LOCUS       NM_030665               7677 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens retinoic acid induced 1 (RAI1), mRNA.
ACCESSION   NM_030665
VERSION     NM_030665.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7677)
  AUTHORS   Brennan,C. and Baiduc,R.R.
  TITLE     Overlapping hearing and communication profiles for the deletion and
            the RAI1 variant form of Smith-Magenis Syndrome (SMS)
  JOURNAL   J Commun Disord 111, 106455 (2024)
   PUBMED   39213791
  REMARK    GeneRIF: Overlapping hearing and communication profiles for the
            deletion and the RAI1 variant form of Smith-Magenis Syndrome (SMS).
REFERENCE   2  (bases 1 to 7677)
  AUTHORS   Yuan,X., Chen,L. and Saffen,D.
  TITLE     Allele-Specific Regulation of the Candidate Autism Liability Gene
            RAI1 by the Enhancer Variant rs4925102 (C/G)
  JOURNAL   Genes (Basel) 15 (4), 460 (2024)
   PUBMED   38674394
  REMARK    GeneRIF: Allele-Specific Regulation of the Candidate Autism
            Liability Gene RAI1 by the Enhancer Variant rs4925102 (C/G).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7677)
  AUTHORS   Yeetong,P., Dembele,M.E., Pongpanich,M., Cisse,L., Srichomthong,C.,
            Maiga,A.B., Dembele,K., Assawapitaksakul,A., Bamba,S., Yalcouye,A.,
            Diarra,S., Mefoung,S.E., Rakwongkhachon,S., Traore,O.,
            Tongkobpetch,S., Fischbeck,K.H., Gahl,W.A., Guinto,C.O.,
            Shotelersuk,V. and Landoure,G.
  TITLE     Pentanucleotide Repeat Insertions in RAI1 Cause Benign Adult
            Familial Myoclonic Epilepsy Type 8
  JOURNAL   Mov Disord 39 (1), 164-172 (2024)
   PUBMED   37994247
  REMARK    GeneRIF: Pentanucleotide Repeat Insertions in RAI1 Cause Benign
            Adult Familial Myoclonic Epilepsy Type 8.
REFERENCE   4  (bases 1 to 7677)
  AUTHORS   Linders,C.C., van Eeghen,A.M., Zinkstok,J.R., van den Boogaard,M.J.
            and Boot,E.
  TITLE     Intellectual and Behavioral Phenotypes of Smith-Magenis Syndrome:
            Comparisons between Individuals with a 17p11.2 Deletion and
            Pathogenic RAI1 Variant
  JOURNAL   Genes (Basel) 14 (8), 1514 (2023)
   PUBMED   37628566
  REMARK    GeneRIF: Intellectual and Behavioral Phenotypes of Smith-Magenis
            Syndrome: Comparisons between Individuals with a 17p11.2 Deletion
            and Pathogenic RAI1 Variant.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7677)
  AUTHORS   Slager,R.E., Newton,T.L., Vlangos,C.N., Finucane,B. and Elsea,S.H.
  TITLE     Mutations in RAI1 associated with Smith-Magenis syndrome
  JOURNAL   Nat Genet 33 (4), 466-468 (2003)
   PUBMED   12652298
  REMARK    GeneRIF: RAI1 may play a role in regulating behavior, as dominant
            frameshift mutations in RAI1 have been found in individuals with
            Smith-Magenis syndrome
REFERENCE   6  (bases 1 to 7677)
  AUTHORS   Bi,W., Yan,J., Stankiewicz,P., Park,S.S., Walz,K., Boerkoel,C.F.,
            Potocki,L., Shaffer,L.G., Devriendt,K., Nowaczyk,M.J., Inoue,K. and
            Lupski,J.R.
