LOCUS       NM_022897               4440 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens RAN binding protein 17 (RANBP17), mRNA.
ACCESSION   NM_022897
VERSION     NM_022897.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4440)
  AUTHORS   Akter,M., Cui,H., Hosain,M.A., Liu,J., Duan,Y. and Ding,B.
  TITLE     RANBP17 Overexpression Restores Nucleocytoplasmic Transport and
            Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons
  JOURNAL   J Neurosci 44 (15), e1728232024 (2024)
   PUBMED   38438257
  REMARK    GeneRIF: RANBP17 Overexpression Restores Nucleocytoplasmic
            Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia
            Motor Neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4440)
  AUTHORS   Mandic,R., Marquardt,A., Terhorst,P., Ali,U., Nowak-Rossmann,A.,
            Cai,C., Rodepeter,F.R., Stiewe,T., Wezorke,B., Wanzel,M., Neff,A.,
            Stuck,B.A. and Bette,M.
  TITLE     The importin beta superfamily member RanBP17 exhibits a role in
            cell proliferation and is associated with improved survival of
            patients with HPV+ HNSCC
  JOURNAL   BMC Cancer 22 (1), 785 (2022)
   PUBMED   35850701
  REMARK    GeneRIF: The importin beta superfamily member RanBP17 exhibits a
            role in cell proliferation and is associated with improved survival
            of patients with HPV+ HNSCC.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4440)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   4  (bases 1 to 4440)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 4440)
  AUTHORS   Lee,J.H., Zhou,S. and Smas,C.M.
  TITLE     Identification of RANBP16 and RANBP17 as novel interaction partners
            for the bHLH transcription factor E12
  JOURNAL   J Cell Biochem 111 (1), 195-206 (2010)
   PUBMED   20503194
  REMARK    GeneRIF: These biochemical and functional data reveal RANBP16 and
            RANBP17 as novel regulators of E2A protein action, and demonstrate
            specific interaction of E12 with RANBP17.
REFERENCE   6  (bases 1 to 4440)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4440)
  AUTHORS   Kutay,U., Hartmann,E., Treichel,N., Calado,A., Carmo-Fonseca,M.,
            Prehn,S., Kraft,R., Gorlich,D. and Bischoff,F.R.
  TITLE     Identification of two novel RanGTP-binding proteins belonging to
            the importin beta superfamily
  JOURNAL   J Biol Chem 275 (51), 40163-40168 (2000)
   PUBMED   11024021
REFERENCE   8  (bases 1 to 4440)
  AUTHORS   Koch,P., Bohlmann,I., Schafer,M., Hansen-Hagge,T.E., Kiyoi,H.,
            Wilda,M., Hameister,H., Bartram,C.R. and Janssen,J.W.
  TITLE     Identification of a novel putative Ran-binding protein and its
            close homologue
  JOURNAL   Biochem Biophys Res Commun 278 (1), 241-249 (2000)
   PUBMED   11071879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC404010.1, AJ271459.1 and AC091980.4.
            
            On Nov 24, 2018 this sequence version replaced NM_022897.4.
