LOCUS       NM_005856               1323 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens receptor activity modifying protein 3 (RAMP3), mRNA.
ACCESSION   NM_005856
VERSION     NM_005856.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1323)
  AUTHORS   Cao,J., Belousoff,M.J., Liang,Y.L., Johnson,R.M., Josephs,T.M.,
            Fletcher,M.M., Christopoulos,A., Hay,D.L., Danev,R., Wootten,D. and
            Sexton,P.M.
  TITLE     A structural basis for amylin receptor phenotype
  JOURNAL   Science 375 (6587), eabm9609 (2022)
   PUBMED   35324283
REFERENCE   2  (bases 1 to 1323)
  AUTHORS   Ogoshi,M., Takahashi,M., Aoyagi,K., Ukena,K., Aizawa,S.,
            Takeuchi,H., Takahashi,S. and Takeuchi,S.
  TITLE     Adrenomedullin 2 and 5 activate the calcitonin receptor-like
            receptor (clr) - Receptor activity-modifying protein 3 (ramp3)
            receptor complex in Xenopus tropicalis
  JOURNAL   Gen Comp Endocrinol 306, 113752 (2021)
   PUBMED   33711314
  REMARK    GeneRIF: Adrenomedullin 2 and 5 activate the calcitonin
            receptor-like receptor (clr) - Receptor activity-modifying protein
            3 (ramp3) receptor complex in Xenopus tropicalis.
REFERENCE   3  (bases 1 to 1323)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1323)
  AUTHORS   Fang,A., Zhou,S., Su,X., Liu,C., Chen,X., Wan,Y., Lei,X., Xie,L.,
            Jia,Y., Wang,W., Yang,L., Song,X. and Yao,Y.
  TITLE     RAMP3 is a prognostic indicator of liver cancer and might reduce
            the adverse effect of TP53 mutation on survival
  JOURNAL   Future Oncol 14 (25), 2615-2625 (2018)
   PUBMED   29882679
  REMARK    GeneRIF: high RAMP3 expression is an independent prognostic factor
            of favorable overall survival and recurrence-free survival in
            patients with HCC and its expression might reduce the negative
            effect of TP53 mutation on survival.
REFERENCE   5  (bases 1 to 1323)
  AUTHORS   Watkins,H.A., Chakravarthy,M., Abhayawardana,R.S., Gingell,J.J.,
            Garelja,M., Pardamwar,M., McElhinney,J.M., Lathbridge,A.,
            Constantine,A., Harris,P.W., Yuen,T.Y., Brimble,M.A., Barwell,J.,
            Poyner,D.R., Woolley,M.J., Conner,A.C., Pioszak,A.A., Reynolds,C.A.
            and Hay,D.L.
  TITLE     Receptor Activity-modifying Proteins 2 and 3 Generate
            Adrenomedullin Receptor Subtypes with Distinct Molecular Properties
  JOURNAL   J Biol Chem 291 (22), 11657-11675 (2016)
   PUBMED   27013657
  REMARK    GeneRIF: interaction of RAMP2 or RAMP3 with CLR induces
            conformational variation in the juxtamembrane region, yielding
            distinct binding pockets, probably via an allosteric mechanism.
REFERENCE   6  (bases 1 to 1323)
  AUTHORS   Kuwasako,K., Shimekake,Y., Masuda,M., Nakahara,K., Yoshida,T.,
            Kitaura,M., Kitamura,K., Eto,T. and Sakata,T.
  TITLE     Visualization of the calcitonin receptor-like receptor and its
            receptor activity-modifying proteins during internalization and
            recycling
  JOURNAL   J Biol Chem 275 (38), 29602-29609 (2000)
   PUBMED   10882736
REFERENCE   7  (bases 1 to 1323)
  AUTHORS   Derst,C., Engel,H., Grzeschik,K. and Daut,J.
  TITLE     Genomic structure and chromosome mapping of human and mouse RAMP
            genes
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 115-118 (2000)
   PUBMED   11060459
REFERENCE   8  (bases 1 to 1323)
  AUTHORS   Christopoulos,G., Perry,K.J., Morfis,M., Tilakaratne,N., Gao,Y.,
            Fraser,N.J., Main,M.J., Foord,S.M. and Sexton,P.M.
  TITLE     Multiple amylin receptors arise from receptor activity-modifying
            protein interaction with the calcitonin receptor gene product
  JOURNAL   Mol Pharmacol 56 (1), 235-242 (1999)
   PUBMED   10385705
REFERENCE   9  (bases 1 to 1323)
  AUTHORS   Foord,S.M. and Marshall,F.H.
  TITLE     RAMPs: accessory proteins for seven transmembrane domain receptors
  JOURNAL   Trends Pharmacol Sci 20 (5), 184-187 (1999)
   PUBMED   10354609
  REMARK    Review article
REFERENCE   10 (bases 1 to 1323)
  AUTHORS   McLatchie,L.M., Fraser,N.J., Main,M.J., Wise,A., Brown,J.,
            Thompson,N., Solari,R., Lee,M.G. and Foord,S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393 (6683), 333-339 (1998)
   PUBMED   9620797
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP347072.1 and BC053852.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005856.2.
