LOCUS       NM_018059               5736 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Rap associating with DIL domain (RADIL), mRNA.
ACCESSION   NM_018059
VERSION     NM_018059.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5736)
  AUTHORS   Choi,B.H., Kou,Z., Colon,T.M., Chen,C.H., Chen,Y. and Dai,W.
  TITLE     Identification of Radil as a Ras binding partner and putative
            activator
  JOURNAL   J Biol Chem 296, 100314 (2021)
   PUBMED   33482197
  REMARK    GeneRIF: Identification of Radil as a Ras binding partner and
            putative activator.
REFERENCE   2  (bases 1 to 5736)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5736)
  AUTHORS   de Kreuk,B.J., Gingras,A.R., Knight,J.D., Liu,J.J., Gingras,A.C.
            and Ginsberg,M.H.
  TITLE     Heart of glass anchors Rasip1 at endothelial cell-cell junctions to
            support vascular integrity
  JOURNAL   Elife 5, e11394 (2016)
   PUBMED   26780829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5736)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
  REMARK    GeneRIF: It was shown that KIF14 associates with the PDZ domain of
            Radil and negatively regulates Rap1-mediated inside-out integrin
            activation by tethering Radil on microtubules. Radil is also
            important for breast cancer cell proliferation and metastasis.
REFERENCE   5  (bases 1 to 5736)
  AUTHORS   Liu,L., Aerbajinai,W., Ahmed,S.M., Rodgers,G.P., Angers,S. and
            Parent,C.A.
  TITLE     Radil controls neutrophil adhesion and motility through
            beta2-integrin activation
  JOURNAL   Mol Biol Cell 23 (24), 4751-4765 (2012)
   PUBMED   23097489
  REMARK    GeneRIF: Studies indicate that Radil regulates neutrophil adhesion
            and motility by linking Rap1 to beta2-integrin activation. +++
            ERROR +++ studies establish that Radil regulates neutrophil
            adhesion and motility by linking Rap1 to beta2-integrin activation.
REFERENCE   6  (bases 1 to 5736)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 5736)
  AUTHORS   Ahmed,S.M., Daulat,A.M., Meunier,A. and Angers,S.
  TITLE     G protein betagamma subunits regulate cell adhesion through Rap1a
            and its effector Radil
  JOURNAL   J Biol Chem 285 (9), 6538-6551 (2010)
   PUBMED   20048162
  REMARK    GeneRIF: Gbetagamma subunits enter in a protein complex with
            activated Rap1a and its effector Radil; this complex is required
            downstream of receptor stimulation for the activation of integrins
            and the positive modulation of cell-matrix adhesiveness.
REFERENCE   8  (bases 1 to 5736)
  AUTHORS   Smolen,G.A., Schott,B.J., Stewart,R.A., Diederichs,S., Muir,B.,
            Provencher,H.L., Look,A.T., Sgroi,D.C., Peterson,R.T. and
            Haber,D.A.
  TITLE     A Rap GTPase interactor, RADIL, mediates migration of neural crest
            precursors
  JOURNAL   Genes Dev 21 (17), 2131-2136 (2007)
   PUBMED   17704304
REFERENCE   9  (bases 1 to 5736)
  AUTHORS   Zhang,Z., Rehmann,H., Price,L.S., Riedl,J. and Bos,J.L.
  TITLE     AF6 negatively regulates Rap1-induced cell adhesion
  JOURNAL   J Biol Chem 280 (39), 33200-33205 (2005)
   PUBMED   16051602
REFERENCE   10 (bases 1 to 5736)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092610.1, BG722917.1, DA241653.1, BC117317.1, BC004919.2 and
            EF560723.1.
            
            On May 17, 2019 this sequence version replaced NM_018059.4.
