LOCUS       NM_006788               4379 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ralA binding protein 1 (RALBP1), mRNA.
ACCESSION   NM_006788 XM_005258080
VERSION     NM_006788.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4379)
  AUTHORS   Bose,C., Kshirsagar,S., Vijayan,M., Kumar,S., Singh,S.P., Hindle,A.
            and Reddy,P.H.
  TITLE     The role of RLIP76 in oxidative stress and mitochondrial
            dysfunction: Evidence based on autopsy brains from Alzheimer's
            disease patients
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166932 (2024)
   PUBMED   37926360
  REMARK    GeneRIF: The role of RLIP76 in oxidative stress and mitochondrial
            dysfunction: Evidence based on autopsy brains from Alzheimer's
            disease patients.
REFERENCE   2  (bases 1 to 4379)
  AUTHORS   Baig,J., Sawant,N., Rawat,P., Reddy,A.P., Reddy,P.H. and
            Kshirsagar,S.
  TITLE     Abnormal interaction of Rlip with mutant APP/Abeta and
            phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip
            function in Alzheimer's disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166858 (2024)
   PUBMED   37633469
  REMARK    GeneRIF: Abnormal interaction of Rlip with mutant APP/Abeta and
            phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip
            function in Alzheimer's disease.
REFERENCE   3  (bases 1 to 4379)
  AUTHORS   Wang,Q., Zhang,C., Zhu,J., Zhang,L., Chen,H., Qian,J. and Luo,C.
  TITLE     Crucial Role of RLIP76 in Promoting Glycolysis and Tumorigenesis by
            Stabilization of HIF-1alpha in Glioma Cells Under Hypoxia
  JOURNAL   Mol Neurobiol 59 (11), 6724-6739 (2022)
   PUBMED   35998001
  REMARK    GeneRIF: Crucial Role of RLIP76 in Promoting Glycolysis and
            Tumorigenesis by Stabilization of HIF-1alpha in Glioma Cells Under
            Hypoxia.
REFERENCE   4  (bases 1 to 4379)
  AUTHORS   Boughrara,W. and Chentouf,A.
  TITLE     The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with
            carbamazepine response in epileptic patient: a systematic review
  JOURNAL   Acta Neurol Belg 122 (4), 871-880 (2022)
   PUBMED   35325436
  REMARK    GeneRIF: The ABCB1, ABCC2 and RALBP1 polymorphisms are associated
            with carbamazepine response in epileptic patient: a systematic
            review.
            Review article
REFERENCE   5  (bases 1 to 4379)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4379)
  AUTHORS   Iouzalen,N., Camonis,J. and Moreau,J.
  TITLE     Identification and characterization in Xenopus of XsmgGDS, a RalB
            binding protein
  JOURNAL   Biochem Biophys Res Commun 250 (2), 359-363 (1998)
   PUBMED   9753634
REFERENCE   7  (bases 1 to 4379)
  AUTHORS   Ikeda,M., Ishida,O., Hinoi,T., Kishida,S. and Kikuchi,A.
  TITLE     Identification and characterization of a novel protein interacting
            with Ral-binding protein 1, a putative effector protein of Ral
  JOURNAL   J Biol Chem 273 (2), 814-821 (1998)
   PUBMED   9422736
REFERENCE   8  (bases 1 to 4379)
  AUTHORS   Yamaguchi,A., Urano,T., Goi,T. and Feig,L.A.
  TITLE     An Eps homology (EH) domain protein that binds to the Ral-GTPase
            target, RalBP1
  JOURNAL   J Biol Chem 272 (50), 31230-31234 (1997)
   PUBMED   9395447
REFERENCE   9  (bases 1 to 4379)
  AUTHORS   Park,S.H. and Weinberg,R.A.
