LOCUS       NM_001278639            1221 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens RAN binding protein 1 (RANBP1), transcript variant 1,
            mRNA.
ACCESSION   NM_001278639
VERSION     NM_001278639.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1221)
  AUTHORS   Kodiha,M., Azad,N., Chu,S., Crampton,N. and Stochaj,U.
  TITLE     Oxidative stress and signaling through EGFR and PKA pathways
            converge on the nuclear transport factor RanBP1
  JOURNAL   Eur J Cell Biol 103 (1), 151376 (2024)
   PUBMED   38011756
  REMARK    GeneRIF: Oxidative stress and signaling through EGFR and PKA
            pathways converge on the nuclear transport factor RanBP1.
REFERENCE   2  (bases 1 to 1221)
  AUTHORS   Kahm,Y.J., Kim,I.G. and Kim,R.K.
  TITLE     RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in
            Lung Cancer and Glioma
  JOURNAL   Int J Mol Sci 24 (7), 6855 (2023)
   PUBMED   37047826
  REMARK    GeneRIF: RanBP1: A Potential Therapeutic Target for Cancer Stem
            Cells in Lung Cancer and Glioma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1221)
  AUTHORS   Nan,G., Zhao,S.H., Wang,T., Chao,D., Tian,R.F., Wang,W.J., Fu,X.,
            Lin,P., Guo,T., Wang,B., Sun,X.X., Chen,X., Chen,Z.N., Wang,S.J.
            and Cui,H.Y.
  TITLE     CD147 supports paclitaxel resistance via interacting with RanBP1
  JOURNAL   Oncogene 41 (7), 983-996 (2022)
   PUBMED   34974521
  REMARK    GeneRIF: CD147 supports paclitaxel resistance via interacting with
            RanBP1.
REFERENCE   4  (bases 1 to 1221)
  AUTHORS   Yau,K.C., Arnaoutov,A., Aksenova,V., Kaufhold,R., Chen,S. and
            Dasso,M.
  TITLE     RanBP1 controls the Ran pathway in mammalian cells through
            regulation of mitotic RCC1 dynamics
  JOURNAL   Cell Cycle 19 (15), 1899-1916 (2020)
   PUBMED   32594833
  REMARK    GeneRIF: RanBP1 controls the Ran pathway in mammalian cells through
            regulation of mitotic RCC1 dynamics.
REFERENCE   5  (bases 1 to 1221)
  AUTHORS   Chi,N.C., Adam,E.J. and Adam,S.A.
  TITLE     Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear
            import factor p97
  JOURNAL   J Biol Chem 272 (10), 6818-6822 (1997)
   PUBMED   9045717
REFERENCE   6  (bases 1 to 1221)
  AUTHORS   Chi,N.C., Adam,E.J., Visser,G.D. and Adam,S.A.
  TITLE     RanBP1 stabilizes the interaction of Ran with p97 nuclear protein
            import
  JOURNAL   J Cell Biol 135 (3), 559-569 (1996)
   PUBMED   8909533
REFERENCE   7  (bases 1 to 1221)
  AUTHORS   Hayashi,N., Yokoyama,N., Seki,T., Azuma,Y., Ohba,T. and
            Nishimoto,T.
  TITLE     RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits
            RCC1 via Ran/TC4
  JOURNAL   Mol Gen Genet 247 (6), 661-669 (1995)
   PUBMED   7616957
REFERENCE   8  (bases 1 to 1221)
  AUTHORS   Ren,M., Villamarin,A., Shih,A., Coutavas,E., Moore,M.S.,
            LoCurcio,M., Clarke,V., Oppenheim,J.D., D'Eustachio,P. and
            Rush,M.G.
  TITLE     Separate domains of the Ran GTPase interact with different factors
            to regulate nuclear protein import and RNA processing
  JOURNAL   Mol Cell Biol 15 (4), 2117-2124 (1995)
   PUBMED   7891706
REFERENCE   9  (bases 1 to 1221)
  AUTHORS   Bischoff,F.R., Krebber,H., Smirnova,E., Dong,W. and Ponstingl,H.
  TITLE     Co-activation of RanGTPase and inhibition of GTP dissociation by
            Ran-GTP binding protein RanBP1
  JOURNAL   EMBO J 14 (4), 705-715 (1995)
   PUBMED   7882974
REFERENCE   10 (bases 1 to 1221)
  AUTHORS   Coutavas,E., Ren,M., Oppenheim,J.D., D'Eustachio,P. and Rush,M.G.
  TITLE     Characterization of proteins that interact with the cell-cycle
            regulatory protein Ran/TC4
  JOURNAL   Nature 366 (6455), 585-587 (1993)
   PUBMED   8255297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC397929.1, CA489474.1,
            X83617.1, AW404614.1 and HY229989.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001278639.1.
