LOCUS       NM_002882               1054 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens RAN binding protein 1 (RANBP1), transcript variant 2,
            mRNA.
ACCESSION   NM_002882
VERSION     NM_002882.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1054)
  AUTHORS   Kodiha,M., Azad,N., Chu,S., Crampton,N. and Stochaj,U.
  TITLE     Oxidative stress and signaling through EGFR and PKA pathways
            converge on the nuclear transport factor RanBP1
  JOURNAL   Eur J Cell Biol 103 (1), 151376 (2024)
   PUBMED   38011756
  REMARK    GeneRIF: Oxidative stress and signaling through EGFR and PKA
            pathways converge on the nuclear transport factor RanBP1.
REFERENCE   2  (bases 1 to 1054)
  AUTHORS   Kahm,Y.J., Kim,I.G. and Kim,R.K.
  TITLE     RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in
            Lung Cancer and Glioma
  JOURNAL   Int J Mol Sci 24 (7), 6855 (2023)
   PUBMED   37047826
  REMARK    GeneRIF: RanBP1: A Potential Therapeutic Target for Cancer Stem
            Cells in Lung Cancer and Glioma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1054)
  AUTHORS   Nan,G., Zhao,S.H., Wang,T., Chao,D., Tian,R.F., Wang,W.J., Fu,X.,
            Lin,P., Guo,T., Wang,B., Sun,X.X., Chen,X., Chen,Z.N., Wang,S.J.
            and Cui,H.Y.
  TITLE     CD147 supports paclitaxel resistance via interacting with RanBP1
  JOURNAL   Oncogene 41 (7), 983-996 (2022)
   PUBMED   34974521
  REMARK    GeneRIF: CD147 supports paclitaxel resistance via interacting with
            RanBP1.
REFERENCE   4  (bases 1 to 1054)
  AUTHORS   Yau,K.C., Arnaoutov,A., Aksenova,V., Kaufhold,R., Chen,S. and
            Dasso,M.
  TITLE     RanBP1 controls the Ran pathway in mammalian cells through
            regulation of mitotic RCC1 dynamics
  JOURNAL   Cell Cycle 19 (15), 1899-1916 (2020)
   PUBMED   32594833
  REMARK    GeneRIF: RanBP1 controls the Ran pathway in mammalian cells through
            regulation of mitotic RCC1 dynamics.
REFERENCE   5  (bases 1 to 1054)
  AUTHORS   Chi,N.C., Adam,E.J. and Adam,S.A.
  TITLE     Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear
            import factor p97
  JOURNAL   J Biol Chem 272 (10), 6818-6822 (1997)
   PUBMED   9045717
REFERENCE   6  (bases 1 to 1054)
  AUTHORS   Chi,N.C., Adam,E.J., Visser,G.D. and Adam,S.A.
  TITLE     RanBP1 stabilizes the interaction of Ran with p97 nuclear protein
            import
  JOURNAL   J Cell Biol 135 (3), 559-569 (1996)
   PUBMED   8909533
REFERENCE   7  (bases 1 to 1054)
  AUTHORS   Hayashi,N., Yokoyama,N., Seki,T., Azuma,Y., Ohba,T. and
            Nishimoto,T.
  TITLE     RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits
            RCC1 via Ran/TC4
  JOURNAL   Mol Gen Genet 247 (6), 661-669 (1995)
   PUBMED   7616957
REFERENCE   8  (bases 1 to 1054)
  AUTHORS   Ren,M., Villamarin,A., Shih,A., Coutavas,E., Moore,M.S.,
            LoCurcio,M., Clarke,V., Oppenheim,J.D., D'Eustachio,P. and
            Rush,M.G.
  TITLE     Separate domains of the Ran GTPase interact with different factors
            to regulate nuclear protein import and RNA processing
  JOURNAL   Mol Cell Biol 15 (4), 2117-2124 (1995)
   PUBMED   7891706
REFERENCE   9  (bases 1 to 1054)
  AUTHORS   Bischoff,F.R., Krebber,H., Smirnova,E., Dong,W. and Ponstingl,H.
  TITLE     Co-activation of RanGTPase and inhibition of GTP dissociation by
            Ran-GTP binding protein RanBP1
  JOURNAL   EMBO J 14 (4), 705-715 (1995)
   PUBMED   7882974
REFERENCE   10 (bases 1 to 1054)
  AUTHORS   Coutavas,E., Ren,M., Oppenheim,J.D., D'Eustachio,P. and Rush,M.G.