            
            Summary: The transport of protein and large RNAs through the
            nuclear pore complexes (NPC) is an energy-dependent and regulated
            process. The import of proteins with a nuclear localization signal
            (NLS) is accomplished by recognition of one or more clusters of
            basic amino acids by the importin-alpha/beta complex; see MIM
            600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a
            key role in NLS-dependent protein import. RAN-binding protein-17 is
            a member of the importin-beta superfamily of nuclear transport
            receptors.[supplied by OMIM, Jul 2002].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ271459.1, AF222747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000523189.6/ ENSP00000427975.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               DC404010.1         137-575
            440-4218            AJ271459.1         440-4218
            4219-4440           AC091980.4         50187-50408
FEATURES             Location/Qualifiers
     source          1..4440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..4440
                     /gene="RANBP17"
                     /note="RAN binding protein 17"
                     /db_xref="GeneID:64901"
                     /db_xref="HGNC:HGNC:14428"
                     /db_xref="MIM:606141"
     exon            1..34
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..3283
                     /gene="RANBP17"
                     /codon_start=1
                     /product="ran-binding protein 17"
                     /protein_id="NP_075048.1"
                     /db_xref="CCDS:CCDS34287.1"
                     /db_xref="GeneID:64901"
                     /db_xref="HGNC:HGNC:14428"
                     /db_xref="MIM:606141"
                     /translation="MALHFQSLAELEVLCTHLYIGTDLTQRIEAEKALLELIDSPECL
                     SKCQLLLEQGTTSYAQLLAATCLSKLVSRVSPLPVEQRMDIRNYILNYVASQPKLAPF
                     VIQALIQVIAKITKLGWFEVQKDQFVFREIIADVKKFLQGTVEHCIIGVIILSELTQE
                     MNLVDYSRPSAKHRKIATSFRDTSLKDVLVLACSLLKEVFAKPLNLQDQCQQNLVMQV
                     LKLVLNCLNFDFIGSSADESADDLCTVQIPTTWRTIFLEPETLDLFFNLYHSLPPLLS
                     QLALSCLVQFASTRRSLFNSPERAKYLGNLIKGVKRILENPQGLSDPGNYHEFCRFLA
                     RLKTNYQLGELVMVKEYPEVIRLIANFTITSLQHWEFAPNSVHYLLTLWQRMVASVPF
                     VKSTEPHLLDTYAPEITKAFITSRLDSVAIVVRDHLDDPLDDTATVFQQLEQLCTVSR
                     CEYEKTCALLVQLFDQNAQNYQKLLHPYSGVTVDITIQEGRLAWLVYLVGTVVGGRLT
                     YTSTDEHDAMDGELSCRVFQLISLMDTGLPRCCNEKIELAILWFLDQFRKTYVGDQLQ
                     RTSKVYARMSEVLGITDDNHVLETFMTKIVTNLKYWGRYEPVISRTLQFLNDLSVGYI
                     LLKKLVKIDAVKFMLKNHTSEHFPFLGISDNHSLSDFRCRTTFYTALTRLLMVDLGED
                     EDEFENFMLPLTVAFETVLQIFNNNFKQEDVKRMLIGLARDLRGIAFALNTKTSYTML
                     FDWMYPTYLPLLQNAVERWYGEPTCTTPILKLMAELMQNRSQRLNFDVSSPNGILLFR
                     EASKMVCTYGNQILSLGSLSKDQIYPMKLKGISICYSALKSALCGNYVSFGVFKLYGD
                     NHFDNVLQAFVKMLLSVSHSDLLQYRKLSQSYYPLLECLTQDHMSFIINLEPPVLMYV
                     LTSISEGLTTLDTVVSSSCCTSLDYIVTYLFKHIAKEGKKPLRCREATQAGQRLLHFM
                     QQNPDVLQQMMSVLMNTIVFEDCRNQWSVSRPLLGLILLNEKYFSELRASLINSQPLP
                     KQEVLAQCFRNLMEGVEQNLSVKNRDRFTQNLSVFRRDVAEALRSDGNTEPCSLDMMS
                     "
     exon            35..181
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            182..272
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            273..439
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            440..505
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            506..610
