LOCUS       NM_016492                831 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens RAN guanine nucleotide release factor (RANGRF),
            transcript variant 1, mRNA.
ACCESSION   NM_016492 NM_014185
VERSION     NM_016492.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 831)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 831)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 831)
  AUTHORS   Yu,G., Liu,Y., Qin,J., Wang,Z., Hu,Y., Wang,F., Li,Y.,
            Chakrabarti,S., Chen,Q. and Wang,Q.K.
  TITLE     Mechanistic insights into the interaction of the MOG1 protein with
            the cardiac sodium channel Nav1.5 clarify the molecular basis of
            Brugada syndrome
  JOURNAL   J Biol Chem 293 (47), 18207-18217 (2018)
   PUBMED   30282806
  REMARK    GeneRIF: The MOG1 domain required for the interaction with Nav1.5
            to the region spanning amino acids 146-174, and a refined deletion
            analysis further narrowed this domain to amino acids146-155.
REFERENCE   4  (bases 1 to 831)
  AUTHORS   Bao,X., Liu,H., Liu,X., Ruan,K., Zhang,Y., Zhang,Z., Hu,Q., Liu,Y.,
            Akram,S., Zhang,J., Gong,Q., Wang,W., Yuan,X., Li,J., Zhao,L.,
            Dou,Z., Tian,R., Yao,X., Wu,J. and Shi,Y.
  TITLE     Mitosis-specific acetylation tunes Ran effector binding for
            chromosome segregation
  JOURNAL   J Mol Cell Biol 10 (1), 18-32 (2018)
   PUBMED   29040603
REFERENCE   5  (bases 1 to 831)
  AUTHORS   Kattygnarath,D., Maugenre,S., Neyroud,N., Balse,E., Ichai,C.,
            Denjoy,I., Dilanian,G., Martins,R.P., Fressart,V., Berthet,M.,
            Schott,J.J., Leenhardt,A., Probst,V., Le Marec,H., Hainque,B.,
            Coulombe,A., Hatem,S.N. and Guicheney,P.
  TITLE     MOG1: a new susceptibility gene for Brugada syndrome
  JOURNAL   Circ Cardiovasc Genet 4 (3), 261-268 (2011)
   PUBMED   21447824
  REMARK    GeneRIF: Results suggest that dominant-negative mutations in MOG1
            can impair the trafficking of Na(v)1.5 to the membrane, leading to
            I(Na) reduction and clinical manifestation of Brugada syndrome.
REFERENCE   6  (bases 1 to 831)
  AUTHORS   Wu,L., Yong,S.L., Fan,C., Ni,Y., Yoo,S., Zhang,T., Zhang,X.,
            Obejero-Paz,C.A., Rho,H.J., Ke,T., Szafranski,P., Jones,S.W.,
            Chen,Q. and Wang,Q.K.
  TITLE     Identification of a new co-factor, MOG1, required for the full
            function of cardiac sodium channel Nav 1.5
  JOURNAL   J Biol Chem 283 (11), 6968-6978 (2008)
   PUBMED   18184654
  REMARK    GeneRIF: in cardiomyocytes, MOG1 is mostly localized in the cell
            membrane and co-localized with Nav1.5, indicating that MOG1 is a
            critical regulator of sodium channel function in the heart
REFERENCE   7  (bases 1 to 831)
  AUTHORS   Steggerda,S.M. and Paschal,B.M.
  TITLE     Identification of a conserved loop in Mog1 that releases GTP from
            Ran
  JOURNAL   Traffic 2 (11), 804-811 (2001)
   PUBMED   11733047
REFERENCE   8  (bases 1 to 831)
  AUTHORS   Marfatia,K.A., Harreman,M.T., Fanara,P., Vertino,P.M. and
            Corbett,A.H.
  TITLE     Identification and characterization of the human MOG1 gene
  JOURNAL   Gene 266 (1-2), 45-56 (2001)
   PUBMED   11290418
REFERENCE   9  (bases 1 to 831)
  AUTHORS   Steggerda,S.M. and Paschal,B.M.
  TITLE     The mammalian Mog1 protein is a guanine nucleotide release factor
            for Ran
  JOURNAL   J Biol Chem 275 (30), 23175-23180 (2000)
   PUBMED   10811801
REFERENCE   10 (bases 1 to 831)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN396019.1 and AF265206.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016492.4.
