LOCUS       NM_007322               3233 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens RAN binding protein 3 (RANBP3), transcript variant
            RANBP3-d, mRNA.
ACCESSION   NM_007322
VERSION     NM_007322.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3233)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   2  (bases 1 to 3233)
  AUTHORS   Tang,W., Zhu,Y., Qin,W., Zhang,H., Zhang,H., Lin,H., Zhen,X.,
            Zhuang,X., Tang,Y. and Jiang,H.
  TITLE     Ran-binding protein 3 is associated with human spermatogenesis and
            male infertility
  JOURNAL   Andrologia 52 (2), e13446 (2020)
   PUBMED   31833110
  REMARK    GeneRIF: Ran-binding protein 3 is associated with human
            spermatogenesis and male infertility.
REFERENCE   3  (bases 1 to 3233)
  AUTHORS   Koyama,M. and Matsuura,Y.
  TITLE     Crystal structure of importin-alpha3 bound to the nuclear
            localization signal of Ran-binding protein 3
  JOURNAL   Biochem Biophys Res Commun 491 (3), 609-613 (2017)
   PUBMED   28760339
  REMARK    GeneRIF: Computational docking simulation indicates that
            phosphorylation of RanBP3 at Ser58 could potentially stabilize the
            association of RanBP3 with importin-alpha through interactions
            between the phosphate moiety of phospho-Ser58 of RanBP3 and a
            cluster of basic residues (Arg96 and Lys97 in importin-alpha3) on
            armadillo repeat 1 of importin-alpha.
REFERENCE   4  (bases 1 to 3233)
  AUTHORS   Pathria,G., Garg,B., Wagner,C., Garg,K., Gschaider,M., Jalili,A.
            and Wagner,S.N.
  TITLE     RanBP3 Regulates Melanoma Cell Proliferation via Selective Control
            of Nuclear Export
  JOURNAL   J Invest Dermatol 136 (1), 264-274 (2016)
   PUBMED   26763446
  REMARK    GeneRIF: RANBP3 regulates melanoma cell proliferation and probably
            a potential target for molecular targeted therapy.
REFERENCE   5  (bases 1 to 3233)
  AUTHORS   Predicala,R. and Zhou,Y.
  TITLE     The role of Ran-binding protein 3 during influenza A virus
            replication
  JOURNAL   J Gen Virol 94 (Pt 5), 977-984 (2013)
   PUBMED   23303829
  REMARK    GeneRIF: RanBP3 is involved in vRNP nuclear export. The function of
            RanBP3 during vRNP nuclear export is regulated by phosphorylation
            at Ser58. RanBP3 phosphorylation is modulated by both PI3K/Akt and
            Ras/ERK/RSK pathways in the late phase of viral infection.
REFERENCE   6  (bases 1 to 3233)
  AUTHORS   Englmeier,L., Fornerod,M., Bischoff,F.R., Petosa,C., Mattaj,I.W.
            and Kutay,U.
  TITLE     RanBP3 influences interactions between CRM1 and its nuclear protein
            export substrates
  JOURNAL   EMBO Rep 2 (10), 926-932 (2001)
   PUBMED   11571268
REFERENCE   7  (bases 1 to 3233)
  AUTHORS   Lindsay,M.E., Holaska,J.M., Welch,K., Paschal,B.M. and Macara,I.G.
  TITLE     Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear
            protein export
  JOURNAL   J Cell Biol 153 (7), 1391-1402 (2001)
   PUBMED   11425870
REFERENCE   8  (bases 1 to 3233)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 3233)
  AUTHORS   Welch,K., Franke,J., Kohler,M. and Macara,I.G.
  TITLE     RanBP3 contains an unusual nuclear localization signal that is
            imported preferentially by importin-alpha3
  JOURNAL   Mol Cell Biol 19 (12), 8400-8411 (1999)
   PUBMED   10567565
REFERENCE   10 (bases 1 to 3233)
  AUTHORS   Mueller,L., Cordes,V.C., Bischoff,F.R. and Ponstingl,H.
  TITLE     Human RanBP3, a group of nuclear RanGTP binding proteins
  JOURNAL   FEBS Lett 427 (3), 330-336 (1998)
   PUBMED   9637251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM786367.1 and AK025300.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007322.2.
