LOCUS       NM_016732               6213 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens RALY heterogeneous nuclear ribonucleoprotein (RALY),
            transcript variant 1, mRNA.
ACCESSION   NM_016732
VERSION     NM_016732.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6213)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6213)
  AUTHORS   Zhou,J., Li,L., Han,Y., Ge,G., Ji,Q. and Li,H.
  TITLE     RNA binding protein RALY facilitates colorectal cancer metastasis
            via enhancing exosome biogenesis in m6A dependent manner
  JOURNAL   Int J Biol Macromol 273 (Pt 2), 133112 (2024)
   PUBMED   38880454
  REMARK    GeneRIF: RNA binding protein RALY facilitates colorectal cancer
            metastasis via enhancing exosome biogenesis in m6A dependent
            manner.
REFERENCE   3  (bases 1 to 6213)
  AUTHORS   Cao,S., Wang,D., Wang,P., Liu,Y., Dong,W., Ruan,X., Liu,L., Xue,Y.,
            E,T., Lin,H. and Liu,X.
  TITLE     SUMOylation of RALY promotes vasculogenic mimicry in glioma cells
            via the FOXD1/DKK1 pathway
  JOURNAL   Cell Biol Toxicol 39 (6), 3323-3340 (2023)
   PUBMED   37906341
  REMARK    GeneRIF: SUMOylation of RALY promotes vasculogenic mimicry in
            glioma cells via the FOXD1/DKK1 pathway.
REFERENCE   4  (bases 1 to 6213)
  AUTHORS   Hu,H., Zhao,K., Fang,D., Wang,Z., Yu,N., Yao,B., Liu,K., Wang,F.
            and Mei,Y.
  TITLE     The RNA binding protein RALY suppresses p53 activity and promotes
            lung tumorigenesis
  JOURNAL   Cell Rep 42 (4), 112288 (2023)
   PUBMED   36952348
  REMARK    GeneRIF: The RNA binding protein RALY suppresses p53 activity and
            promotes lung tumorigenesis.
REFERENCE   5  (bases 1 to 6213)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6213)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   7  (bases 1 to 6213)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   8  (bases 1 to 6213)
  AUTHORS   Khrebtukova,I., Kuklin,A., Woychik,R.P. and Michaud,E.J.
  TITLE     Alternative processing of the human and mouse raly genes(1)
  JOURNAL   Biochim Biophys Acta 1447 (1), 107-112 (1999)
   PUBMED   10500250
REFERENCE   9  (bases 1 to 6213)
  AUTHORS   Rhodes,G.H., Valbracht,J.R., Nguyen,M.D. and Vaughan,J.H.
  TITLE     The p542 gene encodes an autoantigen that cross-reacts with EBNA-1
            of the Epstein Barr virus and which may be a heterogeneous nuclear
            ribonucleoprotein
  JOURNAL   J Autoimmun 10 (5), 447-454 (1997)
   PUBMED   9376072
REFERENCE   10 (bases 1 to 6213)
  AUTHORS   Vaughan,J.H., Valbracht,J.R., Nguyen,M.D., Handley,H.H.,
            Smith,R.S., Patrick,K. and Rhodes,G.H.
  TITLE     Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin
            M autoantibodies to proteins mimicking and not mimicking
            Epstein-Barr virus nuclear antigen-1
  JOURNAL   J Clin Invest 95 (3), 1306-1315 (1995)
   PUBMED   7533788
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG751407.1, AK222915.1,
            AL031668.23 and BM680768.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016732.2.
