LOCUS       NM_002883               3828 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens Ran GTPase activating protein 1 (RANGAP1), transcript
            variant 2, mRNA.
ACCESSION   NM_002883
VERSION     NM_002883.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3828)
  AUTHORS   Zhang,F., Yang,J. and Cheng,Y.
  TITLE     Impact of RANGAP1 SUMOylation on Smad4 nuclear export by
            bioinformatic analysis and cell assays
  JOURNAL   Biomol Biomed 24 (6), 1620-1636 (2024)
   PUBMED   38801243
  REMARK    GeneRIF: Impact of RANGAP1 SUMOylation on Smad4 nuclear export by
            bioinformatic analysis and cell assays.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3828)
  AUTHORS   You,H.J., Ma,L.H., Wang,X., Wang,Y.X., Zhang,H.Y., Bao,E.S.,
            Zhong,Y.J., Liu,X.Y., Kong,D.L., Zheng,K.Y., Kong,F.Y. and
            Tang,R.X.
  TITLE     Hepatitis B virus core protein stabilizes RANGAP1 to upregulate
            KDM2A and facilitate hepatocarcinogenesis
  JOURNAL   Cell Oncol (Dordr) 47 (2), 639-655 (2024)
   PUBMED   37845585
  REMARK    GeneRIF: Hepatitis B virus core protein stabilizes RANGAP1 to
            upregulate KDM2A and facilitate hepatocarcinogenesis.
REFERENCE   3  (bases 1 to 3828)
  AUTHORS   Lin,X., Pang,Q., Hu,J., Sun,J., Dai,S., Yu,Y. and Xu,J.
  TITLE     SUMOylation mediates the disassembly of the Smad4 nuclear export
            complex via RanGAP1 in KELOIDS
  JOURNAL   J Cell Mol Med 27 (8), 1045-1055 (2023)
   PUBMED   36916534
  REMARK    GeneRIF: SUMOylation mediates the disassembly of the Smad4 nuclear
            export complex via RanGAP1 in KELOIDS.
REFERENCE   4  (bases 1 to 3828)
  AUTHORS   Gong,Y., Zou,S., Deng,D., Wang,L., Hu,H., Qiu,Z., Wei,T., Yang,P.,
            Zhou,J., Zhang,Y., Zhu,W., Xie,X., Liao,Z., Yang,J., Zhang,S.,
            Liu,A., Jiang,Y., Zou,Z. and Bai,X.
  TITLE     Loss of RanGAP1 drives chromosome instability and rapid
            tumorigenesis of osteosarcoma
  JOURNAL   Dev Cell 58 (3), 192-210 (2023)
   PUBMED   36696903
  REMARK    GeneRIF: Loss of RanGAP1 drives chromosome instability and rapid
            tumorigenesis of osteosarcoma.
REFERENCE   5  (bases 1 to 3828)
  AUTHORS   Krebber,H. and Ponstingl,H.
  TITLE     Ubiquitous expression and testis-specific alternative
            polyadenylation of mRNA for the human Ran GTPase activator RanGAP1
  JOURNAL   Gene 180 (1-2), 7-11 (1996)
   PUBMED   8973340
REFERENCE   6  (bases 1 to 3828)
  AUTHORS   Gorlich,D., Pante,N., Kutay,U., Aebi,U. and Bischoff,F.R.
  TITLE     Identification of different roles for RanGDP and RanGTP in nuclear
            protein import
  JOURNAL   EMBO J 15 (20), 5584-5594 (1996)
   PUBMED   8896452
REFERENCE   7  (bases 1 to 3828)
  AUTHORS   Becker,J., Melchior,F., Gerke,V., Bischoff,F.R., Ponstingl,H. and
            Wittinghofer,A.
  TITLE     RNA1 encodes a GTPase-activating protein specific for Gsp1p, the
            Ran/TC4 homologue of Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 270 (20), 11860-11865 (1995)
   PUBMED   7744835
REFERENCE   8  (bases 1 to 3828)
  AUTHORS   Bischoff,F.R., Krebber,H., Kempf,T., Hermes,I. and Ponstingl,H.
  TITLE     Human RanGTPase-activating protein RanGAP1 is a homologue of yeast
            Rna1p involved in mRNA processing and transport
  JOURNAL   Proc Natl Acad Sci U S A 92 (5), 1749-1753 (1995)
   PUBMED   7878053
REFERENCE   9  (bases 1 to 3828)
  AUTHORS   Bischoff,F.R., Krebber,H., Smirnova,E., Dong,W. and Ponstingl,H.
  TITLE     Co-activation of RanGTPase and inhibition of GTP dissociation by
            Ran-GTP binding protein RanBP1
  JOURNAL   EMBO J 14 (4), 705-715 (1995)
   PUBMED   7882974
REFERENCE   10 (bases 1 to 3828)
  AUTHORS   Bischoff,F.R., Klebe,C., Kretschmer,J., Wittinghofer,A. and
            Ponstingl,H.