            
            Summary: This gene encodes a protein with a RanBD1 domain that is
            found in both the nucleus and cytoplasm. This protein plays a role
            in nuclear export as part of a heteromeric complex. Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (RANBP3-d) represents the longest
            transcript and encodes the longest isoform (RANBP3-d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025300.1, AL050149.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340578.10/ ENSP00000341483.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BM786367.1         170-171
            3-3233              AK025300.1         8-3238
FEATURES             Location/Qualifiers
     source          1..3233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3233
                     /gene="RANBP3"
                     /note="RAN binding protein 3"
                     /db_xref="GeneID:8498"
                     /db_xref="HGNC:HGNC:9850"
                     /db_xref="MIM:603327"
     exon            1..80
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1762
                     /gene="RANBP3"
                     /note="isoform RANBP3-d is encoded by transcript variant
                     RANBP3-d; ran-binding protein 3; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="ran-binding protein 3 isoform RANBP3-d"
                     /protein_id="NP_015561.1"
                     /db_xref="CCDS:CCDS42478.1"
                     /db_xref="GeneID:8498"
                     /db_xref="HGNC:HGNC:9850"
                     /db_xref="MIM:603327"
                     /translation="MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGE
                     AEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPRELAGRSAGGSSP
                     EGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLP
                     SQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWR
                     SPSEAADEVCALEEKEPQKNESSNASEEEACEKKDPATQQAFVFGQNLRDRVKLINES
                     VDEADMENAGHPSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLSP
                     PKLNEVSSDANRENAAAESGSESSSQEATPEKESLAESAAAYTKATARKCLLEKVEVI
                     TGEEAESNVLQMQCKLFVFDKTSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGS
                     LRLILNTKLWAQMQIDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRI
                     LALRSRVEQEQEAKMPAPEPGAAPSNEEDDSDDDDVLAPSGATAAGAGDEGDGQTTGS
                     T"
     exon            81..136
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            137..340
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..377
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            378..464
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            465..530
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            531..623
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            624..751
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..871
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..975
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1054
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1157
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1267
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1388
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1531
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1718
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..3233
                     /gene="RANBP3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2051
                     /gene="RANBP3"
                     /note="major polyA site"
     regulatory      3215..3220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP3"
                     /note="hexamer: ATTAAA"
     polyA_site      3233
                     /gene="RANBP3"
                     /note="major polyA site"
ORIGIN      
        1 agaaagcagg cgagcctggg ccggcgcggg gccttgtggg agggcttaag gaagtaaaat