  TITLE     Characterization of proteins that interact with the cell-cycle
            regulatory protein Ran/TC4
  JOURNAL   Nature 366 (6455), 585-587 (1993)
   PUBMED   8255297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB459798.1, X83617.1,
            AW404614.1 and HY229989.1.
            
            On Jun 1, 2019 this sequence version replaced NM_002882.3.
            
            Summary: This gene encodes a protein that forms a complex with
            Ras-related nuclear protein (Ran) and metabolizes guanoside
            triphosphate (GTP). This complex participates in the regulation of
            the cell cycle by controlling transport of proteins and nucleic
            acids into the nucleus. There are multiple pseudogenes for this
            gene on chromosomes 9, 12, 17, and X. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) is shorter and has a distinct N-terminus, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.536991.1,
                                           SRR1163657.302666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DB459798.1         84-126
            44-880              X83617.1           1-837
            881-1053            AW404614.1         17-189              c
            1054-1054           HY229989.1         3-3                 c
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..1054
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="RAN binding protein 1"
                     /db_xref="GeneID:5902"
                     /db_xref="HGNC:HGNC:9847"
                     /db_xref="MIM:601180"
     exon            1..160
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..751
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ran-specific GTPase-activating protein; HpaII tiny
                     fragments locus 9A; testis secretory sperm-binding protein
                     Li 221n"
                     /codon_start=1
                     /product="ran-specific GTPase-activating protein isoform
                     2"
                     /protein_id="NP_002873.1"
                     /db_xref="CCDS:CCDS13775.1"
                     /db_xref="GeneID:5902"
                     /db_xref="HGNC:HGNC:9847"
                     /db_xref="MIM:601180"
                     /translation="MAAAKDTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIKTLEED
                     EEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGAIRLLMRRDKTLKICANH
                     YITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRK
                     EIEEREKKAGSGKNDHAEKVAEKLEALSVKEETKEDAEEKQ"
     exon            161..297
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     exon            298..455
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     exon            456..584
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     exon            585..650
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     exon            651..1054
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      864..869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="hexamer: TATAAA"
     polyA_site      882
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="major polyA site"
     regulatory      1029..1034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="hexamer: AATAAA"
     polyA_site      1054
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
ORIGIN      
        1 gttcgggtcg tggggcggag ggaagagcgg gcgggcggga ggcgccggcg ccagacgcgg
       61 agggaaggag ctacgagtag ccgccgagag gccgcggagc cagcgacgac cgacccagcc
      121 gagccgccgc cgccgccgcg cccccatggc ggccgccaag gacactcatg aggaccatga
      181 tacttccact gagaatacag acgagtccaa ccatgaccct cagtttgagc caatagtttc
      241 tcttcctgag caagaaatta aaacactgga agaagatgaa gaggaacttt ttaaaatgcg
      301 ggcaaaactg ttccgatttg cctctgagaa cgatctccca gaatggaagg agcgaggcac
      361 tggtgacgtc aagctcctga agcacaagga gaaaggggcc atccgcctcc tcatgcggag
      421 ggacaagacc ctgaagatct gtgccaacca ctacatcacg ccgatgatgg agctgaagcc
      481 caacgcaggt agcgaccgtg cctgggtctg gaacacccac gctgacttcg ccgacgagtg
      541 ccccaagcca gagctgctgg ccatccgctt cctgaatgct gagaatgcac agaaattcaa
      601 aacaaagttt gaagaatgca ggaaagagat cgaagagaga gaaaagaaag caggatcagg
      661 caaaaatgat catgccgaaa aagtggcgga aaagctagaa gctctctcgg tgaaggagga
      721 gaccaaggag gatgctgagg agaagcaata aatcgtctta ttttattttc ttttcctctc
      781 tttcctttcc tttttttaaa aaattttacc ctgcccctct ttttcggttt gtttttattc
      841 tttcattttt acaagggacg ttatataaag aactgaactc aacattcagg ttgttttttt
      901 tttttgtttc taagtttttg ccctattgaa gatgacttca gaaaatccat tccccagtca
      961 tgaaaatgta ctgtgctaac tttcttttcc atagtggaaa cacttattta tagtcatcaa
     1021 aaatagtgaa taaaaaacac atttggaacc tggg
//
