LOCUS       NM_145000               4625 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens RAN binding protein 3 like (RANBP3L), transcript
            variant 2, mRNA.
ACCESSION   NM_145000
VERSION     NM_145000.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4625)
  AUTHORS   Branciamore,S., Gogoshin,G., Rodin,A.S. and Myers,A.J.
  TITLE     Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with
            APOE E4 to alter risk for late onset Alzheimer's disease
  JOURNAL   Sci Rep 14 (1), 14954 (2024)
   PUBMED   38942763
  REMARK    GeneRIF: Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L
            act with APOE E4 to alter risk for late onset Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4625)
  AUTHORS   Chernyakov,D., Gross,A., Fischer,A., Bornkessel,N., Schultheiss,C.,
            Gerloff,D. and Edemir,B.
  TITLE     Loss of RANBP3L leads to transformation of renal epithelial cells
            towards a renal clear cell carcinoma like phenotype
  JOURNAL   J Exp Clin Cancer Res 40 (1), 226 (2021)
   PUBMED   34233711
  REMARK    GeneRIF: Loss of RANBP3L leads to transformation of renal
            epithelial cells towards a renal clear cell carcinoma like
            phenotype.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4625)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4625)
  AUTHORS   Qian,X., Xu,D., Liu,H., Lin,X., Yu,Y., Kang,J., Sheng,X., Xu,J.,
            Zheng,S., Xu,D. and Qi,J.
  TITLE     Genetic variants in 5p13.2 and 7q21.1 are associated with treatment
            for benign prostatic hyperplasia with the alpha-adrenergic receptor
            antagonist
  JOURNAL   Aging Male 20 (4), 250-256 (2017)
   PUBMED   28787260
  REMARK    GeneRIF: The single nucleotide polymorphism, rs16902947 in RANBP3L
            at 5p13.2 (p = .01), is significantly associated with Benign
            Prostate Hyperplasia.  Rs16902947 in RANBP3L at 5p13.2 (p = .0388)
            is associated withalpha-adrenergic receptor antagonist drug effect
            in Benign Prostate Hyperplasia.
REFERENCE   5  (bases 1 to 4625)
  AUTHORS   Chen,F., Lin,X., Xu,P., Zhang,Z., Chen,Y., Wang,C., Han,J.,
            Zhao,B., Xiao,M. and Feng,X.H.
  TITLE     Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic
            Protein Signaling and Mesenchymal Stem Cell Differentiation
  JOURNAL   Mol Cell Biol 35 (10), 1700-1711 (2015)
   PUBMED   25755279
  REMARK    GeneRIF: Results demonstrate that RanBP3L, as a nuclear exporter
            for BMP-specific Smads, plays a critical role in terminating BMP
            signaling and regulating mesenchymal stem cell differentiation.
            Erratum:[Mol Cell Biol. 2017 Aug 11;37(17):e00287-17. doi:
            10.1128/MCB.00287-17.. PMID: 28801455]
REFERENCE   6  (bases 1 to 4625)
  AUTHORS   Takata,R., Matsuda,K., Sugimura,J., Obara,W., Fujioka,T.,
            Okihara,K., Takaha,N., Miki,T., Ashida,S., Inoue,K., Tanikawa,C.,
            Shuin,T., Sasaki,S., Kojima,Y., Kohri,K., Kubo,M., Yamaguchi,M.,
            Ohnishi,Y. and Nakamura,Y.
  TITLE     Impact of four loci on serum tamsulosin hydrochloride concentration
  JOURNAL   J Hum Genet 58 (1), 21-26 (2013)
   PUBMED   23151678
REFERENCE   7  (bases 1 to 4625)
  AUTHORS   Slavin,T.P., Feng,T., Schnell,A., Zhu,X. and Elston,R.C.
  TITLE     Two-marker association tests yield new disease associations for
            coronary artery disease and hypertension
  JOURNAL   Hum Genet 130 (6), 725-733 (2011)
   PUBMED   21626137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC047660.1 and AC008807.10.
