LOCUS       NM_002881               2247 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RAS like proto-oncogene B (RALB), transcript variant
            1, mRNA.
ACCESSION   NM_002881
VERSION     NM_002881.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2247)
  AUTHORS   Yoshimachi,S., Shirakawa,R., Cao,M., Trinh,D.A., Gao,P., Sakata,N.,
            Miyazaki,K., Goto,K., Miura,T., Ariake,K., Maeda,S., Masuda,K.,
            Ishida,M., Ohtsuka,H., Unno,M. and Horiuchi,H.
  TITLE     Ral GTPase-activating protein regulates the malignancy of
            pancreatic ductal adenocarcinoma
  JOURNAL   Cancer Sci 112 (8), 3064-3073 (2021)
   PUBMED   34009715
  REMARK    GeneRIF: Ral GTPase-activating protein regulates the malignancy of
            pancreatic ductal adenocarcinoma.
REFERENCE   2  (bases 1 to 2247)
  AUTHORS   Wang,Y., Zheng,Y., Chen,Q., Dai,Y. and Li,T.
  TITLE     MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by
            suppressing RalB via the Ral/RAC/PI3K pathway
  JOURNAL   Arch Biochem Biophys 704, 108719 (2021)
   PUBMED   33290747
  REMARK    GeneRIF: MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by
            suppressing RalB via the Ral/RAC/PI3K pathway.
REFERENCE   3  (bases 1 to 2247)
  AUTHORS   Naszai,M., Bellec,K., Yu,Y., Roman-Fernandez,A., Sandilands,E.,
            Johansson,J., Campbell,A.D., Norman,J.C., Sansom,O.J., Bryant,D.M.
            and Cordero,J.B.
  TITLE     RAL GTPases mediate EGFR-driven intestinal stem cell proliferation
            and tumourigenesis
  JOURNAL   Elife 10, e63807 (2021)
   PUBMED   34096503
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2247)
  AUTHORS   Khawaja,H., Campbell,A., Roberts,J.Z., Javadi,A., O'Reilly,P.,
            McArt,D., Allen,W.L., Majkut,J., Rehm,M., Bardelli,A., Di
            Nicolantonio,F., Scott,C.J., Kennedy,R., Vitale,N., Harrison,T.,
            Sansom,O.J., Longley,D.B., Evergren,E. and Van Schaeybroeck,S.
  TITLE     RALB GTPase: a critical regulator of DR5 expression and TRAIL
            sensitivity in KRAS mutant colorectal cancer
  JOURNAL   Cell Death Dis 11 (10), 930 (2020)
   PUBMED   33122623
  REMARK    GeneRIF: RALB GTPase: a critical regulator of DR5 expression and
            TRAIL sensitivity in KRAS mutant colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2247)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2247)
  AUTHORS   Joneson,T. and Bar-Sagi,D.
  TITLE     Ras effectors and their role in mitogenesis and oncogenesis
  JOURNAL   J Mol Med (Berl) 75 (8), 587-593 (1997)
   PUBMED   9297626
  REMARK    Review article
REFERENCE   7  (bases 1 to 2247)
  AUTHORS   Jilkina,O. and Bhullar,R.P.
  TITLE     Generation of antibodies specific for the RalA and RalB GTP-binding
            proteins and determination of their concentration and distribution
            in human platelets
  JOURNAL   Biochim Biophys Acta 1314 (1-2), 157-166 (1996)
   PUBMED   8972729
REFERENCE   8  (bases 1 to 2247)
  AUTHORS   Jullien-Flores,V., Dorseuil,O., Romero,F., Letourneur,F.,
            Saragosti,S., Berger,R., Tavitian,A., Gacon,G. and Camonis,J.H.
  TITLE     Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with
            CDC42/Rac GTPase-activating protein activity
  JOURNAL   J Biol Chem 270 (38), 22473-22477 (1995)
   PUBMED   7673236
REFERENCE   9  (bases 1 to 2247)
  AUTHORS   Hsieh,C.L., Swaroop,A. and Francke,U.
  TITLE     Chromosomal localization and cDNA sequence of human ralB, a GTP
            binding protein
  JOURNAL   Somat Cell Mol Genet 16 (4), 407-410 (1990)
   PUBMED   2120779
REFERENCE   10 (bases 1 to 2247)
  AUTHORS   Chardin,P. and Tavitian,A.
  TITLE     Coding sequences of human ralA and ralB cDNAs
  JOURNAL   Nucleic Acids Res 17 (11), 4380 (1989)
   PUBMED   2662142
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ893549.1, AK127675.1,
            M35416.1 and BC018163.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002881.2.
            
            Summary: This gene encodes a GTP-binding protein that belongs to
            the small GTPase superfamily and Ras family of proteins.