            
            ##Evidence-Data-START##
            CDS exon combination :: EF560723.1, BC143526.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399583.4/ ENSP00000382492.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC092610.1         138862-138873       c
            13-74               BG722917.1         6-67
            75-628              DA241653.1         12-565
            629-2840            BC117317.1         503-2714
            2841-2841           AC092610.1         56996-56996         c
            2842-3485           BC117317.1         2716-3359
            3486-3639           BC004919.2         1325-1478
            3640-3682           EF560723.1         3537-3579
            3683-5736           AC092610.1         52212-54265         c
FEATURES             Location/Qualifiers
     source          1..5736
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..5736
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /note="Rap associating with DIL domain"
                     /db_xref="GeneID:55698"
                     /db_xref="HGNC:HGNC:22226"
                     /db_xref="MIM:611491"
     exon            1..121
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            122..720
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3413
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /note="Rap GTPase interactor; Ras association and DIL
                     domains"
                     /codon_start=1
                     /product="ras-associating and dilute domain-containing
                     protein"
                     /protein_id="NP_060529.4"
                     /db_xref="CCDS:CCDS43544.1"
                     /db_xref="GeneID:55698"
                     /db_xref="HGNC:HGNC:22226"
                     /db_xref="MIM:611491"
                     /translation="MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFS
                     SLGASDDPAELSTQLSAPGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYAL
                     DPRQAGQYVLCDVVGQAGDAGQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELR
                     KRSDVEELAAKEVDTITAGINAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSET
                     SLSPVNALPAAAQGPEEPGPDAMRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVG
                     QRTPSSKPSISLSAPDILPLHCTIRRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGH
                     RTVVLHHGDLLSLGLYYLLLFKDPAQAQPLPARALARLRAVPQSCRLCGAALGARGAA
                     SPTQAALPRRQQLLLEFEPHLEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCIQHSATH
                     FQPGTFGQLLLKIARLIRETVWEKTKELAEKQAQLQEPISLASCAMADLVPDLQPILF
                     WMSNSIELLYFIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLYA
                     FQQCVYYVSKSLYICLPALLECPPFQTERRESWSSAPELPEELRRVVSVYQAALDLLR
                     QLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMR
                     SAGFGAAGEHFFQKLSCTLNLLATPRAQLIQMSWTALRAAFPALSPAQLHRLLTHYQL
                     ASAMGPMSTWEPGAQDSPEAFRSEDVLESYENPPPIVLPSDGFQVDLEANCLDDSIYQ
                     HLLYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVLDGHLEAPSCPLAPRDP
                     GPAAREVAPERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSSCLLTPPSTPLGPEP
                     GDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFC
                     YVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVN
                     GSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKKIHFRTPPL"
     exon            721..968
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1601
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1639
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1800
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1913
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2151
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2324
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2475
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2684
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..3027
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3167
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3307
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..5736
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3663..3668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /note="hexamer: AATAAA"
     polyA_site      3686
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /note="major polyA site"
     regulatory      4794..4799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
                     /note="hexamer: TATAAA"
     polyA_site      4816
                     /gene="RADIL"
                     /gene_synonym="RASIP2"
ORIGIN      
        1 gccccgcccg ttgcgccgcc ggcaggaggc gccgcggcac gcgcgggtct gggcgccggc