            
            On Jun 2, 2019 this sequence version replaced NM_145000.4.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, compared to variant 1. The encoded isoform (2) is
            shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047660.1, SRR14038195.391425.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296604.8/ ENSP00000296604.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-694               BC047660.1         1-694
            695-695             AC008807.10        19597-19597
            696-2338            BC047660.1         696-2338
            2339-2339           AC008807.10        39847-39847
            2340-2536           BC047660.1         2340-2536
            2537-4625           AC008807.10        40045-42133
FEATURES             Location/Qualifiers
     source          1..4625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..4625
                     /gene="RANBP3L"
                     /note="RAN binding protein 3 like"
                     /db_xref="GeneID:202151"
                     /db_xref="HGNC:HGNC:26353"
                     /db_xref="MIM:616391"
     exon            1..577
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             487..1884
                     /gene="RANBP3L"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ran-binding protein 3-like"
                     /codon_start=1
                     /product="ran-binding protein 3-like isoform 2"
                     /protein_id="NP_659437.3"
                     /db_xref="CCDS:CCDS3918.1"
                     /db_xref="GeneID:202151"
                     /db_xref="HGNC:HGNC:26353"
                     /db_xref="MIM:616391"
                     /translation="MTTIPRKGSSHLPGSLHTCKLKLQEDRRQQEKSVIAQPIFVFEK
                     GEQTFKRPAEDTLYEAAEPECNGFPTKRVRSSSFTFHITDSQSQGVRKNNVFMTSALV
                     QSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKALESCKTKEKTNNK
                     ISEGNSYLLSENLSRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENM
                     VERVLGTQKLTQPQLENDSYAKEKPFKSIPKFPVNFLSSRTDSIKNTSLIESAAAFSS
                     QPSRKCLLEKIDVITGEETEHNVLKINCKLFIFNKTTQSWIERGRGTLRLNDTASTDC
                     GTLQSRLIMRNQGSLRLILNSKLWAQMKIQRANHKNVRITATDLEDYSIKIFLIQASA
                     QDTAYLYAAIHHRLVALQSFNKQRDVNQAESLSETAQQLNCESCDENEDDFIQVTKNG
                     SDPSSWTHRQSVACS"
     exon            578..636
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            637..676
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            677..754
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            755..826
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            827..966
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1070
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1155
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1258
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1389
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1510
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1653
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1840
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..4625
                     /gene="RANBP3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4602..4607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP3L"
                     /note="hexamer: ATTAAA"
     polyA_site      4625
                     /gene="RANBP3L"
                     /note="major polyA site"
ORIGIN      
        1 acagagggta actcagatca ggcttagaaa tcacttgact taactcagca gcactttttc
       61 ttttctttgt gtctgtatta ttttagcagc cttctctaaa tactggaggc attggatttc
      121 atgtcgccaa aaggaattta aaaatgacaa aagtgtaatc tgttagaaat agttaatttg
      181 tagaatttta ctctataagg aggtttagtt tcaatttgtt ttgaaatgaa ggaattaagt
      241 tgtgttttta accaaatgaa ttggcatctt tatatttagg agaagtaaca ttggtgatta
      301 tttatttcaa gaatcatgac tggaaaaagc ttggaagttt agtagaggag tatatgttgt
      361 acatgcaaag acaagatctg catgaatcta tgtatttctg ggtgtctggt gaaggccact
      421 ttaggtgact ggccagagaa ggaggtgccc tagtgatcct tgagtcacag ccatactgct
      481 aggaccatga ctaccatacc aagaaaaggc agcagccacc tgcctggcag tttgcacacc
      541 tgtaaactga agctgcagga ggaccggcga cagcaagaaa aatctgtcat tgctcaaccc
      601 atatttgttt ttgaaaaggg agaacaaact tttaagagac ctgcagaaga caccctgtat
      661 gaagcagcag aaccagaatg taatggtttt ccaacaaagc gtgtacggtc ttcatctttt
      721 acttttcata ttacagattc tcagtcccag ggagtgagga aaaacaatgt ttttatgaca
      781 tcagctcttg tgcaaagtag tgttgatata aagagtgctg aacaaggtcc tgtgaaacat
      841 tctaaacatg ttattagacc tgctattttg cagctacctc aagctcgaag ttgtgcaaaa
      901 gtaagaaaaa catttggaca caaggcactg gaatcttgca agactaaaga aaaaacaaat
