LOCUS       NM_006267              11708 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens RAN binding protein 2 (RANBP2), transcript variant 1,
            mRNA.
ACCESSION   NM_006267
VERSION     NM_006267.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11708)
  AUTHORS   Lin,Q., Chen,W., Tan,J., Qian,S., Su,H., Zhao,L., Yuan,L., Ruan,J.,
            Huang,X. and Zhou,H.
  TITLE     Association of RAN and RANBP2 Gene Polymorphisms With Glioma
            Susceptibility in Chinese Children
  JOURNAL   Cancer Rep (Hoboken) 7 (7), e2136 (2024)
   PUBMED   39041645
  REMARK    GeneRIF: Association of RAN and RANBP2 Gene Polymorphisms With
            Glioma Susceptibility in Chinese Children.
REFERENCE   2  (bases 1 to 11708)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   3  (bases 1 to 11708)
  AUTHORS   Yi,J., Zhao,X., Noell,C.R., Helmer,P., Solmaz,S.R. and Vallee,R.B.
  TITLE     Role of Nesprin-2 and RanBP2 in BICD2-associated brain
            developmental disorders
  JOURNAL   PLoS Genet 19 (3), e1010642 (2023)
   PUBMED   36930595
  REMARK    GeneRIF: Role of Nesprin-2 and RanBP2 in BICD2-associated brain
            developmental disorders.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11708)
  AUTHORS   Finsterer,J. and Scorza,F.A.
  TITLE     Intense work-up is required for pediatric COVID-related acute
            necrotizing encephalopathy with RANBP2 variants
  JOURNAL   Eur J Paediatr Neurol 43, 16-17 (2023)
   PUBMED   36857971
  REMARK    GeneRIF: Intense work-up is required for pediatric COVID-related
            acute necrotizing encephalopathy with RANBP2 variants.
REFERENCE   5  (bases 1 to 11708)
  AUTHORS   Di Cesare,E., Moroni,S., Bartoli,J., Damizia,M., Giubettini,M.,
            Koerner,C., Krenn,V., Musacchio,A. and Lavia,P.
  TITLE     Aurora B SUMOylation Is Restricted to Centromeres in Early Mitosis
            and Requires RANBP2
  JOURNAL   Cells 12 (3), 372 (2023)
   PUBMED   36766713
  REMARK    GeneRIF: Aurora B SUMOylation Is Restricted to Centromeres in Early
            Mitosis and Requires RANBP2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11708)
  AUTHORS   Ferreira,P.A., Hom,J.T. and Pak,W.L.
  TITLE     Retina-specifically expressed novel subtypes of bovine cyclophilin
  JOURNAL   J Biol Chem 270 (39), 23179-23188 (1995)
   PUBMED   7559465
  REMARK    GeneRIF: reports identification of the cyclophilin-related protein,
            RanBP2 (note at the time the protein was not designated RanBP2),
            and the cis-trans prolyl isomerase activity of its cyclophilin
            domain
REFERENCE   7  (bases 1 to 11708)
  AUTHORS   Yokoyama,N., Hayashi,N., Seki,T., Pante,N., Ohba,T., Nishii,K.,
            Kuma,K., Hayashida,T., Miyata,T., Aebi,U. et al.
  TITLE     A giant nucleopore protein that binds Ran/TC4
  JOURNAL   Nature 376 (6536), 184-188 (1995)
   PUBMED   7603572
REFERENCE   8  (bases 1 to 11708)
  AUTHORS   Wu,J., Matunis,M.J., Kraemer,D., Blobel,G. and Coutavas,E.
  TITLE     Nup358, a cytoplasmically exposed nucleoporin with peptide repeats,
            Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous
            domain, and a leucine-rich region
  JOURNAL   J Biol Chem 270 (23), 14209-14213 (1995)
   PUBMED   7775481
REFERENCE   9  (bases 1 to 11708)
  AUTHORS   Beddow,A.L., Richards,S.A., Orem,N.R. and Macara,I.G.
  TITLE     The Ran/TC4 GTPase-binding domain: identification by expression
            cloning and characterization of a conserved sequence motif
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3328-3332 (1995)
   PUBMED   7724562
REFERENCE   10 (bases 1 to 11708)
  AUTHORS   Neilson,D.