  TITLE     A putative effector of Ral has homology to Rho/Rac GTPase
            activating proteins
  JOURNAL   Oncogene 11 (11), 2349-2355 (1995)
   PUBMED   8570186
REFERENCE   10 (bases 1 to 4379)
  AUTHORS   Jullien-Flores,V., Dorseuil,O., Romero,F., Letourneur,F.,
            Saragosti,S., Berger,R., Tavitian,A., Gacon,G. and Camonis,J.H.
  TITLE     Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with
            CDC42/Rac GTPase-activating protein activity
  JOURNAL   J Biol Chem 270 (38), 22473-22477 (1995)
   PUBMED   7673236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005432.2, BQ224100.1, BX352266.2, BQ674032.1, L42542.1,
            BF794440.1 and BC013126.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006788.3.
            
            Summary: RALBP1 plays a role in receptor-mediated endocytosis and
            is a downstream effector of the small GTP-binding protein RAL (see
            RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound
            inactive and GTP-bound active forms, which shift from the inactive
            to the active state through the action of RALGDS (MIM 601619),
            which in turn is activated by RAS (see HRAS; MIM 190020) (summary
            by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.144898.1,
                                           SRR1803614.46393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383432.8/ ENSP00000372924.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AP005432.2         73854-73872
            20-34               BQ224100.1         2-16
            35-36               BX352266.2         687-688             c
            37-73               BQ224100.1         19-55
            74-478              BQ674032.1         7-411
            479-2581            L42542.1           468-2570
            2582-2583           BF794440.1         795-796
            2584-4373           BC013126.1         2427-4216
            4374-4379           AP005432.2         136450-136455
FEATURES             Location/Qualifiers
     source          1..4379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.22"
     gene            1..4379
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /note="ralA binding protein 1"
                     /db_xref="GeneID:10928"
                     /db_xref="HGNC:HGNC:9841"
                     /db_xref="MIM:605801"
     exon            1..179
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            180..478
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2202
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="ral-interacting protein 1; DNP-SG ATPase; 76 kDa
                     Ral-interacting protein; dinitrophenyl S-glutathione
                     ATPase"
                     /codon_start=1
                     /product="ralA-binding protein 1"
                     /protein_id="NP_006779.1"
                     /db_xref="CCDS:CCDS11845.1"
                     /db_xref="GeneID:10928"
                     /db_xref="HGNC:HGNC:9841"
                     /db_xref="MIM:605801"
                     /translation="MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRT
                     GEPSPPHDILHEPPDVVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSK
                     MKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVV
                     KQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECID
