LOCUS       NM_001145520            5068 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens retinoic acid induced 14 (RAI14), transcript variant
            2, mRNA.
ACCESSION   NM_001145520
VERSION     NM_001145520.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5068)
  AUTHORS   Jeong,W., Kwon,H., Park,S.K., Lee,I.S. and Jho,E.H.
  TITLE     Retinoic acid-induced protein 14 links mechanical forces to Hippo
            signaling
  JOURNAL   EMBO Rep 25 (9), 4033-4061 (2024)
   PUBMED   39160347
  REMARK    GeneRIF: Retinoic acid-induced protein 14 links mechanical forces
            to Hippo signaling.
REFERENCE   2  (bases 1 to 5068)
  AUTHORS   Cui,R., Zou,J., Zhao,Y., Zhao,T., Ren,L. and Li,Y.
  TITLE     The dual-crosslinked prospective values of RAI14 for the diagnosis
            and chemosurveillance in triple negative breast cancer
  JOURNAL   Ann Med 55 (1), 820-836 (2023)
   PUBMED   36880986
  REMARK    GeneRIF: The dual-crosslinked prospective values of RAI14 for the
            diagnosis and chemosurveillance in triple negative breast cancer.
REFERENCE   3  (bases 1 to 5068)
  AUTHORS   Zhang,R., Hu,M., Chen,H.N., Wang,X., Xia,Z., Liu,Y., Wang,R.,
            Xia,X., Shu,Y., Du,D., Meng,W., Qi,S., Li,Y., Xu,H., Zhou,Z.G. and
            Dai,L.
  TITLE     Phenotypic Heterogeneity Analysis of APC-Mutant Colon Cancer by
            Proteomics and Phosphoproteomics Identifies RAI14 as a Key
            Prognostic Determinant in East Asians and Westerners
  JOURNAL   Mol Cell Proteomics 22 (5), 100532 (2023)
   PUBMED   36934880
  REMARK    GeneRIF: Phenotypic Heterogeneity Analysis of APC-Mutant Colon
            Cancer by Proteomics and Phosphoproteomics Identifies RAI14 as a
            Key Prognostic Determinant in East Asians and Westerners.
REFERENCE   4  (bases 1 to 5068)
  AUTHORS   Yang,Q., Yan,D., Zou,C., Xue,Q., Lin,S., Huang,Q., Li,X., Tang,D.,
            Chen,X. and Liu,J.
  TITLE     The deubiquitinating enzyme STAMBP is a newly discovered driver of
            triple-negative breast cancer progression that maintains RAI14
            protein stability
  JOURNAL   Exp Mol Med 54 (11), 2047-2059 (2022)
   PUBMED   36434041
  REMARK    GeneRIF: The deubiquitinating enzyme STAMBP is a newly discovered
            driver of triple-negative breast cancer progression that maintains
            RAI14 protein stability.
REFERENCE   5  (bases 1 to 5068)
  AUTHORS   Arnett,D.K., Li,N., Tang,W., Rao,D.C., Devereux,R.B., Claas,S.A.,
            Kraemer,R. and Broeckel,U.
  TITLE     Genome-wide association study identifies single-nucleotide
            polymorphism in KCNB1 associated with left ventricular mass in
            humans: the HyperGEN Study
  JOURNAL   BMC Med Genet 10, 43 (2009)
   PUBMED   19454037
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5068)
  AUTHORS   Kutty,R.K., Chen,S., Samuel,W., Vijayasarathy,C., Duncan,T.,
            Tsai,J.Y., Fariss,R.N., Carper,D., Jaworski,C. and Wiggert,B.
  TITLE     Cell density-dependent nuclear/cytoplasmic localization of NORPEG
            (RAI14) protein
  JOURNAL   Biochem Biophys Res Commun 345 (4), 1333-1341 (2006)
   PUBMED   16729964
  REMARK    GeneRIF: Subcellular localization of NORPEG in retinal pigment
            epithelial (ARPE-19) cells varies with cell density, with
            predominantly nuclear localization in nonconfluent cells, but a
            cytoplasmic localization in confluent cultures.
REFERENCE   7  (bases 1 to 5068)
  AUTHORS   Yuan,W., Zheng,Y., Huo,R., Lu,L., Huang,X.Y., Yin,L.L., Li,J.M.,
            Zhou,Z.M. and Sha,J.H.