  TITLE     Susceptibility to Infection-Induced Acute Encephalopathy 3 -
            RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25473726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010095.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006267.4.
            
            Summary: RAN is a small GTP-binding protein of the RAS superfamily
            that is associated with the nuclear membrane and is thought to
            control a variety of cellular functions through its interactions
            with other proteins. This gene encodes a very large RAN-binding
            protein that immunolocalizes to the nuclear pore complex. The
            protein is a giant scaffold and mosaic cyclophilin-related
            nucleoporin implicated in the Ran-GTPase cycle. The encoded protein
            directly interacts with the E2 enzyme UBC9 and strongly enhances
            SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings
            place sumoylation at the cytoplasmic filaments of the nuclear pore
            complex and suggest that, for some substrates, modification and
            nuclear import are linked events. This gene is partially duplicated
            in a gene cluster that lies in a hot spot for recombination on
            chromosome 2q. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1021438.1, D42063.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000283195.11/ ENSP00000283195.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC010095.6         104249-104445
            198-265             AC010095.6         113899-113966
            266-377             AC010095.6         115541-115652
            378-530             AC010095.6         116089-116241
            531-761             AC010095.6         120299-120529
            762-907             AC010095.6         120871-121016
            908-1100            AC010095.6         125256-125448
            1101-1188           AC010095.6         131478-131565
            1189-1398           AC010095.6         133687-133896
            1399-1580           AC010095.6         136031-136212
            1581-1756           AC010095.6         136295-136470
            1757-1880           AC010095.6         136638-136761
            1881-2042           AC010095.6         137765-137926
            2043-2180           AC010095.6         138193-138330
            2181-2327           AC010095.6         138592-138738
            2328-2507           AC010095.6         139672-139851
            2508-2591           AC010095.6         139943-140026
            2592-2727           AC010095.6         143180-143315
            2728-2822           AC010095.6         146868-146962
            2823-7974           AC010095.6         148004-153155
            7975-8145           AC010095.6         156468-156638
            8146-8238           AC010095.6         157256-157348
            8239-8417           AC010095.6         157635-157813
            8418-8622           AC010095.6         160499-160703
            8623-8724           AC010095.6         161897-161998
            8725-8885           AC010095.6         166036-166196
            8886-9159           AC010095.6         166895-167168
            9160-9494           AC010095.6         167295-167629
            9495-11708          AC010095.6         168363-170576
FEATURES             Location/Qualifiers
     source          1..11708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..11708
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /note="RAN binding protein 2"
                     /db_xref="GeneID:5903"
                     /db_xref="HGNC:HGNC:9848"
                     /db_xref="MIM:601181"
     exon            1..197
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..9800
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleoporin 358; nuclear pore complex protein Nup358;
