LOCUS       NM_005854                752 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens receptor activity modifying protein 2 (RAMP2), mRNA.
ACCESSION   NM_005854
VERSION     NM_005854.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 752)
  AUTHORS   Wang,S., Xu,C., Shan,Y. and Zhang,Y.
  TITLE     RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the
            progression of non-small cell lung cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 9-14 (2023)
   PUBMED   38279501
  REMARK    GeneRIF: RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit
            the progression of non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 752)
  AUTHORS   Cao,J., Belousoff,M.J., Liang,Y.L., Johnson,R.M., Josephs,T.M.,
            Fletcher,M.M., Christopoulos,A., Hay,D.L., Danev,R., Wootten,D. and
            Sexton,P.M.
  TITLE     A structural basis for amylin receptor phenotype
  JOURNAL   Science 375 (6587), eabm9609 (2022)
   PUBMED   35324283
REFERENCE   3  (bases 1 to 752)
  AUTHORS   McGlone,E.R., Manchanda,Y., Jones,B., Pickford,P., Inoue,A.,
            Carling,D., Bloom,S.R., Tan,T. and Tomas,A.
  TITLE     Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon
            receptor trafficking in hepatocytes with functional effects on
            receptor signalling
  JOURNAL   Mol Metab 53, 101296 (2021)
   PUBMED   34271220
  REMARK    GeneRIF: Receptor Activity-Modifying Protein 2 (RAMP2) alters
            glucagon receptor trafficking in hepatocytes with functional
            effects on receptor signalling.
REFERENCE   4  (bases 1 to 752)
  AUTHORS   Tanaka,M., Kakihara,S., Hirabayashi,K., Imai,A., Toriyama,Y.,
            Iesato,Y., Sakurai,T., Kamiyoshi,A., Ichikawa-Shindo,Y., Kawate,H.,
            Tanaka,M., Cui,N., Wei,Y., Zhao,Y., Aruga,K., Yamauchi,A.,
            Murata,T. and Shindo,T.
  TITLE     Adrenomedullin-Receptor Activity-Modifying Protein 2 System
            Ameliorates Subretinal Fibrosis by Suppressing
            Epithelial-Mesenchymal Transition in Age-Related Macular
            Degeneration
  JOURNAL   Am J Pathol 191 (4), 652-668 (2021)
   PUBMED   33385343
  REMARK    GeneRIF: Adrenomedullin-Receptor Activity-Modifying Protein 2
            System Ameliorates Subretinal Fibrosis by Suppressing
            Epithelial-Mesenchymal Transition in Age-Related Macular
            Degeneration.
REFERENCE   5  (bases 1 to 752)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 752)
  AUTHORS   Kuwasako,K., Shimekake,Y., Masuda,M., Nakahara,K., Yoshida,T.,
            Kitaura,M., Kitamura,K., Eto,T. and Sakata,T.
  TITLE     Visualization of the calcitonin receptor-like receptor and its
            receptor activity-modifying proteins during internalization and
            recycling
  JOURNAL   J Biol Chem 275 (38), 29602-29609 (2000)
   PUBMED   10882736
REFERENCE   7  (bases 1 to 752)
  AUTHORS   Aldecoa,A., Gujer,R., Fischer,J.A. and Born,W.
  TITLE     Mammalian calcitonin receptor-like receptor/receptor activity
            modifying protein complexes define calcitonin gene-related peptide
            and adrenomedullin receptors in Drosophila Schneider 2 cells
  JOURNAL   FEBS Lett 471 (2-3), 156-160 (2000)
   PUBMED   10767413
REFERENCE   8  (bases 1 to 752)
  AUTHORS   Foord,S.M. and Marshall,F.H.
  TITLE     RAMPs: accessory proteins for seven transmembrane domain receptors
  JOURNAL   Trends Pharmacol Sci 20 (5), 184-187 (1999)
   PUBMED   10354609
  REMARK    Review article
REFERENCE   9  (bases 1 to 752)
  AUTHORS   Kamitani,S., Asakawa,M., Shimekake,Y., Kuwasako,K., Nakahara,K. and
            Sakata,T.
