LOCUS       NM_015577               4986 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens retinoic acid induced 14 (RAI14), transcript variant
            1, mRNA.
ACCESSION   NM_015577
VERSION     NM_015577.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4986)
  AUTHORS   Jeong,W., Kwon,H., Park,S.K., Lee,I.S. and Jho,E.H.
  TITLE     Retinoic acid-induced protein 14 links mechanical forces to Hippo
            signaling
  JOURNAL   EMBO Rep 25 (9), 4033-4061 (2024)
   PUBMED   39160347
  REMARK    GeneRIF: Retinoic acid-induced protein 14 links mechanical forces
            to Hippo signaling.
REFERENCE   2  (bases 1 to 4986)
  AUTHORS   Cui,R., Zou,J., Zhao,Y., Zhao,T., Ren,L. and Li,Y.
  TITLE     The dual-crosslinked prospective values of RAI14 for the diagnosis
            and chemosurveillance in triple negative breast cancer
  JOURNAL   Ann Med 55 (1), 820-836 (2023)
   PUBMED   36880986
  REMARK    GeneRIF: The dual-crosslinked prospective values of RAI14 for the
            diagnosis and chemosurveillance in triple negative breast cancer.
REFERENCE   3  (bases 1 to 4986)
  AUTHORS   Zhang,R., Hu,M., Chen,H.N., Wang,X., Xia,Z., Liu,Y., Wang,R.,
            Xia,X., Shu,Y., Du,D., Meng,W., Qi,S., Li,Y., Xu,H., Zhou,Z.G. and
            Dai,L.
  TITLE     Phenotypic Heterogeneity Analysis of APC-Mutant Colon Cancer by
            Proteomics and Phosphoproteomics Identifies RAI14 as a Key
            Prognostic Determinant in East Asians and Westerners
  JOURNAL   Mol Cell Proteomics 22 (5), 100532 (2023)
   PUBMED   36934880
  REMARK    GeneRIF: Phenotypic Heterogeneity Analysis of APC-Mutant Colon
            Cancer by Proteomics and Phosphoproteomics Identifies RAI14 as a
            Key Prognostic Determinant in East Asians and Westerners.
REFERENCE   4  (bases 1 to 4986)
  AUTHORS   Yang,Q., Yan,D., Zou,C., Xue,Q., Lin,S., Huang,Q., Li,X., Tang,D.,
            Chen,X. and Liu,J.
  TITLE     The deubiquitinating enzyme STAMBP is a newly discovered driver of
            triple-negative breast cancer progression that maintains RAI14
            protein stability
  JOURNAL   Exp Mol Med 54 (11), 2047-2059 (2022)
   PUBMED   36434041
  REMARK    GeneRIF: The deubiquitinating enzyme STAMBP is a newly discovered
            driver of triple-negative breast cancer progression that maintains
            RAI14 protein stability.
REFERENCE   5  (bases 1 to 4986)
  AUTHORS   Arnett,D.K., Li,N., Tang,W., Rao,D.C., Devereux,R.B., Claas,S.A.,
            Kraemer,R. and Broeckel,U.
  TITLE     Genome-wide association study identifies single-nucleotide
            polymorphism in KCNB1 associated with left ventricular mass in
            humans: the HyperGEN Study
  JOURNAL   BMC Med Genet 10, 43 (2009)
   PUBMED   19454037
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4986)
  AUTHORS   Kutty,R.K., Chen,S., Samuel,W., Vijayasarathy,C., Duncan,T.,
            Tsai,J.Y., Fariss,R.N., Carper,D., Jaworski,C. and Wiggert,B.
  TITLE     Cell density-dependent nuclear/cytoplasmic localization of NORPEG
            (RAI14) protein
  JOURNAL   Biochem Biophys Res Commun 345 (4), 1333-1341 (2006)
   PUBMED   16729964
  REMARK    GeneRIF: Subcellular localization of NORPEG in retinal pigment
            epithelial (ARPE-19) cells varies with cell density, with
            predominantly nuclear localization in nonconfluent cells, but a
            cytoplasmic localization in confluent cultures.
REFERENCE   7  (bases 1 to 4986)
  AUTHORS   Yuan,W., Zheng,Y., Huo,R., Lu,L., Huang,X.Y., Yin,L.L., Li,J.M.,
            Zhou,Z.M. and Sha,J.H.