       61 ggcggacctg gcgaacgaag aaaagcctgc cattgctccg cccgtctttg tgtttcagaa
      121 ggataaagga caaaagtccc ctgcagagca aaaaaacttg tcggattcgg gagaggagcc
      181 tcggggggag gctgaggccc cccaccatgg cacgggtcac cccgagtcag ctggcgagca
      241 tgccctagaa cctcctgccc ctgctggcgc ctcagccagc actcctccgc ctcccgctcc
      301 tgaagcccag cttcctcctt ttccgcgaga actggcaggg aggtcagctg gcggctccag
      361 tcctgaaggc ggagaagatt ctgacagaga agatggaaat tactgccctc ctgtcaagcg
      421 agaaagaaca tcctctttaa cccagttccc accctcacag tcagaggaaa ggagcagtgg
      481 cttccggttg aagccaccaa cgctgatcca cggccaagcc cccagcgcag gtctgccaag
      541 ccagaagccc aaggagcagc agcggagcgt gcttcgcccg gcagtgttac aagctccgca
      601 gccaaaggcg ctgtcccaga ctgtccccag cagtggcacc aacggggtca gcctcccagc
      661 agactgcacg ggggcagtgc ccgcagcatc ccctgacact gctgcatgga gaagtccttc
      721 cgaagctgcc gatgaggtgt gtgcacttga ggagaaagag ccccagaaaa atgagtccag
      781 caatgcctct gaagaggaag cctgtgagaa aaaagacccc gccacacagc aagcctttgt
      841 atttgggcag aacttgaggg acagagttaa gctgataaat gagagcgtgg acgaagccga
      901 catggagaat gctggacacc ccagcgcaga cacgccaacc gcaacgaact atttcctcca
      961 gtatatcagt tccagtttag agaactcaac caatagtgcc gacgcctcca gcaacaaatt
     1021 tgtatttggc cagaacatga gcgagcgagt tttgagcccc ccaaaattaa acgaggtcag
     1081 ttcagatgcc aacagggaaa atgcagctgc cgagtcaggg tctgagtcct cgtcccagga
     1141 ggccacccct gagaaagagt ccctggctga gtcggcagcc gcctacacca aggcaacagc
     1201 gcggaagtgt ttgttggaaa aagtggaagt catcaccggg gaggaggcgg agagcaatgt
     1261 gttacagatg cagtgcaagc tgtttgtctt tgacaagacc tcacagtcct gggtggagag
     1321 aggccggggg ctgctcagac tcaatgacat ggcgtccacc gatgacggca cactacagtc
     1381 ccgactagtg atgcggaccc aggggagcct gcgactgatc ctcaacacca agctgtgggc
     1441 ccagatgcag atcgacaagg ccagcgagaa gagcattcgc atcacagcca tggacaccga
     1501 ggaccagggc gtgaaggtct tcctgatctc ggccagctcc aaggacacag gtcagttgta
     1561 tgcagccctg caccaccgca tcctggccct gcgcagccgc gtggagcagg agcaggaggc
     1621 caagatgccc gcgcctgagc ctggggcagc cccatccaac gaggaggacg acagcgacga
     1681 tgacgatgtc ctggctcctt caggggccac cgcagctggt gctggtgacg aaggggacgg
     1741 gcagacgacc gggagcacat agcggccggg agcccggctg cacaccaggc tgctgctttg
     1801 tccgtctatc cacccgccca cccgccccca ccccaccggc agcgtccagg tgcggggccg
     1861 ggaaccacac accccactgg gccggccaca gtctggaccc gcacgtcctg ttcaaaagca
     1921 gactcgggaa ctgcctgaat gtggtttggg acacgagacc tcatcatatt gatgagcgaa
     1981 caaacaagaa catttcctcc ctcccctcct ttgaattgaa atggcacatt aagacttgtc
     2041 acggcttctc actgggactg gagacctcgt tccttcaccc cgcgtgtcgc cagcctctgg
     2101 gtccagccag agcccctggc ttctccgcca cccacaccct tcccaccctg ctgtggggcc
     2161 ctgcctttgt ggggagcagc cagccctctg cccctgccca gggctcccca actataggcc
     2221 tgggaccccc gcccagcttg gggggctgct cgtacgagtg tagacactgg gcccattgga
     2281 cgtgctgtta actactatct tcatttccca cttcccctct ctgattgggg gtgtatattt
     2341 tacatctttt tttcttttta ttttcgaagg ctttgttttg gtttcttagg ttaagatgct
     2401 ctcgagcgtt gagcaggcac agctctgtcg aggtccctgt cccccacctg tggttctggc
     2461 ctctgaggtt gggggactac ttgtttccca ccccaggttc ctccaggcca agtcatgggg
     2521 tgatgaggag ttggggccct gtctgtccta ggcctggaga gtgcctgtct gggaaaaggt
     2581 cactggacct ggaagggtcc ccagggtccc ctgactcccg tctccatctg tcacgtggtt
     2641 caccatcatc aggcaccagg cgcaaactgc ttcccgctgt tggccatccc ttccccagcc
     2701 acaggtgtcc ctgcccccag gacagtccag ggccaggggc ttctgtgaga ggcagagggg
     2761 gaccctcacc aaatcttggt ggaagagccc aggggctggt cccagaacag gcagtctcac
     2821 aagcacgcag cacactggag tggacgcctg tgcccacccg agcctggagc atggccaaga
     2881 gccagcttgc accacccacc tgggaggccg aggaggaggt cccctgggca cagggcctct
     2941 ttgggacttc agaggaaatc tcccagtccc actctcggag ggttaagaga aggcctcctg
     3001 cagctgtgcc gtccacacct ctaggtcgcc agagccctgg cccccagccc ccagcaagcc
     3061 tgagcccggg aagaaccaga ggccctcccg agagacccag tcacacgtct ctgctttaag
     3121 ccttagccag ctagtgacga gtacaacgag ataacgccca tgtgttttgg aacatttatg
     3181 taagattgtc atatgaaatg tatttgggaa ctacattaaa cttttaacta aaa
//