                     P270; acute necrotizing encephalopathy 1 (autosomal
                     dominant); E3 SUMO-protein ligase RanBP2;
                     transformation-related protein 2; nucleoporin Nup358; E3
                     SUMO-protein transferase RanBP2; 358 kDa nucleoporin;
                     ran-binding protein 2"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase RanBP2 isoform 1"
                     /protein_id="NP_006258.3"
                     /db_xref="CCDS:CCDS2079.1"
                     /db_xref="GeneID:5903"
                     /db_xref="HGNC:HGNC:9848"
                     /db_xref="MIM:601181"
                     /translation="MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDL
                     AKKYICTYINVQERDPKAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAE
                     LLCKNDVTDGRAKYWLERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYV
                     RPDDVHVNIRLVEVYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESL
                     QCLESDKSDWRATNTDLLLAYANLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGND
                     ELSATFLEMKGHFYMHAGSLLLKMGQHSSNVQWRALSELAALCYLIAFQVPRPKIKLI
                     KGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKEIVETFANKSGQSALYDALFSS
                     QSPKDTSFLGSDDIGNIDVREPELEDLTRYDVGAIRAHNGSLQHLTWLGLQWNSLPAL
                     PGIRKWLKQLFHHLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHS
                     SYQPLCLPLPVCKQLCTERQKSWWDAVCTLIHRKAVPGNVAKLRLLVQHEINTLRAQE
                     KHGLQPALLVHWAECLQKTGSGLNSFYDQREYIGRSVHYWKKVLPLLKIIKKKNSIPE
                     PIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVNGNIEDAVTAFESIKSVVSYWN
                     LALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKKLPVPLE
                     SVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTRYSLSPSKSYKYSPK
                     TPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHRWPTENYGPDSVPDGYQ
                     GSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGPVYGMNRLPPQQHI
                     YAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDDYFNYNVQQTSTN
                     PPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLPTQAHTTQPTP
                     FKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDGYSGAKPIP
                     GGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKSVFGTPT
                     LETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRF
                     DVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDR
                     SFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
                     RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNL
                     NPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCI
                     ACQNTKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEG
                     SSTKCAACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSC
                     LVRNEANATRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQW
                     DCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQ
                     WDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEG
                     QWDCSVCLVRNEASATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQ
                     WDCSVCCVQNESSSLKCVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFK
                     SNFSEKASKFGNTEQGFKFGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKF
                     GISEPGNQEKKSEKPLENGTGFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEG
                     FQFGKKDPNFKGFSGAGEKLFSSQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPV
                     VQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEVSQWKERGLGNLKILKNEVNGKLRML
