgtgtcagt atatatcctg cctaccctac
     8401 atattttata tttatcaatg atgacagaaa cttcccccct tttacttaga tctaatagta
     8461 atataacaaa cttttctttt tcattttcag acatatccag agggttttct cttcatctca
     8521 cgcatcccac ctttaatcag acatatgtga ttcatatgag agaaaattag tgtttctgag
     8581 accaaatggt ggtgtttata agattttgct tctgcactga attcaatgtt ttatttactg
     8641 cttggttatt ttgtttttgt tttttaagaa atgggaggag tgtaatatct agaggtacat
     8701 gaaaaaaaga aatggaagga atggacaggc ccagaattaa atgataaaaa ctcatctggt
     8761 tggaatgaag tacactgaac atttgaggaa gttagagatt aattcaaccc agtgggtttt
     8821 ggggttttta tatgtgttag tacattcagc gttagggttg ggtttcttgt ctctgtaatc
     8881 acttctcaaa aatgaatttg ggcttctcca gatagccttt ttatccattt attatttcaa
     8941 gtaatggtat aaggaaattg taaccatttg tgtgctttac atgtttaaga tacaaactta
     9001 cagttcccag aagtcaattc agtcattctc tataagagct gttgtggaaa aagttctcac
     9061 ttcacttact cattcctttg cattttccaa ctttagtaaa gcatgacttc atgccttgga
     9121 tcatacagga tttcaacggg agatttataa gtctattttg ttagaataaa aagcaataat
     9181 acttcctgaa atacatcttg ggctctttgc agaagctgaa ctatctggta attactattt
     9241 agcaaacagc taacagctag ctcttaattt ttcagaaata agaggacatc attggccact
     9301 atcataccac taattttatt ccaccaatgc tttcacagag gatgtcacca aagaaagaag
     9361 tggcatccac tacccctccc ccatccttcc actctgaacc agtacaggat attctcatgg
     9421 tcagggcatt ctctccttgg caggatgtag ttaatgacat atgcagaatt aatgacttgg
     9481 ttgccctagg ccccccgtca aggcttttgt tcaagggaga gtaaagagga taggtctcag
     9541 tatgtcatcc aaacaggatg gatacagaat gccaaccagg ttagccctgg caagttaaga
     9601 cattttacag tgccactacc tacctccata ctgtatcaga ggagccagtt gcacagtgtt
     9661 gatctcccta agactattat aataaggaag gggttttttt cttagcccag ttactactaa
     9721 aactcactca gaggagcaag tgaaatttgt cacaattggc tcgactgctt tatctcactt
     9781 tgaaaaagaa aagttacaaa ttctagtaag caaaagattt tttgtgacca ggtctccctg
     9841 acctgcacaa aataaactct tcatgagtta aaccaaaaca gatttaatgt ctaaacttaa
     9901 atctagtttg acattaactt cttttccaaa gagaaataac gttaacaatc tgaaatcatc
     9961 cctgcacaga ctttcttggc tcttcttttc tgccgtccta tgaatcacaa atagaagttt
    10021 aagaaagctg tcaggtaggc gcctcaaatt catttaaaat gaggaatgat gaaagaataa
    10081 gaaaaaccag caaatgatag cttacttatt cagttatttg gcttgatact gcttgaaagt
    10141 gacatttcta gattaaagat ctgataagct ctgatagttg ggaaataata ctagttattt
    10201 cttggacacc ctaagatgtg ccaccattgc tctaagcact ttacatgtgt tgttcaaccc
    10261 tcagcaatgc tatgaaatag gggctgagtc tcctaataga gctaatgaat gcattatatc
    10321 aaaagaatga aatgttaaat atagacactg gaaaataaaa ttacttttgc ttgtattata
    10381 agtgaatacc ttgaaagctc aaaaaaatct attagaagta ttcaggaact tggctggata
    10441 taagataagc atgccaaaaa tcaatagctt ttctttatat ttataaaaaa tacctacaag
    10501 ttgatatagt aaacacgaca gataaaaact aaatgcctta aggtataagg ctaagaaaga
    10561 actattataa actcttattg aaggacataa atcaagatct gaacaaatac actgggaaga
    10621 taatatcata aaaatatcaa ttcccccaaa ttagcatgtt aatgtataat gattacaatt
    10681 taaatttcaa ctggctgagg ctttgttttt gtttttgatt ttttaataga ctggatgttg
    10741 gtcttgaact cctgggctca agcaagtgtc acaccttggc ctcccaaagt ggattatagg
