LOCUS       NM_003610               2385 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribonucleic acid export 1 (RAE1), transcript variant
            1, mRNA.
ACCESSION   NM_003610
VERSION     NM_003610.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Makio,T., Zhang,K., Love,N., Mast,F.D., Liu,X., Elaish,M.,
            Hobman,T., Aitchison,J.D., Fontoura,B.M.A. and Wozniak,R.W.
  TITLE     SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1
            to inhibit nucleocytoplasmic transport
  JOURNAL   Mol Biol Cell 35 (5), ar62 (2024)
   PUBMED   38507240
  REMARK    GeneRIF: SARS-CoV-2 Orf6 is positioned in the nuclear pore complex
            by Rae1 to inhibit nucleocytoplasmic transport.
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Berkel,C. and Cacan,E.
  TITLE     Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in Tumor
            Compared to Adjacent Nonmalignant Stroma in High-Grade Serous
            Ovarian Cancer Patients
  JOURNAL   Reprod Sci 30 (8), 2397-2400 (2023)
   PUBMED   36810690
  REMARK    GeneRIF: Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in
            Tumor Compared to Adjacent Nonmalignant Stroma in High-Grade Serous
            Ovarian Cancer Patients.
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Krachmarova,E., Petkov,P., Lilkova,E., Ilieva,N., Rangelov,M.,
            Todorova,N., Malinova,K., Hristova,R., Nacheva,G., Gospodinov,A.
            and Litov,L.
  TITLE     Insights into the SARS-CoV-2 ORF6 Mechanism of Action
  JOURNAL   Int J Mol Sci 24 (14), 11589 (2023)
   PUBMED   37511350
  REMARK    GeneRIF: Insights into the SARS-CoV-2 ORF6 Mechanism of Action.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A.
  TITLE     Nuclear import of hepatic glucokinase depends upon glucokinase
            regulatory protein, whereas export is due to a nuclear export
            signal sequence in glucokinase
  JOURNAL   J Biol Chem 274 (52), 37125-37130 (1999)
   PUBMED   10601273
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   Pritchard,C.E., Fornerod,M., Kasper,L.H. and van Deursen,J.M.
  TITLE     RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like
            NUP98 motif at the nuclear pore complex through multiple domains
  JOURNAL   J Cell Biol 145 (2), 237-254 (1999)
   PUBMED   10209021
REFERENCE   8  (bases 1 to 2385)
  AUTHORS   Matsuoka,Y., Takagi,M., Ban,T., Miyazaki,M., Yamamoto,T., Kondo,Y.
            and Yoneda,Y.
  TITLE     Identification and characterization of nuclear pore subcomplexes in
            mitotic extract of human somatic cells
  JOURNAL   Biochem Biophys Res Commun 254 (2), 417-423 (1999)
   PUBMED   9918853
REFERENCE   9  (bases 1 to 2385)
  AUTHORS   Bharathi,A., Ghosh,A., Whalen,W.A., Yoon,J.H., Pu,R., Dasso,M. and
            Dhar,R.
  TITLE     The human RAE1 gene is a functional homologue of
            Schizosaccharomyces pombe rae1 gene involved in nuclear export of
            Poly(A)+ RNA
  JOURNAL   Gene 198 (1-2), 251-258 (1997)
   PUBMED   9370289
REFERENCE   10 (bases 1 to 2385)
  AUTHORS   Kraemer,D. and Blobel,G.
  TITLE     mRNA binding protein mrnp 41 localizes to both nucleus and
            cytoplasm
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9119-9124 (1997)
   PUBMED   9256445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL135939.12, U84720.1,
            AY349350.1, AI341915.1 and AL109955.38.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003610.3.
            
            Summary: Mutations in the Schizosaccharomyces pombe Rae1 and
            Saccharomyces cerevisiae Gle2 genes have been shown to result in
            accumulation of poly(A)-containing mRNA in the nucleus, suggesting
            that the encoded proteins are involved in RNA export. The protein
            encoded by this gene is a homolog of yeast Rae1. It contains four
            WD40 motifs, and has been shown to localize to distinct foci in the
            nucleoplasm, to the nuclear rim, and to meshwork-like structures
            throughout the cytoplasm. This gene is thought to be involved in
            nucleocytoplasmic transport, and in directly or indirectly
            attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively
            spliced transcript variants encoding the same protein have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs from variant 2 in the
            5' UTR and encodes the same protein as variant 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.225034.1,
                                           SRR1660803.95178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395841.7/ ENSP00000379182.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL135939.12        58201-58284
            85-858              U84720.1           97-870
            859-1310            AY349350.1         1049-1500
            1311-1646           AI341915.1         4-339               c
            1647-2385           AL109955.38        19477-20215
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.31"
     gene            1..2385
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /note="ribonucleic acid export 1"
                     /db_xref="GeneID:8480"
                     /db_xref="HGNC:HGNC:9828"
                     /db_xref="MIM:603343"
     exon            1..168
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            169..265
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1282