                     MRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELA
                     EEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTK
                     VTEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDSVSSSSVHASPL
                     ASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPAKLNQSGTSVGTDEESDVTQEEERD
                     GQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQNYD
                     NKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTERVWLWTACDFADGERKVEHLAVR
                     FKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERT
                     DVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFGNS
                     SATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNL
                     FASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLP
                     PTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECII
                     VWEKKPTVEEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKVQEAQKSQTEE
                     ITSTTDSVYTGGTEVMVPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTD
                     STSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVG
                     TQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWD
                     RDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNA
                     LVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQQNLMKLQKGHVSLAAELSK
                     ETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSIFHRVIP
                     DFVCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQFVITL
                     KKAEHLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCRRITITECGQI"
     exon            198..265
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..377
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..530
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..761
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..907
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1100
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1188
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1398
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1580
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1756
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1880
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2042
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2180
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2327
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2507
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2591
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2727
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2822
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..7974
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            7975..8145
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8146..8238
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8239..8417
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8418..8622
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8623..8724
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8725..8885
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8886..9159
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            9160..9494
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            9495..11708
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9981..9986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /note="hexamer: AATAAA"
     polyA_site      10004
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /note="major polyA site"
     regulatory      10669..10674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /note="hexamer: AATAAA"
     polyA_site      10690
