LOCUS       NM_018015               3852 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RPA1 related single stranded DNA binding protein,
            X-linked (RADX), transcript variant 1, mRNA.
ACCESSION   NM_018015
VERSION     NM_018015.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3852)
  AUTHORS   Mohamed,T., Adolph,M.B. and Cortez,D.
  TITLE     Oligomerization of DNA replication regulatory protein RADX is
            essential to maintain replication fork stability
  JOURNAL   J Biol Chem 298 (3), 101672 (2022)
   PUBMED   35120927
  REMARK    GeneRIF: Oligomerization of DNA replication regulatory protein RADX
            is essential to maintain replication fork stability.
REFERENCE   2  (bases 1 to 3852)
  AUTHORS   Adolph,M.B., Mohamed,T.M., Balakrishnan,S., Xue,C., Morati,F.,
            Modesti,M., Greene,E.C., Chazin,W.J. and Cortez,D.
  TITLE     RADX controls RAD51 filament dynamics to regulate replication fork
            stability
  JOURNAL   Mol Cell 81 (5), 1074-1083 (2021)
   PUBMED   33453169
  REMARK    GeneRIF: RADX controls RAD51 filament dynamics to regulate
            replication fork stability.
REFERENCE   3  (bases 1 to 3852)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3852)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3852)
  AUTHORS   Bhat,K.P., Krishnamoorthy,A., Dungrawala,H., Garcin,E.B.,
            Modesti,M. and Cortez,D.
  TITLE     RADX Modulates RAD51 Activity to Control Replication Fork
            Protection
  JOURNAL   Cell Rep 24 (3), 538-545 (2018)
   PUBMED   30021152
  REMARK    GeneRIF: RADX buffers RAD51 to ensure the right amount of reversal
            and protection to maintain genome stability.
REFERENCE   6  (bases 1 to 3852)
  AUTHORS   Daakour,S., Hajingabo,L.J., Kerselidou,D., Devresse,A.,
            Kettmann,R., Simonis,N., Dequiedt,F. and Twizere,J.C.
  TITLE     Systematic interactome mapping of acute lymphoblastic leukemia
            cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and
            FBWX7 common interactor
  JOURNAL   BMC Cancer 16, 335 (2016)
   PUBMED   27229929
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3852)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   8  (bases 1 to 3852)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   9  (bases 1 to 3852)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (bases 1 to 3852)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC047503.1, BC011483.1 and BC070110.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018015.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047503.1, BC070110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372548.9/ ENSP00000361628.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2540              BC047503.1         7-2546
            2541-3810           BC011483.1         2510-3779
            3811-3852           BC070110.1         3809-3850
FEATURES             Location/Qualifiers
     source          1..3852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..3852
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /note="RPA1 related single stranded DNA binding protein,
                     X-linked"
                     /db_xref="GeneID:55086"
                     /db_xref="HGNC:HGNC:25486"
     exon            1..746
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2671
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein CXorf57; RPA-related,
                     RAD51-antagonist on X-chromosome; RPA-related and
                     RAD51-antagonist, X-chromosome; RPA-related protein RADX"
                     /codon_start=1
                     /product="RPA-related protein RADX isoform 1"