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            611..776
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            777..850
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            851..970
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1117
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1290
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1484
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1590
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1726
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1800
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1881
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1945
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2054
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2158
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2247
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2355
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2438
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2653
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2792
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2959
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3058
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3186
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..4440
                     /gene="RANBP17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3583..3588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP17"
                     /note="hexamer: AATAAA"
     polyA_site      3604
                     /gene="RANBP17"
                     /note="major polyA site"
     regulatory      4410..4415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP17"
                     /note="hexamer: AGTAAA"
     polyA_site      4440
                     /gene="RANBP17"
ORIGIN      
        1 gccgcctcct gggaagatgg cgctgcactt ccagagtttg gctgaattgg aagtgttatg
       61 tactcatctc tacataggga ctgatcttac acaaagaata gaggctgaga aagcactctt
      121 ggaacttatt gacagtccag aatgtctcag caagtgtcaa cttttattag aacaaggaac
      181 aacatcctat gctcagctcc ttgcagcaac atgtctttca aaacttgtca gccgagtcag
      241 tcctttacct gttgagcaga ggatggacat cagaaactac attctgaatt acgtggcatc
      301 acagcccaag ctggctccct ttgtcatcca agctcttatt caagtcattg ctaaaatcac
      361 taagttgggg tggtttgagg ttcagaaaga ccaatttgtc ttcagagaaa ttattgctga
      421 tgtgaagaag tttctccagg gtactgtgga acactgcata ataggagtaa taatcctttc
      481 tgaattgact caggaaatga acctggttga ttattctaga ccttcagcaa aacacaggaa
      541 aatagctacc tcatttcgtg atacttctct caaagacgtt ttagtgctag catgctctct
      601 tttaaaagag gtgtttgcca aacctttaaa tcttcaggat caatgtcagc aaaatctggt
      661 aatgcaggtc ttgaaactgg tccttaactg ccttaacttt gacttcattg gcagttcagc
      721 agatgaatct gcagatgatc tttgcacggt gcagattcca acaacttgga gaacaatttt
      781 cctggaacca gaaacattgg atcttttctt caatttgtat cattcacttc caccactact
      841 atctcagtta gcactttcat gtttagttca gtttgcttcg acaagaaggt ccttatttaa
      901 cagtcctgaa cgtgccaagt accttggtaa tttaattaag ggagtaaaaa ggatacttga
      961 aaaccctcag ggtttgtctg atccaggtaa ttatcatgaa ttttgtcgat ttttggctcg
     1021 tttaaagaca aattatcagc tgggagaatt agttatggtg aaggaatatc ctgaagttat
     1081 tagattgatt gctaatttta ccattactag cctacagcac tgggaatttg ctcctaacag
     1141 tgttcattat ttattaactc tgtggcaaag gatggtagca tctgttcctt ttgtgaaatc
     1201 aactgaaccc cacctattag acacttatgc accagaaatc acgaaggcct ttatcacttc
     1261 tcggttggac tctgttgcca tagttgtgag agatcactta gatgatccac tggatgatac
     1321 tgccactgtg tttcagcagt tggagcagtt gtgcacggtc agcagatgtg aatatgaaaa
     1381 gacatgtgct cttcttgtgc agttattcga ccaaaatgca cagaattacc aaaaacttct
     1441 gcatccatat tctggtgtaa ctgtggacat caccattcag gaaggacgtc ttgcatggct