            
            Summary: This gene encodes a member of the heterogeneous nuclear
            ribonucleoprotein (hnRNP) gene family. This protein may play a role
            in pre-mRNA splicing and in embryonic development. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). This isoform is also
            known as long isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.434178.1, BC103753.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246194.8/ ENSP00000246194.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BG751407.1         261-303
            44-55               BG751407.1         305-316
            56-1003             AK222915.1         1-948
            1004-1590           AK222915.1         952-1538
            1591-3902           AL031668.23        64048-66359
            3903-4514           BM680768.1         18-629              c
            4515-6213           AL031668.23        66972-68670
FEATURES             Location/Qualifiers
     source          1..6213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..6213
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /note="RALY heterogeneous nuclear ribonucleoprotein"
                     /db_xref="GeneID:22913"
                     /db_xref="HGNC:HGNC:15921"
                     /db_xref="MIM:614663"
     exon            1..221
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     exon            222..304
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     exon            305..569
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1234
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein (autoantigenic); RNA-binding protein
                     (autoantigenic, hnRNP-associated with lethal yellow); RNA
                     binding protein, autoantigenic (hnRNP-associated with
                     lethal yellow homolog); RNA-binding protein Raly;
                     autoantigen p542; hnRNP core protein C-like 2;
                     heterogeneous nuclear ribonucleoprotein C-like 2; hnRNP
                     associated with lethal yellow protein homolog"
                     /codon_start=1
                     /product="RNA-binding protein Raly isoform 1"
                     /protein_id="NP_057951.1"
                     /db_xref="CCDS:CCDS13230.1"
                     /db_xref="GeneID:22913"
                     /db_xref="HGNC:HGNC:15921"
                     /db_xref="MIM:614663"
                     /translation="MSLKLQASNVTNKNDPKSINSRVFIGNLNTALVKKSDVETIFSK
                     YGRVAGCSVHKGYAFVQYSNERHARAAVLGENGRVLAGQTLDINMAGEPKPDRPKGLK
                     RAASAIYSGYIFDYDYYRDDFYDRLFDYRGRLSPVPVPRAVPVKRPRVTVPLVRRVKT
                     NVPVKLFARSTAVTTSSAKIKLKSSELQAIKTELTQIKSNIDALLSRLEQIAAEQKAN
                     PDGKKKGDGGGAGGGGGGGGSGGGGSGGGGGGGSSRPPAPQENTTSEAGLPQGEARTR
                     DDGDEEGLLTHSEEELEHSQDTDADDGALQ"
     exon            570..642
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     exon            643..690
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     exon            691..857
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     exon            858..971
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1189
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1238
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..6213
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1570..1575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /note="hexamer: AATAAA"
     polyA_site      1590
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /note="major polyA site"
     regulatory      6188..6193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
                     /note="hexamer: AATAAA"
     polyA_site      6213
                     /gene="RALY"
                     /gene_synonym="HNRPCL2; P542"
ORIGIN      
        1 gtcagtgcgg cggggcgcgc gagcggcgcc agctcggggc agcggaaccc agagaagctg
