LOCUS       XM_047448649            2958 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens Raf-1 proto-oncogene, serine/threonine
            kinase (RAF1), transcript variant X2, mRNA.
ACCESSION   XM_047448649
VERSION     XM_047448649.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..2958
                     /gene="RAF1"
                     /gene_synonym="c-Raf; CMD1NN; CRAF; NS5; Raf-1"
                     /note="Raf-1 proto-oncogene, serine/threonine kinase;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 102 ESTs, 1693 long SRA reads, 23
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 14 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:5894"
                     /db_xref="HGNC:HGNC:9829"
                     /db_xref="MIM:164760"
     CDS             99..2045
                     /gene="RAF1"
                     /gene_synonym="c-Raf; CMD1NN; CRAF; NS5; Raf-1"
                     /codon_start=1
                     /product="RAF proto-oncogene serine/threonine-protein
                     kinase isoform X1"
                     /protein_id="XP_047304605.1"
                     /db_xref="GeneID:5894"
                     /db_xref="HGNC:HGNC:9829"
                     /db_xref="MIM:164760"
                     /translation="MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASD
                     DGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLL
                     HEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLL
                     NGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMR
                     ESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRM
                     IEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRG
                     QRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRN
                     EVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIAR
                     QTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS
                     VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYA
                     SPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS
                     LHRAAHTEDINACTLTTSPRLPVF"
ORIGIN      
        1 agttttgctt ggggaggagt tgaggaagct tctacactcg aggagacttc tgagtcgagt
       61 tttgaaacac ctgtttaaga attgtttaag ctgcatcaat ggagcacata cagggagctt
      121 ggaagacgat cagcaatggt tttggattca aagatgccgt gtttgatggc tccagctgca
      181 tctctcctac aatagttcag cagtttggct atcagcgccg ggcatcagat gatggcaaac
      241 tcacagatcc ttctaagaca agcaacacta tccgtgtttt cttgccgaac aagcaaagaa
      301 cagtggtcaa tgtgcgaaat ggaatgagct tgcatgactg ccttatgaaa gcactcaagg
      361 tgaggggcct gcaaccagag tgctgtgcag tgttcagact tctccacgaa cacaaaggta
      421 aaaaagcacg cttagattgg aatactgatg ctgcgtcttt gattggagaa gaacttcaag
      481 tagatttcct ggatcatgtt cccctcacaa cacacaactt tgctcggaag acgttcctga
      541 agcttgcctt ctgtgacatc tgtcagaaat tcctgctcaa tggatttcga tgtcagactt
      601 gtggctacaa atttcatgag cactgtagca ccaaagtacc tactatgtgt gtggactgga
      661 gtaacatcag acaactctta ttgtttccaa attccactat tggtgatagt ggagtcccag
      721 cactaccttc tttgactatg cgtcgtatgc gagagtctgt ttccaggatg cctgttagtt
      781 ctcagcacag atattctaca cctcacgcct tcacctttaa cacctccagt ccctcatctg
      841 aaggttccct ctcccagagg cagaggtcga catccacacc taatgtccac atggtcagca
      901 ccaccctgcc tgtggacagc aggatgattg aggatgcaat tcgaagtcac agcgaatcag
      961 cctcaccttc agccctgtcc agtagcccca acaatctgag cccaacaggc tggtcacagc
     1021 cgaaaacccc cgtgccagca caaagagagc gggcaccagt atctgggacc caggagaaaa
     1081 acaaaattag gcctcgtgga cagagagatt caagctatta ttgggaaata gaagccagtg
     1141 aagtgatgct gtccactcgg attgggtcag gctcttttgg aactgtttat aagggtaaat
     1201 ggcacggaga tgttgcagta aagatcctaa aggttgtcga cccaacccca gagcaattcc
     1261 aggccttcag gaatgaggtg gctgttctgc gcaaaacacg gcatgtgaac attctgcttt
     1321 tcatggggta catgacaaag gacaacctgg caattgtgac ccagtggtgc gagggcagca
     1381 gcctctacaa acacctgcat gtccaggaga ccaagtttca gatgttccag ctaattgaca
     1441 ttgcccggca gacggctcag ggaatggact atttgcatgc aaagaacatc atccatagag
     1501 acatgaaatc caacaatata tttctccatg aaggcttaac agtgaaaatt ggagattttg
     1561 gtttggcaac agtaaagtca cgctggagtg gttctcagca ggttgaacaa cctactggct
     1621 ctgtcctctg gatggcccca gaggtgatcc gaatgcagga taacaaccca ttcagtttcc
     1681 agtcggatgt ctactcctat ggcatcgtat tgtatgaact gatgacgggg gagcttcctt
     1741 attctcacat caacaaccga gatcagatca tcttcatggt gggccgagga tatgcctccc
     1801 cagatcttag taagctatat aagaactgcc ccaaagcaat gaagaggctg gtagctgact
     1861 gtgtgaagaa agtaaaggaa gagaggcctc tttttcccca gatcctgtct tccattgagc
     1921 tgctccaaca ctctctaccg aagatcaacc ggagcgcttc cgagccatcc ttgcatcggg
     1981 cagcccacac tgaggatatc aatgcttgca cgctgaccac gtccccgagg ctgcctgtct
     2041 tctagttgac tttgcacctg tcttcaggct gccaggggag gaggagaagc cagcaggcac
     2101 cacttttctg ctccctttct ccagaggcag aacacatgtt ttcagagaag ctgctgctaa
     2161 ggaccttcta gactgctcac agggccttaa cttcatgttg ccttcttttc tatccctttg
     2221 ggccctggga gaaggaagcc atttgcagtg ctggtgtgtc ctgctccctc cccacattcc
     2281 ccatgctcaa ggcccagcct tctgtagatg cgcaagtgga tgttgatggt agtacaaaaa
     2341 gcaggggccc agccccagct gttggctaca tgagtattta gaggaagtaa ggtagcaggc
     2401 agtccagccc tgatgtggag acacatggga ttttggaaat cagcttctgg aggaatgcat
     2461 gtcacaggcg ggactttctt cagagagtgg tgcagcgcca gacattttgc acataaggca
     2521 ccaaacagcc caggactgcc gagactctgg ccgcccgaag gagcctgctt tggtactatg
     2581 gaacttttct taggggacac gtcctccttt cacagcttct aaggtgtcca gtgcattggg
     2641 atggttttcc aggcaaggca ctcggccaat ccgcatctca gccctctcag ggagcagtct
     2701 tccatcatgc tgaattttgt cttccaggag ctgcccctat ggggcggggc cgcagggcca
     2761 gccttgtttc tctaacaaac aaacaaacaa acagccttgt ttctctagtc acatcatgtg
     2821 tatacaagga agccaggaat acaggttttc ttgatgattt gggttttaat tttgttttta
     2881 ttgcacctga caaaatacag ttatctgatg gtccctcaat tatgttattt taataaaata
     2941 aattaaattt aggtgtaa
//
