LOCUS       NM_021785               2187 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens retinoic acid induced 2 (RAI2), transcript variant 2,
            mRNA.
ACCESSION   NM_021785
VERSION     NM_021785.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2187)
  AUTHORS   Besler,K., Weglarz,A., Keller,L., von Amsberg,G., Bednarz-Knoll,N.,
            Offermann,A., Stoupiec,S., Eltze,E., Semjonow,A., Boettcher,L.,
            Schneegans,S., Perner,S., Hauch,S., Todenhofer,T., Peine,S.,
            Pantel,K., Wikman,H. and Werner,S.
  TITLE     Expression Patterns and Corepressor Function of Retinoic
            Acid-induced 2 in Prostate Cancer
  JOURNAL   Clin Chem 68 (7), 973-983 (2022)
   PUBMED   35652463
  REMARK    GeneRIF: Expression Patterns and Corepressor Function of Retinoic
            Acid-induced 2 in Prostate Cancer.
REFERENCE   2  (bases 1 to 2187)
  AUTHORS   Huang,M., Ding,J., Wu,X., Peng,X., Wu,G., Peng,C., Zhang,H., Mao,C.
            and Huang,B.
  TITLE     EZH2 affects malignant progression and DNA damage repair of lung
            adenocarcinoma cells by regulating RAI2 expression
  JOURNAL   Mutat Res 825, 111792 (2022)
   PUBMED   35939884
  REMARK    GeneRIF: EZH2 affects malignant progression and DNA damage repair
            of lung adenocarcinoma cells by regulating RAI2 expression.
REFERENCE   3  (bases 1 to 2187)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   4  (bases 1 to 2187)
  AUTHORS   Nishikawa,S., Uemoto,Y., Kim,T.S., Hisada,T., Kondo,N.,
            Wanifuchi-Endo,Y., Fujita,T., Asano,T., Katagiri,Y., Terada,M.,
            Kato,A., Dong,Y., Sugiura,H., Okuda,K., Kato,H., Osaga,S.,
            Takahashi,S. and Toyama,T.
  TITLE     Low RAI2 expression is a marker of poor prognosis in breast cancer
  JOURNAL   Breast Cancer Res Treat 187 (1), 81-93 (2021)
   PUBMED   33782811
  REMARK    GeneRIF: Low RAI2 expression is a marker of poor prognosis in
            breast cancer.
REFERENCE   5  (bases 1 to 2187)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2187)
  AUTHORS   Werner,S., Brors,B., Eick,J., Marques,E., Pogenberg,V., Parret,A.,
            Kemming,D., Wood,A.W., Edgren,H., Neubauer,H., Streichert,T.,
            Riethdorf,S., Bedi,U., Baccelli,I., Jucker,M., Eils,R., Fehm,T.,
            Trumpp,A., Johnsen,S.A., Klefstrom,J., Wilmanns,M., Muller,V.,
            Pantel,K. and Wikman,H.
  TITLE     Suppression of early hematogenous dissemination of human breast
            cancer cells to bone marrow by retinoic Acid-induced 2
  JOURNAL   Cancer Discov 5 (5), 506-519 (2015)
   PUBMED   25716347
  REMARK    GeneRIF: We specified the role of the RAI2 protein to function as a
            transcriptional regulator that controls the expression of several
            key regulators of breast epithelial integrity and cancer.
REFERENCE   7  (bases 1 to 2187)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2187)
  AUTHORS   Brooks,S., Ebenezer,N., Poopalasundaram,S., Maher,E., Francis,P.,
            Moore,A. and Hardcastle,A.
  TITLE     Refinement of the X-linked cataract locus (CXN) and gene analysis
            for CXN and Nance-Horan syndrome (NHS)
  JOURNAL   Ophthalmic Genet 25 (2), 121-131 (2004)
   PUBMED   15370543
REFERENCE   9  (bases 1 to 2187)
  AUTHORS   Walpole,S.M., Ronce,N., Grayson,C., Dessay,B., Yates,J.R., Trump,D.
            and Toutain,A.