       61 agggggcggt agcggcggcg acggcgacga cgacgactcc cgcgcgtgtg cccagcctct
      121 tcccgccgca gccgcccttt tcctccctcc cttacgtccc cgagtgcggc agtaccgcct
      181 ccttcccagc cgcgcggctt cctccagacc tctcggcgcg ggtgagccct attcccagag
      241 gcaggtggtg ctgaccctgt aacccaaagg aggaaacagc tggctaagct catcattgtt
      301 actggtgggc accatgtcct tgaagcttca ggcaagcaat gtaaccaaca agaatgaccc
      361 caagtccatc aactctcgag tcttcattgg aaacctcaac acagctctgg tgaagaaatc
      421 agatgtggag accatcttct ctaagtatgg ccgtgtggcc ggctgttctg tgcacaaggg
      481 ctatgccttt gttcagtact ccaatgagcg ccatgcccgg gcagctgtgc tgggagagaa
      541 tgggcgggtg ctggccgggc agaccctgga catcaacatg gctggagagc ctaagcctga
      601 cagacccaag gggctaaaga gagcagcatc tgccatatac agtggctaca tctttgacta
      661 tgattactac cgggacgact tctacgacag gctcttcgac taccggggcc gtctgtcgcc
      721 cgtgccagtg cccagggcgg tccctgtgaa gcgaccccgg gtcacagtcc ctttggtccg
      781 gcgtgtcaaa actaacgtac ctgtcaagct ctttgcccgc tccacagctg tcaccaccag
      841 ctcagccaag atcaagttaa agagcagtga gctgcaggcc atcaagacgg agctgacaca
      901 gatcaagtcc aatatcgatg ccctgctgag ccgcttggag cagatcgctg cggagcaaaa
      961 ggccaatcca gatggcaaga agaagggtga tggaggtggc gccggcggcg gcggcggtgg
     1021 tggtggcagc ggtggcggtg gcagtggtgg tggcggtggc ggtggcagca gccggccacc
     1081 agccccccaa gagaacacaa cttctgaggc aggcctgccc cagggggaag cacggacccg
     1141 agacgacggc gatgaggaag ggctcctgac acacagcgag gaagagctgg aacacagcca
     1201 ggacacagac gcggatgatg gggccttgca gtaagcagcc tgacaggagc aatggccacc
     1261 agcaggtgaa gggcatcgct gccccaggcc tcaagccggg cacccaaccc tggatgccac
     1321 cccccagcgg gtaccagagg aaagctggca gcaggcgcct cctcccccaa cgcatcccag
     1381 ccagtgccat gtcctctgca ggtggagtta ctggcctact ccttccccat gagccctccc
     1441 tgtctgcact gcccaggcca gagggtagag cacaggggtt tccccatact acctcccctc
     1501 cccaggacac tcccaggctt gggttttttc tataggtttg gcggggggcc acagggaggg
     1561 gaccctgaca ataaagagat tggatcccaa cctgttctga gatgggatgg tttgtgtttt
     1621 ctcatgaaga tatcccggcc cctctgccaa ccaaaaagct ggtctagggt gcctaatact
     1681 gatccatctg gaccttagtg tcctcagtgg tgattaaaat ggccagtggg gccactgggg
     1741 agggttggat atgctggccc atgagcatct tgctggctga agtgtcaagc agttgtgacc
     1801 cacttggttt accccatagt aggtcaagac cttatctctt tccccagctt ctaagtctgg
     1861 tctttcccag ctcttaaaag gattctagag tctgccagtc tctaccttct ctcttctggc
     1921 ttaggacact ataatttttt catttggacg ttgtcctccc accagcctcc cagtcttctg
     1981 cctctgccct gtaccatctc ccagcagcca cgcagtcttt ctgaaacgta tcccttccct
     2041 gcctaaaatc cctttactga ctcttcatca tcaggacaaa accctacctc ctgaatgtag
     2101 ggtgtaagat cctgcttact ccagcctctc ctgtttcttg tcaccacccc tttcctgccc
     2161 ctgacacaaa ccctacatct cagtctcaca aaacacacaa gttcttcaca ctccgggcag
     2221 gtttggtagc aaggaataga gcgtactcca gtgacagcaa tcagtaggaa gtttgcatcc
     2281 ggagacacgc agcctgtctg cccctgtctt gggccacccg tctagacatt tgttctctaa
     2341 caatcagccg ggttccttca aacgtgtgct gcttatacat gctcattgtg tactgctaat
     2401 gtcacctact tcccccttca ttccccacaa tgaatggatc cattttcccc atgttcaagt
     2461 tcccaagaga gaatcgactg ccactgtaat tttttttcct aatcactcat aggttacaag
     2521 tacctaccct ggtccagtga actgcgggat tcatatgtgg ccacttaggc tggtctcgtt
     2581 ggtatggagc tgtgggaggg cagcacccag aaataggctt tgttccaggc ctggcacgta
     2641 ctcctcctgc tcctactttc tctacctggg aaatagccgc tcaggacgaa gctgctgctg
     2701 tggtgtcgcc acctctgaga agtctcccag accctccgac tgctctttaa ttgcctgttc
     2761 tctcctctgg aagccttccc ccaacacaga aaaattcaat cccatcatca aaaagggctt
     2821 taggttttcc ctccatcttt acgtgttgat caaagtttgc agatctgctg gaatccttat
     2881 tgaaaactcc ccatttcaaa ccaacccggt ctacagcctc cagggaagct tcctcctggg
     2941 ctttggctcc atgttttggt agagggtgga ggctttgggc agtgctcaaa ctccaccggg
     3001 aagtctctct cactgagcag ccctcctgcc tgtcatcctg ggcaggcgag cactctgagg
     3061 ccccagtgta gctctgtgct ttgatattcc caagctctgc tggggcctga ctaggccagc