                     YVEKYGMKCEGIYRVSGIKSKVDELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPE
                     NLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELE
                     TKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLP
                     ETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQE
                     CETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIA
                     SEKEEIERLRAEIAEIQSRQQHGRSETEEYSSESESESEDEEELQIILEDLQRQNEEL
                     EIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAKAEQQAQEDEEPEWRGGAVQPPRDG
                     VLEPKAAKEQPKAGKEPAKPSPSRDRKETSI"
     exon            479..937
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1287
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1449
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1581
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1689
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1811
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1935
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..4379
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4347..4352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /note="hexamer: ATTAAA"
     polyA_site      4379
                     /gene="RALBP1"
                     /gene_synonym="RIP1; RLIP1; RLIP76"
                     /note="major polyA site"
ORIGIN      
        1 ctcgtcccgt tccgtcccaa tcattgtaaa caggcagagg ctgggcgggg tgggaatggg
       61 gcgcccgagg ccggcctggg gcgcagcgca ggaggcggct ccggtggctg cggcggcagc
      121 gtgagcgcga ggaggcggag gctgcggcgg ggcggacggt cgcgcggcgg caggcacagg
      181 tgtaatggat aggtaacaga gaagacctcg tcccttccta gtcagggcat cagcatgact
      241 gagtgcttcc tgccccccac cagcagcccc agtgaacacc gcagggtgga gcatggcagc
      301 gggcttaccc ggacccccag ctctgaagag atcagcccta ctaagtttcc tggattgtac
      361 cgcactggcg agccctcacc tccccatgac atcctccatg agcctcctga tgtagtgtct
      421 gatgatgaga aagatcatgg gaagaaaaaa gggaaattta agaaaaagga aaagaggact
      481 gaaggctatg cagcctttca ggaagatagc tctggagatg aggcagaaag tccttctaaa
      541 atgaagaggt ccaagggaat ccatgttttc aagaagccca gcttttctaa aaagaaggaa
      601 aaggatttta aaataaaaga gaaacccaaa gaagaaaagc ataaagaaga aaagcacaaa
      661 gaagaaaaac ataaagagaa gaagtcaaaa gacttgacag cagctgatgt tgttaaacag
      721 tggaaggaaa agaagaaaaa gaaaaagcca attcaggagc cagaggtgcc tcagattgat
      781 gttccaaatc tcaaacccat ttttggaatt cctttggctg atgcagtaga gaggaccatg
      841 atgtatgatg gcattcggct gccagccgtt ttccgtgaat gtatagatta cgtagagaag
      901 tatggcatga agtgtgaagg catctacaga gtatcaggaa ttaaatcaaa ggtggatgag
      961 ctaaaagcag cctatgaccg ggaggagtct acaaacttgg aagactatga gcctaacact
     1021 gtagccagtt tgctgaagca gtatttgcga gaccttccag agaatttgct taccaaagag
     1081 cttatgccca gatttgaaga ggcttgtggg aggaccacgg agactgagaa agtgcaggaa
     1141 ttccagcgtt tactcaaaga actgccagaa tgtaactatc ttctgatttc ttggctcatt
     1201 gtgcacatgg accatgtcat tgcaaaggaa ctggaaacaa aaatgaatat acagaacatt
     1261 tctatagtgc tcagcccaac tgtgcagatc agcaatcgag tcctgtatgt gtttttcaca
     1321 catgtgcaag aactctttgg aaatgtggta ctaaagcaag tgatgaaacc tctgcgatgg
     1381 tctaacatgg ccacgatgcc cacgctgcca gagacccagg cgggcatcaa ggaggagatc
     1441 aggagacagg agtttctttt gaattgttta catcgagatc tgcagggtgg gataaaggat
     1501 ttgtctaaag aagaaagatt atgggaagta caaagaattt tgacagccct caaaagaaaa
     1561 ctgagagaag ctaaaagaca ggagtgtgaa accaagattg cacaagagat agccagtctt