  TITLE     Expression of a novel alternative transcript of the novel retinal
            pigment epithelial cell gene NORPEG in human testes
  JOURNAL   Asian J Androl 7 (3), 277-288 (2005)
   PUBMED   16110356
REFERENCE   8  (bases 1 to 4986)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   9  (bases 1 to 4986)
  AUTHORS   Kutty,R.K., Kutty,G., Samuel,W., Duncan,T., Bridges,C.C.,
            El-Sherbeeny,A., Nagineni,C.N., Smith,S.B. and Wiggert,B.
  TITLE     Molecular characterization and developmental expression of NORPEG,
            a novel gene induced by retinoic acid
  JOURNAL   J Biol Chem 276 (4), 2831-2840 (2001)
   PUBMED   11042181
REFERENCE   10 (bases 1 to 4986)
  AUTHORS   Peng,Y.F., Mandai,K., Sakisaka,T., Okabe,N., Yamamoto,Y.,
            Yokoyama,S., Mizoguchi,A., Shiozaki,H., Monden,M. and Takai,Y.
  TITLE     Ankycorbin: a novel actin cytoskeleton-associated protein
  JOURNAL   Genes Cells 5 (12), 1001-1008 (2000)
   PUBMED   11168586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA485361.1, AF155135.1 and BC028681.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015577.2.
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (a). Variants 1-3 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052988.1, SRR1660809.229465.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265109.8/ ENSP00000265109.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                DA485361.1         1-85
            86-506              AF155135.1         1-421
            507-666             BC028681.1         672-831
            667-1010            AF155135.1         582-925
            1011-1660           BC028681.1         1176-1825
            1661-4986           AF155135.1         1576-4901
FEATURES             Location/Qualifiers
     source          1..4986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..4986
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /note="retinoic acid induced 14"
                     /db_xref="GeneID:26064"
                     /db_xref="HGNC:HGNC:14873"
                     /db_xref="MIM:606586"
     exon            1..148
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            149..232
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..3139
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /note="isoform a is encoded by transcript variant 1; novel
                     retinal pigment epithelial cell protein; ankycorbin;
                     ankyrin repeat and coiled-coil structure-containing
                     protein; retinoic acid-induced protein 14"
                     /codon_start=1
                     /product="ankycorbin isoform a"
                     /protein_id="NP_056392.2"
                     /db_xref="CCDS:CCDS34142.1"
                     /db_xref="GeneID:26064"
                     /db_xref="HGNC:HGNC:14873"
                     /db_xref="MIM:606586"
                     /translation="MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGA
                     SATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECI
                     RKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAV
                     QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLG
                     YNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAP
                     PPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGAD
                     SLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQT
                     DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEA
                     ERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKL
                     GLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKG
                     TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS
                     DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE
                     KLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTL
