LOCUS       NM_005855                823 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens receptor activity modifying protein 1 (RAMP1),
            transcript variant 1, mRNA.
ACCESSION   NM_005855
VERSION     NM_005855.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 823)
  AUTHORS   Binlateh,T., Leethanakul,C. and Thammanichanon,P.
  TITLE     Involvement of RAMP1/p38MAPK signaling pathway in osteoblast
            differentiation in response to mechanical stimulation: a
            preliminary study
  JOURNAL   J Orthop Surg Res 19 (1), 330 (2024)
   PUBMED   38825686
  REMARK    GeneRIF: Involvement of RAMP1/p38MAPK signaling pathway in
            osteoblast differentiation in response to mechanical stimulation: a
            preliminary study.
            Erratum:[J Orthop Surg Res. 2024 Jul 9;19(1):399. doi:
            10.1186/s13018-024-04872-z. PMID: 38982512]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 823)
  AUTHORS   Cao,J., Belousoff,M.J., Danev,R., Christopoulos,A., Wootten,D. and
            Sexton,P.M.
  TITLE     Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with
            CGRP and Gs Protein
  JOURNAL   Biochemistry 63 (9), 1089-1096 (2024)
   PUBMED   38603770
REFERENCE   3  (bases 1 to 823)
  AUTHORS   Lee,S.
  TITLE     Peptide ligand interaction with maltose-binding protein tagged to
            the calcitonin gene-related peptide receptor: The inhibitory role
            of receptor N-glycosylation
  JOURNAL   Peptides 150, 170735 (2022)
   PUBMED   35007660
  REMARK    GeneRIF: Peptide ligand interaction with maltose-binding protein
            tagged to the calcitonin gene-related peptide receptor: The
            inhibitory role of receptor N-glycosylation.
REFERENCE   4  (bases 1 to 823)
  AUTHORS   Cao,J., Belousoff,M.J., Liang,Y.L., Johnson,R.M., Josephs,T.M.,
            Fletcher,M.M., Christopoulos,A., Hay,D.L., Danev,R., Wootten,D. and
            Sexton,P.M.
  TITLE     A structural basis for amylin receptor phenotype
  JOURNAL   Science 375 (6587), eabm9609 (2022)
   PUBMED   35324283
REFERENCE   5  (bases 1 to 823)
  AUTHORS   Josephs,T.M., Belousoff,M.J., Liang,Y.L., Piper,S.J., Cao,J.,
            Garama,D.J., Leach,K., Gregory,K.J., Christopoulos,A., Hay,D.L.,
            Danev,R., Wootten,D. and Sexton,P.M.
  TITLE     Structure and dynamics of the CGRP receptor in apo and
            peptide-bound forms
  JOURNAL   Science 372 (6538) (2021)
   PUBMED   33602864
  REMARK    GeneRIF: Structure and dynamics of the CGRP receptor in apo and
            peptide-bound forms.
REFERENCE   6  (bases 1 to 823)
  AUTHORS   Kuwasako,K., Shimekake,Y., Masuda,M., Nakahara,K., Yoshida,T.,
            Kitaura,M., Kitamura,K., Eto,T. and Sakata,T.
  TITLE     Visualization of the calcitonin receptor-like receptor and its
            receptor activity-modifying proteins during internalization and
            recycling
  JOURNAL   J Biol Chem 275 (38), 29602-29609 (2000)
   PUBMED   10882736
REFERENCE   7  (bases 1 to 823)
  AUTHORS   Derst,C., Engel,H., Grzeschik,K. and Daut,J.
  TITLE     Genomic structure and chromosome mapping of human and mouse RAMP
            genes
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 115-118 (2000)
   PUBMED   11060459
REFERENCE   8  (bases 1 to 823)
  AUTHORS   Christopoulos,G., Perry,K.J., Morfis,M., Tilakaratne,N., Gao,Y.,
            Fraser,N.J., Main,M.J., Foord,S.M. and Sexton,P.M.
  TITLE     Multiple amylin receptors arise from receptor activity-modifying
            protein interaction with the calcitonin receptor gene product
  JOURNAL   Mol Pharmacol 56 (1), 235-242 (1999)
   PUBMED   10385705
REFERENCE   9  (bases 1 to 823)
  AUTHORS   Foord,S.M. and Marshall,F.H.
