LOCUS       NM_012416               4600 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens RAN binding protein 6 (RANBP6), transcript variant 1,
            mRNA.
ACCESSION   NM_012416 XM_039701
VERSION     NM_012416.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4600)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4600)
  AUTHORS   Oldrini,B., Hsieh,W.Y., Erdjument-Bromage,H., Codega,P.,
            Carro,M.S., Curiel-Garcia,A., Campos,C., Pourmaleki,M., Grommes,C.,
            Vivanco,I., Rohle,D., Bielski,C.M., Taylor,B.S., Hollmann,T.J.,
            Rosenblum,M., Tempst,P., Blenis,J., Squatrito,M. and
            Mellinghoff,I.K.
  TITLE     EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in
            cancer
  JOURNAL   Nat Commun 8 (1), 2035 (2017)
   PUBMED   29229958
  REMARK    GeneRIF: Data indicate a mechanism of epidermal growth factor
            receptor (EGFR) regulation through the importin beta family member
            RAN-binding protein 6 (RanBP6).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4600)
  AUTHORS   Ferreira,M.A., Matheson,M.C., Tang,C.S., Granell,R., Ang,W.,
            Hui,J., Kiefer,A.K., Duffy,D.L., Baltic,S., Danoy,P., Bui,M.,
            Price,L., Sly,P.D., Eriksson,N., Madden,P.A., Abramson,M.J.,
            Holt,P.G., Heath,A.C., Hunter,M., Musk,B., Robertson,C.F., Le
            Souef,P., Montgomery,G.W., Henderson,A.J., Tung,J.Y.,
            Dharmage,S.C., Brown,M.A., James,A., Thompson,P.J., Pennell,C.,
            Martin,N.G., Evans,D.M., Hinds,D.A. and Hopper,J.L.
  CONSRTM   Australian Asthma Genetics Consortium Collaborators
  TITLE     Genome-wide association analysis identifies 11 risk variants
            associated with the asthma with hay fever phenotype
  JOURNAL   J Allergy Clin Immunol 133 (6), 1564-1571 (2014)
   PUBMED   24388013
REFERENCE   4  (bases 1 to 4600)
  AUTHORS   Hinds,D.A., McMahon,G., Kiefer,A.K., Do,C.B., Eriksson,N.,
            Evans,D.M., St Pourcain,B., Ring,S.M., Mountain,J.L., Francke,U.,
            Davey-Smith,G., Timpson,N.J. and Tung,J.Y.
  TITLE     A genome-wide association meta-analysis of self-reported allergy
            identifies shared and allergy-specific susceptibility loci
  JOURNAL   Nat Genet 45 (8), 907-911 (2013)
   PUBMED   23817569
REFERENCE   5  (bases 1 to 4600)
  AUTHORS   Jager,S., Cimermancic,P., Gulbahce,N., Johnson,J.R., McGovern,K.E.,
            Clarke,S.C., Shales,M., Mercenne,G., Pache,L., Li,K., Hernandez,H.,
            Jang,G.M., Roth,S.L., Akiva,E., Marlett,J., Stephens,M., D'Orso,I.,
            Fernandes,J., Fahey,M., Mahon,C., O'Donoghue,A.J., Todorovic,A.,
            Morris,J.H., Maltby,D.A., Alber,T., Cagney,G., Bushman,F.D.,
            Young,J.A., Chanda,S.K., Sundquist,W.I., Kortemme,T.,
            Hernandez,R.D., Craik,C.S., Burlingame,A., Sali,A., Frankel,A.D.
            and Krogan,N.J.
  TITLE     Global landscape of HIV-human protein complexes
  JOURNAL   Nature 481 (7381), 365-370 (2011)
   PUBMED   22190034
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4600)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC334669.1, BC098406.1, AK001982.1 and AI568841.1.