  TITLE     Genes in a refined Smith-Magenis syndrome critical deletion
            interval on chromosome 17p11.2 and the syntenic region of the mouse
  JOURNAL   Genome Res 12 (5), 713-728 (2002)
   PUBMED   11997338
REFERENCE   7  (bases 1 to 7677)
  AUTHORS   Seranski,P., Hoff,C., Radelof,U., Hennig,S., Reinhardt,R.,
            Schwartz,C.E., Heiss,N.S. and Poustka,A.
  TITLE     RAI1 is a novel polyglutamine encoding gene that is deleted in
            Smith-Magenis syndrome patients
  JOURNAL   Gene 270 (1-2), 69-76 (2001)
   PUBMED   11404004
REFERENCE   8  (bases 1 to 7677)
  AUTHORS   Seranski,P., Heiss,N.S., Dhorne-Pollet,S., Radelof,U., Korn,B.,
            Hennig,S., Backes,E., Schmidt,S., Wiemann,S., Schwarz,C.E.,
            Lehrach,H. and Poustka,A.
  TITLE     Transcription mapping in a medulloblastoma breakpoint interval and
            Smith-Magenis syndrome candidate region: identification of 53
            transcriptional units and new candidate genes
  JOURNAL   Genomics 56 (1), 1-11 (1999)
   PUBMED   10036180
REFERENCE   9  (bases 1 to 7677)
  AUTHORS   Potocki,L., Neira-Fresneda,J. and Yuan,B.
  TITLE     Potocki-Lupski Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28837307
REFERENCE   10 (bases 1 to 7677)
  AUTHORS   Smith,A.C.M., Boyd,K.E., Brennan,C., Charles,J., Elsea,S.H.,
            Finucane,B.M., Foster,R., Gropman,A., Girirajan,S. and
            Haas-Givler,B.
  TITLE     Smith-Magenis Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301487
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078903.11, AB058723.1,
            AY172136.1 and AL834468.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_030665.3.
            
            Summary: This gene is located within the Smith-Magenis syndrome
            region on chromosome 17. It is highly similar to its mouse
            counterpart and is expressed at high levels mainly in neuronal
            tissues. The protein encoded by this gene includes a polymorphic
            polyglutamine tract in the N-terminal domain. Expression of the
            mouse counterpart in neurons is induced by retinoic acid. This gene
            is associated with both the severity of the phenotype and the
            response to medication in schizophrenic patients. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY172136.1, SRR14038193.1141789.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353383.6/ ENSP00000323074.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC078903.11        70587-70601         c
            16-1803             AB058723.1         1-1788
            1804-4387           AY172136.1         1790-4373
            4388-6084           AL834468.1         2042-3738
            6085-7677           AY172136.1         6071-7663
FEATURES             Location/Qualifiers
