LOCUS       NM_006325               2474 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RAN, member RAS oncogene family (RAN), transcript
            variant 1, mRNA.
ACCESSION   NM_006325
VERSION     NM_006325.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2474)
  AUTHORS   Lin,Q., Chen,W., Tan,J., Qian,S., Su,H., Zhao,L., Yuan,L., Ruan,J.,
            Huang,X. and Zhou,H.
  TITLE     Association of RAN and RANBP2 Gene Polymorphisms With Glioma
            Susceptibility in Chinese Children
  JOURNAL   Cancer Rep (Hoboken) 7 (7), e2136 (2024)
   PUBMED   39041645
  REMARK    GeneRIF: Association of RAN and RANBP2 Gene Polymorphisms With
            Glioma Susceptibility in Chinese Children.
REFERENCE   2  (bases 1 to 2474)
  AUTHORS   Gao,W., Zhou,J., Huang,J., Zhang,Z., Chen,W., Zhang,R., Kang,T.,
            Liao,D. and Zhong,L.
  TITLE     Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer
            stem-like cells population during heterogeneous tumor generation
  JOURNAL   Cancer Lett 586, 216708 (2024)
   PUBMED   38336287
  REMARK    GeneRIF: Up-regulation of RAN by MYBL2 maintains osteosarcoma
            cancer stem-like cells population during heterogeneous tumor
            generation.
REFERENCE   3  (bases 1 to 2474)
  AUTHORS   Garg,R., Endzhievskaya,S. and Williamson,M.
  TITLE     B-type Plexins promote the GTPase activity of Ran to affect
            androgen receptor nuclear translocation in prostate cancer
  JOURNAL   Cancer Gene Ther 30 (11), 1513-1523 (2023)
   PUBMED   37563360
  REMARK    GeneRIF: B-type Plexins promote the GTPase activity of Ran to
            affect androgen receptor nuclear translocation in prostate cancer.
REFERENCE   4  (bases 1 to 2474)
  AUTHORS   El-Tanani,M., Platt-Higgins,A., Nsairat,H., Matalka,I.I.,
            Ahmed,K.A., Zhang,S.D., Alshaer,W., Awidi,A., Matchett,K.B.,
            Aljabali,A.A., Mishra,V., Serrano-Aroca,A., Tambuwala,M.M. and
            Rudland,P.S.
  TITLE     Development and validation of Ran as a prognostic marker in stage I
            and stage II primary breast cancer
  JOURNAL   Life Sci 329, 121964 (2023)
   PUBMED   37473800
  REMARK    GeneRIF: Development and validation of Ran as a prognostic marker
            in stage I and stage II primary breast cancer.
            Erratum:[Life Sci. 2023 Oct 15;331:122075. doi:
            10.1016/j.lfs.2023.122075.. PMID: 37696731]
REFERENCE   5  (bases 1 to 2474)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2474)
  AUTHORS   Yokoyama,N., Hayashi,N., Seki,T., Pante,N., Ohba,T., Nishii,K.,
            Kuma,K., Hayashida,T., Miyata,T., Aebi,U. et al.
  TITLE     A giant nucleopore protein that binds Ran/TC4
  JOURNAL   Nature 376 (6536), 184-188 (1995)
   PUBMED   7603572
REFERENCE   7  (bases 1 to 2474)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   8  (bases 1 to 2474)
  AUTHORS   Bischoff,F.R. and Ponstingl,H.
  TITLE     Mitotic regulator protein RCC1 is complexed with a nuclear
            ras-related polypeptide
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10830-10834 (1991)
   PUBMED   1961752
REFERENCE   9  (bases 1 to 2474)
  AUTHORS   Matsumoto,T. and Beach,D.
  TITLE     Premature initiation of mitosis in yeast lacking RCC1 or an
            interacting GTPase
  JOURNAL   Cell 66 (2), 347-360 (1991)
   PUBMED   1855255
REFERENCE   10 (bases 1 to 2474)
  AUTHORS   Drivas,G.T., Shih,A., Coutavas,E., Rush,M.G. and D'Eustachio,P.
