LOCUS       NM_020850               5245 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RAN binding protein 10 (RANBP10), transcript variant
            1, mRNA.
ACCESSION   NM_020850 XM_043069
VERSION     NM_020850.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5245)
  AUTHORS   Hou,J., Liu,Y., Huang,P., Wang,Y., Pei,D., Tan,R., Zhang,Y. and
            Cui,H.
  TITLE     RANBP10 promotes glioblastoma progression by regulating the
            FBXW7/c-Myc pathway
  JOURNAL   Cell Death Dis 12 (11), 967 (2021)
   PUBMED   34671019
  REMARK    GeneRIF: RANBP10 promotes glioblastoma progression by regulating
            the FBXW7/c-Myc pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5245)
  AUTHORS   Lai,K.Y., Rizzato,M., Aydin,I., Villalonga-Planells,R.,
            Drexler,H.C.A. and Schelhaas,M.
  TITLE     A Ran-binding protein facilitates nuclear import of human
            papillomavirus type 16
  JOURNAL   PLoS Pathog 17 (5), e1009580 (2021)
   PUBMED   33974675
  REMARK    GeneRIF: A Ran-binding protein facilitates nuclear import of human
            papillomavirus type 16.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5245)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5245)
  AUTHORS   Lampert,F., Stafa,D., Goga,A., Soste,M.V., Gilberto,S., Olieric,N.,
            Picotti,P., Stoffel,M. and Peter,M.
  TITLE     The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell
            proliferation and targets the transcription factor Hbp1 for
            degradation
  JOURNAL   Elife 7, e35528 (2018)
   PUBMED   29911972
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5245)
  AUTHORS   Her,L.S., Mao,S.H., Chang,C.Y., Cheng,P.H., Chang,Y.F., Yang,H.I.,
            Chen,C.M. and Yang,S.H.
  TITLE     miR-196a Enhances Neuronal Morphology through Suppressing RANBP10
            to Provide Neuroprotection in Huntington's Disease
  JOURNAL   Theranostics 7 (9), 2452-2462 (2017)
   PUBMED   28744327
  REMARK    GeneRIF: Authors provide evidence that enhancement of neuronal
            morphology through RANBP10 is one of the neuroprotective mechanisms
            for miR-196a.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5245)
  AUTHORS   Hosono,K., Noda,S., Shimizu,A., Nakanishi,N., Ohtsubo,M.,
            Shimizu,N. and Minoshima,S.
  TITLE     YPEL5 protein of the YPEL gene family is involved in the cell cycle
            progression by interacting with two distinct proteins RanBPM and
            RanBP10
  JOURNAL   Genomics 96 (2), 102-111 (2010)
   PUBMED   20580816
REFERENCE   7  (bases 1 to 5245)
  AUTHORS   Rex,E.B., Rankin,M.L., Yang,Y., Lu,Q., Gerfen,C.R., Jose,P.A. and
            Sibley,D.R.
  TITLE     Identification of RanBP 9/10 as interacting partners for protein
            kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation
            of PKC-mediated receptor phosphorylation
  JOURNAL   Mol Pharmacol 78 (1), 69-80 (2010)
   PUBMED   20395553
  REMARK    GeneRIF: data support the idea that RanBP9 and RanBP10 may function
            as signaling integrators and dictate the efficient regulation of
            D(1) receptor signaling by PKCdelta and PKCgamma
REFERENCE   8  (bases 1 to 5245)
  AUTHORS   Schulze,H., Dose,M., Korpal,M., Meyer,I., Italiano,J.E. Jr. and
            Shivdasani,R.A.
  TITLE     RanBP10 is a cytoplasmic guanine nucleotide exchange factor that
            modulates noncentrosomal microtubules
  JOURNAL   J Biol Chem 283 (20), 14109-14119 (2008)
   PUBMED   18347012
  REMARK    GeneRIF: RanBP10 might serve as a molecular link between Ran and
            noncentrosomal microtubules
REFERENCE   9  (bases 1 to 5245)
  AUTHORS   Woo,J.S., Imm,J.H., Min,C.K., Kim,K.J., Cha,S.S. and Oh,B.H.
