LOCUS       NM_001394057            6524 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens retinoic acid early transcript 1E (RAET1E), transcript
            variant 6, mRNA.
ACCESSION   NM_001394057
VERSION     NM_001394057.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6524)
  AUTHORS   Lazarova,M., Kim,Y. and Steinle,A.
  TITLE     The NKG2D ligand ULBP4 is not expressed by human monocytes
  JOURNAL   PLoS One 16 (2), e0246726 (2021)
   PUBMED   33556116
  REMARK    GeneRIF: The NKG2D ligand ULBP4 is not expressed by human
            monocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6524)
  AUTHORS   Bowden,M., Nadal,R., Zhou,C.W., Werner,L., Barletta,J.,
            Juanpere,N., Lloreta,J., Hernandez-Llodra,S., Morote,J., de
            Torres,I., Orsola,A., Cejas,P., Long,H. and Bellmunt,J.
  TITLE     Transcriptomic analysis of micropapillary high grade T1 urothelial
            bladder cancer
  JOURNAL   Sci Rep 10 (1), 20135 (2020)
   PUBMED   33208770
  REMARK    GeneRIF: Transcriptomic analysis of micropapillary high grade T1
            urothelial bladder cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6524)
  AUTHORS   Posadas-Sanchez,R., Roque-Ramirez,B., Rodriguez-Perez,J.M.,
            Perez-Hernandez,N., Fragoso,J.M., Villarreal-Molina,T.,
            Coral-Vazquez,R., Tejero-Barrera,M.E., Posadas-Romero,C. and
            Vargas-Alarcon,G.
  TITLE     Raet1e Polymorphisms Are Associated with Increased Risk of
            Developing Premature Coronary Artery Disease and with Some
            Cardiometabolic Parameters: The GEA Mexican Study
  JOURNAL   Mediators Inflamm 2018, 1847696 (2018)
   PUBMED   30662365
  REMARK    GeneRIF: An association of the raet1e polymorphisms with an
            increased risk of developing premature CAD and with cardiometabolic
            parameters has been shown for the first time.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6524)
  AUTHORS   Zuo,J., Willcox,C.R., Mohammed,F., Davey,M., Hunter,S., Khan,K.,
            Antoun,A., Katakia,P., Croudace,J., Inman,C., Parry,H., Briggs,D.,
            Malladi,R., Willcox,B.E. and Moss,P.
  TITLE     A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target
            cell killing by enhancing the stability of NKG2D ligand binding
  JOURNAL   Sci Signal 10 (481) (2017)
   PUBMED   28559451
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6524)
  AUTHORS   Han,B., Zhao,Y., Lin,Y., Fu,S., Wang,L., Zhang,M., Tie,R., Wang,B.,
            Luo,Y., Liu,L., Yu,J. and Huang,H.
  TITLE     Hydroxychloroquine sensitizes chronic myeloid leukemia cells to
            Vgamma9Vdelta2 T cell-mediated lysis independent of autophagy
  JOURNAL   Int J Oncol 50 (5), 1810-1820 (2017)
   PUBMED   28339029
  REMARK    GeneRIF: Blocking the interaction of NKG2D with its ligands deleted
            the sensitizing effects of HCQ. In addition, we showed that HCQ did
            not affect the synthesis or degradation of ULBP4, but induced the
            translocation of ULBP4 from the cytoplasm to the cell membrane
REFERENCE   6  (bases 1 to 6524)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 6524)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 6524)
  AUTHORS   Conejo-Garcia,J.R., Benencia,F., Courreges,M.C., Khang,E.,
            Zhang,L., Mohamed-Hadley,A., Vinocur,J.M., Buckanovich,R.J.,
            Thompson,C.B., Levine,B. and Coukos,G.