  TITLE     Characterization of four novel ras-like genes expressed in a human
            teratocarcinoma cell line
  JOURNAL   Mol Cell Biol 10 (4), 1793-1798 (1990)
   PUBMED   2108320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF054183.1, BC000852.1 and AC073912.38.
            
            On Nov 22, 2018 this sequence version replaced NM_006325.4.
            
            Summary: RAN (ras-related nuclear protein) is a small GTP binding
            protein belonging to the RAS superfamily that is essential for the
            translocation of RNA and proteins through the nuclear pore complex.
            The RAN protein is also involved in control of DNA synthesis and
            cell cycle progression. Nuclear localization of RAN requires the
            presence of regulator of chromosome condensation 1 (RCC1).
            Mutations in RAN disrupt DNA synthesis. Because of its many
            functions, it is likely that RAN interacts with several other
            proteins. RAN regulates formation and organization of the
            microtubule network independently of its role in the
            nucleus-cytosol exchange of macromolecules. RAN could be a key
            signaling molecule regulating microtubule polymerization during
            mitosis. RCC1 generates a high local concentration of RAN-GTP
            around chromatin which, in turn, induces the local nucleation of
            microtubules.  RAN is an androgen receptor (AR) coactivator that
            binds differentially with different lengths of polyglutamine within
            the androgen receptor. Polyglutamine repeat expansion in the AR is
            linked to Kennedy's disease (X-linked spinal and bulbar muscular
            atrophy). RAN coactivation of the AR diminishes with polyglutamine
            expansion within the AR, and this weak coactivation may lead to
            partial androgen insensitivity during the development of Kennedy's
            disease. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.236645.1,
                                           SRR1803612.63815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543796.6/ ENSP00000446215.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               AF054183.1         44-485
            443-1074            BC000852.1         437-1068
            1075-2474           AC073912.38        175818-177217
FEATURES             Location/Qualifiers
     source          1..2474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..2474
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /note="RAN, member RAS oncogene family"
                     /db_xref="GeneID:5901"
                     /db_xref="HGNC:HGNC:9846"
                     /db_xref="MIM:601179"
     exon            1..61
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /inference="alignment:Splign:2.1.0"
     exon            62..107
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..722
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GTP-binding nuclear protein Ran; guanosine triphosphatase
                     Ran; RanGTPase; member RAS oncogene family; GTPase Ran;
                     ras-like protein TC4; ras-related nuclear protein;
                     androgen receptor-associated protein 24"
                     /codon_start=1
                     /product="GTP-binding nuclear protein Ran isoform 1"
                     /protein_id="NP_006316.1"
                     /db_xref="CCDS:CCDS9271.1"
                     /db_xref="GeneID:5901"
                     /db_xref="HGNC:HGNC:9846"
                     /db_xref="MIM:601179"
                     /translation="MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLG
                     VEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVP
                     NWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKP
                     FLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL"
     exon            108..192
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /inference="alignment:Splign:2.1.0"