  TITLE     Structural and functional insights into the B30.2/SPRY domain
  JOURNAL   EMBO J 25 (6), 1353-1363 (2006)
   PUBMED   16498413
REFERENCE   10 (bases 1 to 5245)
  AUTHORS   Wang,D., Li,Z., Schoen,S.R., Messing,E.M. and Wu,G.
  TITLE     A novel MET-interacting protein shares high sequence similarity
            with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling
  JOURNAL   Biochem Biophys Res Commun 313 (2), 320-326 (2004)
   PUBMED   14684163
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY337313.1 and AI275875.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020850.2.
            
            Summary: RAN is a small GTPase involved in the assembly of
            microtubules to form mitotic spindles. The protein encoded by this
            gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that
            binds beta-tubulin and has GEF activity toward RAN. The encoded
            protein plays a role in the formation of noncentrosomal
            microtubules. In addition, this protein may be involved in the
            regulation of D(1) receptor signaling by protein kinase C delta and
            protein kinase C gamma. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.37311.1, BC099917.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317506.8/ ENSP00000316589.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5213              AY337313.1         93-5305
            5214-5245           AI275875.1         14-45               c
FEATURES             Location/Qualifiers
     source          1..5245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..5245
                     /gene="RANBP10"
                     /note="RAN binding protein 10"
                     /db_xref="GeneID:57610"
                     /db_xref="HGNC:HGNC:29285"
                     /db_xref="MIM:614031"
     exon            1..259
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1887
                     /gene="RANBP10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Ran-binding protein 10"
                     /codon_start=1
                     /product="ran-binding protein 10 isoform 1"
                     /protein_id="NP_065901.1"
                     /db_xref="CCDS:CCDS32469.1"
                     /db_xref="GeneID:57610"
                     /db_xref="HGNC:HGNC:29285"
                     /db_xref="MIM:614031"
                     /translation="MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYP
                     AVNQQETPLPRSWSPKDKYNYIGLSQGNLRVHYKGHGKNHKDAASVRATHPIPAACGI
                     YYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYG
                     PTFTTGDVIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFG
                     QQPFLFDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATA
                     FARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKC
                     RQFVEMVNGTDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHMHNTGADSPSCSNG
                     VASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKSQHHSSTSNQET
                     SDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQLCGGNQAAT
                     ERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQLDPIQRE
                     PVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFARVDDYLH"
     exon            260..371
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            372..424
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            425..592
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            593..615
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            616..800
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            801..913