      961 aataagattt ctgagggaaa ttcctatttg ttaagtgaaa atttatcaag ggctagaatt
     1021 tcagtccagc tgtctactaa ccaggacttt ttaggtgcaa catcagtagg atgtcaacca
     1081 aatgaagata aatgttcttt taaaagctgc agttccaatt ttgtttttgg agaaaacatg
     1141 gtagaaagag ttttgggtac tcaaaaactc acccagcctc aacttgaaaa tgattcatat
     1201 gccaaggaaa aaccattcaa atccattccg aaatttcctg tcaacttttt aagttcaaga
     1261 acagactcta ttaaaaatac ttccctaatt gaatcagctg ctgcattctc ttcccaacca
     1321 tcacgaaaat gcttgctgga gaaaattgat gttataacag gggaggaaac agaacataat
     1381 gtgttaaaga taaactgcaa gcttttcata ttcaacaaaa caacacaatc ctggattgaa
     1441 aggggcagag gaacgttgag actgaatgac acagcaagca ctgactgtgg aacattacag
     1501 tcaagactaa ttatgcgcaa tcaaggcagt ctaaggctga tcctcaacag caaactctgg
     1561 gcccaaatga agattcaaag agcaaaccac aaaaatgtac gaataacagc tactgattta
     1621 gaagactata gcatcaaaat atttttaatt caggccagtg cccaagatac agcatatttg
     1681 tatgcagcaa tacatcatcg tcttgttgca cttcaaagct tcaataagca gagagatgtc
     1741 aatcaagctg aaagcctgtc agaaacagcc caacaattga actgcgaaag ctgtgatgag
     1801 aatgaggatg atttcatcca agtcactaaa aatggatcag atccttctag ttggactcac
     1861 agacagtcgg ttgcctgttc atgaatacta cctactataa acatgacatc tacaaaaaga
     1921 ggggtcaccc tactgaaaat actaaaccac cctaactaat gagaagattc tattcattcc
     1981 ttgaagagtt tttatagaaa agtttaagaa atgtaatttg ttgcaattaa catttttatg
     2041 ttttacattt tacattttga ttattgtgca gaaactgaca gaatttaaaa aaatggactt
     2101 cagaagttca aaatttatca tttttgaaga agtttattta gaataggatt ttataactaa
     2161 tttggactct tcatcacatt gatggatata atacttagaa ttataaattg ctagatttga
     2221 taaataccta acaaaatgtt tatttttttc agtcatactt gaccacaaaa caaatatttt
     2281 actaaatttc cagagtcatt tctctgaaaa atagtataat ggcatgataa catttcacta
     2341 aatcctattt atcttctggg aaatatttta atttagcttt tggatttcct aatatgataa
     2401 gcttatatat tcatggtatg aattccttta aaaagagcat ctgctcttgg acttgtatct
     2461 gttgcatctt gtcaatgttt gactcatggt cagcatccaa tagttgttaa atgaataaat
     2521 aaaatataat acattaccta tgtatcaaaa agcatgtgta agaaagccaa atatgttaac
     2581 tgttctactt tatttatgta attatatttt cattagtatt ttagtagatg gggctgtata
     2641 gaaaaacaaa tgtatcatat gtagccaaat gaatcttttt cttaaatgat attattatag
     2701 taggctacag taatttcaac aattttacaa tagagttttg atcctcttct ttgcgatttg
     2761 tttcagagac acctcatgaa tcacacaaga aaattagtct cagtacttat agccctattt
     2821 catttttcaa ttcagtttta tcacaccatg gcttcgaagt gactttgatt gtgaccccta
     2881 agcaattatc tgattagggg ataaaaattc ataattccaa gatgtttctg aaaatgttct
     2941 gaacaatgac aacatatttg gaatgagggc gtaatttcac taagtgatgc ttcgaagaac
     3001 aatattcatt tggatatgca aacacacatt ttcaaaagtt atattactgt gttaccatac
     3061 ctgttataaa ataataaaaa tatataagta tttattaagt caaacttcag ctactgcctg
     3121 aaagtttagc atatgaaatt taaattaagt ctttcagatt atgattatga caattgttca
     3181 acattttgtc cttccttata actgagaaag cataacttaa tataactact aagagaggcc
     3241 cattcattct tccagtgatt ctagaagaaa tatggcacat aatatccttt acttctaaat
     3301 aaaggagtca atgactcaga aaataaagag gaaaaataaa gtaaatgtga gagagatgaa
     3361 gaaaagatag aaggggaaaa agagatttag tacgaaagaa aggacaaaaa gaatggacaa
     3421 cagaaatact cttttttaaa atcaagaaga gtgactctga tgcggaacac actcagcaga
     3481 aaattttcat tagaaacata acacagagag atatttggag aagataataa agcactggtt
     3541 ctcttttatt gttaagatct cagctgatgt gggaacattg tgattgcact ataaattgct
     3601 aaagtgaaga agagaacaaa taacttcatt tatttatttt gtttgttttt tagacagagt
     3661 ctcgctctgt cacccaggtt ggagtgcagt ggcacgattt cggctcactt caacctcccc
     3721 ctcccgggtt caagggattc tcgtgcctca ctcagcctcc tgagtagctg ggattacagg
     3781 cgcccgccat catacctggc taatttttgt atttttagta gagacggggt ttcaccatgt
     3841 tggccaggct ggtcttgaac tcctgatctc aagtgataca ctttgcctca gcctcccaaa
     3901 gtgttgggat tacaggcgtg agccaccaca cctggtcatc tttatctttt tgacatgttc
     3961 atcctcgtcc ccacactaag gtagagataa agcaattatc ttctcaatgc ttgaaacatt
     4021 ttaagttgaa ttcattctat gattttcttt agatttctcc gcatatatca atggaaaaaa
     4081 ttaactatct taatttctca tctatataga aatgccagtg caacaaaacc aaatgtaggg
     4141 ttagaatatc agcaaggcaa agagagaaga gaaaattccc agattatgaa atggagaaga
     4201 agaacagaaa catgatattt agctcacaac tctttcaacc cattttctat acactccatt
     4261 attctttctt agaattctta cacaaatatt tagtacaatt ttggaggaat agtagaaaca
     4321 ttttatagtt tttccttgtc ctgtatcttc atctagcctt cttttcagct ttcctatgtc
     4381 ctttgttctc cttttataag gagagatgag ttgtacaata acatccattt tcataagtta
     4441 tttaggtaaa ttattttgaa gtatacatgt tggatttcca aagcagctgt ttttaattaa
     4501 aatttaatta actaatttat gtcattatat atcttgtgtt aagacaacct taactttctt
     4561 ttagtaagat tttacccaac tgtttaccct aattatagac aattaaaatg ttctctctta
     4621 aaaaa
//