  TITLE     Expression of a novel alternative transcript of the novel retinal
            pigment epithelial cell gene NORPEG in human testes
  JOURNAL   Asian J Androl 7 (3), 277-288 (2005)
   PUBMED   16110356
REFERENCE   8  (bases 1 to 5068)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   9  (bases 1 to 5068)
  AUTHORS   Kutty,R.K., Kutty,G., Samuel,W., Duncan,T., Bridges,C.C.,
            El-Sherbeeny,A., Nagineni,C.N., Smith,S.B. and Wiggert,B.
  TITLE     Molecular characterization and developmental expression of NORPEG,
            a novel gene induced by retinoic acid
  JOURNAL   J Biol Chem 276 (4), 2831-2840 (2001)
   PUBMED   11042181
REFERENCE   10 (bases 1 to 5068)
  AUTHORS   Peng,Y.F., Mandai,K., Sakisaka,T., Okabe,N., Yamamoto,Y.,
            Yokoyama,S., Mizoguchi,A., Shiozaki,H., Monden,M. and Takai,Y.
  TITLE     Ankycorbin: a novel actin cytoskeleton-associated protein
  JOURNAL   Genes Cells 5 (12), 1001-1008 (2000)
   PUBMED   11168586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB037755.1, AY317139.1 and AF155135.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-3 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-598               AB037755.1         1-598
            599-3220            AY317139.1         846-3467
            3221-5068           AF155135.1         3078-4925
FEATURES             Location/Qualifiers
     source          1..5068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..5068
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /note="retinoic acid induced 14"
                     /db_xref="GeneID:26064"
                     /db_xref="HGNC:HGNC:14873"
                     /db_xref="MIM:606586"
     exon            1..206
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            207..290
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..3197
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /note="isoform a is encoded by transcript variant 2; novel
                     retinal pigment epithelial cell protein; ankycorbin;
                     ankyrin repeat and coiled-coil structure-containing
                     protein; retinoic acid-induced protein 14"
                     /codon_start=1
                     /product="ankycorbin isoform a"
                     /protein_id="NP_001138992.1"
                     /db_xref="CCDS:CCDS34142.1"
                     /db_xref="GeneID:26064"
                     /db_xref="HGNC:HGNC:14873"
                     /db_xref="MIM:606586"
                     /translation="MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGA
                     SATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECI
                     RKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAV
                     QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLG
                     YNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAP
                     PPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGAD
                     SLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQT
                     DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEA
                     ERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKL
                     GLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKG
                     TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS
                     DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE
                     KLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTL
                     RTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLES
                     EVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKF
                     QQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQ
                     SQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTM
                     CKNQSQKK"