     exon            193..318
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /inference="alignment:Splign:2.1.0"
     exon            319..506
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /inference="alignment:Splign:2.1.0"
     exon            507..677
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /inference="alignment:Splign:2.1.0"
     exon            678..2474
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2122..2127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /note="hexamer: AATAAA"
     polyA_site      2142
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
     regulatory      2449..2454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /note="hexamer: AATATA"
     polyA_site      2474
                     /gene="RAN"
                     /gene_synonym="ARA24; Gsp1; TC4"
                     /note="major polyA site"
ORIGIN      
        1 gaattgcgct tccgccatct ttccagcctc agtcggacgg gcgcggagac gcttctggaa
       61 ggaacgccgc gatggctgcg cagggagagc cccaggtcca gttcaaactt gtattggttg
      121 gtgatggtgg tactggaaaa acgaccttcg tgaaacgtca tttgactggt gaatttgaga
      181 agaagtatgt agccaccttg ggtgttgagg ttcatcccct agtgttccac accaacagag
      241 gacctattaa gttcaatgta tgggacacag ccggccagga gaaattcggt ggactgagag
      301 atggctatta tatccaagcc cagtgtgcca tcataatgtt tgatgtaaca tcgagagtta
      361 cttacaagaa tgtgcctaac tggcatagag atctggtacg agtgtgtgaa aacatcccca
      421 ttgtgttgtg tggcaacaaa gtggatatta aggacaggaa agtgaaggcg aaatccattg
      481 tcttccaccg aaagaagaat cttcagtact acgacatttc tgccaaaagt aactacaact
      541 ttgaaaagcc cttcctctgg cttgctagga agctcattgg agaccctaac ttggaatttg
      601 ttgccatgcc tgctctcgcc ccaccagaag ttgtcatgga cccagctttg gcagcacagt
      661 atgagcacga cttagaggtt gctcagacaa ctgctctccc ggatgaggat gatgacctgt
      721 gagaatgaag ctggagccca gcgtcagaag tctagtttta taggcagctg tcctgtgatg
      781 tcagcggtgc agcgtgtgtg ccacctcatt attatctagc taagcggaac atgtgcttca
      841 tctgtgggat gctgaaggag atgagtgggc ttcggagtga atgtggcagt ttaaaaaata
      901 acttcattgt ttggacctgc atatttagct gttttggaac gcagttgatt ccttgagttt
      961 catatataag actgctgcag tcacatcaca atattcagtg gtgaaatctt gtttgttact
     1021 gtcattccca ttccttttcg tttagaatca gaataaagtt gtatttcaaa tatctaagca
     1081 agtgaactca tcccttgttt ataaatagca tttggaaacc actaaagtag ggaagtttta
     1141 tgccatgtta atatttgaat tgccttgctt ttatcactta atttgaaatc tattgggtta
     1201 atttctccct atgtttattt ttgtacattt gagccatgtc acacaaactg atgatgacag
     1261 gtcagcagta ttctatttgg ttagaagggt tacatggtgt aaatattagt gcagttaagc
     1321 taaagcagtg tttgctccac cttcatattg gctaggtagg gtcacctagg gaagcacttg
     1381 ctcaaaatct gtgacctgtc agaataaaaa tgtggtttgt acatatcaaa tagatatttt
     1441 aagggtaata ttttctttta tggcaaaagt aatcatgttt taatgtagaa cctcaaacag
     1501 gatggaacat cagtggatgg caggaggttg ggaattcttg ctgttaaaaa taattacaaa
     1561 ttttgcactt ttttgtttga atgttagatg cttagtgtga agttgatacg caaggaaaat
     1621 ggtccatgtt tacccacagt tttcaggtac tcctagactt taaagatgtc ttgaacattt
     1681 aagttcttca gcagttcaca ctacaccgtt tttttgtttt tttttccccc ccgggagggt
     1741 ttttttgtag ggcagcacag cagagcagga catggatgaa atactaggaa tatgcacagt
     1801 ggggcagtgt gggggcttct cagtaatgga gaacagttgg tgaaactttt tttttttttt
     1861 aactaagcat ttaatttatc ttgcatattt tccacattta aaaatgaatt aggtctatta
     1921 ggataattag gagtttgatc ccatcaacac tattcttgta gcagttagga atcttgagct
     1981 atttttttct catacgatta ctatagtcca gtttaccaaa gttttcttta gatgtctgat
     2041 aatcttgaga tgattgctta ccttaaaagg tatagaaagg atcacttaaa tatatggaaa
     2101 aatgaaataa gggtgaagct gaataaagtt ctacttactg tattaactgg caacagttga
     2161 gtttcttaag atctgaattg ctgtgtatgt tacgctgtat tcagaaccag tttctaacca
     2221 gcctgtgaga tgggaagttt tttccccata attgggatga aacctttcat tcaggtattt
     2281 tgaattgaag gtgtatgtgt tgtttgtaac cttgtggaga ttgcaagtgg tgttgacatt
     2341 ctggatcttc tatgtaacag ttgaaatttg gaagtgacgt cacttacctg tctaacgtgg
     2401 tgtgggagag aatttacaag tcctttattg aaagaataat tgttgcaaaa tatattgctt
     2461 ctactttgcc tgga
//