    10801 catgagccac cgtgccagac ttgggtgagg ttttgaaatt gaaattaagc aaaatgggcc
    10861 gggcacggtg gctcacacct gtaatcccag cactttcgga ggccgagggg ggcggatcac
    10921 gaggtcagga gatggagacc atcctggcta acatggtgaa accccgtctc tactaaaaat
    10981 acaaaaatta gccaggcatg gtggcaggtg cctgtaatcc cagctactct ggaggctgag
    11041 gcaggagaat cgcttgaacc caggaggcag agggtgcagt agctgagatt gtaccactgc
    11101 actccagcct gggtgacaga gcaaatctct atctcaagaa aaagaaaaaa gaaaagaaat
    11161 taagcaaaat gatcttaaag ttcaagtgaa agagtagagt agaactgagt ccagaactag
    11221 attccagtat atgacgttta tacgtgacaa aaatatattt ctttttcttt cttttttttt
    11281 tttttttttt tgagacagtt tccctcttgt tgcccagact ggagtataat ggcacgatct
    11341 tggttcacca caacctccgc ctcccaggtt caagtgattc tcctgcctca gcctcccgag
    11401 tagctgggat tacaggcatg tgccaccacg cctgggctaa ttttgtattt tagtagagat
    11461 ggggtttctc catgttggtc aggctagttg cgaactccca acctcaggtc atctgcccgc
    11521 ctcagcctcc caaagtactg ggattacagg tgtgagccac tgtgcccggc cgacaaaaat
    11581 atatttcaat agaaaatagt atcagtaaaa tgctagcaca actaactatc tgtctaaaga
    11641 caataaaagt tcaaccccta tatcatgcaa aaagcacttt ccagatatat taaaatgttt
    11701 tcaagctata aagtaaaaca gtagaagtct tagaagaaaa tctaagagac tagaaatcta
    11761 gagatagggt agaccttctt agctaatttt taaaaatgaa gctatattta agatatatat
    11821 ttcaagtaaa taataagtgt gtgtgtgtgt acacacagat gcttctcagc ttacaatggg
    11881 gttatgtccc aataagccca tcagaagtca aaaatgtaag tcgaaaatgc atttaatacc
    11941 ctgataaatc catcacaaag ctgaaaaatt ataagtaaaa ctgtaagtca cagactgtat
    12001 atataaattt aaaatttggc aaaatatatt gcaaagtcaa atttgggaaa gtatagcaca
    12061 gataaaagat taaactattc acggccaggc acggtggatc atgcctgtaa tcccaacact
    12121 ttgggaggcc gaggcgggtg gatcacctga ggtcaggagt ttgagactag cctggccaac
    12181 gtggagaaac cccatctcta ctaaaaatac aaaattagct gggtgtggtg gtgcatgcct
    12241 gtaatcctag ctactcagga ggctgaggca ggagaattgc ttgaacctag gaggcgaaag
    12301 ttgcagtgag ccaagatggt gccattgcac tccagcctgg gcaacaagag tgatactccg
    12361 tttaaaaaaa aaaaaaaaaa aaaaggtaaa ctattcaaaa gataaatggt tgaaagatat
    12421 ataactaggc agtttagata agaacaaatc caaatggccc atcaacataa aaagatgctc
    12481 taactgtagc cagagaaata cgaatcaaag taccaacgag cccaacacat ggacgaaaac
    12541 ttcagagaac actacagtcc cagaagagag gtaaagggca agaaatgaat catttattgc
    12601 tgatggaaat gtgcattgta gagctgatat ctgttcaaat taaatatgca tatttgacct
    12661 caattctact actgatatct acaccaagga aatgaaagga aatgcacaag attatttatt
    12721 gccacactct agaaggaaaa acagagtgca tgcccatcaa tagaatagtt gaataaatta
    12781 tgattcatgc ataatataga acattatgca ttcatttaaa aatgagtttg atgtttaaag
    12841 gttgacttag aaggattccc gtgcaaagtg aacaaaacag aataccgaga aggatgtatg
    12901 tgagggatgc atgtgggcac ctgggaaagg agatgaagaa agcaactgaa ggatatttac
    12961 caagttgtta atatgcatta cctgacatgg tgatatagga gtaggggtga ggaagtgaag
    13021 gatctgagta ggtggaaaaa gaaaagcaaa agtacaacag cgggagaaaa aacaggatga
    13081 ctcgtctaga agagacattg tcagtaacaa gtaaataaca ttttctggaa tataaaaaaa
    13141 aaagctatat gaatgtcatc attatatgta aaatatgaat gtaaaataca tgggaggata
    13201 atatgcatta ataaaaatta tggtgctggc aacagta
//
