LOCUS       NM_005402               2787 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens RAS like proto-oncogene A (RALA), mRNA.
ACCESSION   NM_005402
VERSION     NM_005402.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Xia,W., Veeragandham,P., Cao,Y., Xu,Y., Rhyne,T.E., Qian,J.,
            Hung,C.W., Zhao,P., Jones,Y., Gao,H., Liddle,C., Yu,R.T.,
            Downes,M., Evans,R.M., Ryden,M., Wabitsch,M., Wang,Z., Hakozaki,H.,
            Schoneberg,J., Reilly,S.M., Huang,J. and Saltiel,A.R.
  TITLE     Obesity causes mitochondrial fragmentation and dysfunction in white
            adipocytes due to RalA activation
  JOURNAL   Nat Metab 6 (2), 273-289 (2024)
   PUBMED   38286821
  REMARK    GeneRIF: Obesity causes mitochondrial fragmentation and dysfunction
            in white adipocytes due to RalA activation.
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Cao,M., Li,X., Trinh,D.A., Yoshimachi,S., Goto,K., Sakata,N.,
            Ishida,M., Ohtsuka,H., Unno,M., Wang,Y., Shirakawa,R. and
            Horiuchi,H.
  TITLE     Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma
            via elevation of TGF-beta1 production
  JOURNAL   J Biol Chem 299 (6), 104754 (2023)
   PUBMED   37116704
  REMARK    GeneRIF: Ral GTPase promotes metastasis of pancreatic ductal
            adenocarcinoma via elevation of TGF-beta1 production.
REFERENCE   3  (bases 1 to 2787)
  AUTHORS   Fan,G., Zhu,Y., Zhu,H., Yu,L., Wang,Z., Zhai,C., Zhou,G., Zhao,J.
            and Wang,Y.
  TITLE     Identification of RALA as a Therapeutic Target and Prognostic
            Predictor of Osteosarcoma
  JOURNAL   Biomed Res Int 2023, 1150768 (2023)
   PUBMED   36817861
  REMARK    GeneRIF: Identification of RALA as a Therapeutic Target and
            Prognostic Predictor of Osteosarcoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2787)
  AUTHORS   Tian,L., Zhao,L., Sze,K.M., Kam,C.S., Ming,V.S., Wang,X.,
            Zhang,V.X., Ho,D.W., Cheung,T.T., Chan,L.K. and Ng,I.O.
  TITLE     Dysregulation of RalA signaling through dual regulatory mechanisms
            exerts its oncogenic functions in hepatocellular carcinoma
  JOURNAL   Hepatology 76 (1), 48-65 (2022)
   PUBMED   34767674
  REMARK    GeneRIF: Dysregulation of RalA signaling through dual regulatory
            mechanisms exerts its oncogenic functions in hepatocellular
            carcinoma.
REFERENCE   5  (bases 1 to 2787)
  AUTHORS   Kano,T., Tsumagari,R., Nakashima,A., Kikkawa,U., Ueda,S.,
            Yamanoue,M., Takei,N. and Shirai,Y.
  TITLE     RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways
            in DGKbeta-Induced Neurite Outgrowth
  JOURNAL   Biomolecules 11 (12), 1814 (2021)
   PUBMED   34944458
  REMARK    GeneRIF: RalA, PLD and mTORC1 Are Required for Kinase-Independent
            Pathways in DGKbeta-Induced Neurite Outgrowth.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2787)
  AUTHORS   Cantor,S.B., Urano,T. and Feig,L.A.
  TITLE     Identification and characterization of Ral-binding protein 1, a
            potential downstream target of Ral GTPases
  JOURNAL   Mol Cell Biol 15 (8), 4578-4584 (1995)
   PUBMED   7623849
REFERENCE   7  (bases 1 to 2787)
  AUTHORS   Kinsella,B.T., Erdman,R.A. and Maltese,W.A.
  TITLE     Carboxyl-terminal isoprenylation of ras-related GTP-binding
            proteins encoded by rac1, rac2, and ralA
  JOURNAL   J Biol Chem 266 (15), 9786-9794 (1991)
   PUBMED   1903399
REFERENCE   8  (bases 1 to 2787)
  AUTHORS   Polakis,P.G., Weber,R.F., Nevins,B., Didsbury,J.R., Evans,T. and
            Snyderman,R.