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1022
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1171
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1376
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1498
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1644
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1756
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..5245
                     /gene="RANBP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5223..5228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP10"
                     /note="hexamer: ATTAAA"
     polyA_site      5245
                     /gene="RANBP10"
                     /note="major polyA site"
ORIGIN      
        1 gacacaatag tagctccctc caagatggcg gcagcgacgg cagacccggg agctgggaac
       61 ccgcagcctg gggactcctc cggcgggggc gctgggggcg ggctgccgtc ccctggggag
      121 caggagctga gccggcgctt gcagcgcctg tatcccgcgg tcaaccagca agagactccg
      181 ctgccgcgct cctggagccc caaggacaaa tacaactaca ttggtctctc ccagggcaac
      241 ctccgcgtcc actacaaagg tcatggcaaa aatcacaaag atgcggcctc agtgcgtgcc
      301 acccacccca tacctgctgc ctgtggcatt tattactttg aagtgaagat tgtcagcaaa
      361 ggaagagatg gttacatggg aataggactc tcggctcaag gcgtcaacat gaacagactt
      421 cctggttggg acaaacattc ctatggttac catggtgatg atgggcattc gttctgctcc
      481 tcggggactg gccagcccta tggtcccaca ttcaccacag gagacgtgat cggctgctgt
      541 gtcaacctca tcaatggcac ctgcttctac accaagaatg gccacagcct tggtatagcc
      601 ttcacagacc tcccggccaa cctctacccc accgtaggcc tgcagacacc tggggagatt
      661 gtggacgcca actttgggca gcagcccttc ctgtttgaca ttgaggacta catgcgggag
      721 tggcgtgcca aggtccaggg cacggtccac tgcttcccca tcagtgcccg gcttggcgag
      781 tggcaggcag tgctgcagaa catggtttca tcttacctcg tgcatcatgg gtattgtgcc
      841 acagccacgg cttttgctcg aatgactgaa accccgattc aggaagaaca ggcgtccata
      901 aagaacagac aaaagatcca gaagctggtg ctggagggcc gtgtgggcga ggccatcgag
      961 accacccagc gcttctaccc agggctgctg gagcacaacc ccaacctcct cttcatgctc
     1021 aagtgccggc agtttgtgga gatggtgaat gggacggaca gtgaggtccg aagtttgagc
     1081 tcccgaagcc ccaagtccca ggacagctac cctggctccc ccagcctcag tccccgacat
     1141 ggccccagta gttcccacat gcacaacaca ggagcagaca gtcccagctg tagcaatggc
     1201 gtcgcgtcca ccaagagcaa acagaaccac agtaaatacc ctgcacccag ctcctcatcc
     1261 tcgtcctcct cctcctcctc gtcctcttcc ccatcctccg tcaattactc cgagtccaac
     1321 tcaacagact ccaccaagtc ccagcaccac agcagtacca gtaaccagga gaccagcgac
     1381 agtgagatgg agatggaggc agagcactac cccaacggtg tgctaggaag catgtccaca
     1441 cgcattgtta atggtgccta caagcatgag gacctgcaga cggatgagtc cagcatggat
     1501 gacaggcatc ctcggcggca gctctgcggg ggcaaccagg ctgccacaga aaggatcatt
     1561 ctgtttggcc gcgagttgca ggcattgagt gagcagttgg gccgggagta cggcaagaat
     1621 ttggcccaca cagagatgct gcaggatgcc ttcagcctgc tggcatactc agacccctgg
     1681 agctgcccag ttggccagca gcttgacccc atccagaggg aacctgtgtg tgctgccctc
     1741 aacagcgcca ttttagagtc ccagaacctg ccaaagcagc cccctctgat gctcgccctg
     1801 ggccaggcat ctgagtgtct ccggctcatg gcccgagcag gcctgggttc ttgctccttt
     1861 gccagagttg atgactactt gcactagctg actgtgctgg ctggctctgg ctggccctcc
     1921 actggcccca gggctggagc tgccctgccc tccataggca actggtgcag ggactgggaa
     1981 accatagaca gagtccactc ctcctgcctg gcctttcccc ctctcccttt ccttccttcc
     2041 ttcctttctc tgcccaccac cccgctcagt ctctctctct ctccccttca cgtgcagcgg
     2101 cctgtaacac agtattggct ggttactctc atgtagcgcc ttctattttg aaaggggggt
     2161 tttgttttga ggaggggttg gggtttttaa atttttttct cctgactgag ccaccagtat
     2221 ttatctctgg agagtttgtg ctgagctggt ttctgctaat ttagtgatga agcctatcca
     2281 agttggtgat agcttattat tttcataagt aaaaaacaaa tgagattata tatatatata
