LOCUS       NM_130900               1346 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens retinoic acid early transcript 1L (RAET1L), mRNA.
ACCESSION   NM_130900 XM_011535486
VERSION     NM_130900.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1346)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1346)
  AUTHORS   Soremekun,O.S. and Soliman,M.E.S.
  TITLE     From genomic variation to protein aberration: Mutational analysis
            of single nucleotide polymorphism present in ULBP6 gene and
            implication in immune response
  JOURNAL   Comput Biol Med 111, 103354 (2019)
   PUBMED   31302457
  REMARK    GeneRIF: From genomic variation to protein aberration: Mutational
            analysis of single nucleotide polymorphism present in ULBP6 gene
            and implication in immune response.
REFERENCE   3  (bases 1 to 1346)
  AUTHORS   Zuo,J., Willcox,C.R., Mohammed,F., Davey,M., Hunter,S., Khan,K.,
            Antoun,A., Katakia,P., Croudace,J., Inman,C., Parry,H., Briggs,D.,
            Malladi,R., Willcox,B.E. and Moss,P.
  TITLE     A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target
            cell killing by enhancing the stability of NKG2D ligand binding
  JOURNAL   Sci Signal 10 (481) (2017)
   PUBMED   28559451
  REMARK    GeneRIF: ULBP6 polymorphisms affect the strength of human
            lymphocyte responses to cellular stress signals and is increased in
            abundance in hematopoietic tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1346)
  AUTHORS   Wennerberg,E., Pfefferle,A., Ekblad,L., Yoshimoto,Y., Kremer,V.,
            Kaminskyy,V.O., Juhlin,C.C., Hoog,A., Bodin,I., Svjatoha,V.,
            Larsson,C., Zedenius,J., Wennerberg,J. and Lundqvist,A.
  TITLE     Human anaplastic thyroid carcinoma cells are sensitive to NK
            cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells
  JOURNAL   Clin Cancer Res 20 (22), 5733-5744 (2014)
   PUBMED   25212604
  REMARK    GeneRIF: Human anaplastic thyroid carcinoma cells are sensitive to
            NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.
REFERENCE   5  (bases 1 to 1346)
  AUTHORS   Antoun,A., Vekaria,D., Salama,R.A., Pratt,G., Jobson,S., Cook,M.,
            Briggs,D. and Moss,P.
  TITLE     The genotype of RAET1L (ULBP6), a ligand for human NKG2D (KLRK1),
            markedly influences the clinical outcome of allogeneic stem cell
            transplantation
  JOURNAL   Br J Haematol 159 (5), 589-598 (2012)
   PUBMED   23025544
  REMARK    GeneRIF: RAET1L may have an important influence on regulating the
            strength of the alloreactive immune response in hematologic
            maliganacies treated with allogeneic stem cell transplantation.
REFERENCE   6  (bases 1 to 1346)
  AUTHORS   Antoun,A., Jobson,S., Cook,M., O'Callaghan,C.A., Moss,P. and
            Briggs,D.C.
  TITLE     Single nucleotide polymorphism analysis of the NKG2D ligand cluster
            on the long arm of chromosome 6: Extensive polymorphisms and
            evidence of diversity between human populations
  JOURNAL   Hum Immunol 71 (6), 610-620 (2010)
   PUBMED   20219610
  REMARK    GeneRIF: genetic polymorphism among the ethnic groups
            GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1346)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1346)
  AUTHORS   Eagle,R.A., Traherne,J.A., Hair,J.R., Jafferji,I. and Trowsdale,J.
  TITLE     ULBP6/RAET1L is an additional human NKG2D ligand
  JOURNAL   Eur J Immunol 39 (11), 3207-3216 (2009)
   PUBMED   19658097
  REMARK    GeneRIF: Here, we show that a sixth gene, ULBP6/RAET1L, is a
            polymorphic locus that expresses a functional transcript
REFERENCE   9  (bases 1 to 1346)
  AUTHORS   Romphruk,A.V., Romphruk,A., Naruse,T.K., Raroengjai,S.,
            Puapairoj,C., Inoko,H. and Leelayuwat,C.
  TITLE     Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in
            northeastern Thais
  JOURNAL   Immunogenetics 61 (9), 611-617 (2009)
   PUBMED   19688209
  REMARK    GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1346)
  AUTHORS   Radosavljevic,M., Cuillerier,B., Wilson,M.J., Clement,O.,
            Wicker,S., Gilfillan,S., Beck,S., Trowsdale,J. and Bahram,S.
  TITLE     A cluster of ten novel MHC class I related genes on human
            chromosome 6q24.2-q25.3
  JOURNAL   Genomics 79 (1), 114-123 (2002)
   PUBMED   11827464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA442768.1, AY039682.1 and AL355497.14.
            
            On or before Apr 15, 2019 this sequence version replaced
            XM_011535486.2, NM_130900.2.