     source          1..7677
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..7677
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /note="retinoic acid induced 1"
                     /db_xref="GeneID:10743"
                     /db_xref="HGNC:HGNC:9834"
                     /db_xref="MIM:607642"
     exon            1..336
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /inference="alignment:Splign:2.1.0"
     exon            337..468
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /inference="alignment:Splign:2.1.0"
     exon            469..6049
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..6205
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /note="Smith-Magenis syndrome chromosome region"
                     /codon_start=1
                     /product="retinoic acid-induced protein 1"
                     /protein_id="NP_109590.3"
                     /db_xref="CCDS:CCDS11188.1"
                     /db_xref="GeneID:10743"
                     /db_xref="HGNC:HGNC:9834"
                     /db_xref="MIM:607642"
                     /translation="MQSFRERCGFHGKQQNYQQTSQETSRLENYRQPSQAGLSCDRQR
                     LLAKDYYNPQPYPSYEGGAGTPSGTAAAVAADKYHRGSKALPTQQGLQGRPAFPGYGV
                     QDSSPYPGRYAGEESLQAWGAPQPPPPQPQPLPAGVAKYDENLMKKTAVPPSRQYAEQ
                     GAQVPFRTHSLHVQQPPPPQQPLAYPKLQRQKLQNDIASPLPFPQGTHFPQHSQSFPT
                     SSTYSSSVQGGGQGAHSYKSCTAPTAQPHDRPLTASSSLAPGQRVQNLHAYQSGRLSY
                     DQQQQQQQQQQQQQQALQSRHHAQETLHYQNLAKYQHYGQQGQGYCQPDAAVRTPEQY
                     YQTFSPSSSHSPARSVGRSPSYSSTPSPLMPNLENFPYSQQPLSTGAFPAGITDHSHF
                     MPLLNPSPTDATSSVDTQAGNCKPLQKDKLPENLLSDLSLQSLTALTSQVENISNTVQ
                     QLLLSKAAVPQKKGVKNLVSRTPEQHKSQHCSPEGSGYSAEPAGTPLSEPPSSTPQST
                     HAEPQEADYLSGSEDPLERSFLYCNQARGSPARVNSNSKAKPESVSTCSVTSPDDMST
                     KSDDSFQSLHGSLPLDSFSKFVAGERDCPRLLLSALAQEDLASEILGLQEAIGEKADK
                     AWAEAPSLVKDSSKPPFSLENHSACLDSVAKSAWPRPGEPEALPDSLQLDKGGNAKDF
                     SPGLFEDPSVAFATPDPKKTTGPLSFGTKPTLGVPAPDPTTAAFDCFPDTTAASSADS
                     ANPFAWPEENLGDACPRWGLHPGELTKGLEQGGKASDGISKGDTHEASACLGFQEEDP
                     PGEKVASLPGDFKQEEVGGVKEEAGGLLQCPEVAKADRWLEDSRHCCSTADFGDLPLL
                     PPTSRKEDLEAEEEYSSLCELLGSPEQRPGMQDPLSPKAPLICTKEEVEEVLDSKAGW
                     GSPCHLSGESVILLGPTVGTESKVQSWFESSLSHMKPGEEGPDGERAPGDSTTSDASL
                     AQKPNKPAVPEAPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRAPVLPKDLLLPESC
                     TGPPQGQMEGAGAPGRGASEGLPRMCTRSLTALSEPRTPGPPGLTTTPAPPDKLGGKQ
                     RAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKETDSPSTPGKDQRSMIL
                     RSRTKTQEIFHSKRRRPSEGRLPNCRATKKLLDNSHLPATFKVSSSPQKEGRVSQRAR