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
     regulatory      11667..11672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /note="hexamer: ATTAAA"
     polyA_site      11687
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
     regulatory      11689..11694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
                     /note="hexamer: AATAAA"
     polyA_site      11708
                     /gene="RANBP2"
                     /gene_synonym="ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2"
ORIGIN      
        1 acagtggtcc tccgccggct acggcgctgc gtcactggtt tgcaggcgct ttcctcttgg
       61 aagtggcgac tgctgcgggc ctgagcgctg gtctcacgcg cctcgggagc caggttggcg
      121 gcgcgatgag gcgcagcaag gctgacgtgg agcggtacat cgcctcggtg cagggctcca
      181 ccccgtcgcc tcgacagaag tcaatgaaag gattctattt tgcaaagctg tattatgaag
      241 ctaaagaata tgatcttgct aaaaaataca tatgtactta cattaatgtg caagagaggg
      301 atcccaaagc tcacagattt ctgggtcttc tttatgaatt ggaagaaaac acagacaaag
      361 ccgttgaatg ttacaggcgt tcagtggaat taaacccaac acaaaaagat cttgtgttga
      421 agattgcaga attgctttgt aaaaatgatg ttactgatgg aagagcaaaa tactggcttg
      481 aaagagcagc caaacttttc ccaggaagtc ctgcaattta taaactaaag gaacagcttc
      541 tagattgtga aggtgaagat ggatggaata aactttttga cttgattcag tcagaacttt
      601 atgtaagacc tgatgacgtc catgtgaaca tccggctagt ggaggtgtat cgctcaacta
      661 aaagattgaa ggatgctgtg gcccactgcc atgaggcaga gaggaacata gctttgcgtt
      721 caagtttaga atggaattcg tgtgttgtac agacccttaa ggaatatctg gagtctttac
      781 agtgtttgga gtctgataaa agtgactggc gagcaaccaa tacagactta ctgctggcct
      841 atgctaatct tatgcttctt acgctttcca ctagagatgt gcaggaaagt agagaattac
      901 tgcaaagttt tgatagtgct cttcagtctg tgaaatcttt gggtggaaat gatgaactgt
      961 cagctacttt cttagaaatg aaaggacatt tctacatgca tgctggttct ctgcttttga
     1021 agatgggtca gcatagtagt aatgttcaat ggcgagctct ttctgagctg gctgcattgt
     1081 gctatctcat agcatttcag gttccaagac caaagattaa attaataaaa ggtgaagctg
     1141 gacaaaatct gctggaaatg atggcctgtg accgactgag ccaatcaggg cacatgttgc
     1201 taaacttaag tcgtggcaag caagattttt taaaagagat tgttgaaact tttgccaaca
     1261 aaagcgggca gtctgcatta tatgatgctc tgttttctag tcagtcacct aaggatacat
     1321 cttttcttgg tagcgatgat attggaaaca ttgatgtacg agaaccagag cttgaagatt
     1381 tgactagata cgatgttggt gctattcgag cacataatgg tagtcttcag caccttactt
     1441 ggcttggctt acagtggaat tcattgcctg ctttacctgg aatccgaaaa tggctaaaac
     1501 agcttttcca tcatttgccc catgaaacct caaggcttga aacaaatgca cctgaatcaa
     1561 tatgtatttt agatcttgaa gtatttctcc ttggagtagt atataccagc cacttacaat
     1621 taaaggagaa atgtaattct caccacagct cctatcagcc gttatgcctg ccccttcctg
     1681 tgtgtaaaca gctttgtaca gaaagacaaa aatcttggtg ggatgcggtt tgtactctga
     1741 ttcacagaaa agcagtacct ggaaacgtag caaaattgag acttctagtt cagcatgaaa
     1801 taaacactct aagagcccag gaaaaacatg gccttcaacc tgctctgctt gtacattggg
     1861 cagaatgcct tcagaaaacg ggcagcggtc ttaattcttt ttatgatcaa cgagaataca
     1921 tagggagaag tgttcattat tggaagaaag ttttgccatt gttgaagata ataaaaaaga
     1981 agaacagtat tcctgaacct attgatcctc tgtttaaaca ttttcatagt gtagacattc
     2041 aggcatcaga aattgttgaa tatgaagaag acgcacacat aacttttgct atattggatg
     2101 cagtaaatgg aaatatagaa gatgctgtga ctgcttttga atctataaaa agtgttgttt
     2161 cttattggaa tcttgcactg atttttcaca ggaaggcaga agacattgaa aatgatgccc
     2221 tttctcctga agaacaagaa gaatgcaaaa attatctgag aaagaccagg gactacctaa
     2281 taaagattat agatgacagt gattcaaatc tttcagtggt caagaaattg cctgtgcccc
     2341 tggagtctgt aaaagagatg cttaattcag tcatgcagga actcgaagac tatagtgaag
     2401 gaggtcctct ctataaaaat ggttctttgc gaaatgcaga ttcagaaata aaacattcta
     2461 caccgtctcc taccagatat tcactatcac caagtaaaag ttacaagtat tctcccaaaa
     2521 caccacctcg atgggcagaa gatcagaatt ctttactgaa aatgatttgc caacaagtag