            
            Summary: RAET1L belongs to the RAET1 family of major
            histocompatibility complex (MHC) class I-related genes, which are
            located within a 180-kb cluster on chromosome 6q24.2-q25.3. The
            REAT1 genes encode glycoproteins that contain extracellular alpha-1
            and alpha-2 domains, but they lack the membrane proximal Ig-like
            alpha-3 domain. Most RAET1 glycoproteins are anchored to the
            membrane via glycosylphosphatidylinositol (GPI) linkage
            (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM,
            Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138509.52765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367341.6/ ENSP00000356310.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               DA442768.1         65-219
            156-314             AY039682.1         95-253
            315-315             AL355497.14        68189-68189         c
            316-802             AY039682.1         255-741
            803-824             AL355497.14        66222-66243         c
            825-1346            AL355497.14        64448-64969         c
FEATURES             Location/Qualifiers
     source          1..1346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..1346
                     /gene="RAET1L"
                     /gene_synonym="RAET1H; ULBP6"
                     /note="retinoic acid early transcript 1L"
                     /db_xref="GeneID:154064"
                     /db_xref="HGNC:HGNC:16798"
                     /db_xref="MIM:611047"
     exon            1..146
                     /gene="RAET1L"
                     /gene_synonym="RAET1H; ULBP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..802
                     /gene="RAET1L"
                     /gene_synonym="RAET1H; ULBP6"
                     /note="UL16 binding protein 6; retinoic acid early
                     transcript 1L protein; retinoic acid early transcript 1H"
                     /codon_start=1
                     /product="UL16-binding protein 6 precursor"
                     /protein_id="NP_570970.2"
                     /db_xref="CCDS:CCDS5224.1"
                     /db_xref="GeneID:154064"
                     /db_xref="HGNC:HGNC:16798"
                     /db_xref="MIM:611047"
                     /translation="MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFR
                     PGPRWCAVQGQVDEKTFLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILT
                     EQLLDIQLENYTPKEPLTLQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTT
                     VHPGARKMKEKWENDKDVAMSFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSG
                     TTQLRATATTLILCCLLIILPCFILPGI"
     exon            147..410
                     /gene="RAET1L"
                     /gene_synonym="RAET1H; ULBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            411..692
                     /gene="RAET1L"
                     /gene_synonym="RAET1H; ULBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            693..824
                     /gene="RAET1L"
                     /gene_synonym="RAET1H; ULBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1346
                     /gene="RAET1L"
                     /gene_synonym="RAET1H; ULBP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAET1L"
                     /gene_synonym="RAET1H; ULBP6"
                     /note="hexamer: AATAAA"
     polyA_site      1346
                     /gene="RAET1L"
                     /gene_synonym="RAET1H; ULBP6"
                     /note="major polyA site"
ORIGIN      
        1 gatttcatct tccaggatcc accttgatta aatctcttgt ccccagccct cctggtcccc
       61 aatggcagca gccgccatcc cagctttgct tctgtgcctc ccgcttctgt tcctgctgtt
      121 cggctggtcc cgggctaggc gagacgaccc tcactctctt tgctatgaca tcaccgtcat
      181 ccctaagttc agacctggac cacggtggtg tgcggttcaa ggccaggtgg atgaaaagac
      241 ttttcttcac tatgactgtg gcaacaagac agtcacaccc gtcagtcccc tggggaagaa
      301 actaaatgtc acaatggcct ggaaagcaca gaacccagta ctgagagagg tggtggacat
      361 acttacagag caactgcttg acattcagct ggagaattac acacccaagg aacccctcac
      421 cctgcaggca aggatgtctt gtgagcagaa agctgaagga cacagcagtg gatcttggca
      481 gttcagtatc gatggacaga ccttcctact ctttgactca gagaagagaa tgtggacaac
      541 ggttcatcct ggagccagaa agatgaaaga aaagtgggag aatgacaagg atgtggccat
      601 gtccttccat tacatctcaa tgggagactg cataggatgg cttgaggact tcttgatggg
      661 catggacagc accctggagc caagtgcagg agcaccactc gccatgtcct caggcacaac
      721 ccaactcagg gccacagcca ccaccctcat cctttgctgc ctcctcatca tcctcccctg
      781 cttcatcctc cctggcatct gaggagagtc ctttagagtg acaggttaaa gatgatacca
      841 aaaagcccct gtgagcacgg tcttgatcaa cctcgccctt ctgtctggcc agctgcccac
      901 cacctacggt gtatgtccag cagcctccag cagatgatga tgacaccatg gacccaatag
      961 ctcattcact gccttgattc cttttgccaa caatttaacc agtgattatt cctaacatat
     1021 tatgcaattt tctcttggtg ctacctgatg gaattcctgc acttaaagtt ctggctgact
     1081 aaacaagata tgtcaacatt ttctttcttc tctttttgtt tggaaaatca agtacttctt
     1141 tgaatgatga tttctttctt tcattactga catgattgtc agtaaaacaa tcatgttaga
     1201 cttcagacct ccagggattc tttccatgtc ctgaaagaga attgtttaat tatttaataa
     1261 gaaaaaaatt tatattaatg attgtttcct ttagtaattt attgctgtgt actgatattt
     1321 aaataaagag ttatatttcc caaaaa
//