                     RTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLES
                     EVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKF
                     QQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQ
                     SQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTM
                     CKNQSQKK"
     exon            233..363
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            364..452
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            453..517
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            518..575
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            576..646
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            647..753
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            754..932
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            933..961
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1048
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1135
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1190
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1309
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..2845
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2995
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3061
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..4986
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4965..4970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /note="hexamer: AATAAA"
     polyA_site      4986
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /note="major polyA site"
ORIGIN      
        1 actgaccccc gcagcggggg aggaggaggg actgcggcgc aggaagccga gcaggaagcg
       61 agcccggcgg ccgcgttttc ctggggaagc ggcgggcggg gtggagcagc cagctgggtc
      121 cggggagcgc cgccgccgcc tcgatggggt gttgaaaagt ctcctctaga gctttggaag
      181 gctgaatgca ctaaacatga agagcttgaa agcgaagttc aggaagagtg acaccaatga
      241 gtggaacaag aatgatgacc ggctactgca ggccgtggag aatggagatg cggagaaggt
      301 ggcctcactg ctcggcaaga agggggccag tgccaccaaa cacgacagtg agggcaagac
      361 cgctttccat cttgctgctg caaaaggaca cgtggaatgc ctcagggtca tgattacaca
      421 tggtgtggat gtgacagccc aagatactac cggacacagc gccttacatc tcgcagccaa
      481 gaacagccac catgaatgca tcaggaagct gcttcagtct aaatgcccag ccgaaagtgt
      541 cgacagctct gggaaaacag ctttacatta tgcagcggct cagggctgcc ttcaagctgt
      601 gcagattctc tgcgaacaca agagccccat aaacctcaaa gatttggatg ggaatatacc
      661 gctgcttctt gctgtacaaa atggtcacag tgagatctgt cactttctcc tggatcatgg
      721 agcagatgtc aattccagga acaaaagtgg aagaactgct ctcatgctgg cctgtgagat
      781 tggcagctct aacgctgtgg aagccttaat taaaaagggt gcagacctaa accttgtaga
      841 ttctcttgga tacaatgcct tacattattc caaactctca gaaaatgcag gaattcaaag
      901 ccttctatta tcaaaaatct ctcaggatgc tgatttaaag accccaacaa aaccaaagca
      961 gcatgaccaa gtctctaaaa taagctcaga aagaagtgga actccaaaaa aacgcaaagc
     1021 tccaccacct cctatcagtc ctacccagtt gagtgatgtc tcttccccaa gatcaataac
     1081 ttcgactcca ctatcgggaa aggaatcggt attttttgct gaaccaccct tcaaggctga
     1141 gatcagttct atacgagaaa acaaagacag actaagtgac agtactacag gtgctgatag
     1201 cttattggat ataagttctg aagctgacca acaagatctt ctctctctat tgcaagcaaa
     1261 agttgcttcc cttaccttac acaataagga gttacaagat aaattacagg ccaaatcacc
     1321 caaggaggcg gaagcagacc taagctttga ctcataccat tccacccaaa ctgacttggg
     1381 cccatccctg ggaaaacctg gtgaaacctc tcccccagac tccaaatcat ctccatctgt
     1441 cttaatacat tctttaggta aatccactac tgacaatgat gtcagaattc agcaactgca
     1501 agagattttg caagatctac agaagagatt agagagctct gaagcagaga gaaaacagct
     1561 acaggtcgaa ctccaatccc gaagggcaga actggtatgc ttaaacaaca ctgagatttc
     1621 agagaacagc tctgacctca gccagaaact taaagaaact cagagcaaat acgaggaggc
     1681 tatgaaagaa gtccttagtg tgcagaagca gatgaaactc ggtcttgtct cacctgaaag
     1741 catggataat tattcacatt tccacgagct gagggtcacg gaagaggaaa taaatgtgct
     1801 aaagcaggat ctgcagaatg cattagaaga aagtgaaaga aataaagaga aagtgagaga