                     /protein_id="NP_060485.4"
                     /db_xref="CCDS:CCDS14519.1"
                     /db_xref="GeneID:55086"
                     /db_xref="HGNC:HGNC:25486"
                     /translation="MSGESGQPEAGPSHAGLDWPNPERNRAGVPGGVIRRAGSQGPRS
                     WIQKVLEQIMDSPRQCVTPSEVVPVTVLAVQRYLLEDEPRDTVPKPPLYCYDVTISDG
                     VYQEKCYLDPSLNSLVYQNILKVGIQMRISRVSCLYNEKRIGQGILCIDNVHCGETSD
                     SISLETPFRNRAHQEKPERPLRGGKSHYLALWNNEDPYGDIWLTDKQPEEHNFSDTKI
                     ISLSHLEMTWTNRRNFPALLVRILHKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSV
                     IMWNALCPEWYKSLRVGLVLLLQDYSVKKSYPFRIQPVPVDPQIKLISTMEICLNLRD
                     PPTNIIIIPEKQVKPEWRLPKLNHRFTTRSELDDMPENCICDVIGLLVFVGRVQRSKK
                     KENREDFWSYRWIHIADGTSEQPFIVELFSTSQPEIFENIYPMAYFVCTQLKVVRNDN
                     QVPKLLYLTTTNESGVFITGHRGQPYTYDAKVKNFIQWIRTKSDSGEQKNMVIGGYYP
                     YPPVPETFSKYSSSIKVESLLTAISEVRKEIEDLQYREQKRIAIQGIITAIKYIPHSS
                     ATESASASETLRNANRPSTSQAARVEIQERNGKRHQDDEPVNSQYFQTTSTNLSLSNK
                     IRILQGPHANPVAVPQPGASVQTKGIKPGMPSIFNRRANINANLQGKARKTISDRWES
                     QLWREKKFGLIDHLHYSRVYPESIPRKFMFEHRKFLSDQYNSQPAKYVPPEGRPPKLD
                     DFKSARSLGHFEVTILGLNHEIAIDVAFLPMYCPEDIRTSQIDTLLTSMNYSCAYPQD
                     TTGNDRLPGPRAVAGDIIKAATELDRVHIVGILDICNLGNNKVEVYLHKIYSPENTS"
     exon            747..889
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1082
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1191
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1283
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1406
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1511
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1676
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1837
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2007
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2081
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2372
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2540
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..3852
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3832..3837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /note="hexamer: ATTAAA"
     polyA_site      3852
                     /gene="RADX"
                     /gene_synonym="CXorf57"
                     /note="major polyA site"
ORIGIN      
        1 ggcagagtag cgatcgtcgc caaagcgcgc ggttttattt ctctccgctt tggacggggc
       61 aaactagctt ttgggagtga agcgggtacg cagttatcca acaatgtctg gtgagtcagg
      121 acagcctgag gctggtccct cacatgcagg gctagattgg ccgaaccctg agaggaatcg
      181 ggctggggtc ccgggagggg tgatccgaag agctggttcc caagggccca ggtcctggat
      241 ccaaaaggtt cttgagcaga ttatggactc acctcgccag tgtgtcaccc cctcggaggt
      301 ggtgcctgta actgtgctgg ccgtccagag gtacctgtta gaggatgagc cacgcgacac
      361 ggtgcccaag cctccccttt attgctatga tgtgacgatc tcagatgggg tgtaccagga
      421 gaagtgctac ctggacccca gcttgaactc tctcgtatat caaaatattc ttaaagttgg
      481 cattcaaatg agaatttcca gggtctcatg tctttacaat gagaaaagga taggccaggg
      541 gatcctgtgc atagataacg tccactgtgg ggagacttca gacagtattt ctttagaaac
      601 tcccttcaga aatagagcgc accaggagaa accagagagg cctttaagag gcgggaagag
      661 tcattacctg gcgctgtgga ataacgaaga tccctatgga gatatctggt taacagacaa
      721 gcaacctgag gaacacaact ttagcgatac caaaataatt tccctttctc atcttgaaat
      781 gacctggact aacagaagaa attttcctgc attgcttgtg aggatcttac ataaatcaaa
      841 actgcgatac tatggaaaac ctgataaaaa gatgattgaa ccatatcaga cctttttgga
      901 agttgctgac agttcaggca cagtgtcagt gattatgtgg aatgccctgt gtcctgagtg