  TITLE     Letal, A tumor-associated NKG2D immunoreceptor ligand, induces
            activation and expansion of effector immune cells
  JOURNAL   Cancer Biol Ther 2 (4), 446-451 (2003)
   PUBMED   14508119
REFERENCE   9  (bases 1 to 6524)
  AUTHORS   Chalupny,N.J., Sutherland,C.L., Lawrence,W.A., Rein-Weston,A. and
            Cosman,D.
  TITLE     ULBP4 is a novel ligand for human NKG2D
  JOURNAL   Biochem Biophys Res Commun 305 (1), 129-135 (2003)
   PUBMED   12732206
REFERENCE   10 (bases 1 to 6524)
  AUTHORS   Radosavljevic,M., Cuillerier,B., Wilson,M.J., Clement,O.,
            Wicker,S., Gilfillan,S., Beck,S., Trowsdale,J. and Bahram,S.
  TITLE     A cluster of ten novel MHC class I related genes on human
            chromosome 6q24.2-q25.3
  JOURNAL   Genomics 79 (1), 114-123 (2002)
   PUBMED   11827464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355312.24.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene belong to the RAET1 family, which consists of
            major histocompatibility complex (MHC) class I-related genes
            located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G
            protein differ from other RAET1 proteins in that they have type I
            membrane-spanning sequences at their C termini rather than
            glycosylphosphatidylinositol anchor sequences. This protein
            functions as a ligand for NKG2D receptor, which is expressed on the
            surface of several types of immune cells, and is involved in innate
            and adaptive immune responses. Alternatively spliced transcript
            variants encoding different isoforms have been found for this
            gene.[provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2769119.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357183.9/ ENSP00000349709.4
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AL355312.24        179560-179652       c
            94-280              AL355312.24        177385-177571       c
            281-498             AL355312.24        172356-172573       c
            499-759             AL355312.24        171424-171684       c
            760-1035            AL355312.24        170887-171162       c
            1036-6524           AL355312.24        164718-170206       c
FEATURES             Location/Qualifiers
     source          1..6524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..6524
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /note="retinoic acid early transcript 1E"
                     /db_xref="GeneID:135250"
                     /db_xref="HGNC:HGNC:16793"
                     /db_xref="MIM:609243"
     exon            1..93
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            94..280
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            281..498
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..1205
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 6; lymphocyte effector toxicity activation ligand;
                     NKG2D ligand 4; RAE-1-like transcript 4; UL16-binding
                     protein 4"
                     /codon_start=1
                     /product="retinoic acid early transcript 1E isoform 1
                     precursor"
                     /protein_id="NP_001380986.1"