     3121 cccaaggtgg ccagagttct ggcttcatac ctgagccaaa agccccaatc catgcttggc
     3181 cattgcctga gtattagctg ccccaggggg atcacggtcc ccatatattt gcttgccatg
     3241 gaccctgggc agcagggaga gagtagagat ttgtcaagag cccatggtgg aggctgaggc
     3301 cctgaggcca tgagatgcag gcatggggtg agaaacaggc cccttggaat tgggctgggc
     3361 cttggcccag cttagtcaaa tcaaaaggct tctatttgga gagctgaaga gggtgtacag
     3421 aggaaggggc taggtctgca aggagtgcct catctccctg aagagctctc agtggaacat
     3481 acttcaccca tccatgtacc cacatctttc cttgcccaga aggcgagagc cagctataac
     3541 agacccattt caataccctg gcaagtcatt actgccctta gctcttggtg tccccatctg
     3601 tgaaacatgg gggacagctg ctagcctgga ttggaacttg ggcaaagtcc aaagaatggg
     3661 atttagagct gaatgaacct cacactgagg gcacaatagc actaggcact gcccccagag
     3721 cctagtgcta tatgcctgct gcaggtccta cccaagcatg ctttactgag gaactcaacg
     3781 tttcagagct tgagggtcag gttgatcatg ggcttgtgac cataggcttc cttagtatgc
     3841 caggcttgga gaaccgtgag aaaagcaggg aagatacctt caagggtagc aggcatcagc
     3901 tctactcacc ttggcccata aggctttgcc tggtcatgct ggcaccgggt catatgctgg
     3961 acagggagaa cgagagtccc atcctggaac tccagaaaag cccctggatg ctccagcccc
     4021 tgggaaagca cacagccagg cccttgggtg ggaggttggc ttctaacagt gcatacacat
     4081 gcccttcctc tgagtcgggg cagcaaaaac atccattccg ctgcgcaaca gttgtcattt
     4141 ttctaacatc tgaaaactcc agaaggagat ggtgataaat gtggtaccgg attctgccta
     4201 aaggatcagt ctttagatgt tttcagattg aaagcctcat ttgtgatcct cacagccatc
     4261 ttgaaagaat agagcagcca gtgggtatac tggattgtga gctaagaggc ctgggacttt
     4321 ccccctgttg ctgccagcca ggttgatgac cctgggcaag tctttttcct taccaggtct
     4381 cagtttcctc agctgtaaaa tgagaggttg atctggatca gggatagtaa atgggccttt
     4441 gttcagttac tgactgttgt ataacaaacc acccccaaat ttagtagcct taataaacat
     4501 ttattagctc ctgagtgagt ggcttggcag tttgggctgt gttcagtgtg gtggttctta
     4561 tctcatctgg gccctcgtgt ggctgaagtg agctggcaga tcagctgggg actggctggt
     4621 ctcagatggc ctcgcccgcc tgtcaggtgg ttggctgggc aactgggcca cacgttccag
     4681 catctagcag gctgacccag gattctagac atcatggctg agttccaaaa accgcaagag
     4741 aagacaagcc cagtatgcga gtgctcttga ggatattgct atgacgtatc ttttggccaa
     4801 agtaagtcac atggctaagc ccaaattctt cttaacagga ggagcttcaa aatatggcca
     4861 tatttaaaaa atctacctca ggactcattt cacttgccaa ctcagaactt ttagtagcag
     4921 ctgcctggag tgccttttga ggatctgcag caattttcag actgtttgga aatactgaca
     4981 tgatagtttg gcagtttctc ttatgagcat ggaattcaag tgtgggcacg tgagcgtcag
     5041 gtatttgcca tccctggcca ggttgacccg taaggtcata acctgcccca taggatgtta
     5101 tatgcagtag gcctgtctga caagaccaca gaaatagaga aggcaaagca gagcaaaaga
     5161 ttctgagcca ggcatccttg gttttcatcc caaccagatc attgattgat tgaggtttta
     5221 ggcaaatcaa aatccctcca ccagtagcca gattcttcat aataaacttc ctccataaca
     5281 gtaaaccatt tcctgaacac ctgctgttaa aaagcacatt ttacatttac ttaatctcca
     5341 caaccaccct cagtaggtgt agtaaggact tctggttaca agttacagaa actgaattca
     5401 gtcctgctta gtgggaggaa gtttattggc tcacaaattg taaagtccag ggatcttcag
     5461 acatggggac ttgggttcaa aagctgccat cgagaatccg gttagccagg catggtgaca
     5521 cgtgcctgta gtccccgcta cttgggggac tacagtggga gatcatttgc acctaggagg
     5581 ttaatgctgc ggtgagccat gatcctgccg ctgcactcca gcctgggtga caaagcgaga
     5641 ccccaactca aggggaaaaa atctggtttt cgggcaggtt ccaagaagtg gtagagcatg
     5701 gccatagggc ctgtgagaat agagggacag aggggagaat ccccaaaagg agagcaaggc
     5761 ttggctaaca aaaacaggca tccactgtgt ggttatgtct attctataga ttttgtagat
     5821 gaggtttaaa agcatggccc caagtaaagg tggcatctct atcctatcct cgcctttatc
     5881 taaactctgt gaccgatcaa tagcatatga tggtggtggt gctctgccag tctcccagtc
     5941 ccagactgaa gcactagcag cttccactta ttatctcttg ggactctagc tcttgggacc
     6001 caaccaccat gctgtgaagc agcccaggcc acacagagag gccacgtgta catgttcagc
     6061 tgacagcagt atcaaatgtc agacatgaga gaggaaggct tcaagatgac tccagcccag
     6121 ccaccgtctg agaacaaagt aagaactgcc tcactgatgc cattcaaagc ccagcaccat
     6181 gagagataat aaaacgttgt ttgaagatgc taa
//