            
            Summary: This gene encodes a protein that has been shown to
            function as a guanine nucleotide release factor in mouse and to
            regulate the expression and function of the Nav1.5 cardiac sodium
            channel in human. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longest isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF168714.1, SRR5189667.169191.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226105.11/ ENSP00000226105.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 CN396019.1         21-21
            2-831               AF265206.1         1-830
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..831
                     /gene="RANGRF"
                     /gene_synonym="HSPC165; HSPC236; MOG1; RANGNRF"
                     /note="RAN guanine nucleotide release factor"
                     /db_xref="GeneID:29098"
                     /db_xref="HGNC:HGNC:17679"
                     /db_xref="MIM:607954"
     exon            1..196
                     /gene="RANGRF"
                     /gene_synonym="HSPC165; HSPC236; MOG1; RANGNRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..680
                     /gene="RANGRF"
                     /gene_synonym="HSPC165; HSPC236; MOG1; RANGNRF"
                     /note="isoform A is encoded by transcript variant 1; MOG1
                     homolog; ran-binding protein MOG1"
                     /codon_start=1
                     /product="ran guanine nucleotide release factor isoform A"
                     /protein_id="NP_057576.2"
                     /db_xref="CCDS:CCDS11137.1"
                     /db_xref="GeneID:29098"
                     /db_xref="HGNC:HGNC:17679"
                     /db_xref="MIM:607954"
                     /translation="MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTD
                     QSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEA
                     WVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSP
                     APWSLGDFEQLVTSLTLHDPNIFGPQ"
     exon            197..313
                     /gene="RANGRF"
                     /gene_synonym="HSPC165; HSPC236; MOG1; RANGNRF"
                     /inference="alignment:Splign:2.1.0"
     exon            314..470
                     /gene="RANGRF"
                     /gene_synonym="HSPC165; HSPC236; MOG1; RANGNRF"
                     /inference="alignment:Splign:2.1.0"
     exon            471..556
                     /gene="RANGRF"
                     /gene_synonym="HSPC165; HSPC236; MOG1; RANGNRF"
                     /inference="alignment:Splign:2.1.0"
     exon            557..831
                     /gene="RANGRF"
                     /gene_synonym="HSPC165; HSPC236; MOG1; RANGNRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      810..815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANGRF"
                     /gene_synonym="HSPC165; HSPC236; MOG1; RANGNRF"
                     /note="hexamer: AATAAA"
     polyA_site      831
                     /gene="RANGRF"
                     /gene_synonym="HSPC165; HSPC236; MOG1; RANGNRF"
                     /note="major polyA site"
ORIGIN      
        1 gggagctaag ccagacccgg gtggcggtgg cagctgcgaa acccagggag ccgatgccac
       61 gtgacccaat gtggacttct tttaaacctt tctaatgccc ataacccagc ctcagaccca
      121 tggagcccac gagagactgc ccgctgttcg ggggcgcctt ttccgccatc ctccccatgg
      181 gggccattga cgtaagcgac ctccgaccgg tcccggacaa tcaagaagtt ttctgccatc
      241 ccgtgacgga ccagagcctg atagtggaac ttctcgagct gcaggcccac gtacggggcg
      301 aagcggctgc gcggtaccac tttgaggatg ttggtggcgt gcagggggct agggctgtcc
      361 atgtggagtc tgttcagcct ctcagtttgg agaacctggc cctgaggggc cgctgtcaag
      421 aagcctgggt cctctctggc aagcagcaga tagctaagga aaaccagcag gtagcaaagg
      481 acgtgacact tcatcaggcc ttgctgaggc tgccccagta ccagactgat ctcttgctta
      541 ccttcaatca gcccccccct gacaacaggt catctcttgg ccccgaaaat ctgtcacctg
      601 caccctggag cctgggtgac tttgaacagc tggtgaccag tctgaccctt cacgatccta
      661 acatctttgg tccccagtaa aggcgctgaa gcactgcatg atgttgctga gaacttgggg
      721 actcggttct gtgaggggga aaagaggttg aaaagagggt ttcctcttat ttcttccctg
      781 tgcgtaaaca taagacaatc cctcttcaga ataaacttgc tttataatca a
//