                     VPKPGAGSKLSDRPLHALKRKSAFMAPVPTKKRNLVLRSRSSSSSNASGNGGDGKEER
                     PEGSPTLFKRMSSPKKAKPTKGNGEPATKLPPPETPDACLKLASRAAFQGAMKTKVLP
                     PRKGRGLKLEAIVQKITSPSLKKFACKAPGASPGNPLSPSLSDKDRGLKGAGGSPVGV
                     EEGLVNVGTGQKLPTSGADPLCRNPTNRSLKGKLMNSKKLSSTDCFKTEAFTSPEALQ
                     PGGTALAPKKRSRKGRAGAHGLSKGPLEKRPYLGPALLLTPRDRASGTQGASEDNSGG
                     GGKKPKMEELGLASQPPEGRPCQPQTRAQKQPGHTNYSSYSKRKRLTRGRAKNTTSSP
                     CKGRAKRRRQQQVLPLDPAEPEIRLKYISSCKRLRSDSRTPAFSPFVRVEKRDAFTTI
                     CTVVNSPGDAPKPHRKPSSSASSSSSSSSFSLDAAGASLATLPGGSILQPRPSLPLSS
                     TMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKVRPE
                     GTCEEASLPLERTLKGPECAAAATAGKPPRPDGPADPAKQGPLRTSARGLSRRLQSCY
                     CCDGREDGGEEAAPADKGRKHECSKEAPAEPGGEAQEHWVHEACAVWTGGVYLVAGKL
                     FGLQEAMKVAVDMMCSSCQEAGATIGCCHKGCLHTYHYPCASDAGCIFIEENFSLKCP
                     KHKRLP"
     exon            6050..6143
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /inference="alignment:Splign:2.1.0"
     exon            6144..6193
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /inference="alignment:Splign:2.1.0"
     exon            6194..7677
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7649..7654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /note="hexamer: AATAAA"
     polyA_site      7677
                     /gene="RAI1"
                     /gene_synonym="SMCR; SMS"
                     /note="major polyA site"
ORIGIN      
        1 gcattcctcg cggcacccgc ggacaccagg caggcccggc cgggtgcgcg gccaaggccc
       61 gctccccgcg tccccgggcg ccgcccccgc ccgcggctgg gctccgagag acgagtggga
      121 gagcgagtgc agcgagggcg agaggcgagc cgagcaggcc gccctgcccg cggccctagc
      181 gccggcgcga ggagggggcg ccgcggccca ccctccttcc tgcctggccg cgggccggcc
      241 gggccgccgc gccccgaccc ccatggccac ccaggcctcc gggccgcgaa gtcgcagcgc
      301 cagacccaag gcccccgagt gagcgcgggc gccgaggatc tcatctggcc accgcgttct
      361 ggaagaggcg agagggagag cgtgcgcgag aggagagaga cggcggggga aagggagacg
      421 gcgagacgcg cagcgccggc gcccgggaga cccaggagga gcccgcagat aaccagcccg
      481 agtcatgcag tcttttcgag aaaggtgtgg tttccatggc aaacaacaga actaccagca
      541 gacctcgcag gaaacatcac gcctagagaa ttacaggcag ccgagtcagg ccgggctaag
      601 ctgcgaccgg cagcggctgc tcgccaagga ctattataac ccgcagcctt acccgagcta
      661 tgagggtggc gctggcacgc cctctggcac tgcagccgcg gtggccgccg acaagtacca
      721 ccgaggcagc aaggccctgc ccacacagca aggcctgcag gggaggccgg ctttccctgg
      781 ctacggcgtc caggacagca gcccctaccc aggccgctat gctggtgagg agagccttca
      841 ggcttggggg gccccacagc caccaccccc acagccgcag ccactacctg caggggtggc
      901 caagtatgat gagaacttga tgaaaaagac agcagtgccc cccagcaggc agtatgcaga
      961 gcagggcgcc caggtgccct ttcggactca ctccctgcac gtccagcagc caccgccgcc
