LOCUS       NM_001001788            1150 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens retinoic acid early transcript 1G (RAET1G), transcript
            variant 1, mRNA.
ACCESSION   NM_001001788 NM_001007521
VERSION     NM_001001788.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Lanier,L.L.
  TITLE     NKG2D Receptor and Its Ligands in Host Defense
  JOURNAL   Cancer Immunol Res 3 (6), 575-582 (2015)
   PUBMED   26041808
  REMARK    Review article
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   Fujita,H., Hatanaka,Y., Sutoh,Y., Suzuki,Y., Oba,K., Hatanaka,K.C.,
            Mitsuhashi,T., Otsuka,N., Fugo,K., Kasahara,M. and Matsuno,Y.
  TITLE     Immunohistochemical validation and expression profiling of NKG2D
            ligands in a wide spectrum of human epithelial neoplasms
  JOURNAL   J Histochem Cytochem 63 (3), 217-227 (2015)
   PUBMED   25473094
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   Cho,H., Chung,J.Y., Kim,S., Braunschweig,T., Kang,T.H., Kim,J.,
            Chung,E.J., Hewitt,S.M. and Kim,J.H.
  TITLE     MICA/B and ULBP1 NKG2D ligands are independent predictors of good
            prognosis in cervical cancer
  JOURNAL   BMC Cancer 14, 957 (2014)
   PUBMED   25510288
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1150)
  AUTHORS   Wennerberg,E., Pfefferle,A., Ekblad,L., Yoshimoto,Y., Kremer,V.,
            Kaminskyy,V.O., Juhlin,C.C., Hoog,A., Bodin,I., Svjatoha,V.,
            Larsson,C., Zedenius,J., Wennerberg,J. and Lundqvist,A.
  TITLE     Human anaplastic thyroid carcinoma cells are sensitive to NK
            cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells
  JOURNAL   Clin Cancer Res 20 (22), 5733-5744 (2014)
   PUBMED   25212604
  REMARK    GeneRIF: Human anaplastic thyroid carcinoma cells are sensitive to
            NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.
REFERENCE   5  (bases 1 to 1150)
  AUTHORS   Raulet,D.H., Gasser,S., Gowen,B.G., Deng,W. and Jung,H.
  TITLE     Regulation of ligands for the NKG2D activating receptor
  JOURNAL   Annu Rev Immunol 31, 413-441 (2013)
   PUBMED   23298206
  REMARK    Review article
REFERENCE   6  (bases 1 to 1150)
  AUTHORS   Rareongjai,S., Romphruk,A., Romphruk,A.V., Sakuntabhai,A. and
            Leelayuwat,C.
  TITLE     Linkage disequilibrium of polymorphic RAET1 genes in Thais
  JOURNAL   Tissue Antigens 76 (3), 230-235 (2010)
   PUBMED   20522206
REFERENCE   7  (bases 1 to 1150)
  AUTHORS   Cao,W., Xi,X., Wang,Z., Dong,L., Hao,Z., Cui,L., Ma,C. and He,W.
  TITLE     Four novel ULBP splice variants are ligands for human NKG2D
  JOURNAL   Int Immunol 20 (8), 981-991 (2008)
   PUBMED   18544572
REFERENCE   8  (bases 1 to 1150)
  AUTHORS   Ebihara,T., Masuda,H., Akazawa,T., Shingai,M., Kikuta,H., Ariga,T.,
            Matsumoto,M. and Seya,T.
  TITLE     Induction of NKG2D ligands on human dendritic cells by TLR ligand
            stimulation and RNA virus infection
  JOURNAL   Int Immunol 19 (10), 1145-1155 (2007)
   PUBMED   17878262
REFERENCE   9  (bases 1 to 1150)
  AUTHORS   Bacon,L., Eagle,R.A., Meyer,M., Easom,N., Young,N.T. and
            Trowsdale,J.
  TITLE     Two human ULBP/RAET1 molecules with transmembrane regions are
            ligands for NKG2D
  JOURNAL   J Immunol 173 (2), 1078-1084 (2004)
   PUBMED   15240696
  REMARK    GeneRIF: Binds the activating receptor NKG2D and the the human
            cytomegalovirus protein UL16.
REFERENCE   10 (bases 1 to 1150)
  AUTHORS   Radosavljevic,M., Cuillerier,B., Wilson,M.J., Clement,O.,
            Wicker,S., Gilfillan,S., Beck,S., Trowsdale,J. and Bahram,S.
  TITLE     A cluster of ten novel MHC class I related genes on human
            chromosome 6q24.2-q25.3
  JOURNAL   Genomics 79 (1), 114-123 (2002)
   PUBMED   11827464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY165961.1, AY172579.1 and
            AY172580.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001001788.3.