                     /db_xref="CCDS:CCDS5221.1"
                     /db_xref="GeneID:135250"
                     /db_xref="HGNC:HGNC:16793"
                     /db_xref="MIM:609243"
                     /translation="MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSR
                     PGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLR
                     MLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVI
                     NHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHW
                     SSSSLPDRWIILGAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS"
     exon            499..759
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1035
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..6524
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5907..5912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /note="hexamer: AATAAA"
     polyA_site      5929
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /note="major polyA site"
     regulatory      6401..6406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /note="hexamer: AATAAA"
     polyA_site      6423
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
     regulatory      6503..6508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
                     /note="hexamer: TATAAA"
     polyA_site      6524
                     /gene="RAET1E"
                     /gene_synonym="bA350J20.7; LETAL; N2DL-4; NKG2DL4;
                     RAET1E2; RL-4; ULBP4"
ORIGIN      
        1 agagagtttg cacagagact ctgaggaagc agtcacctca ggcctctcca tcctagagac
       61 ggcagaagga caaacatctc ctgctggcac aaggaagtca taactcatgt gagtggagcc
      121 atgtgggatt aagaagtgat aggagagctt gctgtctgtc tctgctctcc actgtgtgag
      181 gatacaacag gaagacagcc atctggtgag gaagagaggg ccctcgccag ataccggacc
      241 tgctgacacc ttgatcttgg acttcccatc ttccaggaag gcctgacctc agttgttcca
      301 gggtaaagaa tttgggcagt gcccacaccc acgctgttgg ataacatttc ttcaccatac
      361 cagtgagggt gaatgtgtac acgcccagct tcctgcctgt tactctccac agtatgcgaa
      421 gaatatccct gacttctagc cctgtgcgcc ttcttttgtt tctgctgttg ctactaatag
      481 ccttggagat catggttggt ggtcactctc tttgcttcaa cttcactata aaatcattgt
      541 ccagacctgg acagccctgg tgtgaagcgc aggtcttctt gaataaaaat cttttccttc
      601 agtacaacag tgacaacaac atggtcaaac ctctgggcct cctggggaag aaggtatatg
      661 ccaccagcac ttggggagaa ttgacccaaa cgctgggaga agtggggcga gacctcagga
      721 tgctcctttg tgacatcaaa ccccagataa agaccagtga tccttccact ctgcaagtcg
      781 agatgttttg tcaacgtgaa gcagaacggt gcactggtgc atcctggcag ttcgccacca
      841 atggagagaa atccctcctc tttgacgcaa tgaacatgac ctggacagta attaatcatg
      901 aagccagtaa gatcaaggag acatggaaga aagacagagg gctggaaaag tatttcagga
      961 agctctcaaa gggagactgc gatcactggc tcagggaatt cttagggcac tgggaggcaa
     1021 tgccagaacc gacagtgtca ccagtaaatg cttcagatat ccactggtct tcttctagtc
     1081 taccagatag atggatcatc ctgggggcat tcatcctgtt agttttaatg ggaattgttc
     1141 tcatctgtgt ctggtggcaa aatggtgagt ggcaggctgg tctctggccc ttgaggacgt
     1201 cttagtctgg taaggactca agagaggtga atcatgggtc tcatccaagc ccccgctccc
     1261 tgatccatct ctctccacag aaatggtgca ctgccttagt cttgagcccc cacactacac
     1321 agcagggctg gcagcacaat gtgcagtgag aggagggatg aagcaatcat ctcctctcga
