LOCUS       NM_173848               2983 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RALY RNA binding protein like (RALYL), transcript
            variant 3, mRNA.
ACCESSION   NM_173848
VERSION     NM_173848.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2983)
  AUTHORS   Xia,Y., Ye,S., Yang,Y., Liu,Y. and Tong,G.
  TITLE     Over-expression of RALYL suppresses the progression of ovarian
            clear cell carcinoma through inhibiting MAPK and CDH1 signaling
            pathways
  JOURNAL   Int J Med Sci 18 (3), 785-791 (2021)
   PUBMED   33437214
  REMARK    GeneRIF: Over-expression of RALYL suppresses the progression of
            ovarian clear cell carcinoma through inhibiting MAPK and CDH1
            signaling pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2983)
  AUTHORS   Zhang,Y., Wang,J., Liu,X. and Liu,H.
  TITLE     Exploring the role of RALYL in Alzheimer's disease reserve by
            network-based approaches
  JOURNAL   Alzheimers Res Ther 12 (1), 165 (2020)
   PUBMED   33298176
  REMARK    GeneRIF: Exploring the role of RALYL in Alzheimer's disease reserve
            by network-based approaches.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2983)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2983)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   5  (bases 1 to 2983)
  AUTHORS   Cobb,J., Cule,E., Moncrieffe,H., Hinks,A., Ursu,S., Patrick,F.,
            Kassoumeri,L., Flynn,E., Bulatovic,M., Wulffraat,N., van Zelst,B.,
            de Jonge,R., Bohm,M., Dolezalova,P., Hirani,S., Newman,S.,
            Whitworth,P., Southwood,T.R., De Iorio,M., Wedderburn,L.R. and
            Thomson,W.
  CONSRTM   Childhood Arthritis Response to Medication Study (CHARMS);
            Childhood Arthritis Prospective Study (CAPS); BSPAR study group
  TITLE     Genome-wide data reveal novel genes for methotrexate response in a
            large cohort of juvenile idiopathic arthritis cases
  JOURNAL   Pharmacogenomics J 14 (4), 356-364 (2014)
   PUBMED   24709693
REFERENCE   6  (bases 1 to 2983)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 2983)
  AUTHORS   Xin,X., Rual,J.F., Hirozane-Kishikawa,T., Hill,D.E., Vidal,M.,
            Boone,C. and Thierry-Mieg,N.
  TITLE     Shifted Transversal Design smart-pooling for high coverage
            interactome mapping
  JOURNAL   Genome Res 19 (7), 1262-1269 (2009)
   PUBMED   19447967
REFERENCE   8  (bases 1 to 2983)
  AUTHORS   Ji,C.N., Chen,J.Z., Xie,Y., Wang,S., Qian,J., Zhao,E., Jin,W.,
            Wu,X.Z., Xu,W.X., Ying,K. and Mao,Y.M.
  TITLE     A novel cDNA encodes a putative hRALY-like protein, hRALYL
  JOURNAL   Mol Biol Rep 30 (1), 61-67 (2003)
   PUBMED   12688537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012400.11, AC027043.7, AC087368.7 and AC009901.6.
            
            On Nov 23, 2018 this sequence version replaced NM_173848.6.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon, compared to variant 1. Variants 2 through 4
            encode the same isoform (2), which has a shorter N-terminus
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.165454.1,
                                           SRR1803617.268874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521268.6/ ENSP00000430367.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1151              AC012400.11        121365-122515
            1152-1430           AC027043.7         124526-124804
            1431-1506           AC087368.7         162918-162993
            1507-1539           AC009901.6         11534-11566
            1540-1587           AC009901.6         56744-56791
            1588-1745           AC009901.6         69060-69217
            1746-1859           AC009901.6         80048-80161
            1860-2032           AC009901.6         94368-94540
            2033-2983           AC009901.6         127658-128608
FEATURES             Location/Qualifiers
     source          1..2983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.2"
     gene            1..2983
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /note="RALY RNA binding protein like"
                     /db_xref="GeneID:138046"
                     /db_xref="HGNC:HGNC:27036"
                     /db_xref="MIM:614648"
     exon            1..1151
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1430
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1175..2050
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /note="isoform 2 is encoded by transcript variant 3;
                     RNA-binding Raly-like protein; hnRNP core protein C-like
                     3; heterogeneous nuclear ribonucleoprotein C-like 3"
                     /codon_start=1
                     /product="RNA-binding Raly-like protein isoform 2"
                     /protein_id="NP_776247.3"
                     /db_xref="CCDS:CCDS55253.1"
                     /db_xref="GeneID:138046"
                     /db_xref="HGNC:HGNC:27036"