  TITLE     RanGAP1 induces GTPase activity of nuclear Ras-related Ran
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2587-2591 (1994)
   PUBMED   8146159
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA269460.1, BC014044.2,
            BC004990.1, HY062550.1 and HY251691.1.
            
            On Jun 2, 2019 this sequence version replaced NM_002883.3.
            
            Summary: This gene encodes a protein that associates with the
            nuclear pore complex and participates in the regulation of nuclear
            transport. The encoded protein interacts with Ras-related nuclear
            protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding
            and exchange. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1799467.1, BC014044.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356244.8/ ENSP00000348577.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               DA269460.1         65-242
            179-1787            BC014044.2         158-1766
            1788-2995           BC004990.1         427-1634
            2996-3382           HY062550.1         121-507
            3383-3828           HY251691.1         33-478              c
FEATURES             Location/Qualifiers
     source          1..3828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..3828
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /note="Ran GTPase activating protein 1"
                     /db_xref="GeneID:5905"
                     /db_xref="HGNC:HGNC:9854"
                     /db_xref="MIM:602362"
     exon            1..202
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            203..352
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..2004
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /note="segregation distorter homolog"
                     /codon_start=1
                     /product="ran GTPase-activating protein 1"
                     /protein_id="NP_002874.1"
                     /db_xref="CCDS:CCDS14012.1"
                     /db_xref="GeneID:5905"
                     /db_xref="HGNC:HGNC:9854"
                     /db_xref="MIM:602362"
                     /translation="MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKE
                     IEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALIS
                     LGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGK
                     ILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQN
                     GINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLV
                     RSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLG
                     EEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEE
                     EEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPPPADVSTFLAFPSPEKLLRLG
                     PKSSVLIAQQTDTSDPEKVVSAFLKVSSVFKDEATVRMAVQDAVDALMQKAFNSSSFN
                     SNTFLTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKP
                     NSALESCSFARHSLLQTLYKV"
     exon            353..480
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            481..540
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            541..720
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            721..855
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1014
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1128
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1228
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1313
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1500
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1620
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1723
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1812
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1934
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..3828
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2974..2979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /note="hexamer: AATAAA"
     polyA_site      2996
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /note="major polyA site"
     regulatory      3807..3812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
                     /note="hexamer: CATAAA"
     polyA_site      3828
                     /gene="RANGAP1"
                     /gene_synonym="Fug1; RANGAP; SD"
ORIGIN      
        1 gccgcggtgc ggagagcagg tggtgctgga agcgcgtgag gccgggagct cgagagagct
       61 aacagactag ccggctggac atctggaccg ctggatccgg aggtggcgac cccggcctga
      121 cccggaccct aaatccgtcc ccgccccaga gggcggaggc gcgcgctcga ttccccccac