  TITLE     The RAMP2/CRLR complex is a functional adrenomedullin receptor in
            human endothelial and vascular smooth muscle cells
  JOURNAL   FEBS Lett 448 (1), 111-114 (1999)
   PUBMED   10217420
REFERENCE   10 (bases 1 to 752)
  AUTHORS   McLatchie,L.M., Fraser,N.J., Main,M.J., Wise,A., Brown,J.,
            Thompson,N., Solari,R., Lee,M.G. and Foord,S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393 (6683), 333-339 (1998)
   PUBMED   9620797
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL548945.3 and BC027975.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005854.2.
            
            Summary: The protein encoded by this gene is a member of the RAMP
            family of single-transmembrane-domain proteins, called receptor
            (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I
            transmembrane proteins with an extracellular N terminus and a
            cytoplasmic C terminus. RAMPs are required to transport
            calcitonin-receptor-like receptor (CRLR) to the plasma membrane.
            CRLR, a receptor with seven transmembrane domains, can function as
            either a calcitonin-gene-related peptide (CGRP) receptor or an
            adrenomedullin receptor, depending on which members of the RAMP
            family are expressed. In the presence of this (RAMP2) protein, CRLR
            functions as an adrenomedullin receptor. The RAMP2 protein is
            involved in core glycosylation and transportation of adrenomedullin
            receptor to the cell surface. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL548945.3, AJ001015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253796.10/ ENSP00000253796.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL548945.3         40-160
            122-752             BC027975.1         104-734
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..752
                     /gene="RAMP2"
                     /note="receptor activity modifying protein 2"
                     /db_xref="GeneID:10266"
                     /db_xref="HGNC:HGNC:9844"
                     /db_xref="MIM:605154"
     exon            1..132
                     /gene="RAMP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..563
                     /gene="RAMP2"
                     /note="calcitonin receptor-like receptor activity
                     modifying protein 2; receptor (G protein-coupled) activity
                     modifying protein 2; receptor (calcitonin) activity
                     modifying protein 2; CRLR activity-modifying protein 2"
                     /codon_start=1
                     /product="receptor activity-modifying protein 2 precursor"
                     /protein_id="NP_005845.2"
                     /db_xref="CCDS:CCDS11437.1"
                     /db_xref="GeneID:10266"
                     /db_xref="HGNC:HGNC:9844"
                     /db_xref="MIM:605154"
                     /translation="MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQP
                     LPTTGTPGSEGGTVKNYETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEH
                     FAELFDLGFPNPLAERIIFETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFL
                     ITLVVWRSKDSEAQA"
     exon            133..198
                     /gene="RAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..307
                     /gene="RAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..752
                     /gene="RAMP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      730..735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAMP2"
                     /note="hexamer: AATAAA"
     polyA_site      752
                     /gene="RAMP2"
                     /note="major polyA site"
ORIGIN      
        1 agcgccgccg ccgctcctcg cctccttgct gcacgatggc ctcgctccgg gtggagcgcg
       61 ccggcggccc gcgtctccct aggacccgag tcgggcggcc ggcagcgctc cgcctcctcc
      121 tcctgctggg cgctgtcctg aatccccacg aggccctggc tcagcctctt cccaccacag
      181 gcacaccagg gtcagaaggg gggacggtga agaactatga gacagctgtc caattttgct
      241 ggaatcatta taaggatcaa atggatccta tcgaaaagga ttggtgcgac tgggccatga
      301 ttagcaggcc ttatagcacc ctgcgagatt gcctggagca ctttgcagag ttgtttgacc
      361 tgggcttccc caatcccttg gcagagagga tcatctttga gactcaccag atccactttg
      421 ccaactgctc cctggtgcag cccaccttct ctgacccccc agaggatgta ctcctggcca
      481 tgatcatagc ccccatctgc ctcatcccct tcctcatcac tcttgtagta tggaggagta
      541 aagacagtga ggcccaggcc tagggggcca cgagcttctc aacaaccatg ttactccact
      601 tccccacccc caccaggcct ccctcctccc ctcctactcc cttttctcac tctcatcccc
      661 accacagatc cctggattgc tgggaatgga agccaggtgg ggtcatggca caagttctgt
      721 aatcttcaaa ataaaacttt ttttttgtac aa
//