  TITLE     Exclusion of RAI2 as the causative gene for Nance-Horan syndrome
  JOURNAL   Hum Genet 104 (5), 410-411 (1999)
   PUBMED   10394933
REFERENCE   10 (bases 1 to 2187)
  AUTHORS   Walpole,S.M., Hiriyana,K.T., Nicolaou,A., Bingham,E.L., Durham,J.,
            Vaudin,M., Ross,M.T., Yates,J.R., Sieving,P.A. and Trump,D.
  TITLE     Identification and characterization of the human homologue (RAI2)
            of a mouse retinoic acid-induced gene in Xp22
  JOURNAL   Genomics 55 (3), 275-283 (1999)
   PUBMED   10049581
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z93929.1 and Z93242.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_021785.5.
            
            Summary: Retinoic acid plays a critical role in development,
            cellular growth, and differentiation. The specific function of this
            retinoic acid-induced gene has not yet been determined but it may
            play a role in development. The chromosomal location of this gene
            designates it to be a candidate for diseases such as Nance-Horan
            syndrome, sensorineural deafness, non-specific X-linked cognitive
            disability, oral-facial-digital syndrome, and Fried syndrome.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.967780.1, AK314631.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451717.6/ ENSP00000401323.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               Z93929.1           9037-9237           c
            202-2187            Z93242.1           40775-42760
FEATURES             Location/Qualifiers
     source          1..2187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.13"
     gene            1..2187
                     /gene="RAI2"
                     /note="retinoic acid induced 2"
                     /db_xref="GeneID:10742"
                     /db_xref="HGNC:HGNC:9835"
                     /db_xref="MIM:300217"
     exon            1..201
                     /gene="RAI2"
                     /inference="alignment:Splign:2.1.0"
     exon            202..2187
                     /gene="RAI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1818
                     /gene="RAI2"
                     /note="isoform 1 is encoded by transcript variant 2;
                     retinoic acid-induced protein 2"
                     /codon_start=1
                     /product="retinoic acid-induced protein 2 isoform 1"
                     /protein_id="NP_068557.4"
                     /db_xref="CCDS:CCDS14183.1"
                     /db_xref="GeneID:10742"
                     /db_xref="HGNC:HGNC:9835"
                     /db_xref="MIM:300217"
                     /translation="MDDLQSQNLSMDMTDSPPALANNRLENGMAQLITTEAWNINSTD
                     LVKKALVTVPAPSILNPPAESQSGMALKVAATVLQPLCLGESPVVMPIHMQVEGSSAP
                     ELNPNGNATYVMTTQGPVQLPVVLEQHVFQHLNSPLVLPQEAPCSSSTIHNNLFQGAE
                     DPEAQPQLLDLRIPSQPQEPTLPFEAVLQNLFPSQGTLGPPPCQPPPGYAPVPPQPFS
                     SPLSPLVPPATLLVPYPVIVPLPVPVPIPIPIPMPQSSESKFSSSFPKPPSSFGLHPF
                     KGTQTPLEKDELKPFDILQPKEYFQLSRHTVIKMGSENEALDLSMKSVPWLKAGEVSP
                     PIFQEDAALDLSVAAHRKSEPPPETLYDSGASVDSSGHTVMEKLPSGMEISFAPATSH