            GTP-binding proteins mediate the transmembrane signaling initiated
            by the occupancy of certain cell surface receptors. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.321124.1,
                                           SRR3476690.805409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272519.10/ ENSP00000272519.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BQ893549.1         22-36
            16-129              AK127675.1         15-128
            130-1333            M35416.1           124-1327
            1334-2246           AK127675.1         1396-2308
            2247-2247           BC018163.1         2166-2166
FEATURES             Location/Qualifiers
     source          1..2247
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..2247
                     /gene="RALB"
                     /note="RAS like proto-oncogene B"
                     /db_xref="GeneID:5899"
                     /db_xref="HGNC:HGNC:9840"
                     /db_xref="MIM:179551"
     exon            1..129
                     /gene="RALB"
                     /inference="alignment:Splign:2.1.0"
     exon            130..290
                     /gene="RALB"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..797
                     /gene="RALB"
                     /EC_number="3.6.5.2"
                     /note="RAS-like protein B; v-ral simian leukemia viral
                     oncogene homolog B (ras related; GTP binding protein); ras
                     related GTP binding protein B; RALB Ras like
                     proto-oncogene B"
                     /codon_start=1
                     /product="ras-related protein Ral-B"
                     /protein_id="NP_002872.1"
                     /db_xref="CCDS:CCDS2131.1"
                     /db_xref="GeneID:5899"
                     /db_xref="HGNC:HGNC:9840"
                     /db_xref="MIM:179551"
                     /translation="MAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYE
                     PTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFT
                     ATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARSKAEEWGVQYVETSAK
                     TRANVDKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERCCLL"
     exon            291..499
                     /gene="RALB"
                     /inference="alignment:Splign:2.1.0"
     exon            500..677
                     /gene="RALB"
                     /inference="alignment:Splign:2.1.0"
     exon            678..2247
                     /gene="RALB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2226..2231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RALB"
                     /note="hexamer: AATAAA"
     polyA_site      2247
                     /gene="RALB"
                     /note="major polyA site"
ORIGIN      
        1 gaaagcgagc ccggcagctc aatgacaaat cggtggagga cggctggggt ccggccccgg
       61 gagggggcgg ggcgcgttta agagctgcgg gccgggtgcg gacggcggag gcggcgggac
      121 tggtccctgc tcttcagtgg gtcatctgtg tgtcacagcc tcagaagacc agcgagatgg
      181 ctgccaacaa gagtaagggc cagagctcct tggccctcca caaggtgatc atggttggca
      241 gcggaggcgt tggcaagtca gccctgacgc ttcagttcat gtatgacgag tttgtagaag
      301 actatgaacc taccaaagct gacagttata gaaagaaagt ggttcttgat ggggaagaag
      361 ttcagataga tattctggac accgctgggc aagaggacta cgcagccatt cgagataact
      421 actttcggag tggggaaggg tttcttcttg tgttctcaat cacagaacat gaatccttta
      481 cagcaactgc cgaattcagg gaacagattc tccgtgtgaa ggctgaagaa gataaaattc
      541 cactgctcgt cgtgggaaac aagtctgacc tagaggagcg gaggcaggtg cctgtggagg
      601 aggccaggag taaagccgaa gagtggggcg tgcagtacgt ggagacgtca gcgaagaccc
      661 gggccaacgt ggacaaggtg ttctttgacc taatgagaga aatcagaaca aagaagatgt
      721 cagaaaacaa agacaagaat ggcaagaaaa gcagcaagaa caagaaaagt tttaaagaaa
      781 gatgttgctt actatgagtg tcaaggtgac ggatgaagcc agctgctcct aaggacacag
      841 ggctgggttg gtaaagagaa ggctatggtt gacttcttgc ttgtgcttcc cactctcccc
      901 gacttcattc actcaaactt ctttaaatgg ggaaaaatat ttgtgactct gtggctggca
      961 gaagaaataa gcccatgcaa gtggaagggc tgctttgtca ggaggttgtg gaatttcttt
     1021 cttctcccct tcttccctcc caaaagctta gctatgtata aagtgccaca gataggaaac
     1081 agctgttaat tacaaagaga aagaattgtc atagcatctt attttgttcc tagttttata
     1141 acattaccat ccttcgtttt gaactacaga tgttgtagtg ggttttggag gagggagtgg
     1201 agtaagatgc cctcccactt ttatcagttt agtagtagta ctgagaaaaa tcccttcagc
     1261 tctaagaaca ctgaaaaatc caccgatttt ttgggtaagc ttcttggcaa taccctgtgg
     1321 atctgaaaca gctaaaaaaa tgaatttgaa ttgcgccaga taggtcaata ccaagcttct
     1381 gattcctcct cacatatgaa aagtgaaagt tgtgagttgt tttcctctta tttaaacatt
     1441 ggcctattat aatctgtgtt ggttattttt ctcctgtaag catcctgatt tttctgtagg
     1501 aacttttctt tggcagacca agtgaagact caggaatggt gtgcattata aatgacacac
     1561 attgccactt gtgtagatat ttttaagttc tttggctaag tcctctccta actgcctgtc
     1621 ctctggttag gcccctccct ctccactagt ggtgaatgca tgtgtctgtc tgatcagcat
     1681 cactgcacac ggaggtctag tgagcctctt gctaagtgtc acacacactc ttcccaaaga
     1741 cgtgatgagt taaagttgta ttctgaaatc atgaagccag agcctgtgcc agaccttctg
     1801 ctacctctca tagaattgct ctgtaattct aaatttaaaa ttagaagtag agagagataa
     1861 gccatcgccc ctttgcctct gagaattggc tgctgtttct aatataatta ttttctaaga
     1921 tagccagata gttagaaaaa gattttcatt gatgacatat ctttaaactt tcttgcatca
     1981 gtattctaaa ttgagcaaac tgaaagattt tcatcaggaa aggagcactg tgggaagagc
     2041 ccagtattca cattttttcc ccatttttca gaagcgacat ttcatatata ggtgccaaaa
     2101 gtgaatcggg gtgcggagag tgggaacctt ttgaatttat gattgtcaca gagatggtag
     2161 aaattatgat ctgactggaa aacaatcctg tatcccctcc caaagaatca tgggcttttt
     2221 ttttgaataa aaaagcagac aaataga
//