  TITLE     Identification of the ral and rac1 gene products, low molecular
            mass GTP-binding proteins from human platelets
  JOURNAL   J Biol Chem 264 (28), 16383-16389 (1989)
   PUBMED   2550440
REFERENCE   9  (bases 1 to 2787)
  AUTHORS   Chardin,P. and Tavitian,A.
  TITLE     Coding sequences of human ralA and ralB cDNAs
  JOURNAL   Nucleic Acids Res 17 (11), 4380 (1989)
   PUBMED   2662142
REFERENCE   10 (bases 1 to 2787)
  AUTHORS   Rousseau-Merck,M.F., Bernheim,A., Chardin,P., Miglierina,R.,
            Tavitian,A. and Berger,R.
  TITLE     The ras-related ral gene maps to chromosome 7p15-22
  JOURNAL   Hum Genet 79 (2), 132-136 (1988)
   PUBMED   3292391
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC313757.1 and BC039858.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005402.3.
            
            Summary: The product of this gene belongs to the small GTPase
            superfamily, Ras family of proteins. GTP-binding proteins mediate
            the transmembrane signaling initiated by the occupancy of certain
            cell surface receptors. This gene encodes a low molecular mass
            ras-like GTP-binding protein that shares about 50% similarity with
            other ras proteins. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.815446.1,
                                           SRR1803612.213239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000005257.7/ ENSP00000005257.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DC313757.1         20-57
            39-2787             BC039858.1         4-2752
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..2787
                     /gene="RALA"
                     /gene_synonym="HINCONS; RAL"
                     /note="RAS like proto-oncogene A"
                     /db_xref="GeneID:5898"
                     /db_xref="HGNC:HGNC:9839"
                     /db_xref="MIM:179550"
     exon            1..254
                     /gene="RALA"
                     /gene_synonym="HINCONS; RAL"
                     /inference="alignment:Splign:2.1.0"
     exon            255..405
                     /gene="RALA"
                     /gene_synonym="HINCONS; RAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..912
                     /gene="RALA"
                     /gene_synonym="HINCONS; RAL"
                     /EC_number="3.6.5.2"
                     /note="Ras-related protein Ral-A; RAS-like protein A; ras
                     related GTP binding protein A; Ras family small GTP
                     binding protein RALA; v-ral simian leukemia viral oncogene
                     homolog A (ras related); RALA Ras like proto-oncogene A"
                     /codon_start=1
                     /product="ras-related protein Ral-A precursor"
                     /protein_id="NP_005393.2"
                     /db_xref="CCDS:CCDS5460.1"
                     /db_xref="GeneID:5898"
                     /db_xref="HGNC:HGNC:9839"
                     /db_xref="MIM:179550"
                     /translation="MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYE
                     PTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFA
                     ATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRAEQWNVNYVETSAKT
                     RANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL"
     exon            406..614
                     /gene="RALA"
                     /gene_synonym="HINCONS; RAL"
                     /inference="alignment:Splign:2.1.0"
     exon            615..789
                     /gene="RALA"
                     /gene_synonym="HINCONS; RAL"
                     /inference="alignment:Splign:2.1.0"
     exon            790..2787
                     /gene="RALA"
                     /gene_synonym="HINCONS; RAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2767..2772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RALA"