            
            On May 17, 2019 this sequence version replaced NM_012416.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803614.99977.1, BX537405.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259569.6/ ENSP00000259569.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DC334669.1         18-27
            11-3404             BC098406.1         2-3395
            3405-4581           AK001982.1         752-1928
            4582-4600           AI568841.1         13-31               c
FEATURES             Location/Qualifiers
     source          1..4600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..4600
                     /gene="RANBP6"
                     /note="RAN binding protein 6"
                     /db_xref="GeneID:26953"
                     /db_xref="HGNC:HGNC:9851"
     exon            1..4600
                     /gene="RANBP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..3335
                     /gene="RANBP6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Ran-GTP binding protein; ran-binding protein 6"
                     /codon_start=1
                     /product="ran-binding protein 6 isoform 1"
                     /protein_id="NP_036548.1"
                     /db_xref="CCDS:CCDS6467.1"
                     /db_xref="GeneID:26953"
                     /db_xref="HGNC:HGNC:9851"
                     /translation="MAATASAGVPATVSEKQEFYQLLKNLINPSCMVRRQAEEIYENI
                     PGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLLSSGFEEVYPNLPADVQRDVKIELI
                     LAVKLETHASMRKKLCDIFAVLARNLIDEDGTNHWPEGLKFLIDSIYSKNVVLWEVAL
                     HVFWHFPGIFGTQERHDLDIIKRLLDQCIQDQEHPAIRTLSARAAAAFVLANENNIAL
                     FKDFADLLPGILQAVNDSCYQDDDSVLESLVEIADTVPKYLGPYLEDTLQLSLKLCGD
                     SRLSNLQRQLALEVIVTLSETATPMLKKHTNIIAQAVPHILAMMVDLQDDEDWVNADE
                     MEEDDFDSNAVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSA
                     IGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHETV
                     IAALLRTMENQGNQRVQSHAASALIIFIEDCPKSLLVLYVDSMVKNLHSVLVIKLQEL
                     IRNGTKLALEQLVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQKELKLLRGKTI
                     ECISHIGLAVGKEKFMQDASNVMQLLLKTQSDLNNMEDDDPQTSYMVSAWARMCKILG
                     KDFQQYLPLVIEPLIKTASAKPDVALLDTQDVENMSDDDGWQFVNLGDQQSFGIKTSG
                     LEAKATACQMLVYYAKELREGFVEYTEQVVKLMVPLLKFYFHDNVRVAAAESMPFLLE
                     CARIRGPEYLAQMWQFICDPLIKAIGTEPDTDVLSEIMNSFAKSIEVMGDGCLNDEHL
                     EELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSDILHS
                     LFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYF
                     RWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKK
                     NVIATENCISAIGKILKFKPNCVNVDEVLPHWLSWLPLHEDKEEAIQTLSFLCDLIES
                     NHPVVIGPNNSNLPKIISIIAEGKINETINYEDPCAKRLANVVRQVQTSEDLWLECVS
                     QLDDEQQEALQELLNFA"
     regulatory      4565..4570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP6"