                     EAPAMMDSHISSSDAATEMLSQPNHPSGEVKAENNIEMVGESQAAKVIVSVEDAVPTI
                     FCGKIKGLSGVSTKNFSFKREDSVLQGYDINSQGEESMGNAEPLRKPIKNRSIKLKKV
                     NSQEIHMLPIKKQRLATFFPRK"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAI2"
                     /note="hexamer: AATAAA"
     polyA_site      2187
                     /gene="RAI2"
                     /note="major polyA site"
ORIGIN      
        1 acacactcgc caggacacag gcgcacacac gctcacgcac aaccagcagc ggcggcggcg
       61 acagcgactc ggtgacagcg gcgacggcgg ctcccaccgc ggcgcacccc cttcaggcgg
      121 ccggcggcga ggccagaccg gagagttcca gcacactcga ccaccccgcg gcttcctgga
      181 ggcggcggcc gcgattgcga ggccaagtgg catcagagct gagtgatgga cgacctgcag
      241 tcccagaacc tctccatgga catgactgac tcccctcctg ccttggctaa taacagactg
      301 gagaatggca tggctcagct gatcaccacc gaggcctgga acatcaactc cactgacctg
      361 gtaaagaagg ccctggtgac cgtgccagcc ccatccattc tgaacccccc tgccgagtct
      421 cagagtggca tggctctgaa ggtggcggcc actgtgttgc agcccctgtg cctcggggag
      481 agcccagtgg tgatgcccat tcacatgcag gtggagggaa gctccgcacc agagctcaat
      541 ccgaatggca atgccaccta cgtcatgacc acccagggcc ccgtgcaact gcccgtggtg
      601 ctggagcagc acgtctttca gcacctcaac tcccctctgg tcctgccgca ggaggcccca
      661 tgctcctcca gtaccatcca caacaacctc ttccagggag cggaggaccc cgaggcccag
      721 ccccagctcc tggacctgag gatccccagc cagccgcagg agcccacttt gccatttgaa
      781 gctgtgctcc agaatttgtt tccctcccag ggcactctcg ggcccccacc ctgtcagcct
      841 cctcctggct atgcccctgt gcccccacag ccttttagct cccccttgtc ccccctggtc
      901 ccaccagcca ccctcttggt gccgtatcct gtaatcgtcc ccttgcctgt gccagtccct
      961 attcccatcc ccatcccgat gcctcagagt tctgaatcca agttcagctc cagtttcccc
     1021 aagccaccat cttccttcgg cctgcacccc tttaaaggca cccagacccc tctggaaaaa
     1081 gatgaactga agccctttga catcctccag cctaaggagt acttccagct cagccgccac
     1141 acggtcatta agatgggaag tgagaacgag gccctggatc tctccatgaa gtcagtgccc
     1201 tggctcaagg ctggtgaagt cagtccccca atcttccagg aagatgcagc cctagacctg
     1261 tcagtggcag cccaccggaa atccgagcct ccccctgaga cactgtatga cagtggtgca
     1321 tcagtggaca gctcaggtca cacagtgatg gagaaacttc ccagtggcat ggaaatttct
     1381 tttgcccctg ccacgtccca tgaggcccca gccatgatgg atagtcacat cagcagcagt
     1441 gatgctgcta ccgagatgct cagccagccc aaccacccca gcggcgaagt caaggctgaa
     1501 aataacattg agatggtggg cgagtcccag gcggccaagg tcattgtctc tgtcgaagat
     1561 gctgtgccta ccatattctg tggcaagatc aaaggcctct caggggtgtc caccaaaaac
     1621 ttctccttca aaagagaaga ctccgtgctt cagggctatg acatcaacag ccaaggggaa
     1681 gagtccatgg gaaatgcaga gccccttagg aaacccatca aaaaccggag cataaagtta
     1741 aagaaagtga actcccagga aatacacatg ctcccaatca aaaaacaacg gctggccacc
     1801 ttttttccaa gaaagtaaat aacggctttt taaaatttgt atgattataa tatggggaaa
     1861 ggtgcattgg ttttataaaa aggcatttaa aacaaattat ctttgttaat tattttgggg
     1921 agtagttggg aaatggaaag gtgaattggc tctagaggcc ctgtatgcta gtatcatttt
     1981 cttttttaat ttttgacttt tcacaaatga gtaaataaga gcaacctatt tttcaagcag
     2041 attgcacatt ttttgcagct ttaatggaat attgggtgaa ttagaggggt aaaaaaagct
     2101 attttcattg ccacaaagtg ctttgatgat gtaataccta ataaagggta ggatgaatat
     2161 ttcacaataa atgtttgttt gcactaa
//