                     /gene_synonym="HINCONS; RAL"
                     /note="hexamer: AATAAA"
     polyA_site      2787
                     /gene="RALA"
                     /gene_synonym="HINCONS; RAL"
                     /note="major polyA site"
ORIGIN      
        1 gtggcggctg ctgcagagcc gccaggagga gggtggatct ccccagagca aagcgtcgga
       61 gtcctcctcc tccttctcct cctcctcctc ctcctcctcc agccgcccag gctcccccgc
      121 cacccgtcag actcctcctt cgaccgctcc cggcgcgggg ccttccaggc gacaaggacc
      181 gagtaccctc cggccggagc cacgcagccg cggcttccgg agccctcggg gcggcggact
      241 ggctcgcggt gcagattctt cttaatcctt tggtgaaaac tgagacacaa aatggctgca
      301 aataagccca agggtcagaa ttctttggct ttacacaaag tcatcatggt gggcagtggt
      361 ggcgtgggca agtcagctct gactctacag ttcatgtacg atgagtttgt ggaggactat
      421 gagcctacca aagcagacag ctatcggaag aaggtagtgc tagatgggga ggaagtccag
      481 atcgatatct tagatacagc tgggcaggag gactacgctg caattagaga caactacttc
      541 cgaagtgggg aggggttcct ctgtgttttc tctattacag aaatggaatc ctttgcagct
      601 acagctgact tcagggagca gattttaaga gtaaaagaag atgagaatgt tccatttcta
      661 ctggttggta acaaatcaga tttagaagat aaaagacagg tttctgtaga agaggcaaaa
      721 aacagagctg agcagtggaa tgttaactac gtggaaacat ctgctaaaac acgagctaat
      781 gttgacaagg tattttttga tttaatgaga gaaattcgag cgagaaagat ggaagacagc
      841 aaagaaaaga atggaaaaaa gaagaggaaa agtttagcca agagaatcag agaaagatgc
      901 tgcattttat aatcaaagcc caaactcctt tcttatcttg accatactaa taaatataat
      961 ttataagcat tgccattgaa ggcttaattg actgaaatta ctttaacatt ttggaaattg
     1021 ttgtatatca ctaaaagcat gaattggaac tgcaatgaaa gtcaaattta ctttaaaaag
     1081 aaattaatat ggcttcacca agaagcaaag ttcaacttat ttcataattg cctacattta
     1141 tcatggtcct gaatgtagcg tgtaagcttg tgtttcttgg gcagtctttc ttgaaattga
     1201 agaggtgaaa tgggggtggg gagtgggagg aaaggtgact tcctctggtg tttattataa
     1261 agcttaaatt ttatatcatt ttaaaatgtc ttggtcttct actgccttga aaaatgacaa
     1321 ttgtgaacat gatagttaaa ctaccacttt ttttaaccat tattatgcaa aatttagaag
     1381 aaaagttatt ggcatggttg ttgcatatag ttaaactgag agtaattcat ctgtgaatct
     1441 gctttaatta cctggtgagt aacttagaaa agtggtgtaa acttgtacat ggaatttttt
     1501 gaatatgcct taatttagaa actgaaaaat atctggttat atcattctgg gtgtgttctt
     1561 actgacacca ggggtccgct gccccatgtg tcctggtgag aaaatatatg cctggcacag
     1621 cttttgtata gaaaattctt gagaagtaac tgtccgctag aagtctgtcc aaatttaaaa
     1681 tgtgtgccat attctggttc ttgaaaataa gattccagag ctctttgatc gcttttaata
     1741 aactgcaagt tcattttaaa tgaagggcca gcatatatac ttgcaagata attttcagct
     1801 gcaaggattc agcaccagtt atgtttgaat gaaccctcct tttctctgag attctggtcc
     1861 ctggaaatcc ctttctgcta gtggtgagca tgtaagtgtt aagtttttaa tctgggagca
     1921 gggcatagga agaaaatgtc agtagtgcta atgcattttg cactagaacg cttcgggaaa
     1981 atattcatgc ttgccatctg ttcatttcta aatttatatt cataaagtta cagtttgata
     2041 caggaattat taggagtaat tcttttctgt ttctgtttat aatgaagaac actgtagcta
     2101 cattttcaga agttaacatc aagccatcaa acctgggtat agtgcagaaa acgtggcaca
     2161 cactgaccac acattaggct gtgtcaccat tgtgtggtgt acctgctgga agaattctag
     2221 catgctactt ggggacataa tttcagtggg aaatatgcca ctgaccgatt tttttttttt
     2281 cctctttgca gtggggctag gacagttgat tcaacaaagt atttttttct tttttctcag
     2341 tcctaatttg aacaggtcaa agatgtgttc aggcattcca ggtaacaggt gtgtatgtaa
     2401 agttaaaaat aggcttttta ggaactcact ctttagatat ttacatccag cttctcatgt
     2461 taaatatttg tccttaaagg gtttgagatg tacatctttc atttcgtatt tctcataggc
     2521 tatgccatgt gcggaattca agttaccaat gtaacactgg ccagcgggcc cagcaatctc
     2581 catgtgtact tattacagtc ttatttaacc aggggtccta accactaaca ttgtgacttt
     2641 gctttgagac ctttcctctc ctgggtactg aggtgctatg aagccaactg acaaagatgc
     2701 atcacgtgtc ttaggctgat gccactaccc gatttgttta tttgcaattt gagccattta
     2761 aagaccaata aacttccttt tttaaaa
//