      181 gcggcggcgc cgcctgttta cgtctgcaga tctccagggg agcccaccag cctagtcaac
      241 atggcctcgg aagacattgc caagctggca gagacacttg ccaagactca ggtggccggg
      301 ggacagctga gtttcaaagg caagagcctc aaactcaaca ctgcagaaga tgctaaagat
      361 gtgattaaag agattgaaga ctttgacagc ttggaggctc tgcgtctgga aggcaacaca
      421 gtgggcgtgg aagcagccag ggtcatcgcc aaggccttag agaagaagtc ggagttgaag
      481 cgctgccact ggagtgacat gttcacggga aggctgcgga ccgagatccc accagccctg
      541 atctcactag gggaaggact catcacagct ggggctcagc tggtggagct ggacttaagc
      601 gacaacgcat tcgggcccga cggtgtgcaa ggcttcgagg ccctgctcaa gagctcagcc
      661 tgcttcaccc tgcaggaact caagctcaac aactgtggca tgggcattgg cggcggcaag
      721 atcctggctg cagctctgac cgaatgtcac cggaaatcca gtgcccaagg caagcctctg
      781 gccctgaagg tctttgtggc tggcagaaac cgtctggaga atgatggcgc cactgccttg
      841 gcagaagctt ttagggtcat cgggaccctg gaggaggtcc acatgccaca gaatgggatc
      901 aaccaccctg gcatcactgc cctggcccag gctttcgctg tcaaccccct gctgcgggtc
      961 atcaacctga atgacaacac cttcactgag aagggcgccg tggccatggc cgagaccttg
     1021 aagaccttgc ggcaggtgga ggtgattaat tttggggact gcctggtgcg ctccaagggt
     1081 gcagttgcca ttgcagatgc catccgcggc ggcctgccca agctaaagga gctgaacttg
     1141 tcattctgtg aaatcaagag ggatgctgcc ctggctgttg ctgaggccat ggcagacaaa
     1201 gctgagctgg agaagctgga cctgaatggc aacaccctgg gagaagaagg ctgtgaacag
     1261 cttcaggagg tgctggaggg cttcaacatg gccaaggtgc tggcgtccct cagtgatgac
     1321 gaggacgagg aggaggagga ggaaggagaa gaggaagaag aggaagcaga agaagaggag
     1381 gaggaagatg aggaagagga ggaagaagag gaggaggagg aggaagaaga gcctcagcag
     1441 cgagggcagg gagagaagtc agccacgccc tcacggaaga ttctggaccc taacactggg
     1501 gagccagctc ccgtgctgtc ctccccacct cctgcagacg tctccacctt cctggctttt
     1561 ccctctccag agaagctgct gcgcctaggg cccaagagct ccgtgctgat agcccagcag
     1621 actgacacgt ctgaccccga gaaggtggtc tctgccttcc taaaggtgtc atctgtgttc
     1681 aaggacgaag ctactgtgag gatggcagtg caggatgcag tagatgccct gatgcagaag
     1741 gctttcaact cctcgtcctt caactccaac accttcctca ccaggctgct cgtgcacatg
     1801 ggtctgctca agagtgaaga caaggtcaag gccattgcca acctgtacgg ccccctgatg
     1861 gcgctgaacc acatggtgca gcaggactat ttccccaagg cccttgcacc cctgctgctg
     1921 gcgttcgtga ccaagcccaa cagcgccctg gaatcctgct ccttcgcccg ccacagtctg
     1981 ctgcagacgc tgtacaaggt ctagactcaa agcctctccc atcccttggc ctggaccagt
     2041 gagctgggga gggactcgga tgaactgagg cgcagcctac gccattgcct tggacaggac
     2101 tctggccaca ggcagggcgg gtctgtgtcc catgtgtcct gtcagtcccc tgagtatgtg
     2161 tgtgggtgtg gcgcatgtgc aggtctgtgc ctcctgtcgg gatttgggtt ttaacgtctt
     2221 ctgctggccc agccctgctc tgttgtgggg agttggcccc caggggaaag ggctgtgagc
     2281 tgctccgcca ttaaactcac ctccacctga gggcgctctg ctgatctccg cctgggccct
     2341 gatggccgtc cccacccacc tgccttccgg cccggctccc tggcggagcc agaacccagg
     2401 gagttgcccg cgtgctgtcc ttcccctctg tgttgtgatt gggttgtttc ctgccctgcc
     2461 tggggctgct tctcgtcacc aagccctggt cctgcggcag ctgtcacccc taccatccat
     2521 accactgtgc tgaccgctca gcctgaagag cagagaatgc catgggtggg actgtggggg
     2581 tcggatcgtg gggttgttgg cagagggcaa ccctgggccc cacaccgtgt ggacaggcag
     2641 acaccagatt gtccaggagc aggagctgct gggactgcgc tggccccgga cctagtgggc
     2701 cttctcctgg ctgctgagat gtcgtctgtg actggcctgg ctggaggggg agtgttgaca
     2761 acccaaagct gttctccagt ctggggaggg agaggcaggg tccccaatgt ccgagctgca
     2821 tctggacgct gctcttaaag gacctcctgg ggcaggggag cggtagggtc tggactgggc
     2881 agatgctgta tgacctccct gagcacccgt gactgcccca tgctttcccc tttgtgctct
     2941 gtgtgtgtct gggctgtgcc cgggggcttc acaaataaag tcgtgtggca gcttcagaga
     3001 ctcagaaact ctcactgaaa gcgggatagt ctcgggggcc gttgtacgtg gagtcccacc
     3061 tcggcagagc atgcggcccc gcagcagtct gtggggcagt cagccctgca gaagggcccg
     3121 gcctcggcct caggccacta cctgggaagt ggcagtcctg agtgggggcc cattttcctg
     3181 cctggccaca cctcacccag caccctgcct ttgggctgca gctcgcttgg cttctgcgtt
     3241 gctccttcac tatggaagcc acctcccttg ggatcctttg ctccactgcc acatatgtga
     3301 ggacagccca gccaaccttc cttacctcct accctacacc atgtatgtgc tttgggagcc
     3361 catgtccccc acaaacggcc tccaagaagt ccctccaagg tttcttagag ggcaatattt
     3421 tctcattggc agtcggccac gtaggtgacc aggtggcaga ggatactgct ggccctgtcc
     3481 cctgtcttct gtgtgagttg atacggtagg gggtgggtgt ggggctggca ttaagttctg
     3541 atgccagcta caacgtggat gaactttgaa aacatgttaa atgaaataag ccagacacaa
     3601 aaggacaaat atgattccat ttagatgagg catctagaat aagcaaattc agagacaaga
     3661 aggtagaggt tgccagggct aggggaaggg tggaataggg agtgaggctg caaacagatt
     3721 ctctgggatg atgaagatgt tctggaaatg gagagtggtg atggttgcat aacattgtga
     3781 atgtacttaa tgcactgaat tgtacacata aaaatggtta aaatgata
//