     1021 ccagcagccc ctggcatacc ccaagctcca aaggcagaag ctgcagaacg acattgcctc
     1081 ccctctgccc ttcccccagg gtacccactt tcctcagcat tcccagtcct tccccacctc
     1141 ctccacctac tcctcctctg tccagggtgg tgggcagggg gcccactcct ataagagttg
     1201 cacagcaccg actgcccagc cccatgacag gccgctgact gccagctcca gcctggcccc
     1261 ggggcagcgg gtccagaatc ttcatgccta ccagtcgggc cgcctcagct atgaccagca
     1321 gcagcagcag cagcagcagc agcagcagca gcagcaagcc cttcagagcc ggcaccatgc
     1381 ccaggaaacc ctccattacc aaaacctcgc caagtatcag cactacgggc agcaaggcca
     1441 gggctactgc cagccggacg cagccgtccg gaccccagag cagtactacc agaccttcag
     1501 ccccagctcc agccactcac ccgcccgctc cgtgggccgc tcaccttcct acagttccac
     1561 accgtcgccg ctgatgccaa acctggagaa ctttccctac agccagcagc cgctcagcac
     1621 cggggccttc cccgcaggga tcactgacca cagccacttc atgcccctgc tcaatccctc
     1681 cccaacggat gccaccagct ctgtggacac ccaggctggc aactgcaagc cccttcagaa
     1741 ggacaagctc cctgagaacc tgctgtcgga tctcagcctg cagagcctca cggcgctgac
     1801 ctcacaggtg gagaacatct ccaacaccgt ccagcagctg ctgctctcca aggctgctgt
     1861 gccgcagaag aaaggtgtca agaacctcgt gtccaggacc ccagagcagc ataaaagcca
     1921 gcactgcagc cccgaaggga gcggctactc agccgagccc gcaggcacac cgctgtcaga
     1981 gccgccgagc agcacgccac agtccacgca tgcggagccg caggaggccg actacctgag
     2041 cggctccgag gacccactgg agcgcagctt cctctactgc aaccaggccc gtggcagccc
     2101 tgccagggtc aacagcaact cgaaggccaa gcccgagtcc gtgtccacct gttctgtgac
     2161 ctctcctgac gacatgtcca ccaaatctga cgactccttc cagagcctac acggcagtct
     2221 gccgctcgac agcttctcca agttcgtggc gggtgagcgg gactgtccgc ggctgctgct
     2281 cagcgccctg gcacaggagg acctggcctc cgagatcctg gggctgcagg aagccatcgg
     2341 tgagaaggcc gacaaagctt gggctgaagc acccagcctg gtcaaggaca gcagcaagcc
     2401 acccttctcg ctggagaacc acagcgcctg cctggactct gtggccaaga gtgcgtggcc
     2461 ccggcctggg gagccggagg ccctgcccga ctccttgcag ctggacaagg gcggcaatgc
     2521 caaggacttc agcccagggc tgtttgaaga cccttccgtg gccttcgcta cgcctgaccc
     2581 caaaaagaca actggtcctc tctcctttgg taccaagccc acccttgggg ttcctgctcc
     2641 agaccccact acagcagctt ttgactgttt cccggacaca accgctgcca gctcagcgga
     2701 cagcgccaac ccctttgcct ggccagagga aaacctgggg gatgcttgtc ccaggtgggg
     2761 attgcaccct ggcgagctta ccaagggcct ggagcagggt gggaaggcct cagatggcat
     2821 cagcaaaggg gacacccatg aggcttcggc ctgcctgggc ttccaggagg aggacccccc
     2881 tggggagaag gtggcctcgt tgcccgggga cttcaagcag gaggaggtgg gtggggtgaa
     2941 ggaggaggca ggtgggctgc tgcagtgccc cgaggtggcc aaggctgacc ggtggctgga
     3001 ggacagccgg cactgctgtt ccaccgccga cttcggggac ctcccactgc tgccacccac
     3061 cagcaggaag gaggacctgg aagctgagga ggagtactcc tccctatgtg agctcctggg
     3121 cagccccgag cagaggcctg gcatgcagga cccgctgtca cccaaggccc cactcatctg
     3181 caccaaggag gaggtggagg aggtgctgga ctccaaggcc ggctggggct ctccgtgcca