                     /db_xref="MIM:614648"
                     /translation="MTGKTQTSNVTNKNDPKSINSRVFIGNLNTAIVKKVDIEAIFSK
                     YGKIVGCSVHKGYAFVQYMSERHARAAVAGENARVIAGQPLDINMAGEPKPYRPKPGN
                     KRPLSALYRLESKEPFLSVGGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPR
                     VAVTTTRRGKGVFSMKGGSRSTASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLE
                     KIEKQQKAEAEAQKKQLEESLVLIQEECVSEIADHSTEEPAEGGPDADGEEMTDGIEE
                     DFDEDGGHELFLQIK"
     exon            1431..1506
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1539
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1587
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1745
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1859
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2032
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2983
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2957..2962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /note="hexamer: AATAAA"
     polyA_site      2983
                     /gene="RALYL"
                     /gene_synonym="HNRPCL3"
                     /note="major polyA site"
ORIGIN      
        1 acagcgaagg cagcctcgcc gcgagctgcc gctgccgctg ctgccgccac tggtgttgcc
       61 gctctcaggc gccaggctcc ccgtcgccgc cgccgccgcc tcgccagcca gagttgggct
      121 ccgtgggctt cccccctcgc agcctcggtc cttccccgct gcctgcaagt cagcctggct
      181 ccgagtcacg tgtcagtgcc tgaggcagag actgcgagaa aaaaacgcgc ttcattcctt
      241 cttccaccgc catactgtat tttatactaa atctcatttt tattccaaca ttttactccc
      301 gctcggtgag taccttctca gtggcattct tgtcctattc ttttttttgt cctttttttt
      361 ggttttttgt tttttttgtt tttgtttttt ttcttttttt ccacttcttt gattattgtt
      421 tatatttggg aaagctggag gagcatggtt ttgagccttt tcctgaatcc aagtttttct
      481 agcatgcgat cgttctgtag acaaggcgct gtgtctcgga gtccgcggcg accgtgcccg
      541 ctgggagcgt ctcccaagtc cagcaaaatg tgcaactggt tttatggaaa aagcgatgtg
      601 aagtatggtg cctatttttt tcctttgtaa aaataaaaag catgtttcta actctttttt
      661 tgcatactct ttttctgata acatttttgt ataggtggga ttttacggca gtgtttacaa
      721 gtttgtggtc ttgcaatact ggtgcaaacc actgagcaaa gacattaatt ttatattttt
      781 tgtgcccttt ttggaagccg gtgaaaacaa attcgttttt tttccctcct gtttttgata
      841 cccattgata acatgaaact tttcttacag ctggtgattg ggatcatttt taagcaaaat
      901 acttttttcc tcctttaaat taactatgac ttttgcacat ttgacttttt taaaaaaccg
      961 agataatttt atgatagata tcctgatatc tatatctata ttgtccctta tttctccccc
     1021 ttccctcccc gtaaatcaat tttcaaatga tggcagtgga aggtttttct ggaaaaaaaa
     1081 aaatgaagtg cggtttggtt tccttgtcaa cggaggatga agtgaacagc tgagcagctc
     1141 gcagagagca ggattaaagc aaggagagcc aatcatgact ggcaaaacac agaccagcaa
     1201 cgtcaccaat aagaatgacc ccaagtccat caactcccgt gttttcatcg gcaatctaaa
     1261 tacggcaatt gtcaagaaag ttgacattga agccattttt tcaaagtatg gaaaaatagt
     1321 tggatgttcc gttcacaaag gttatgcatt tgtacagtac atgagtgagc gacatgcaag
     1381 agctgcagtg gctggagaaa atgccagagt catcgccggc caaccacttg atatcaacat
     1441 ggcaggagag cccaaaccat acagaccaaa acctggaaac aagaggcccc tttctgcact
     1501 ttacagactt gaatcaaagg aacctttcct gtctgttggc ggttatgtct ttgactatga
     1561 ttactacaga gatgatttct acaatcggtt atttgattac cacgggcgtg tgcctccacc
     1621 tccccgtgca gtaattccgc tgaagcgtcc cagagtggca gtcacaacga ctcgcagggg
     1681 gaaaggagtc ttttccatga aaggtggatc gagatctact gccagtgggt caacaggttc
     1741 taaattgaaa tcagatgagt tacagaccat caagaaagaa ttaacccaga tcaaaactaa
     1801 aattgactcc ttgctagggc gcctggagaa gattgagaaa cagcagaagg cggaggcaga
     1861 agctcagaag aagcaattgg aagagagtct agtgctgatc caagaggaat gtgtgtcaga
     1921 gattgcagat cactctacag aggagcctgc tgaaggaggg ccagatgccg atggagaaga
     1981 gatgacagat gggatagagg aggacttcga tgaagatggg ggtcatgagc tgtttctaca
     2041 gataaagtga tctgaaataa cgcatgatgc cacaaagcag aaaagagaaa ctgtgacaac
     2101 ccccagaaat gtgaaaggag gtttcttact ggacagcagc atctttggtt caatttatat
     2161 aaaaacccaa ataaataaaa tggacagtat tgctcagttt tagaaattcc atttcttcta
     2221 tgttttaagc tgtacaattg tcaggttttt atggtttaaa ttgtaaatgt gttttcccct
     2281 ttgctaatta tgtttttttt ttcagtctta aaatgtgaaa ggcatttatg aatggtaagg
     2341 gaaacactat atacaaatgt atatttgtaa aagctatttt tatgattagc atgtttcact
     2401 gttgatcata tataaagtca ggtgatattg caattctgta tttaaagctt atttccaaca
     2461 atgtcatgta agaaaagatg catcttatgc tagtttttat aatttattta taatttatag
     2521 tttaaagtac ttcagatcat aatgataaaa tacttgaaaa agttatattt ctgccctgta
     2581 taagcaccct ttttattaat aaagaatgca gatatttcag atgtgatata atagttaaag
     2641 aactgttggt ttgatctgtg attaagttga gcatgctccg ctctactgaa ctaaatgatc
     2701 caattattac ttcagtctgg gtatgagatt ccatggacaa gtaaggacta gattgccaag
     2761 gaaaagactg tcttgccctt ggatccaaaa gtttaaatta gtgcatacat catgtcattt
     2821 cacctcctgt tcctaggaac tctccattcc caagcattgc cagtgttttc cagataatct
     2881 tagctgttgt cttgtgctgt ggaaatggaa gaaaccatct tcacagaccg taggagaatt
     2941 caacatataa tttcttaata aatactgttt cttttaaaac aaa
//