     1381 ggaggggcaa ggtcaaagat ctggaacgcc tgcctggggt gttgtctcct tgccatccgg
     1441 cccaggtttc atccagctct ttgacggaaa gtttgtttgc tgtctgcgtt taccgtgatt
     1501 tagctcagca ggtcccatcc ccttttcccg ttcaccctga gaagacttgc tggtggcgct
     1561 tgtggctgca gcatttactc ccagataaca tacaagatgt ggtataagaa atcctttcac
     1621 caccctctaa acattacagt gccgaactac atcctacatt tttagtagag atggggtttc
     1681 tccatgttgg tcaggctcgt cttgaactcc cgacctcagg tgatgctccc gcctcggcct
     1741 cccaaagcgc tgggattaca gggggagcca acacacctgg ctgagagaac tattatatgc
     1801 cagacacatt gccagacatc ttctgctctt tggtcctgtt tctccgccac tgctctgaca
     1861 tgaagaattc atttctttct tccattgctg tctttgtcct catagtgtct tctctaaatt
     1921 gacccaggca gacctcaaca ttttcaagta cagcaatttg gaaaagttaa gtagagctct
     1981 agggttcaag tcacagttcc tggggctctc tctgtggagt tcaaagttag gattccctct
     2041 aatgagaaaa ataggctact ccatctgact cactgaggat caatgtttct gatgtaagaa
     2101 atgattctac ccttttcatt gcttaaacga ataccatgac tcagatatgt gtctgttttg
     2161 caggggccct gacatgaaaa gtgagtttgc caagatcggt gtcacaacag gcttggcaag
     2221 atatggcttg agtcagataa gggccactgg tccagaaggg gctcgtgtgg tgggtggtgt
     2281 gatggcagca ggaacccagg gagtgaatat gctgagatag gaaggggtcc cacccacaga
     2341 gctgcaggca aaggggtccc accttaatcc ctggtggaag gtgactgaga aggacttaac
     2401 tgccccaacc aagcaggctg ggacttcagt gccattgaca atagtgaagg ggattggtga
     2461 gtaggaaggg aggcaaaaga acagttttag aagctgggtc tgaacagtag ggatttaaag
     2521 gaggtgggac ctccatagac acctgggagt tcctggcctc tagcctcatc ctggtaaccg
     2581 agtcggctgc tgaagggctt cctgtctggg caggagcagg cagggatcaa gcgccggtgg
     2641 aggtcagtgc ccacagctga gctgaacaga agtgggaggc agagtgggcc tggggaaagg
     2701 tgtattacaa ttcaagggga aaaaaatata tctgccaccc tttggggagg gcctccccac
     2761 tgtgtcgcat ggatttctct gtcacgggga agagcagcac ccagggaaaa agagctttgt
     2821 gtgcccatga cacattccta ttttgttgtc tctggcattt ctgggcattg tttctgctga
     2881 agtgacagaa gagagaaaaa gctgatcaaa gctaaatgac agagcaaagg ggttgacagg
     2941 gagtgtcttt tcaaatacac agggacattc accaagaagg gccatttttg gatcataaaa
     3001 taaatctcat ctgggcgtga tagctcactc ctgtaatccc agcactttgg gaggccaagt
     3061 tgggtggatc atttgaggtc aggagttcga gaccagcctg gccaacatgg cgaaaccctg
     3121 tctctactaa aaatacaaaa attagccggg tgtggtggca tgggcctgta atcccagcta
     3181 ctcgggaggc tgagacagga gaatcgcttg aactcaggag gcggagtttg cagtgagctg
     3241 atattgcgcc attgcactcc agcctgggtg acagagtgag attccatctc aataaataaa
     3301 taaataaata aatctcaaca tatgtaaagg gttaaaatca tgcgaagcat cttgtccaag
     3361 cacaatggaa ataaactaga aatcaacagc aggaagctat ctggaaaaat cctcaaatgt
     3421 ttggatatca aataatatgc ttccaaataa ctatatatca aattaaaaag tacaaggaaa
     3481 actagaaagt attttgaaat gaatgaaaat gataatacaa aatatcaaaa tctatcagac
     3541 acagataaga aaatgtctag aggcatccac actgaacttt ttgatctctg aatcaccgtg
     3601 catcattgct gccaaatttt ttgctcatgc tcatctctgc ctggaatttt ctttcttacc
     3661 tgaccgaatt ccagacagct atccaagtcc agtttaactg tcacctcctc taagaagtca
     3721 ccattcttcc tggatagaat taactacccc cactcgtagc tcagaaactc tgaccacaga
     3781 aaaattatca cattgtttta tgattgggtg tatgtcagta aattgatgcg cttacttgag
     3841 gacattactt ttgtaacctg agaatctatc atggctgcta tatagtagac gctcaggaca
     3901 tgtgaggact tgagtggcag cggaggtaag ggtcatctcc tgggtatgga gcttggacaa