     3241 cctctcaggg gagtccgtca tcctgctggg ccctacagtg ggcaccgagt caaaggtcca
     3301 gagctggttt gagtcctctc tgtcacacat gaagccaggt gaagaggggc ctgatgggga
     3361 gcgagctcca ggggattcca ccacctcgga cgcctctctg gcccagaagc ccaacaagcc
     3421 tgctgtgccc gaggcgccca tcgcaaagaa agagcctgtg ccacggggca aaagcttacg
     3481 gagccgtcgg gtgcaccggg ggctgcccga ggccgaggac tccccatgca gggcaccagt
     3541 gctgcccaaa gacctcttgc tccctgaatc ctgcacaggg cccccccagg gacagatgga
     3601 aggggctgga gccccaggcc ggggggcctc ggaagggctc cccaggatgt gtactcgttc
     3661 tctcacggcc ctgagtgagc cccgcacgcc cggaccccca ggcctgacca ccacccctgc
     3721 acccccagac aaactggggg gcaagcagcg agccgccttc aagtcgggca agcgggtggg
     3781 gaagccctca cccaaggctg cctccagccc cagcaacccg gccgccctgc ctgtggcctc
     3841 cgacagcagc ccgatgggct ccaagaccaa ggagacagac tcacccagca cgcctggcaa
     3901 ggaccagcgc tccatgatcc ttcggtcacg caccaaaacc caggagatct tccactccaa
     3961 gcggcggagg ccctctgagg gccggctccc caactgccgt gccaccaaga agctcctcga
     4021 caacagccac ttgcccgcca cattcaaggt ctccagcagc ccccagaagg agggcagggt
     4081 gagccagcgg gcaagggtcc ccaaacctgg tgcaggcagc aagctctctg accggcccct
     4141 ccatgcgctc aaaaggaagt cggccttcat ggcgccggtc cccaccaaga agcggaacct
     4201 ggtcttgcgg agccgcagca gcagcagcag caacgccagt ggcaatgggg gagatgggaa
     4261 ggaggagagg cctgagggtt cccccaccct cttcaagagg atgtcttctc ccaagaaagc
     4321 caagcccacc aagggcaatg gcgagcctgc cacaaagctc ccacccccgg agacccccga
     4381 tgcctgcctc aagctcgcct ctcgggcagc cttccagggg gccatgaaga ccaaggtgct
     4441 gccaccccgg aagggccggg gcctgaagct ggaagccatc gtgcagaaga tcacctcgcc
     4501 cagcctcaag aagttcgcat gtaaagcgcc aggggcctct cctggtaatc ctctgagccc
     4561 atccctttcc gacaaagacc gtgggctcaa gggtgctggg ggcagcccag tgggggtgga
     4621 agaaggcctg gtaaatgtgg gcaccgggca gaagctccca acttctgggg ctgatccgtt
     4681 atgcagaaat ccaaccaaca gatccttaaa aggcaaactc atgaacagta agaaactgtc
     4741 ttctactgac tgtttcaaaa ccgaggcctt cacatccccg gaggccctgc agcctggggg
     4801 gactgccctg gcgcctaaga agaggagccg gaaaggccgg gcaggggccc atggactctc
     4861 caaaggcccg ctggagaagc ggccctatct tggcccggct ctgctcctga ctccccgaga
     4921 cagggccagt ggcacacaag gggccagtga ggacaactct ggtggaggag gcaagaagcc
     4981 aaagatggag gagctgggcc tggcctccca gcccccggag ggcaggccct gccagcccca
     5041 gacaagggca cagaaacagc caggccacac caactacagc agctattcca agcggaagcg
     5101 cctcactcgg ggccgggcca agaacaccac ctcttcaccc tgtaaggggc gtgccaagcg
     5161 acgacgacag cagcaggtgc tgcccctgga tcccgcagag cctgaaatcc gcctcaagta
     5221 catttcctct tgcaagcggc tgaggtcaga cagccggacc cccgccttct cacccttcgt
     5281 gcgggtggag aagcgagacg cgttcaccac catatgcact gttgtcaact cccctggaga
     5341 tgcgcccaag ccccacagga agccttcctc ctctgcctcc tcttcctcat cctcgtcctc
     5401 gttctccttg gatgcagccg gggcctccct ggccacactc cctggaggct ccatcctgca