            
            Summary: This gene encodes a protein that forms a complex with
            Ras-related nuclear protein (Ran) and metabolizes guanoside
            triphosphate (GTP). This complex participates in the regulation of
            the cell cycle by controlling transport of proteins and nucleic
            acids into the nucleus. There are multiple pseudogenes for this
            gene on chromosomes 9, 12, 17, and X. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.220377.1,
                                           SRR5189661.170025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430524.6/ ENSP00000401564.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               DC397929.1         167-340
            175-431             CA489474.1         31-287
            432-1047            X83617.1           222-837
            1048-1220           AW404614.1         17-189              c
            1221-1221           HY229989.1         3-3                 c
FEATURES             Location/Qualifiers
     source          1..1221
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..1221
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="RAN binding protein 1"
                     /db_xref="GeneID:5902"
                     /db_xref="HGNC:HGNC:9847"
                     /db_xref="MIM:601180"
     exon            1..327
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..918
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ran-specific GTPase-activating protein; HpaII tiny
                     fragments locus 9A; testis secretory sperm-binding protein
                     Li 221n"
                     /codon_start=1
                     /product="ran-specific GTPase-activating protein isoform
                     1"
                     /protein_id="NP_001265568.1"
                     /db_xref="CCDS:CCDS74823.1"
                     /db_xref="GeneID:5902"
                     /db_xref="HGNC:HGNC:9847"
                     /db_xref="MIM:601180"
                     /translation="MGSALGRARRTLSGRPFQRAPCKTRRALSLSAALRNVTKAQGGC
                     PKSLVLWGCRPKRPRKRRTSLKLAWRGTFCSSSLKISEDTHEDHDTSTENTDESNHDP
                     QFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEK
                     GAIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIR
                     FLNAENAQKFKTKFEECRKEIEEREKKAGSGKNDHAEKVAEKLEALSVKEETKEDAEE
                     KQ"
     exon            328..464
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     exon            465..622
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     exon            623..751
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     exon            752..817
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1221
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1031..1036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="hexamer: TATAAA"
     polyA_site      1049
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="major polyA site"
     regulatory      1196..1201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
                     /note="hexamer: AATAAA"
     polyA_site      1221
                     /gene="RANBP1"
                     /gene_synonym="HTF9A"
ORIGIN      
        1 actgtccata gaggggtcac cacgtcggcc actcgtgtta ctggtggctc actctcaccc
       61 tcctgtcgcc tcctcctggc catggggtcg gccttgggcc gggccaggcg cacactgagt
      121 gggcggcctt tccagagggc accatgcaaa acgcgcaggg ccttgtccct ctctgcagcg
      181 ctgcggaatg tcacaaaggc gcagggtggt tgcccaaaga gtttggtttt gtggggctgc
      241 agaccaaagc ggcccaggaa gcgccggacg tcgctgaagc tggcgtggcg aggcacgttc
      301 tgcagctcca gtttaaagat ctcagaggac actcatgagg accatgatac ttccactgag
      361 aatacagacg agtccaacca tgaccctcag tttgagccaa tagtttctct tcctgagcaa
      421 gaaattaaaa cactggaaga agatgaagag gaacttttta aaatgcgggc aaaactgttc
      481 cgatttgcct ctgagaacga tctcccagaa tggaaggagc gaggcactgg tgacgtcaag
      541 ctcctgaagc acaaggagaa aggggccatc cgcctcctca tgcggaggga caagaccctg
      601 aagatctgtg ccaaccacta catcacgccg atgatggagc tgaagcccaa cgcaggtagc
      661 gaccgtgcct gggtctggaa cacccacgct gacttcgccg acgagtgccc caagccagag
      721 ctgctggcca tccgcttcct gaatgctgag aatgcacaga aattcaaaac aaagtttgaa
      781 gaatgcagga aagagatcga agagagagaa aagaaagcag gatcaggcaa aaatgatcat
      841 gccgaaaaag tggcggaaaa gctagaagct ctctcggtga aggaggagac caaggaggat
      901 gctgaggaga agcaataaat cgtcttattt tattttcttt tcctctcttt cctttccttt
      961 ttttaaaaaa ttttaccctg cccctctttt tcggtttgtt tttattcttt catttttaca
     1021 agggacgtta tataaagaac tgaactcaac attcaggttg tttttttttt ttgtttctaa
     1081 gtttttgccc tattgaagat gacttcagaa aatccattcc ccagtcatga aaatgtactg
     1141 tgctaacttt cttttccata gtggaaacac ttatttatag tcatcaaaaa tagtgaataa
     1201 aaaacacatt tggaacctgg g
//