     3961 gaacctgcac tcttctgttc catttcacct caaccatcca tgtccccaac cacatctcca
     4021 ccatcctacc tgtaccaagt gctaatcctt tgaatcatgt cagtgactat cttcagctca
     4081 atcccaatca caggtcagga gggagggcat caggtatact gtgagcaaaa cagagtatga
     4141 gatggggcca actggcctct ggattagggg cagggcttgt cctgtatgag gacagggaga
     4201 aatgaggttg ctaagtctcc ccaagacccc tgccaaatct caccatagac ataagatgag
     4261 gtgaatttca tttatcgcct gggcattcac gacctgagag gcttagctct gggtcaagtt
     4321 gagccctctc tgtccctggc caacaggaga aaggcaaagg ctgaatgagt ctcggggact
     4381 gtctctgctt tgcaagtggg ccctgaggtg aacagggacc tttccaaatt aatgcatcca
     4441 cagcggtttg gcaaagtcgg gctttaaacc agggtcactc tccaggggtt gcctatgtga
     4501 tgggtggtct gatggacaga aacacagagg gtgggcaaga cacaattttg ggtggggcag
     4561 cagcttgatg atctgaccat ctgaccatgg gaaagtatat cacatgccaa aggttgaggg
     4621 gtctctaggt ttaattccta ggaggacata atgaagaagg ctgcctgggc tccaacaaag
     4681 caggctggag gcagggccac acagaccgtg ggagagggga ttgtgagcag aagggaaggc
     4741 tgaaagtgaa ccctagacac tctgtgagga cagcaaggac tagaaggtgg gattcctttg
     4801 acacctgggt ttctggttca cccctgacac aggaatcctg gcaaatggcg tcgtgccaag
     4861 ccccaccctc agtgctctgg acctgccgca gggataccct tgcccacagc tggaagactc
     4921 ttgcccccgc tgtgggcctt cccactgtgt tcccactgat actttgcctt ccttggctct
     4981 gaacccctaa aatctctgct ggggtctggg tctaactaat gatgaagtaa cggaaagtga
     5041 acaatcataa actagatgac agagaggcag aatgtgaaca atagcggctg atctctccct
     5101 gagagagagg tgggatctga gtcctgagag atcacggagg ggtcaatcct gagctgatct
     5161 gacccagggt tctgcactct tttgtctcct tcctaaaggc agaagatcca cctagaggtg
     5221 ataccacggc ggcgcagagt tgttcacctg tggtcctcga tcgctgacag ccttggctcc
     5281 cactgctgtg tgttccctga gtcaagtgga ggcggagcct gcaatgagcg gagatcgcgc
     5341 ctctgcattc cagtcttggc aacagagcaa gactccgtct caaaaaaaaa aaattttttt
     5401 tcagtacata ttttttaaaa gatagggctg ggcacagcag ctcacatcta taatcccaac
     5461 actttgggag gcctaggcag gaggatcact tgagcccagg aatctgaagc tgcagtgagc
     5521 ctttgctcgt gagattgtgg acctatgatc ctaccaccag cccacctggt tctaacaccc
     5581 cctcctctat gtgtgagagg gagagaagaa aagtgaggga gaaaagagag ataagcaaag
     5641 aacagagagg aaaaatggaa aataagagga aattggggga attaaacaga ggggagggca
     5701 tggatccccg ggagttagaa gagtagcagc ttgtggatta ctacgcagtg gaggaagaag
     5761 agttgttgga aattatttga gaggtagtat aatcatttgt gaggcagttt tctgcattca
     5821 ccatttctca cagactaagt tactcataag caaacgtgca attcacatta cactgaaatt
     5881 cttccctaat acatcatttg cattggaata aagtacggtt ttcaaacaac ctgatatagc
     5941 agaactgact gtataaatta tgtgagcaca gtgcaagtaa ttctttgttt gtttgtttgt
     6001 ttttttgaga cagagtctca ctctatctcc caggctggag tgtagtggtg cgatcccggc
     6061 tcactgcaac ctcgatctcc caggctcaag cgattcccct gcctcagcct cctgagtagc
     6121 tgggattaca ggcatgagcc accacgcccg gctaattttt gtatttttag tagagacggg
     6181 gtttcaccct gttggccagg ctggtctcga actacggacc tcaggtgatc tgcccccctc
     6241 agcctctcaa agtgctggga ttatagcatg agccactgag cccagacaca agtagttctt
     6301 tctgataaac actttaacac tgaatgcaaa aaaaaaaaaa aaattgtgtg tgtacttttt
     6361 ttaattttac tttaaaatag acacaccaaa catgtttcta aataaatgta atatggaaat
     6421 ctttcttttt ctcctccatt ctcagtgatg atatggttgt aaattcttat catctgataa
     6481 tttttatcag atctttacaa attataaact tatttgcaac tctg
//