     2581 aggccattaa gaaagaaatg caggagttga aactaaatag cagtaactca gcatcccctc
     2641 atcgttggcc cacagagaat tatggaccag actcagtgcc tgatggatat caggggtcac
     2701 agacatttca tggggctcca ctaacagttg caactactgg cccttcagta tattatagtc
     2761 agtcaccagc atataattcc cagtatcttc tcagaccagc agctaatgtt actcccacaa
     2821 agggcccagt ctatggcatg aataggcttc caccccaaca gcatatttat gcctatccgc
     2881 aacagatgca cacaccgcca gtgcaaagct catctgcttg tatgttctct caggagatgt
     2941 atggtcctcc tgcattgcgt tttgagtctc ctgcaacggg aattctatcg cccaggggtg
     3001 atgattactt taattacaat gttcaacaga caagcacaaa tccacctttg ccagaaccag
     3061 gatatttcac aaaacctccg attgcagctc atgcttcaag atctgcagaa tctaagacta
     3121 tagaatttgg gaaaactaat tttgttcagc ccatgccggg tgaaggatta aggccatctt
     3181 tgccaacaca agcacacaca acacagccaa ctccttttaa atttaactca aatttcaaat
     3241 caaatgatgg tgacttcacg ttttcctcac cacaggttgt gacacagccc cctcctgcag
     3301 cttacagtaa cagtgaaagc cttttaggtc tcctgacttc agataaaccc ttgcaaggag
     3361 atggctatag tggagccaaa ccaattcctg gtggtcaaac cattgggcct cgaaatacat
     3421 tcaattttgg aagcaaaaat gtgtctggaa tttcatttac agaaaacatg gggtcgagtc
     3481 agcaaaagaa ttctggtttt cggcgaagtg atgatatgtt tactttccat ggtccaggga
     3541 aatcagtatt tggaacaccc actttagaga cagcaaacaa gaatcatgag acagatggag
     3601 gaagtgccca tggggatgat gatgatgacg gtcctcactt tgagcctgta gtacctcttc
     3661 ctgataagat tgaagtaaaa actggtgagg aagatgaaga agaattcttt tgcaaccgcg
     3721 cgaaattgtt tcgtttcgat gtagaatcca aagaatggaa agaacgtggg attggcaatg
     3781 taaaaatact gaggcataaa acatctggta aaattcgcct tctaatgaga cgagagcaag
     3841 tattgaaaat ctgtgcaaat cattacatca gtccagatat gaaattgaca ccaaatgctg
     3901 gatcagacag atcttttgta tggcatgccc ttgattatgc agatgagttg ccaaaaccag
     3961 aacaacttgc tattaggttc aaaactcctg aggaagcagc actttttaaa tgcaagtttg
     4021 aagaagccca gagcatttta aaagccccag gaacaaatgt agccatggcg tcaaatcagg
     4081 ctgtcagaat tgtaaaagaa cccacaagtc atgataacaa ggatatttgc aaatctgatg
     4141 ctggaaacct gaattttgaa tttcaggttg caaagaaaga agggtcttgg tggcattgta
     4201 acagctgctc attaaagaat gcttcaactg ctaagaaatg tgtatcatgc caaaatctaa
     4261 acccaagcaa taaagagctc gttggcccac cattagctga aactgttttt actcctaaaa
     4321 ccagcccaga gaatgttcaa gatcgatttg cattggtgac tccaaagaaa gaaggtcact
     4381 gggattgtag tatttgttta gtaagaaatg aacctactgt atctaggtgc attgcgtgtc
     4441 agaatacaaa atctgctaac aaaagtggat cttcatttgt tcatcaagct tcatttaaat
     4501 ttggccaggg agatcttcct aaacctatta acagtgattt cagatctgtt ttttctacaa
     4561 aggaaggaca gtgggattgc agtgcatgtt tggtacaaaa tgaggggagc tctacaaaat
     4621 gtgctgcttg tcagaatccg agaaaacaga gtctacctgc tacttctatt ccaacacctg
     4681 cctcttttaa gtttggtact tcagagacaa gtaaaactct aaaaagtgga tttgaagaca
     4741 tgtttgctaa gaaggaagga cagtgggatt gcagttcatg cttagtgcga aatgaagcaa
     4801 atgctacaag atgtgttgct tgtcagaatc cggataaacc aagtccatct acttctgttc
     4861 cagctcctgc ctcttttaag tttggtactt cagagacaag caaggctcca aagagcggat
     4921 ttgagggaat gttcactaag aaggagggac agtgggattg cagtgtgtgc ttagtaagaa
     4981 atgaagccag tgctaccaaa tgtattgctt gtcagaatcc aggtaaacaa aatcaaacta
     5041 cttctgcagt ttcaacacct gcctcttcag agacaagcaa ggctccaaag agcggatttg
     5101 agggaatgtt cactaagaag gagggacagt gggattgcag tgtgtgctta gtaagaaatg
     5161 aagccagtgc taccaaatgt attgcttgtc agaatccagg taaacaaaat caaactactt
     5221 ctgcagtttc aacacctgcc tcttcagaga caagcaaggc tccaaagagc ggatttgagg
     5281 gaatgttcac taagaaggaa ggacagtggg attgcagtgt gtgcttagta agaaatgaag
     5341 ccagtgctac caaatgtatt gcttgtcagt gtccaagtaa acaaaatcaa acaactgcaa
     5401 tttcaacacc tgcctcttcg gagataagca aggctccaaa gagtggattt gaaggaatgt
     5461 tcatcaggaa aggacagtgg gattgtagtg tttgctgtgt acaaaatgag agttcttcct
     5521 taaaatgtgt ggcttgtgat gcctctaaac caactcataa acctattgca gaagctcctt
     5581 cagctttcac actgggctca gaaatgaagt tgcatgactc ttctggaagt caggtgggaa