     2341 taaaaatata tatattaaaa aaaaagacag tatttatcgt agcattagtg gtccagcacc
     2401 tcttgggtga ggctgtccag gcaccatgtt ttctttgagt ccaactcatt aaaaaagaag
     2461 aatctctgtc acctcagcca agtgatttat tttttgctcc cccttttttg agtcacaggc
     2521 cgagctgcag cctaggaaac ccaaataggg tttggtgggc cacttagtgg gcatggttac
     2581 attggtttat agcatcccaa gaactgtaga tccctaggcc cctgagagct ggacagagca
     2641 gagaactaca gggccaaggg tccagagaag tgataacttg gcccagggcc acacagcaga
     2701 ggtagagggt ccttggccag cacactatct accactctac cccacctccc actgcctgcc
     2761 ttgctcccct ttcctccctt ttcaataccc tatcttccct tgttgttaag atggccaaat
     2821 aatacattta ctctaaattg attgcctgga aactacctgc cttcgtcctg agagcttctg
     2881 tgtgtcaggc tgctggaaag aagactccat tcccaggaca gaggcccttg agtacagggg
     2941 ctgctttctt cctgcctaga tcttcaccat ctctgcacag ctctgagaga atggatgctt
     3001 tctgttgaga aaccagtacc ttgtggaggc aggttcttgg gctgctactc cagggagtgg
     3061 atggaatcct tggtccccta ggccagactt cactgccact gtgccagaca gctccctgca
     3121 gctgggccct agccactctt aggaaagact attgggagta tttgctggcc agagaatggg
     3181 actctatcag ctttacacat gtcccaccag ctgtttcaga tagatcctta cagctggcag
     3241 agtaaaagtg gtcccgctac cattggggaa tcaggaaagg aaagactgag atggttgcca
     3301 ggacttgggg tggcccacct gtggagagga ctggctgccc tggaggagga aagggaggaa
     3361 gtctacacag aggagcacca ggacggctgg aatttccata tgtgcttcac attgtgaggg
     3421 gagtgcacaa gccgcccatg caaagagtag ggtcagccat ggcaaggccg gaagttgaac
     3481 tttcagtccc tgcctgaatc tgggctttgc aagctcctgc tccatattgg tggacatggg
     3541 aatggttggt gtggcctgag atacccattg ctcaccaggc ctcactgggc ccacagctgg
     3601 gcaacaagaa aaatgtttga attggaccaa ctgctggtga tggggccagg gccctgggcc
     3661 ctgtgctgtc agaattctgc cttgggaaat gatcctatag ctgctgcttt ttcttggtcc
     3721 ttggggctgg cagacccata gaccatggcc tgttaggagg cgtcctgtct gtaaaggaaa
     3781 ttcatctctt gtgacagcct ggggctacct agctcccaaa cccagaagtt ggagacatca
     3841 ggctgtttaa atgatcatag cctagcagga ttggattaaa accacaggct tttgcagctg
     3901 gaatggggtt cagtgaacat ctcccccatt cctctcttgc tacaaataag gaaacaggcc
     3961 caggagatta agtgacttgg ctaaagtcac atagcaaatt agtagcagag ccgggactat
     4021 cccttatccc tgtgggttgg gcaacactat ttagtcctga aaccgaatgg cagataaacc
     4081 ccatgagggg tcaggctgat gtgccctcca gcagtatctg agaagctgct accttcaggg
     4141 gtgtgtcagg gatgaggacg ggtgcctgag cttaggttgt ggagtggctg agagggccca
     4201 ggagggctcg ggacagctgt gtgctgcatg gggttgggtg tctgcctggc tcgcacttgg
     4261 tacccatggc cacctcccca ttttctgtgc cttatctcac tgtttcagct gagtccaagt
     4321 tgtttactct gttcctctcc agaggggctc tctgtcccag ttgggcagct cacctttggg
     4381 acataagcct ttgccccaca agctgtggag agggccaaaa ccaagctgct tgagcccact
     4441 ctcttgctga gagtccaggc ctgcctgcct gccagccaga ggtgcccctt atgcacatcc
     4501 agtcctacca gcctgcttcc aggagcctag agtgggaaag gcacctgggg gagccctggt
     4561 gaagggctgg acctgaccca tggaggcagg aggaagacct ggctttcttg gtttgtccgg
     4621 ccctggggag cagccttccc tactcacttt ccccttgcgg caccaaatgg tcactccttc
     4681 cagagcaaaa actggcactc atagcaagcc agaaccccca tccccatcct catgggtctg
     4741 tggctgggtg caggccatca aaatggacac cacgagacag aagtggggac tgcctggcca
     4801 cctagcgcct tcccactcct taagcaagca caaagaagat gaggcagaga attgtcagag
     4861 ctgaaagttc ctttggttgc tcacaactca ggtatgcacc catgtggcag ccaggcagcg
     4921 gagccctact agactgccag tctcatgcac ccagacctgt ggccagattg tggcctctgg
     4981 ctgcctcagg cattttcctc tttgcattgg gttttcctgc attagtaact acagctgcaa
     5041 cagacatcct ccacattgtg cacactggtt ttgcctttgt cctcaagagt tgatacttgg
     5101 cattagcatg aaacttgtgg gtgtgggagg atggagagag aactctaaca caaaacatct
     5161 tattaaaatt gtacttgaga gacaaaaaaa aaactctgtt gtattttgac agaattattt
     5221 ttattaaaat acacatccat gagca
//