     exon            291..421
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            422..510
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            511..575
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            576..633
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            634..704
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            705..811
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            812..990
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1019
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1106
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1193
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1248
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1367
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..2903
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3053
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3119
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..5044
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5023..5028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /note="hexamer: AATAAA"
     polyA_site      5044
                     /gene="RAI14"
                     /gene_synonym="NORPEG; RAI13"
                     /note="major polyA site"
ORIGIN      
        1 ggagttggga ggctcccggc gcggggtccc gggctcgtgt ccccgccttt gtgtctggag
       61 ctcgggcgcg ggaggcgctg gggacggcgc ccgggcggag cggctgagcg ggctgcagcc
      121 ggggtcccgc cacctctccc tggtccaccg ccggcagccc actgtctgcg gagagcagat
      181 ctggggacaa gaggaaggag aggaaggtgt tgaaaagtct cctctagagc tttggaaggc
      241 tgaatgcact aaacatgaag agcttgaaag cgaagttcag gaagagtgac accaatgagt
      301 ggaacaagaa tgatgaccgg ctactgcagg ccgtggagaa tggagatgcg gagaaggtgg
      361 cctcactgct cggcaagaag ggggccagtg ccaccaaaca cgacagtgag ggcaagaccg
      421 ctttccatct tgctgctgca aaaggacacg tggaatgcct cagggtcatg attacacatg
      481 gtgtggatgt gacagcccaa gatactaccg gacacagcgc cttacatctc gcagccaaga
      541 acagccacca tgaatgcatc aggaagctgc ttcagtctaa atgcccagcc gaaagtgtcg
      601 acagctctgg gaaaacagct ttacattatg cagcggctca gggctgcctt caagctgtgc
      661 agattctctg cgaacacaag agccccataa acctcaaaga tttggatggg aatataccgc
      721 tgcttcttgc tgtacaaaat ggtcacagtg agatctgtca ctttctcctg gatcatggag
      781 cagatgtcaa ttccaggaac aaaagtggaa gaactgctct catgctggcc tgtgagattg
      841 gcagctctaa cgctgtggaa gccttaatta aaaagggtgc agacctaaac cttgtagatt
      901 ctcttggata caatgcctta cattattcca aactctcaga aaatgcagga attcaaagcc
      961 ttctattatc aaaaatctct caggatgctg atttaaagac cccaacaaaa ccaaagcagc
     1021 atgaccaagt ctctaaaata agctcagaaa gaagtggaac tccaaaaaaa cgcaaagctc
     1081 caccacctcc tatcagtcct acccagttga gtgatgtctc ttccccaaga tcaataactt
     1141 cgactccact atcgggaaag gaatcggtat tttttgctga accacccttc aaggctgaga
     1201 tcagttctat acgagaaaac aaagacagac taagtgacag tactacaggt gctgatagct
     1261 tattggatat aagttctgaa gctgaccaac aagatcttct ctctctattg caagcaaaag
     1321 ttgcttccct taccttacac aataaggagt tacaagataa attacaggcc aaatcaccca
     1381 aggaggcgga agcagaccta agctttgact cataccattc cacccaaact gacttgggcc
     1441 catccctggg aaaacctggt gaaacctctc ccccagactc caaatcatct ccatctgtct
     1501 taatacattc tttaggtaaa tccactactg acaatgatgt cagaattcag caactgcaag
     1561 agattttgca agatctacag aagagattag agagctctga agcagagaga aaacagctac
     1621 aggtcgaact ccaatcccga agggcagaac tggtatgctt aaacaacact gagatttcag
     1681 agaacagctc tgacctcagc cagaaactta aagaaactca gagcaaatac gaggaggcta
     1741 tgaaagaagt ccttagtgtg cagaagcaga tgaaactcgg tcttgtctca cctgaaagca
     1801 tggataatta ttcacatttc cacgagctga gggtcacgga agaggaaata aatgtgctaa
     1861 agcaggatct gcagaatgca ttagaagaaa gtgaaagaaa taaagagaaa gtgagagagt
     1921 tagaggaaaa actggtagag agggagaaag gtacagtgat taagccacct gtggaagagt
     1981 acgaggaaat gaaaagttca tattgctctg ttattgagaa tatgaataag gagaaagcat