     1861 gttagaggaa aaactggtag agagggagaa aggtacagtg attaagccac ctgtggaaga
     1921 gtacgaggaa atgaaaagtt catattgctc tgttattgag aatatgaata aggagaaagc
     1981 atttttgttt gagaaatacc aagaagccca agaagaaatc atgaaattaa aagacacact
     2041 aaaaagtcag atgacacagg aagccagtga tgaagctgag gacatgaaag aagccatgaa
     2101 taggatgata gatgaactca ataaacaggt gagcgagctg tcacagctgt acaaagaagc
     2161 ccaggctgag ctggaggatt acaggaagag gaaatctcta gaggatgtca cagctgaata
     2221 tatccataaa gcagagcatg agaaactgat gcaattgaca aacgtgtcca gggctaaagc
     2281 agaagatgca ctgtctgaaa tgaagtctca gtattcaaaa gtgttgaatg agttgaccca
     2341 gctcaaacaa ctggtggatg cacaaaaaga gaactctgtc tctatcacag aacatttgca
     2401 agtgataacc acgctgcgga ctgcagcaaa agagatggaa gaaaaaataa gcaatcttaa
     2461 ggaacacctt gcaagcaagg aagtggaagt agcaaagctg gagaaacaac tcttagaaga
     2521 gaaagctgct atgactgatg caatggtacc tcggtcttcc tatgaaaaac tccagtcatc
     2581 cttagagagt gaagtgagtg tgttggcatc gaaattaaag gaatctgtga aagagaaaga
     2641 gaaggtccat tcagaggttg tccagattag aagtgaggtc tcacaggtga aaagagaaaa
     2701 ggaaaatatt cagactctct tgaaatccaa agagcaagaa gtaaatgaac ttctgcaaaa
     2761 attccagcaa gctcaggaag aacttgcaga aatgaaaaga tacgctgaga gctcttcaaa
     2821 actggaggaa gataaagata aaaagataaa tgagatgtcg aaggaagtca ccaaattgaa
     2881 ggaggccttg aacagcctct cccagctctc ctactcaaca agctcatcca aaaggcagag
     2941 tcagcagctg gaggcgctgc agcagcaagt caaacagctc cagaaccagc tggcggaatg
     3001 caagaaacaa caccaggagg tcatatcagt ttacagaatg catcttctgt atgctgtgca
     3061 gggccagatg gatgaagatg tccagaaagt actgaagcaa atccttacca tgtgtaaaaa
     3121 ccagtctcaa aagaagtaaa gtggattcct tggcaggaca ctgccccttg tcatctgtct
     3181 ttgtgttaga tccagagttg tcggcagccg ctgccattgt tctcattcgt ggtatgcact
     3241 gtggcctagc gtagcttctt ccctttccaa aggtttctga ggacttctcc caggagaaga
     3301 ctgcccgcct cagaactgct tagagacttc aaaccagcag aggtgaaagt ccctgtcatc
     3361 ccttcagatt ccagagctgg gatcagccat gcccagaggt ctggtcctga tgctggcagg
     3421 ggggccccct cctccatccc tgactggctg agtggcttta tcaccaccga gtgatgtgct
     3481 gaggcctcct gcagtgaatg ctccttccat tcctgtactc gggcagtgcc attcagcaca
     3541 ggagagctct ttttgccttt ggctttcaat tccaaaacat gatttaattt ctaactaaat
     3601 tagtatggca ctagttatga agtatctgct taaaaccctt catcatgata tcctgtggat
     3661 ttaaaaactc taattccatg ttttcttccc atctgcctta tatatctcat caccctgctt
     3721 atcaatattc agtttgatga gcactattaa ctaaaatatg aaacttaaaa acaaaagcaa
     3781 gttgtcctta aaagttcttt ttttaagtaa attgttgaca tactgcaaat tttctatgca
     3841 aacttgcctc ctgctgttat ctgtgaagct caggaaatcc aaacatttgt gtttcaacaa
     3901 gggacagtaa actgtgtgtt tacagccaaa agaaatgcct catagttctt aacctcaact
     3961 tttgtagaag tatttttttc tctgtaatat ttttattggc tcataaagat gttttcatat
     4021 ctgaactcct aaataagtga aattacagta gattatatta acaaaatact ttttaggtag
     4081 ccatgcttga gactttttaa aaatataact ttttccttaa agttttcagc tatagcaaaa
     4141 ggtagttatg tatgccagac ctaatatgag ctgccaccaa cacccctaga actttcagcc
     4201 atggtgtctt cagaattgta gcgcatttct gaatctagca aatcctcctt ttacccgttg
     4261 aatgttttga atgccctgac tctaccagcg cccataaatg atctctagaa ggactgttag
     4321 taccaatctg tttttcaact ttgaagctaa aaaccctgat atggtaatat tatggtgcat
     4381 agcagaggtc tcggaaaaaa aatatttctg ttcactttac tttcaggtta aaaatgtttc
     4441 taacacgctt gcaacttccc ttatggcatt aatcttgttg agggagagag acagaatcct
     4501 ggactctcca aagtatttaa ctgaaagtag ggcctgctct gacagggccc atgtcccaca
     4561 aggctgcttg gcctcagtgg gtgcttggct gtgctggatg atatgttgat ctgtattgga
     4621 taaggaccaa tgacagcaaa gcaaaaatgg ctttaaagct tggtgttact tttcttaagt
     4681 tgtttaatta tagttaagca atttcaaaaa tgctccaaag aaatgtgaaa ggaccttttg
     4741 tcacagcact tcagaaaata cacaacagcc ccttctgccc ccgcacagaa atgctgcaga
     4801 gtatataaaa cttgagacat ttttgtagga tgcctgacga ggtgtagcct tttatcttgt
     4861 ttccggatgc atatttatta cgagtactct ggttaaatat tgaaaagtta tatgctgtag
     4921 tttttagtat tttgtctttg taatttacag aagttattgg agaaaataaa cttgtttcat
     4981 tttgca
//