     1501 ggtatactta gttgggacag ttgtaggagg aagattaaca tataccagta cagatgagca
     1561 tgatgctatg gatggagaat tatcctgtcg agtttttcag cttatatctt taatggatac
     1621 cggattgcct cgatgttgta atgagaaaat agagcttgca attctgtggt tcttggatca
     1681 gtttcgtaaa acatatgttg gtgatcaact tcaaagaacc tcaaaggtat atgctcgtat
     1741 gtcagaagtc ttaggaataa cagatgacaa ccacgttcta gagacgttca tgacaaaaat
     1801 tgttacaaac cttaaatact ggggaagata tgagcctgta atttcaagga ctcttcagtt
     1861 cctaaatgac ctttctgttg gttatatcct tttaaaaaaa cttgtgaaga tagatgctgt
     1921 gaaattcatg ctaaaaaacc acacgagtga acacttccct tttcttggca tcagtgacaa
     1981 tcatagtctc agcgacttca ggtgtcgaac aaccttctac acagcgctca ctcgccttct
     2041 gatggtagat ctgggtgaag atgaggatga atttgagaat ttcatgctgc ctcttacagt
     2101 tgcttttgaa acagtattac aaatattcaa caacaacttt aaacaagaag atgtaaagcg
     2161 tatgttgatc gggctggcaa gagatcttcg agggattgcc tttgcactga acacaaagac
     2221 cagctacacc atgctgtttg actggatgta cccaacgtac cttccccttc ttcagaatgc
     2281 tgttgaacgg tggtatggag agccaacatg tacaactccc atcttgaaac ttatggcaga
     2341 acttatgcaa aacagatccc agcgtttgaa ttttgatgta tcatctccta atggaattct
     2401 tctcttcaga gaagctagta aaatggtttg cacttatggt aatcagatcc tgtcccttgg
     2461 gagcctctca aaagatcaga tttatccaat gaaactcaag ggcatctcca tctgctattc
     2521 agctctcaag tctgccttgt gtggaaatta tgtcagcttt ggcgtcttca agttgtatgg
     2581 ggacaaccat tttgacaatg tactccaggc ttttgtcaaa atgctgctgt cagtgtccca
     2641 cagtgacttg ctacaatacc ggaaactgag ccagtcttat tatccactcc tggaatgtct
     2701 cactcaggac catatgagct tcatcatcaa cttagagcct cctgtactca tgtatgttct
     2761 cacatctatc tcagagggac tcactactct tgatacagtt gtctcctcca gctgctgtac
     2821 cagtttagac tacatcgtca cctacctctt caagcacata gcaaaagagg gcaagaagcc
     2881 acttcgatgc agagaggcta cccaggctgg tcagagacta ttacatttta tgcagcaaaa
     2941 cccagatgtc ctgcagcaga tgatgtctgt cctcatgaac accattgtct ttgaagactg
     3001 tcggaaccag tggtcagtat ccaggcctct cctggggctc atcctgctca atgagaagta
     3061 tttcagtgaa ctgagagcaa gtttgataaa cagccagccc ctccccaagc aggaggtcct
     3121 tgcccagtgc ttcagaaacc taatggaagg agtggagcag aacctgtccg tcaagaacag
     3181 agacaggttc acccaaaatc tgtctgtatt cagaagagat gtggcagagg cgttgcgcag
     3241 tgatggcaac actgaaccat gcagtctcga catgatgagc tgacccgact tttctgacca
     3301 tgtgcggagc agcctttatc aagagactcc tgaaggtctg ggtctcagga cagtgatgtt
     3361 ggctagccca ggggaatgta tttttcaaaa catacaagca acagcaaaag ccctaacttc
     3421 ttatacgtct agcctaatta taagaatttc taacagtacc agtgtaaatt cagtcttttc
     3481 tctgaaaagc aaaggatgtg ttttcagtct ttctatcaaa tattatcttt gttctcctaa
     3541 tgctctgaaa ggatgtagaa acaatattta accaaagaac gtaataaacc aggtttgcac
     3601 ctaagtgtgt actagtttat ggttctgcag tcaaggttgt caatttgttg gagatgcagc
     3661 cttcaccatg gatcctggat tgagacgaat gccattggaa cctgttaaat gagtagtttg
     3721 ttatgtgtct ggaagaagca gcgttaggga ctttgggctg tgagcattta gaacgagcct
     3781 ggaagcacta cagagcatcc cacaggacca cacgcaggcc tccctgcctc agctgcatct
     3841 gataaagttg agagacagta acacaattaa atgacttaga aacaatgttt gcttttcact
     3901 ggcataaatc tgaagtggtt cagtctagaa gaattaagct gtgcaattac tgcctgcaga
     3961 gatatttctt caggaggagt catgtagccc cagtcagaag ttctgggtgg tgccagcacc
     4021 cagtcctctg cctccattta atttttaaga gaaggtgaag gtaactatta gaatataata
     4081 tttgaagcag ctctgccttc ttagggctac ccaaaacagt tctaggtgct aaaattcaga
     4141 ttttcagagg atgagaaata gctggtttcc aactctccac aaaaactctt attactgttg
     4201 ggacttggga ttctgactca ccccaaaccc agaacatgaa gaagaccttt acagtttgtg
     4261 ctctactgtt actaggctat taatttgaga tcgtccactg tcaagtgttt tactatctca
     4321 ctgctgtttt tatgattcag gcttataaca aatattgtat cctttatttc tgataagaca
     4381 tgaaaggttg gccttactgt tgaacaataa gtaaatccac aggctcctgt tgtaatctca
//
