LOCUS       XM_047448650            2981 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens Raf-1 proto-oncogene, serine/threonine
            kinase (RAF1), transcript variant X3, mRNA.
ACCESSION   XM_047448650
VERSION     XM_047448650.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2981
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..2981
                     /gene="RAF1"
                     /gene_synonym="c-Raf; CMD1NN; CRAF; NS5; Raf-1"
                     /note="Raf-1 proto-oncogene, serine/threonine kinase;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 102 ESTs, 1693 long SRA reads, 23
                     Proteins, and 98% coverage of the annotated genomic
                     feature by RNAseq alignments, including 23 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:5894"
                     /db_xref="HGNC:HGNC:9829"
                     /db_xref="MIM:164760"
     CDS             122..2068
                     /gene="RAF1"
                     /gene_synonym="c-Raf; CMD1NN; CRAF; NS5; Raf-1"
                     /codon_start=1
                     /product="RAF proto-oncogene serine/threonine-protein
                     kinase isoform X1"
                     /protein_id="XP_047304606.1"
                     /db_xref="GeneID:5894"
                     /db_xref="HGNC:HGNC:9829"
                     /db_xref="MIM:164760"
                     /translation="MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASD
                     DGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLL
                     HEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLL
                     NGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMR
                     ESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRM
                     IEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRG
                     QRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRN
                     EVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIAR
                     QTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS
                     VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYA
                     SPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS
                     LHRAAHTEDINACTLTTSPRLPVF"
ORIGIN      
        1 agaaatgggg tcttgctgtg ttgaccaggc tggtcttgaa ctcttggcct caagctgtcc
       61 tcccatctgg gcctcccaaa gtgctgggat tacaggttta agaattgttt aagctgcatc
      121 aatggagcac atacagggag cttggaagac gatcagcaat ggttttggat tcaaagatgc
      181 cgtgtttgat ggctccagct gcatctctcc tacaatagtt cagcagtttg gctatcagcg
      241 ccgggcatca gatgatggca aactcacaga tccttctaag acaagcaaca ctatccgtgt
      301 tttcttgccg aacaagcaaa gaacagtggt caatgtgcga aatggaatga gcttgcatga
      361 ctgccttatg aaagcactca aggtgagggg cctgcaacca gagtgctgtg cagtgttcag
      421 acttctccac gaacacaaag gtaaaaaagc acgcttagat tggaatactg atgctgcgtc
      481 tttgattgga gaagaacttc aagtagattt cctggatcat gttcccctca caacacacaa
      541 ctttgctcgg aagacgttcc tgaagcttgc cttctgtgac atctgtcaga aattcctgct
      601 caatggattt cgatgtcaga cttgtggcta caaatttcat gagcactgta gcaccaaagt
      661 acctactatg tgtgtggact ggagtaacat cagacaactc ttattgtttc caaattccac
      721 tattggtgat agtggagtcc cagcactacc ttctttgact atgcgtcgta tgcgagagtc
      781 tgtttccagg atgcctgtta gttctcagca cagatattct acacctcacg ccttcacctt
      841 taacacctcc agtccctcat ctgaaggttc cctctcccag aggcagaggt cgacatccac
      901 acctaatgtc cacatggtca gcaccaccct gcctgtggac agcaggatga ttgaggatgc
      961 aattcgaagt cacagcgaat cagcctcacc ttcagccctg tccagtagcc ccaacaatct
     1021 gagcccaaca ggctggtcac agccgaaaac ccccgtgcca gcacaaagag agcgggcacc
     1081 agtatctggg acccaggaga aaaacaaaat taggcctcgt ggacagagag attcaagcta
     1141 ttattgggaa atagaagcca gtgaagtgat gctgtccact cggattgggt caggctcttt
     1201 tggaactgtt tataagggta aatggcacgg agatgttgca gtaaagatcc taaaggttgt
     1261 cgacccaacc ccagagcaat tccaggcctt caggaatgag gtggctgttc tgcgcaaaac
     1321 acggcatgtg aacattctgc ttttcatggg gtacatgaca aaggacaacc tggcaattgt
     1381 gacccagtgg tgcgagggca gcagcctcta caaacacctg catgtccagg agaccaagtt
     1441 tcagatgttc cagctaattg acattgcccg gcagacggct cagggaatgg actatttgca
     1501 tgcaaagaac atcatccata gagacatgaa atccaacaat atatttctcc atgaaggctt
     1561 aacagtgaaa attggagatt ttggtttggc aacagtaaag tcacgctgga gtggttctca
     1621 gcaggttgaa caacctactg gctctgtcct ctggatggcc ccagaggtga tccgaatgca
     1681 ggataacaac ccattcagtt tccagtcgga tgtctactcc tatggcatcg tattgtatga
     1741 actgatgacg ggggagcttc cttattctca catcaacaac cgagatcaga tcatcttcat
     1801 ggtgggccga ggatatgcct ccccagatct tagtaagcta tataagaact gccccaaagc
     1861 aatgaagagg ctggtagctg actgtgtgaa gaaagtaaag gaagagaggc ctctttttcc
     1921 ccagatcctg tcttccattg agctgctcca acactctcta ccgaagatca accggagcgc
     1981 ttccgagcca tccttgcatc gggcagccca cactgaggat atcaatgctt gcacgctgac
     2041 cacgtccccg aggctgcctg tcttctagtt gactttgcac ctgtcttcag gctgccaggg
     2101 gaggaggaga agccagcagg caccactttt ctgctccctt tctccagagg cagaacacat
     2161 gttttcagag aagctgctgc taaggacctt ctagactgct cacagggcct taacttcatg
     2221 ttgccttctt ttctatccct ttgggccctg ggagaaggaa gccatttgca gtgctggtgt
     2281 gtcctgctcc ctccccacat tccccatgct caaggcccag ccttctgtag atgcgcaagt
     2341 ggatgttgat ggtagtacaa aaagcagggg cccagcccca gctgttggct acatgagtat
     2401 ttagaggaag taaggtagca ggcagtccag ccctgatgtg gagacacatg ggattttgga
     2461 aatcagcttc tggaggaatg catgtcacag gcgggacttt cttcagagag tggtgcagcg
     2521 ccagacattt tgcacataag gcaccaaaca gcccaggact gccgagactc tggccgcccg
     2581 aaggagcctg ctttggtact atggaacttt tcttagggga cacgtcctcc tttcacagct
     2641 tctaaggtgt ccagtgcatt gggatggttt tccaggcaag gcactcggcc aatccgcatc
     2701 tcagccctct cagggagcag tcttccatca tgctgaattt tgtcttccag gagctgcccc
     2761 tatggggcgg ggccgcaggg ccagccttgt ttctctaaca aacaaacaaa caaacagcct
     2821 tgtttctcta gtcacatcat gtgtatacaa ggaagccagg aatacaggtt ttcttgatga
     2881 tttgggtttt aattttgttt ttattgcacc tgacaaaata cagttatctg atggtccctc
     2941 aattatgtta ttttaataaa ataaattaaa tttaggtgta a
//