                     /note="hexamer: AATAAA"
     polyA_site      4600
                     /gene="RANBP6"
                     /note="major polyA site"
ORIGIN      
        1 agctttgaca gagcgcaatg gcggcaaccg cgtctgcagg ggtgccggcg accgtgtcag
       61 aaaagcaaga gttttaccag cttctgaaga acctgatcaa tccaagctgt atggtgcgga
      121 ggcaagcaga ggaaatctat gaaaatatcc caggtctgtg taagactacc ttcctcttag
      181 atgccgtcag aaatagaaga gcaggttatg aggtgagaca aatggctgcc gcactgctac
      241 gacggctttt gtcctctggg tttgaggagg tttatccaaa tctgcctgct gatgttcaga
      301 gagatgtcaa gattgaactg attctggctg ttaagttaga aacacatgct agcatgagga
      361 aaaaactttg tgatattttt gcagtgctgg ccaggaattt gatagatgag gatggcacta
      421 accactggcc ggaaggtctg aagtttctta ttgattcaat ctactccaaa aatgtggttc
      481 tatgggaagt tgcacttcac gttttctggc actttcctgg gatttttggg acccaagagc
      541 ggcatgattt ggatatcatc aaacggttgt tggaccagtg tattcaagat caagaacatc
      601 cagcaatcag gacattatcc gctagagctg cagctgcatt tgtacttgct aatgagaata
      661 atattgctct tttcaaagac tttgcagact tgcttcctgg aatcttacag gctgtgaatg
      721 actcatgcta ccaggatgat gattcagtgc tagaatccct tgttgagatt gcagataccg
      781 tacctaagta cttgggtcct tatttagaag atactctaca gttgagtttg aagttatgtg
      841 gagactctag gcttagtaat ctgcagcgcc agctggccct cgaagttata gtgaccttgt
      901 ctgaaactgc cactccgatg ttgaaaaaac atacaaatat tattgcacag gcagttcctc
      961 atatattagc aatgatggtt gatctacaag atgatgagga ctgggtaaat gctgatgaaa
     1021 tggaagaaga tgattttgac agcaatgcag ttgctgcgga gagtgcacta gacagactgg
     1081 cttgtgggct tggtggaaaa gttgttttac caatgaccaa ggagcatatc atgcagatgc
     1141 ttcagagccc tgactggaag tatcgacatg ctggattaat ggccttatct gccattggag
     1201 aaggatgcca tcaacaaatg gaatcaattc tagatgaaac agttaactcc gttttgcttt
     1261 ttcttcagga tcctcatcca agggtgaggg ctgcagcctg tactacactt ggacagatgg
     1321 ctacagattt tgcacctaat ttccaaaaga aatttcatga aacagtgatt gcagctctgt
     1381 tacgtaccat ggaaaatcaa ggtaatcagc gtgtgcaatc acatgcagct tctgctctta
     1441 ttatttttat tgaagactgc cctaaatcat tgctagttct atatgtggat agtatggtga
     1501 aaaatctaca ttccgtcttg gtgattaaac ttcaagagtt gattcggaat ggaactaagt
     1561 tggctttgga acaacttgtg acaaccattg catcagttgc agatacaata gaagaaaaat
     1621 ttgtcccata ttatgatata ttcatgccct cactaaagca cattgttgag cttgctgttc
     1681 agaaggaact caagcttctg agaggaaaaa ctatcgagtg cattagccat attggtcttg
     1741 ctgttgggaa ggaaaaattt atgcaagatg catcaaatgt gatgcagctg ttgttgaaga
     1801 cacaatcaga cttaaataat atggaagatg atgaccctca gacctcttac atggtttcag
     1861 catgggctag aatgtgtaaa attcttggaa aagattttca acagtacctt ccactggtta
     1921 tcgagcctct tattaagact gcttcagcta aacctgatgt tgctctctta gacacacagg
     1981 atgtggaaaa tatgagtgac gatgatggct ggcaatttgt aaatcttgga gaccagcaga
     2041 gttttggaat taaaacttca ggacttgaag caaaagcaac tgcttgccaa atgttggttt
     2101 actatgctaa ggagttaagg gaagggtttg tggaatatac agaacaagtt gtgaagctga
     2161 tggttccttt actgaaattt tatttccatg acaatgttcg agtggcagca gcagagtcca