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /note="homolog of yeast Rae1 (Bharathi) mRNA-associated
                     protein of 41 kDa (Kraemer); mRNA-associated protein MRNP
                     41; mRNA export protein; RAE1 RNA export 1 homolog;
                     mRNA-binding protein, 41-kD; mRNA export factor;
                     migration-inducing gene 14; rae1 protein homolog"
                     /codon_start=1
                     /product="mRNA export factor RAE1"
                     /protein_id="NP_003601.1"
                     /db_xref="CCDS:CCDS13458.1"
                     /db_xref="GeneID:8480"
                     /db_xref="HGNC:HGNC:9828"
                     /db_xref="MIM:603343"
                     /translation="MSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGC
                     LSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVF
                     TASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRS
                     SNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCV
                     AIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAV
                     NGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYAS
                     SYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK"
     exon            266..370
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            371..463
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            464..550
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            551..637
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            638..709
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            710..817
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            818..924
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1000
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1195
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..2385
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1618..1623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /note="hexamer: AATAAA"
     polyA_site      1640
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /note="major polyA site"
     regulatory      2362..2367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
                     /note="hexamer: AATAAA"
     polyA_site      2385
                     /gene="RAE1"
                     /gene_synonym="dJ481F12.3; dJ800J21.1; Gle2; MIG14;
                     Mnrp41; MRNP41"
ORIGIN      
        1 gtttccgcgg tagtcagggc agtttctacc gcaggcttaa ggaggcttcg ggctcctggg
       61 atttctgtcc gcgctcctgg ccctcgtcct tcgcgccaga gcaggttcgc aaactcctca
      121 gacccttctg ctcccggccg ccgctttccg ccggggcgag acccccaggt tcaaaatgag
      181 cctgtttgga acaacctcag gttttggaac cagtgggacc agcatgtttg gcagtgcaac
      241 tacagacaat cacaatccca tgaaggatat tgaagtaaca tcatctcctg atgatagcat
      301 tggttgtctg tcttttagcc caccaacctt gccggggaac tttcttattg caggatcatg
      361 ggctaatgat gttcgctgct gggaagttca agacagtgga cagaccattc caaaagccca
      421 gcagatgcac actgggcctg tgcttgatgt ctgctggagt gacgatggga gcaaagtgtt
      481 tacggcatcg tgtgataaaa ctgccaaaat gtgggacctc agcagtaacc aagcgataca
      541 gatcgcacag catgatgctc ctgttaaaac catccattgg atcaaagctc caaactacag
      601 ctgtgtgatg actgggagct gggataagac tttaaagttt tgggatactc gatcgtcaaa
      661 tcctatgatg gttttgcaac tccctgaaag gtgttactgt gctgacgtga tataccccat
      721 ggctgtggtg gcaactgcag agaggggcct gattgtctat cagctagaga atcaaccttc
      781 tgaattcagg aggatagaat ctccactgaa acatcagcat cggtgtgtgg ctatttttaa
      841 agacaaacag aacaagccta ctggttttgc cctgggaagt atcgagggga gagttgctat
      901 tcactatatc aaccccccga accccgccaa agataacttc acctttaaat gtcatcgatc
      961 taatggaacc aacacttcag ctcctcagga catttatgcg gtaaatggaa tcgcgttcca
     1021 tcctgttcat ggcacccttg caactgtggg atctgatggt agattcagct tctgggacaa
     1081 agatgccaga acaaaactaa aaacttcgga acagttagat cagcccatct cagcttgctg
     1141 tttcaatcac aatggaaaca tatttgcata cgcttccagc tacgactggt caaagggaca
     1201 tgaattttat aatccccaga aaaaaaatta cattttcctg cgtaatgcag ccgaagagct
     1261 aaagcccagg aataagaagt agtggctgga gactctggct cagccagagt tgtttctctc
     1321 cactctgcct catctctgta cgaatttggg tcccagcctt gttgggttgt cagccatgga
     1381 catggatttc aacccctgga gaaaacgatg tcattgttca gcagctgaga gcccaggcgt
     1441 ccgcggcgac ttgccgtctc tccattccac tgcctgttgc agagtttttc tgtaactaag
     1501 ggggttgagg ttattgtaga cgttagattg cgggcaccgc cagggatttt gcagcgcttc
     1561 agtgtacgtg ttagagaata ttggaaaagc gtctgtgagc cccgtgctgt attttgtaat
     1621 aaagtctttt gcagattgct tcccgagctt cctttgtcct tttctcccct tgcccacccc
     1681 gtaacctcag gaacatgcgt cctgcccagc atcagcgtgg ggttttgagt tgagatttca
     1741 gacaccctct gggaaatgcg gcaaccttag gggaaaggga gtccccagct gcgctcactt
     1801 ctgctgcgcg gaacggcagc ctctgtgagc cctggtgggc agagtttgaa tgtgtttttc
     1861 cttgcttccc tcattcccat cttcaaaatc cccagtgctt tctggccttg ctgctcagat
     1921 ttccgagtga ctcaaatggg gactgttact tgtgctgggt gacaggccat ttgtgggtaa
     1981 cctcctaagg cccaagtggg tgacacttgc gtgactttca agttagaacc caagccccct
     2041 gcatgggaat tgccctgaac tcttacccac cccggtcccc tgcatgggaa ttgccctgaa
     2101 ccctcagtag tggttgtttg gctgttcttt tgtattttgt gtaatttaaa attcctggtt
     2161 ggtaagtatt caaaatgaaa ttcagctggg ctgagaaaaa gtgtgacttt tgggtctgtc
     2221 actgtatttc tcacctgtga tctcaaatgc ttcttaggcc tttctgtttg gactaatgtg
     2281 tgaagtctga cttgctgagt gtaaaattct agtatcgata gtgttgtaag atgtgtttgc
     2341 ctactcataa aaaacaatga aaataaaatt ttctactgga agaga
//