     2041 ttttgtttga gaaataccaa gaagcccaag aagaaatcat gaaattaaaa gacacactaa
     2101 aaagtcagat gacacaggaa gccagtgatg aagctgagga catgaaagaa gccatgaata
     2161 ggatgataga tgaactcaat aaacaggtga gcgagctgtc acagctgtac aaagaagccc
     2221 aggctgagct ggaggattac aggaagagga aatctctaga ggatgtcaca gctgaatata
     2281 tccataaagc agagcatgag aaactgatgc aattgacaaa cgtgtccagg gctaaagcag
     2341 aagatgcact gtctgaaatg aagtctcagt attcaaaagt gttgaatgag ttgacccagc
     2401 tcaaacaact ggtggatgca caaaaagaga actctgtctc tatcacagaa catttgcaag
     2461 tgataaccac gctgcggact gcagcaaaag agatggaaga aaaaataagc aatcttaagg
     2521 aacaccttgc aagcaaggaa gtggaagtag caaagctgga gaaacaactc ttagaagaga
     2581 aagctgctat gactgatgca atggtacctc ggtcttccta tgaaaaactc cagtcatcct
     2641 tagagagtga agtgagtgtg ttggcatcga aattaaagga atctgtgaaa gagaaagaga
     2701 aggtccattc agaggttgtc cagattagaa gtgaggtctc acaggtgaaa agagaaaagg
     2761 aaaatattca gactctcttg aaatccaaag agcaagaagt aaatgaactt ctgcaaaaat
     2821 tccagcaagc tcaggaagaa cttgcagaaa tgaaaagata cgctgagagc tcttcaaaac
     2881 tggaggaaga taaagataaa aagataaatg agatgtcgaa ggaagtcacc aaattgaagg
     2941 aggccttgaa cagcctctcc cagctctcct actcaacaag ctcatccaaa aggcagagtc
     3001 agcagctgga ggcgctgcag cagcaagtca aacagctcca gaaccagctg gcggaatgca
     3061 agaaacaaca ccaggaggtc atatcagttt acagaatgca tcttctgtat gctgtgcagg
     3121 gccagatgga tgaagatgtc cagaaagtac tgaagcaaat ccttaccatg tgtaaaaacc
     3181 agtctcaaaa gaagtaaagt ggattccttg gcaggacact gccccttgtc atctgtcttt
     3241 gtgttagatc cagagttgtc ggcagccgct gccattgttc tcattcgtgg tatgcactgt
     3301 ggcctagcgt agcttcttcc ctttccaaag gtttctgagg acttctccca ggagaagact
     3361 gcccgcctca gaactgctta gagacttcaa accagcagag gtgaaagtcc ctgtcatccc
     3421 ttcagattcc agagctggga tcagccatgc ccagaggtct ggtcctgatg ctggcagggg
     3481 ggccccctcc tccatccctg actggctgag tggctttatc accaccgagt gatgtgctga
     3541 ggcctcctgc agtgaatgct ccttccattc ctgtactcgg gcagtgccat tcagcacagg
     3601 agagctcttt ttgcctttgg ctttcaattc caaaacatga tttaatttct aactaaatta
     3661 gtatggcact agttatgaag tatctgctta aaacccttca tcatgatatc ctgtggattt
     3721 aaaaactcta attccatgtt ttcttcccat ctgccttata tatctcatca ccctgcttat
     3781 caatattcag tttgatgagc actattaact aaaatatgaa acttaaaaac aaaagcaagt
     3841 tgtccttaaa agttcttttt ttaagtaaat tgttgacata ctgcaaattt tctatgcaaa
     3901 cttgcctcct gctgttatct gtgaagctca ggaaatccaa acatttgtgt ttcaacaagg
     3961 gacagtaaac tgtgtgttta cagccaaaag aaatgcctca tagttcttaa cctcaacttt
     4021 tgtagaagta tttttttctc tgtaatattt ttattggctc ataaagatgt tttcatatct
     4081 gaactcctaa ataagtgaaa ttacagtaga ttatattaac aaaatacttt ttaggtagcc
     4141 atgcttgaga ctttttaaaa atataacttt ttccttaaag ttttcagcta tagcaaaagg
     4201 tagttatgta tgccagacct aatatgagct gccaccaaca cccctagaac tttcagccat
     4261 ggtgtcttca gaattgtagc gcatttctga atctagcaaa tcctcctttt acccgttgaa
     4321 tgttttgaat gccctgactc taccagcgcc cataaatgat ctctagaagg actgttagta
     4381 ccaatctgtt tttcaacttt gaagctaaaa accctgatat ggtaatatta tggtgcatag
     4441 cagaggtctc ggaaaaaaaa tatttctgtt cactttactt tcaggttaaa aatgtttcta
     4501 acacgcttgc aacttccctt atggcattaa tcttgttgag ggagagagac agaatcctgg
     4561 actctccaaa gtatttaact gaaagtaggg cctgctctga cagggcccat gtcccacaag
     4621 gctgcttggc ctcagtgggt gcttggctgt gctggatgat atgttgatct gtattggata
     4681 aggaccaatg acagcaaagc aaaaatggct ttaaagcttg gtgttacttt tcttaagttg
     4741 tttaattata gttaagcaat ttcaaaaatg ctccaaagaa atgtgaaagg accttttgtc
     4801 acagcacttc agaaaataca caacagcccc ttctgccccc gcacagaaat gctgcagagt
     4861 atataaaact tgagacattt ttgtaggatg cctgacgagg tgtagccttt tatcttgttt
     4921 ccggatgcat atttattacg agtactctgg ttaaatattg aaaagttata tgctgtagtt
     4981 tttagtattt tgtctttgta atttacagaa gttattggag aaaataaact tgtttcattt
     5041 tgcaaaaaaa aaaaaaaaaa aaaaaaaa
//