  TITLE     RAMPs: accessory proteins for seven transmembrane domain receptors
  JOURNAL   Trends Pharmacol Sci 20 (5), 184-187 (1999)
   PUBMED   10354609
  REMARK    Review article
REFERENCE   10 (bases 1 to 823)
  AUTHORS   McLatchie,L.M., Fraser,N.J., Main,M.J., Wise,A., Brown,J.,
            Thompson,N., Solari,R., Lee,M.G. and Foord,S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393 (6683), 333-339 (1998)
   PUBMED   9620797
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI017108.1, AJ001014.1 and
            BM126103.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005855.3.
            
            Summary: The protein encoded by this gene is a member of the RAMP
            family of single-transmembrane-domain proteins, called receptor
            (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I
            transmembrane proteins with an extracellular N terminus and a
            cytoplasmic C terminus. RAMPs are required to transport
            calcitonin-receptor-like receptor (CRLR) to the plasma membrane.
            CRLR, a receptor with seven transmembrane domains, can function as
            either a calcitonin-gene-related peptide (CGRP) receptor or an
            adrenomedullin receptor, depending on which members of the RAMP
            family are expressed. In the presence of this (RAMP1) protein, CRLR
            functions as a CGRP receptor. The RAMP1 protein is involved in the
            terminal glycosylation, maturation, and presentation of the CGRP
            receptor to the cell surface. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.377035.1,
                                           SRR5189655.207626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254661.5/ ENSP00000254661.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AI017108.1         80-100
            22-821              AJ001014.1         1-800
            822-823             BM126103.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..823
                     /gene="RAMP1"
                     /note="receptor activity modifying protein 1"
                     /db_xref="GeneID:10267"
                     /db_xref="HGNC:HGNC:9843"
                     /db_xref="MIM:605153"
     exon            1..105
                     /gene="RAMP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..500
                     /gene="RAMP1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; calcitonin receptor-like receptor activity
                     modifying protein 1; receptor (calcitonin) activity
                     modifying protein 1; CRLR activity-modifying protein 1;
                     receptor (G protein-coupled) activity modifying protein 1"
                     /codon_start=1
                     /product="receptor activity-modifying protein 1 isoform 1
                     precursor"
                     /protein_id="NP_005846.1"
                     /db_xref="CCDS:CCDS2522.1"
                     /db_xref="GeneID:10267"
                     /db_xref="HGNC:HGNC:9843"
                     /db_xref="MIM:605153"
                     /translation="MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQF
                     QVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFR
                     SCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV"
     exon            106..244
                     /gene="RAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..823
                     /gene="RAMP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      803..808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAMP1"
                     /note="hexamer: ATTAAA"
     polyA_site      823
                     /gene="RAMP1"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcagc ggggcgcgtg gcgagcggac tcgactcggc accgctgtgc accatggccc
       61 gggccctgtg ccgcctcccg cggcgcggcc tctggctgct cctggcccat cacctcttca
      121 tgaccactgc ctgccaggag gctaactacg gtgccctcct ccgggagctc tgcctcaccc
      181 agttccaggt agacatggag gccgtcgggg agacgctgtg gtgtgactgg ggcaggacca
      241 tcaggagcta cagggagctg gccgactgca cctggcacat ggcggagaag ctgggctgct
      301 tctggcccaa tgcagaggtg gacaggttct tcctggcagt gcatggccgc tacttcagga
      361 gctgccccat ctcaggcagg gccgtgcggg acccgcccgg cagcatcctc taccccttca
      421 tcgtggtccc catcacggtg accctgctgg tgacggcact ggtggtctgg cagagcaagc
      481 gcactgaggg cattgtgtag gcggggccca ggctgcccgc gggtgcaccc aggctgcagg
      541 gtgaggccag gcaggcctgg gtaggggcag cttctggagc cttgggacag agcaggccca
      601 caatgccccc cttcttccag ccaagaagag ctcacaggag tccagagtag ccgaggctct
      661 ggtattaacc tggaagcccc cctggctgga ggccaccgcc accctaggaa gggggcaggg
      721 acgtgacctt gacttacctc tggaaagggt cccagcctag actgcttacc ccatagccac
      781 atttgtggat gagtggtttg tgattaaaag ggatgttctt gaa
//