     5461 gccgcggccc tccttgcccc tctcctccac gatgcacttg gggcctgtgg tttccaaggc
     5521 cctgagtacc tcttgccttg tttgctgcct ctgccaaaac ccggccaact tcaaggacct
     5581 tggggacctc tgtgggccct actaccctga acactgcctc cccaaaaaga agccaaaact
     5641 caaggagaag gtgcggccag aaggcacctg tgaggaggcc tcgctgccgc ttgagagaac
     5701 actcaaaggt cccgagtgtg cagctgccgc cactgccggg aagcccccca ggcctgacgg
     5761 cccagctgac ccggccaagc agggcccact gcgcaccagt gcccggggcc tgtcccggag
     5821 gctgcagagc tgctactgct gtgatggccg ggaggatggg ggcgaggagg cagccccagc
     5881 cgacaagggt cgcaaacatg agtgcagcaa ggaggctccg gcagagcccg gcggggaggc
     5941 ccaggagcac tgggtgcatg aggcctgtgc cgtgtggacc ggcggcgtct acctggtggc
     6001 cgggaagctc tttgggctgc aggaggccat gaaggtggcc gtggacatga tgtgttccag
     6061 ctgccaagaa gccggggcca ccattgggtg ctgccacaaa ggatgcctcc acacctacca
     6121 ctacccgtgt gccagcgatg caggttgcat attcatcgaa gagaactttt ctttgaaatg
     6181 tcccaaacat aagaggctgc cgtagtaatc caccccaacg gccggaggag ccgccggagc
     6241 ccgcctgccc gcccgccgcc gaaggagagg agccgcctgc gcagcccccg ggcctttgag
     6301 ctgctcccag cgctggtcca gagccgatcc ttgatccggg tcccggatcg tggatccggc
     6361 cgcctagggc tcagacttgc ggccccgggt tgggaggaaa acccgttccg gagccgcctg
     6421 ctcccggaac cggacggcac agggcgttct tgcccacccc aggggccagg cttgcggagg
     6481 gggagcccgc ggagcggcca gactccccgg ggcgctcagc ctccggcgag ggtgggagac
     6541 ggctttgtcc tggggacact ttccctctgg aatctcaaga cgacgtggca cacattccac
     6601 gtgggtgctg ccgccacccc agtcggtcgt ggcgtgcagc tgggagccct gggcttgggg
     6661 gtgggggtcg aaacagtact ggaagaggcg gagggcggct cctagctccg tggactaggc
     6721 gggggagaaa ggaagccttt ctgagagcgg gctaggccgg cactggagag gccggagcct
     6781 ttggaacaaa ccgtgcggaa cgcgtccagg ggccttcccg cccagccttt gccagatctc
     6841 tcgtgcggtt cgggcaaagc cggggtagac ctgggctatg ctcagttagg ggttgcggga
     6901 tccccgagtg tgggcgggac tgggacaccc tttggcctct gtttgtcccc tttccagtcc
     6961 tccaccccac ccctggagcc cagcctggga gcgcaaaacc caagaagcgg ccagaacgca
     7021 cctccggctc cggcggacgc gcgaccgttg tgcaccacca gggaccgccg cgcctactct
     7081 gcacgggagc agggacagcg ctagatttcg tgtacaaaac ctgtgtaccc ctctatatat
     7141 atgttacata gaatgtatat atgttgggaa catgctcgct tctcccgtgt gtcgccgccg
     7201 tgcgtcgtgc gcccgcaaca gagccccaac cgggcctttg ccgggtaagg ggctaccgcg
     7261 acgccacttg tccacgcagc caccaccggc ccgggccagt ccctgccagt ccgtccgcct
     7321 gtccgtccgt gtcctcagct ctgtccacgc ttcgataggc ctgacgcagc ccccagccca
     7381 gggccgccct agcaacttcc tgtacatatg actgtaaaat ggtaaacgtg tgtattatat
     7441 ctggcctcgt tatatagtgt atatatatgt atacatatac atatatataa tatatatgaa
     7501 gactgtaaat gttaagacga ctagtgttct tattagtata ttgcttcaca ctgaagattg
     7561 tgtgtatcga gctgtttcta aaagatgttt attttcctta agagtaaaaa acagtcattg
     7621 cattcagaaa aaaaaaaaaa aaaaagtcaa taaagataca acgattgttt tggaaaa
//