            
            Summary: This gene encodes a member of the major histocompatibility
            complex (MHC) class I family of proteins. Although the encoded
            protein includes C-terminal transmembrane and cytoplasmic domains,
            proteolytic processing results in the removal of these domains and
            subsequent tethering to the plasma membrane by a
            glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is
            one of several related ligands of the natural killer group 2,
            member D (NKG2D) receptor, which functions as an activating
            receptor in innate and adaptive immunity. This gene is present in a
            gene cluster on chromosome 6. [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1, also known as RAET1G1)
            represents the longer transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY172579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367360.7/ ENSP00000356329.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                HY165961.1         34-76
            44-932              AY172579.1         1-889
            933-1150            AY172580.1         722-939
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..1150
                     /gene="RAET1G"
                     /gene_synonym="ULBP5"
                     /note="retinoic acid early transcript 1G"
                     /db_xref="GeneID:353091"
                     /db_xref="HGNC:HGNC:16795"
                     /db_xref="MIM:609244"
     exon            1..196
                     /gene="RAET1G"
                     /gene_synonym="ULBP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1116
                     /gene="RAET1G"
                     /gene_synonym="ULBP5"
                     /note="UL-16 binding protein 5; retinoic acid early
                     transcript 1G protein"
                     /codon_start=1
                     /product="UL-16 binding protein 5 preproprotein"
                     /protein_id="NP_001001788.2"
                     /db_xref="CCDS:CCDS43514.1"
                     /db_xref="GeneID:353091"
                     /db_xref="HGNC:HGNC:16795"
                     /db_xref="MIM:609244"
                     /translation="MAAAASPAFLLRLPLLLLLSSWCRTGLADPHSLCYDITVIPKFR
                     PGPRWCAVQGQVDEKTFLHYDCGSKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILT
                     EQLLDIQLENYIPKEPLTLQARMSCEQKAEGHGSGSWQLSFDGQIFLLFDSENRMWTT
                     VHPGARKMKEKWENDKDMTMSFHYISMGDCTGWLEDFLMGMDSTLEPSAGAPPTMSSG
                     TAQPRATATTLILCCLLIMCLLICSRHSLTQSHGHHPQSLQPPPHPPLLHPTWLLRRV
                     LWSDSYQIAKRPLSGGHVTRVTLPIIGDDSHSLPCPLALYTINNGAARYSEPLQVSIS
                     "
     exon            197..460
                     /gene="RAET1G"
                     /gene_synonym="ULBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            461..742
                     /gene="RAET1G"
                     /gene_synonym="ULBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            743..953
                     /gene="RAET1G"
                     /gene_synonym="ULBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1150
                     /gene="RAET1G"
                     /gene_synonym="ULBP5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1150
                     /gene="RAET1G"
                     /gene_synonym="ULBP5"
                     /note="major polyA site"
ORIGIN      
        1 actggagttt agggctgcat tcagacgggc tgcattcaga cagcctgcga gccgccaggt
       61 gatccacggg ctgggcttcg cttctgctgt cccctgcgat ccaactcccc aatggcagcg
      121 gccgccagcc ccgcgttcct tctacgcctc ccgcttctgc tcctgctgtc cagctggtgc
      181 aggaccgggc tggccgaccc tcactctctt tgctatgaca tcaccgtcat ccctaagttc
      241 agacctggac cacggtggtg tgcggttcaa ggccaggtgg atgaaaagac ttttcttcac
      301 tatgactgtg gcagcaagac agtcacaccc gtcagtcccc tggggaagaa actaaatgtc
      361 acaacggcct ggaaagcaca gaacccagta ctgagagagg tggtggacat acttacagag
      421 caactgcttg acattcagct ggagaattac atacccaagg aacccctcac cctgcaggcc
      481 aggatgtctt gtgagcagaa agccgaagga cacggcagtg gatcttggca gctcagtttc
      541 gatggacaga tcttcctcct ctttgactca gaaaacagaa tgtggacaac ggttcatcct
      601 ggagccagaa agatgaaaga aaagtgggag aatgacaagg atatgaccat gtccttccat
      661 tacatctcaa tgggagactg cacaggatgg cttgaggact tcttgatggg catggacagc
      721 accctggagc caagtgcagg agcaccaccc accatgtcct caggcacagc ccaacccagg
      781 gccacggcca ccaccctcat cctttgctgc ctcctcatca tgtgtctcct catatgctcc
      841 aggcacagtc tgacccaaag ccatggccac caccctcagt ccctgcagcc tcctcctcat
      901 cctcccctgc ttcatcctac ctggctgctg aggagagtcc tttggagtga cagctaccaa
      961 atagcgaagc gccccttgtc tggtggacac gtgactcgcg tgactttacc tatcattgga
     1021 gacgactcac actccttacc ctgccctctt gccttgtata caataaataa cggcgcagcc
     1081 aggtattcgg agccactaca ggtctccata tcttgatggt tccctgggcc cagctgtctt
     1141 ttcttccgtc
//