     1621 tcaaaagagg atgtttccaa agaagagatg aatgaaaatg aagaagttat aaatattctc
     1681 cttgctcagg agaatgagat cctgactgaa caggaggagc tcctggccat ggagcagttt
     1741 ctgcgccggc agattgcctc agaaaaagaa gagattgaac gcctcagagc tgagattgct
     1801 gaaattcaga gtcgccagca gcacggccga agtgagactg aggagtactc ctccgagagc
     1861 gagagcgaga gtgaggatga ggaggagctg cagatcattc tggaagactt acagagacag
     1921 aacgaagagc tggaaataaa gaacaatcat ttgaatcaag caattcatga ggagcgcgag
     1981 gccatcatcg agctgcgcgt gcagctgcgg ctgctccaga tgcagcgagc caaggccgag
     2041 cagcaggcgc aggaggacga ggagcctgag tggcgcgggg gtgccgtcca gccgcccaga
     2101 gacggcgtcc ttgagccaaa agcagctaaa gagcagccaa aggcaggcaa ggagccggca
     2161 aagccatcgc ccagcaggga taggaaggag acgtccatct gagcagcctg cgtggccgtc
     2221 tggagtccgt gagactgaaa ggacccgtgc atcttactgt aacccggggg ccaggccggc
     2281 tctctcgctg tacattctgt aaaggtgtct tctcttctca gactcttcct ctgtcacacg
     2341 tctgactcct tcacgtcagg ctcaggttcc atgggaggac gaagcagtgg acgcattgtg
     2401 ggctttaggg acagatgagt tttccagata gtgtcagctt atttgaagat taattttctt
     2461 tgttaactta aaataactat tttaaccctt gagtggcttc tttttaaacc aaaaaccgtc
     2521 tttctttgct tttttatcac agcagaatca ggatctcttt ctcattcaag gggggaacca
     2581 ccccaggtca gcgctgcgcc tgctgtggcc gccgcgagcc acgccctctg ggatctctgg
     2641 taccgtcact cttgcttgtg ccttccacac cttctcggtg cagatcccta tgggggagct
     2701 gcctcacgtt ctctgactgg tcagagcagc gcctggtggg tgttccctgg cccactctcc
     2761 tctctccttc tgcagttcta aaccacagtc tataagcccg agtcaccagg acggcctgtc
     2821 tggccacaga caggggctgc ctgtggagcc tgcccaccgg cccccggcag tgcagtccag
     2881 cggggaggag gctgcccgtt cctgccagtt cctcactgcg gggaccagca aaggccttct
     2941 cactgggttg gtcaaaggta gtcaccttgg cctggtgcat ccacagagga tgttgttcaa
     3001 accagaaatc ttttaaacga ctgaccttcc ttaaaaacag aatgactccg attgcttgct
     3061 tgggctagaa tgtacacgtc tccttgcctg aataagccat atatatgctc ttaaacaaaa
     3121 gtttgaaatt atccatatca tctcagtgaa cctactggtg gactcccaat tgacaagatt
     3181 gagcaataga aaaaaattcc tttcctttga atgatagctg tgattcaccc caccccattt
     3241 tcttgtttct ggtccatccg atgagacgga tgctctgatg ctctgaggct tctgggaggc
     3301 tgggccctgg aggcaacgtg ctgcaggcgc actctgtcag agtgaacagc accgcgagac
     3361 aggccaggct cgtggctcgg aagacaaacc ccacacacac tcaaggggtc gaaaacaaac
     3421 cccacacgag ggctctcacc tccttctcct aggtagtatt tattttcagc acctgtttga
     3481 tgcagttttt aatcctctac ctattgcact gttgtgactc gttggccatt atttgatttt
     3541 tgtacgaaaa aaagctttgt tatagaaatc agcatactat ttttttaaat ctggagagaa
     3601 gatattctgg tgactgaaag tatggtcggg tgtcagatat aaatgtgcaa atgccttctt
     3661 gctgtcctgt cggtctcagt acgttcactt tatagctgct ggcaatatcg aaggttcctt
     3721 ttttgtttgt gtaaactcta atttctatca aggtgtcatg gatttttaaa attagtattt
     3781 cattacaaat gtctcagcat tggttaacta atttttgcca ggaccattat tgatcaagca
     3841 aataaattca acagccattt gggaaaaaga aaagcttcta gtttttttgt acacattctt
     3901 tctgtgagga gattgagtac tctgcagctg gcgaggagtt ggttgaggca cttcttcaag
     3961 gccaaggggg aacacagtgt tttgtttcca gctcactttg tacccctcac ctctgcagac
     4021 acggggagaa ccccggaccc ctggcatgca tgctggcggc ggcatgcctc ccttccacaa
     4081 gcccatgctg ctgcagaggg agcctgtgtt tgcaaaaccc agtggactgg gctgggtctg
     4141 ctgtctgagc agctcctggc tccggtggga actgcacaca agtccactgg cctggcttgg
     4201 ccccaggcat tgcaattgac agacatttgc atttcatacg gtaaatgagg actcagcaca
     4261 gccaaccata atcagcatgt ctgggataga ctggtctaga ataaaaatga agtttccatt
     4321 gctttgtttg ctttaaaaat tccacaatta aaatatctgt cattgaaagc ttagacaaa
//