     5641 caggatttaa aagtaatttc tcagaaaaag cttctaagtt tggcaataca gagcaaggat
     5701 tcaaatttgg gcatgtggat caagaaaatt caccttcatt tatgtttcag ggttcttcta
     5761 atacagaatt taagtcaacc aaagaaggat tttccatccc tgtgtctgct gatggattta
     5821 aatttggcat ttcggaacca ggaaatcaag aaaagaaaag tgaaaagcct cttgaaaatg
     5881 gtactggctt ccaggctcag gatattagtg gccagaagaa tggccgtggt gtgatttttg
     5941 gccaaacaag tagcactttt acatttgcag atcttgcaaa atcaacttca ggagaaggat
     6001 ttcagtttgg caaaaaagac cccaatttca agggattttc aggtgctgga gaaaaattat
     6061 tctcatcaca atacggtaaa atggccaata aagcaaacac ttccggtgac tttgagaaag
     6121 atgatgatgc ctataagact gaggacagcg atgacatcca ttttgaacca gtagttcaaa
     6181 tgcccgaaaa agtagaactt gtaacaggag aagaagatga aaaagttctg tattcacagc
     6241 gggtaaaact atttagattt gatgctgagg taagtcagtg gaaagaaagg ggcttgggga
     6301 acttaaaaat tctcaaaaac gaggtcaatg gcaaactaag aatgctgatg cgaagagaac
     6361 aagtactaaa agtgtgtgct aatcattgga taacgactac gatgaacctg aagcctctct
     6421 ctggatcaga tagagcatgg atgtggttag ccagtgattt ctctgatggt gatgccaaac
     6481 tagagcagtt ggcagcaaaa tttaaaacac cagagctggc tgaagaattc aagcagaaat
     6541 ttgaggaatg ccagcggctt ctgttagaca taccacttca aactccccat aaacttgtag
     6601 atactggcag agctgccaag ttaatacaga gagctgaaga aatgaagagt ggactgaaag
     6661 atttcaaaac atttttgaca aatgatcaaa caaaagtcac tgaggaagaa aataagggtt
     6721 caggtacagg tgcggccggt gcctcagaca caacaataaa acccaatcct gaaaacactg
     6781 ggcccacatt agaatgggat aactatgatt taagggaaga tgctttggat gatagtgtca
     6841 gtagtagctc agtacatgct tctccattgg caagtagccc tgtgagaaaa aatcttttcc
     6901 gttttggtga gtcaacaaca ggatttaact tcagttttaa atctgctttg agtccatcta
     6961 agtctcctgc caagttgaat cagagtggga cttcagttgg cactgatgaa gaatctgatg
     7021 ttactcaaga agaagagaga gatggacagt actttgaacc tgttgttcct ttacctgatc
     7081 tagttgaagt atccagtggt gaggaaaatg aacaagttgt ttttagtcac agggcaaaac
     7141 tctacagata tgataaagat gttggtcaat ggaaagaaag gggcattggt gatataaaga
     7201 ttttacagaa ttatgataat aagcaagttc gtatagtgat gagaagggac caagtattaa
     7261 aactttgtgc caatcacaga ataactccag acatgacttt gcaaaatatg aaagggacag
     7321 aaagagtatg gttgtggact gcatgtgatt ttgcagatgg agaaagaaaa gtagagcatt
     7381 tagctgttcg ttttaaacta caggatgttg cagactcgtt taagaaaatt tttgatgaag
     7441 caaaaacagc ccaggaaaaa gattctttga taacacctca tgtttctcgg tcaagcactc
     7501 ccagagagtc accatgtggc aaaattgctg tagctgtatt agaagaaacc acaagagaga
     7561 ggacagatgt tattcagggt gatgatgtag cagatgcaac ttcagaagtt gaagtgtcta
     7621 gcacatctga aacaacacca aaagcagtgg tttctcctcc aaagtttgta tttggttcag
     7681 agtctgttaa aagcattttt agtagtgaaa aatcaaaacc atttgcattc ggcaacagtt
     7741 cagccactgg gtctttgttt ggatttagtt ttaatgcacc tttgaaaagt aacaatagtg
     7801 aaactagttc agtagcccag agtggatctg aaagcaaagt ggaacctaaa aaatgtgaac
     7861 tgtcaaagaa ctctgatatc gaacagtctt cagatagcaa agtcaaaaat ctctttgctt
     7921 cctttccaac ggaagaatct tcaatcaact acacatttaa aacaccagaa aaggcaaaag
     7981 agaagaaaaa acctgaagat tctccctcag atgatgatgt tctcattgta tatgaactaa
     8041 ctccaaccgc tgagcagaaa gcccttgcaa ccaaacttaa acttcctcca actttcttct
     8101 gctacaagaa tagaccagat tatgttagtg aagaagagga ggatgatgaa gatttcgaaa
     8161 cagctgtcaa gaaacttaat ggaaaactat atttggatgg ctcagaaaaa tgtagaccct
     8221 tggaagaaaa tacagcagat aatgagaaag aatgtattat tgtttgggaa aagaaaccaa
     8281 cagttgaaga gaaggcaaaa gcagatacgt taaaacttcc acctacattt ttttgtggag
     8341 tctgtagtga tactgatgaa gacaatggaa atggggagga ctttcaatca gagcttcaaa
     8401 aagttcagga agctcaaaaa tctcagacag aagaaataac tagcacaact gacagtgtat
     8461 atacaggtgg gactgaagtg atggtacctt ctttctgtaa atctgaagaa cctgattcta
     8521 ttaccaaatc cattagttca ccatctgttt cctctgaaac tatggacaaa cctgtagatt
     8581 tgtcaactag aaaggaaatt gatacagatt ctacaagcca aggggaaagc aagatagttt
     8641 catttggatt tggaagtagc acagggctct catttgcaga cttggcttcc agtaattctg