            
            Summary: The protein encoded by this gene is a member of the RAMP
            family of single-transmembrane-domain proteins, called receptor
            (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I
            transmembrane proteins with an extracellular N terminus and a
            cytoplasmic C terminus. RAMPs are required to transport
            calcitonin-receptor-like receptor (CRLR) to the plasma membrane.
            CRLR, a receptor with seven transmembrane domains, can function as
            either a calcitonin-gene-related peptide (CGRP) receptor or an
            adrenomedullin receptor, depending on which members of the RAMP
            family are expressed. In the presence of this (RAMP3) protein, CRLR
            functions as an adrenomedullin receptor. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.309688.1,
                                           SRR5189667.82182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242249.8/ ENSP00000242249.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-459               BP347072.1         24-482
            460-1323            BC053852.1         449-1312
FEATURES             Location/Qualifiers
     source          1..1323
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..1323
                     /gene="RAMP3"
                     /note="receptor activity modifying protein 3"
                     /db_xref="GeneID:10268"
                     /db_xref="HGNC:HGNC:9845"
                     /db_xref="MIM:605155"
     exon            1..96
                     /gene="RAMP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..485
                     /gene="RAMP3"
                     /note="calcitonin receptor-like receptor activity
                     modifying protein 3; receptor (calcitonin) activity
                     modifying protein 3; CRLR activity-modifying protein 3;
                     receptor (G protein-coupled) activity modifying protein 3"
                     /codon_start=1
                     /product="receptor activity-modifying protein 3 precursor"
                     /protein_id="NP_005847.1"
                     /db_xref="CCDS:CCDS5503.1"
                     /db_xref="GeneID:10268"
                     /db_xref="HGNC:HGNC:9845"
                     /db_xref="MIM:605155"
                     /translation="METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAF
                     ADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFS
                     NCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL"
     exon            97..229
                     /gene="RAMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            230..1323
                     /gene="RAMP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1300..1305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAMP3"
                     /note="hexamer: AGTAAA"
     polyA_site      1323
                     /gene="RAMP3"
                     /note="major polyA site"
ORIGIN      
        1 agcgggaccg agcgtgaccc agctgcggcc ggccagccat ggagactgga gcgctgcggc
       61 gcccgcaact tctcccgttg ctgctgctgc tctgcggtgg gtgtcccaga gcaggcggct
      121 gcaacgagac aggcatgttg gagaggctgc ccctgtgtgg gaaggctttc gcagacatga
      181 tgggcaaggt ggacgtctgg aagtggtgca acctgtccga gttcatcgtg tactatgaga
      241 gtttcaccaa ctgcaccgag atggaggcca atgtcgtggg ctgctactgg cccaaccccc
      301 tggcccaggg cttcatcacc ggcatccaca ggcagttctt ctccaactgc accgtggaca
      361 gggtccactt ggaggacccc ccagacgagg ttctcatccc gctgatcgtt atacccgtcg
      421 ttctgactgt cgccatggct ggcctggtgg tgtggcgcag caaacgcacc gacacgctgc
      481 tgtgagggtc ccggtgagat ggagtgggtc acacctggca agctggaaga aagttccctg
      541 gggatgggag agcgggtggg tgctgccaat ctccagctac tgtggccaca ccccacctgg
      601 tcatgggcag acccctccct tcctgggctg acctgctccc tcgaggccag cctgctccct
      661 ggctgaggct caggctatcc gcccaagctc tttgctcatt ctagggccag tggaggaaaa
      721 tgtgataagg ccagagcttg tgtgctgggc acagaaatca cctgctgcat cctgtgctcc
      781 gcaggctggg ccggagcctc tgcccgcagg tttctatgct gtttcttagc acagaatcca
      841 gcctagcctt agccgcagtc taggccctgc ttggactagg actccttgct tgaccccatc
      901 tctggttcct gccctggctc ctgcaccagc cccagctcct gcctacatcc aggcagaaag
      961 ataggcaggg gctcttggaa gacgttccgt gctgtgacct ccgagccctc ctggtgggaa
     1021 gacagctgga aaggctggga ggagaaggga ggggctgggg gttcccagga gccatgcgtg
     1081 gcctgcagag tccattccat catgatgctg tgcccgctat gggctgtgtc catgaccaga
     1141 ggctggagtg ggggtgtgtt agagcccctc accgggactt gctgtgcgga tggggcctgg
     1201 gcctccttcc tacaggggct cctctgtggg tgaggggccc tctggaatgg catcccatga
     1261 gcttgtggcc tctatctgct accatctgtg ttttatctga gtaaagttac cttacttctg
     1321 gaa
//