     2221 tgccttttct cctggaatgt gcaagaattc gtggcccaga gtatcttgca cagatgtggc
     2281 aattcatatg tgacccctta atcaaggcta ttggtactga accagataca gatgtgctct
     2341 cagaaataat gaattctttt gcaaagtcca ttgaagttat gggagatggt tgccttaatg
     2401 atgaacactt ggaagaactg ggaggaatac tgaaagcaaa acttgaaggg cactttaaaa
     2461 accaagaatt gagacaggtg aaaagacagg aagaaaacta tgatcaacag gttgagatgt
     2521 ctctgcaaga tgaggatgaa tgtgatgttt atattctgac caaagtatca gatattttgc
     2581 actcattatt tagtacttat aaggaaaaga ttttaccatg gtttgaacaa ctacttccat
     2641 taattgtaaa tctaatttgt tcaagtaggc catggccaga cagacagtgg ggattgtgca
     2701 tatttgatga catcatagag cactgcagtc caacttcatt taaatatgta gaatattttc
     2761 ggtggccaat gctactaaat atgcgagata acaaccctga agtcaggcaa gctgctgctt
     2821 atggcctggg tgtcatggca cagtttggtg gagatgatta tcgttcttta tgttcagaag
     2881 ctgttccact tctggtaaaa gttattaagt gtgcaaattc caaaaccaaa aaaaatgtca
     2941 ttgctacaga gaactgtatc tcagcaatag ggaagatttt gaagtttaag cctaactgtg
     3001 taaatgtaga tgaagttctt ccacactggt tatcatggct tccactgcat gaagataaag
     3061 aggaagctat tcagactttg agttttctct gtgacctaat tgaaagtaac cacccagttg
     3121 taattggtcc aaataattcc aatcttccca aaataatcag tataattgca gaaggaaaaa
     3181 ttaatgagac tattaactat gaggatcctt gtgccaaacg cctagctaat gtcgtgcgtc
     3241 aggtacagac ttctgaagat ttatggttgg aatgtgtatc acaacttgat gatgaacagc
     3301 aggaagcctt acaggagttg ctaaattttg cttgaagcac tttaatataa cttgaatatt
     3361 atctattata aaagtaacta caaataagtg ttgtgaatag attttattat aaatcagaga
     3421 actgttttct ccctgctaag cagtttatag ttcttctcca tgtttctcca gaattaatca
     3481 gtgttagtcc tctgtttatc tcgcatgttt tatcttccaa acacagacct tggtgataac
     3541 ctgtgcttca aactgtctta aacaatgttt gtcacctttc ccctagttga tgtaaagtat
     3601 ataaattgtt gctatttgtt tgaactatta ttgatgctag ccaagcagta tacttgatgt
     3661 gaagatgtca tgctatcaca atatgctaag agctcacaaa aataagatag aatttccagg
     3721 acaaacatct ttggaattgt gagtgaagga tatagtggca ggcttgtccc tctttaatta
     3781 atactcttgg tatttgtggt gatgggagga tgctgttact aggagagttt tgagatactg
     3841 cagtggatgt gggatgtata tgaacttctt cataatgtac tcctgggaac tgggtaggac
     3901 atatccatat tgtagttccc aaggtgtctg gttgagagtt agagaacttt taaatttctt
     3961 tagccagaca ggtctctatt tttttaagtt atccaggact ccaagaacca tagttactga
     4021 aaagggagtc ctgatacatc taatattggt agcatgtaac agtgtttgac aaagagtaag
     4081 taagcagtat tcttgggagt cagtgttatg tgtttcagca gagtattatt ttgtatatgt
     4141 atgccatttt ctccctgcaa agcagctcaa caagagaaaa agctctagtt atagggctta
     4201 aattgatttc tatttcaaat aatttcctaa gagattctag agtagaactg aagagtattc
     4261 tattggaaaa gtgaaaggaa agaaatgtaa ttttctttga acatgaaaaa gaaaacaact
     4321 ttgagagtag tcatttagca gtagatgtgc attattatga gaaaacagtt ctataagtcc
     4381 agggttaatt atattaattg gaatgtcagt ctttaatgtc gagcttattg tagggtagaa
     4441 aagagctttc tactcagcta acgattactc attgatccaa aacttaaata catctataat
     4501 ttcctggggc tattgtgagt actgtgtatg tatttagcaa atatttaaga cctagtaagt
     4561 gctcaataaa ttgtagctgt tattgctgtt gttgtttgta
//