      961 gtataaaagt ttgcgggttg gtttagttct tctgcttcaa gactattctg ttaaaaagag
     1021 ttatccattc agaatacagc ctgtccccgt ggatccacag atcaaactaa tttctacaat
     1081 ggaaatctgc ctgaatcttc gagatccccc aacaaatata attatcattc cagaaaagca
     1141 ggtgaaacca gaatggagac tgccaaagct aaatcaccga tttaccacaa ggtcagaact
     1201 ggatgatatg ccagaaaatt gcatctgtga tgttattggc cttttagttt ttgtaggaag
     1261 ggtccagcgg tcaaaaaaga aagaaaaccg tgaagatttt tggtcatatc gctggattca
     1321 cattgctgac ggtacttcag aacaaccatt tatagtggaa ctgttttcaa catcgcagcc
     1381 agaaatcttt gaaaatattt acccaatggc atattttgtg tgtacacagt tgaaagttgt
     1441 cagaaatgac aatcaagtac ctaagctgct ttacctcacc actacaaatg agagtggagt
     1501 gtttattact ggtcatagag gccagccgta tacgtatgat gccaaggtaa aaaactttat
     1561 tcaatggatt agaacaaagt ctgattccgg ggaacagaag aatatggtta ttggtggata
     1621 ttacccctat ccaccagtgc cagagacatt ttccaagtat agtagttcta ttaaagttga
     1681 gtcgctcttg acagctataa gtgaagtcag gaaggagatt gaagacttgc agtataggga
     1741 acaaaagcgc attgcaattc aggggataat tactgctata aagtatatcc cccatagcag
     1801 tgcgactgaa agtgcctcag catcagaaac acttcggaat gctaacagac cctcgacctc
     1861 tcaagcagct agagtagaaa ttcaagaaag aaatggtaaa cggcatcaag atgatgagcc
     1921 tgtgaattct cagtatttcc aaactacatc tacaaattta agtctgagca ataaaataag
     1981 aattcttcaa ggcccacacg ctaatccagt tgctgtacct caaccaggag cttctgtaca
     2041 aacaaaggga attaaaccgg gcatgccaag catcttcaac cgtcgagcaa atataaatgc
     2101 taatctgcaa gggaaagcca gaaaaactat aagtgatagg tgggagagtc agctgtggag
     2161 agagaaaaag tttggcttaa tagatcacct acactacagc cgtgtttatc ctgaaagtat
     2221 tccacggaaa tttatgtttg aacacagaaa gtttcttagt gaccagtata attctcagcc
     2281 tgcgaaatat gtaccaccag aaggaaggcc cccaaaactt gatgatttta agagcgcccg
     2341 aagccttgga cattttgaag taaccatact aggtctgaac catgagatag caatcgatgt
     2401 tgctttccta cccatgtatt gtccagaaga tattcgaaca tctcaaatag acacactgtt
     2461 gacctccatg aattacagct gtgcatatcc acaggacaca actggaaatg accgattgcc
     2521 aggtccaaga gcggttgcag gtgatattat aaaagcagca actgaactgg atagagtgca
     2581 tatcgtcggt atcttggata tctgtaattt gggtaataat aaagtggaag tctatttgca
     2641 caagatttat agtccagaga atacttctta aaagttagca aatgaaatta ttacagatta
     2701 tacgagtgta ctgctttaaa gatattccat cattttgctg gtaatttcag taactgtttt
     2761 cagcaagaat attacatgag ctctaaagtt attaagcagt tttatgttcg ttttgtgttt
     2821 agggagcttt ttaaaacact tcatttcaga ttcattattg aaaaaggtca tcaaaataat
     2881 ttttgtgtat aagggaattt accttgctta ccttactagt atgactatta tcttgacttc
     2941 tggtaattta tgttcactat tccatttgtg aagtgtactt tcattctaaa gcctcagtat
     3001 aaggcatcct aacttacaag agtaactttc catggacatt taacatcctt ccaattttat
     3061 tcacatataa tgggaaattt tgaattgcca gtttgaagac tgttctccta aagtgttcaa
     3121 cctgcacttc ttacaaccaa ggtagtttgt atcattttca aaagtacaca ttattagggt
     3181 ctagttgccc ctggtcctta gcttgctcag ctgcaaaata agcgtgctaa attaaattgt
     3241 cttaaggttt ttccacttca ttttgtgact ttgtgtggtt cgaatttctc agtattttaa
     3301 ccagtgtgtt gatgttaaag tcaaaggctg cagtatgtct atattcttgc tgtactcatt
     3361 ggtagtttca gtatatgtaa tgtgagttta aatagtgaaa ttgtatctca tattaacatt
     3421 tcaaatgctc atattgaaaa tggaaaatag taaacacggg aattgatttt attctggttg
     3481 tctataatac ttcattttaa atgtaaatgg ccactctgca tttgcaaggc ccggtggttg
     3541 acatctgtgt ggtttgttag atgagacaaa atgaccatta aatgagttta tagattattc
     3601 tgtatcaaga taaatctgat tccagttaag ctataaactt gtgggatttt cttgtagccc
     3661 tatagttctg tgacttcatt tgctatacgc tttaaatgtg ttgagcagcc tatgaaccta
     3721 aagacatact gcagtttgtt cataaatgta ttcagtcttt tattctttat aattgtgtgt
     3781 aaatgttaac taaacagtgg attcctctcg tgttacagtt ttgagtgaat tattaaagaa
     3841 gttaaaatgc aa
//