     8701 gagattttgc ttttggttct aaagataaaa atttccaatg ggcaaatact ggagcagctg
     8761 tgtttggaac acagtcagtc ggaacccagt cagccggtaa agttggtgaa gatgaagatg
     8821 gtagtgatga agaagtagtt cataatgaag atatccattt tgaaccaata gtgtcactac
     8881 cagaggtaga agtaaaatct ggagaagaag atgaagaaat tttgtttaaa gagagagcca
     8941 aactttatag atgggatcgg gatgtcagtc agtggaagga gcgcggtgtt ggagatataa
     9001 agattctttg gcatacaatg aagaattatt accggatcct aatgagaaga gaccaggttt
     9061 ttaaagtgtg tgcaaaccac gttattacta aaacaatgga attaaagccc ttaaatgttt
     9121 caaataatgc tttagtttgg actgcctcag attatgctga tggagaagca aaagtagaac
     9181 agcttgcagt gagatttaaa actaaagaag tagctgattg tttcaagaaa acatttgaag
     9241 aatgtcagca gaatttaatg aaactccaga aaggacatgt atcactggca gcagaattat
     9301 caaaggagac caatcctgtg gtgttttttg atgtttgtgc ggacggtgaa cctctagggc
     9361 ggataactat ggaattattt tcaaacattg ttcctcggac tgctgagaac ttcagagcac
     9421 tatgcactgg agagaaaggc tttggtttca agaattccat ttttcacaga gtaattccag
     9481 attttgtttg ccaaggagga gatatcacca aacatgatgg aacaggcgga cagtccattt
     9541 atggagacaa atttgaagat gaaaattttg atgtgaaaca tactggtcct ggtttactat
     9601 ccatggccaa tcaaggccag aataccaata attctcaatt tgttataaca ctgaagaaag
     9661 cagaacattt ggactttaag catgtagtat ttgggtttgt taaggatggc atggatactg
     9721 tgaaaaagat tgaatcattt ggttctccca aagggtctgt ttgtcgaaga ataactatca
     9781 cagaatgtgg acagatataa aatcattgtt gttcatagaa aatttcatct gtataagcag
     9841 ttggattgaa gcttagctat tacaatttga tagttatgtt cagcttttga aaatggacgt
     9901 ttccgattta caaatgtaaa attgcagctt atagctgttg tcacttttta atgtgttata
     9961 attgaccttg catggtgtga aataaaagtt taaacactgg tgtatttcag gtgtacttgt
    10021 gtttatgtac tcctgacgta ttaaaatgga ataatactaa tcttgttaaa agcaatagac
    10081 ctcaaactat tgaaggaata tgatatatgc aatttaattt taattccttt taagatattt
    10141 ggacttcctg catggatata cttaccattt gaataaaggg accacaactt ggataattta
    10201 attttaggtt tgaaatatat ttggtaatct taactattgg tgtactcatt tatgcataga
    10261 gactcgttta tgaatgggta gagccacaga acgtatagag ttaaccaaag tgctcttctc
    10321 tagaatcttt acacctcctg tgtggttaca agttaacttt gtaagtagcg taccttcctt
    10381 ccttaaaata tctagcttcc tgtgcccttt catagatatt cgattaattt ttacatttta
    10441 aacaagttga ctatttcctt taggggtttt gtttcaaact tttctgtcat ctgtctctac
    10501 tacctcagaa actgcagctt ggttctgatg atagaaattg aatttttcct tgtagttatt
    10561 gtgataaagt atgaatattt ttagaaagtc tataccatgt tctttcgtta aagatttgct
    10621 ttatacaaga ttgttgcagt acctttttct ggtaaatttt gtagcagaaa taaaatgaca
    10681 attcctaaga gccactgaca tccaaaaaat tcattactta cgcttcgggt tcattctaaa
    10741 gtaaggaaga caatttaaag gcagtaaatt caaactgctg cataatttcc agagctccta
    10801 gtttctcaag tttgatacac accaaaaacg tatttggaaa tggcttgtat caaatgttag
    10861 gcaaattgct aaagaaaaga ggatgttctt attggcctac tcaatatgga actacaaaga
    10921 atccaggtag aacacaaaat tttgtatatt gcaattatga atattgactg tcttccaccc
    10981 atctgtgttc tttcgggtga aattacctca ttttatttag tgaggaaaga caggtttatt
    11041 ccctgttaca tggggatttg gaaattgggt atcctaaagc aagtaactgt tcaaccacca
    11101 gtcaaaagag gggagggatg ttgtgcgagt aatgagtgat ggtataccat caccattcca
    11161 ctcggccaca aagccagata cttgaaataa acctactcca aatgtatcag ttcagtcttg
    11221 aaccatggat tacatatgtt tacactaaat atttcaaatt ggcttatttg gaaatctatg
    11281 taatataaac tgatgtaaag tgtgttgtaa cttttcagct gagacagttg atgccttcgt
    11341 catgatttta gaataaattc ttaagttaat gcaagtgctt tttaagagac tttttacaga
    11401 tttgtatgct ttcctaaagc actaaagtta caaattaaaa agctttaaaa actttgacca
    11461 aaaatttgac aaaatgacat gtaaactgac ttttcccgta ttagtattcc aaagatgctt
    11521 aaaagtggct tgtggcattt atgagaaagt ctttgtgtca catttcagga aaggactttg
    11581 atttctcttt gttatttaat cactgatgtg gtctaaaccc acgataatat gtatctttcc
    11641 ttttaaactg gattttatgt tgtctcatta aaatctgctt aaagatagaa taaaattcat
    11701 tatttgta
//