       61 cccagccaac ggcgggtggg agcagcgcgg gaacgtggcg gcgcggcggg ttgtgccgga
      121 ggtcacggcc tccccacatc ctttggctga agcccacagt cctcatccat gaagcctcac
      181 ccaccatgtt ttatgggacg cacttcatca tgtccccgcc caccaagagc aaactgaagc
      241 ggcagagcca gctgttgtcc agcatgctgt cccggacgct gagctacaag taccgggacc
      301 tggactccac cttctccagc ctgggcgcca gcgatgaccc cgccgagctc tccacccagc
      361 tgtcggcccc tggtgtcctg aaggtgtttg gggacagtgt ctgcacagga acccactaca
      421 agagcgtcct ggccaccggc acctccagcg cccgtgagct ggtgaaggag gcgctggagc
      481 ggtacgccct ggaccccagg caggccggcc agtacgtgct gtgtgacgtg gtgggccaag
      541 ccggcgatgc tgggcagcgg tggcaggccc ggtgctttcg ggtgtttggg gacagtgaga
      601 agcccctctt gatccaggaa ttatggaaac cccgagaagg tttatcccgg aggtttgagc
      661 tgaggaagag gtcggacgtg gaggagctgg cagccaagga ggtggacacc atcacggcag
      721 ggataaacgc ccaggcccgg aggctgcagc ggagtcgcgc gaagggaacc ccgaccccgg
      781 ccctggggga tgcccggagc tctcctccac cccggttgcg ccgcacagtc agtgagacca
      841 gcctgagccc agtgaacgcc ctgcccgctg ccgcccaggg ccccgaggag cccggccccg
      901 acgccatgcg gtactcgctg taccagtccc cgcatctgct ccttctgcag ggctacagcc
      961 agcagcacga cagcctggtg tatgtgctca accgggaccg gcacacggtg ggccagcgga
     1021 ccccctccag caagcccagc atcagcctct cagcccccga catcctgcct ctacactgca
     1081 ccatccgccg gcaaccgctc ccggacagcg gccaggccgc ggggaggctg gtcctggagc
     1141 ccatccccgg ggcgcacatc tccgtcaact tctccgaggt ggggcacagg accgtggtgc
     1201 tgcaccacgg ggacctgctc tccctggggc tctactacct gctgctattc aaggaccccg
     1261 cgcaggccca gcccctgccc gcccgggcct tggcgcgcct ccgggctgtg ccgcagagct
     1321 gccggctgtg cggggccgcg ctcggggccc ggggagccgc ctcccctact caggccgccc
     1381 tgccccggcg ccagcagctg ctcctggagt ttgagcccca cctggaggac acgctgctgc
     1441 agaggatcat gacgttgatc gagccggggg gcgacgacca caagctgacc cccgccttcc
     1501 tcctgtgcct ctgcatccag cactcggcca cccacttcca gccgggcaca ttcgggcagc
     1561 tcctgctcaa gatagccagg ctgatccgcg agactgtctg ggagaaaacc aaagaactag
     1621 cagagaagca ggcgcaactc caggagccca tctcgctggc cagctgcgcc atggctgatc
     1681 tggttccaga cttgcagccc attcttttct ggatgtctaa ctccatcgag ctcctgtact
     1741 ttatccagca gaaatgccca ctctacatgc agagcatgga ggagcagctg gacatcacag
     1801 gctcgaagga atcgctgttc tcctgcacgc tgacggccag cgaggaggcc atggcggtgc
     1861 tggaggaggt ggtgctgtac gccttccagc agtgcgtcta ctatgtctcc aagtccctgt
     1921 acatctgcct cccggcactc ctggagtgcc cgccattcca gacggagcgc cgtgagagct
     1981 ggtcctcggc ccccgaactg cccgaggagc tgcgccgcgt ggtgtctgtg taccaggcag
     2041 ccctggacct cctgcggcag ctgcaggtgc accccgaggt ggcctcgcag atgctcgcct
     2101 acctcttctt cttctccggg acactgcttc tcaaccagct cctcgacagg ggcccctccc
     2161 tgagctgctt ccactggccc agaggtgtcc aggcctgcgc ccgcctgcag cagctcctgg
     2221 agtggatgcg gagcgccggc ttcggggcgg ctggagagca cttcttccag aagctctcct
     2281 gcaccctcaa cctgctggcc acacccaggg cccagctcat ccagatgagc tggacagccc
     2341 tgcgggctgc gttccccgca ctgagcccag cacagctgca ccggctgctg actcactacc
     2401 agctggcctc ggccatgggc cccatgagca cctgggagcc aggggcccag gacagccccg
     2461 aggccttcag gtcagaggat gttctggagt cctacgaaaa ccccccaccc atcgtcctgc
     2521 ccagcgacgg cttccaggtg gacttggaag ccaactgcct ggacgacagc atctaccagc
     2581 acctgctcta cgtccgccac tttctgtggg gtctgcggag cagagccagc cccggcagcc
     2641 ctggcaggcc tggcagtggg gcctcccagc cagtgtgccc cgagggtatg caccacgtgg
     2701 tccttgacgg gcacctggag gccccgagct gccccctggc tcccagggac cctggcccag
     2761 cagcccggga agtggccccg gagcgtactc ttcccttgag gggggctccc tgggcacagg
     2821 ccccccctgg aaggcaaccc agccgtgggg gctcccaggc tggccccccg cacacggact
     2881 cgtcctgctt gctcacgcct cccagcactc cacttggccc tgagcctggg gaccccgact
     2941 ggccagagtc cggcggcccc tgtggaaaag cgctcccaga gaggcagagg aacggactca
     3001 gcggcctccg gggtgcagct ccggaaggag actctgcagc ccttgcggag gagtcccctc
     3061 cagccccgtc cagccgcagc tccagcaccg aggacttctg ctacgtcttc acggtggagc
     3121 tggaacgagg cccctccggg ctggggatgg gcctgatcga cgggatgcac acgcacctgg
     3181 gcgcccccgg gctctacatc cagaccctgc tcccgggcag ccccgcagcg gccgacgggc
     3241 gcctgtcgct gggggaccgt atcctggagg tgaatggcag cagcctcctg ggccttggct
     3301 acctgagagc tgtggacctg atccgtcatg gcgggaagaa gatgcggttc ctggtcgcga
     3361 agtccgacgt ggaaacagcc aagaagatcc atttccgcac gccccctctc taggggggct
     3421 gcgaggacac ccccacaggc ccggcacccg gtcccacctg gtgacactgg gcttcctccc
     3481 gccttcgtcc ctgttttgta actgaccaag ttgggtcccg ggtggggagc ctcaccctgg
     3541 ggacatgcct gttgataaca tgcatctcag tgtaggttct atttatatgg cagatgacgt
     3601 gaaattgtga tgtttgttac agagctttta tgtttaaaga cttcaatgga gaagtacggt
     3661 tcaataaact atttttcccg ttcttagagg gtgccctgct ggggtctcaa ctcgggcagc
     3721 aggcgtgggc tgctcggagg ggccgcaggg gctccccatg gcctctgcct gccaccggca
     3781 cgggagaatg cagtgacagc tgtcatcagg ggatcatctg aactgactct ccctgccccc
     3841 gtcccaccca gacacagggc actgcaggaa gcagctccaa cagcccctcc cagctgaagc
     3901 agggccagac ctggcagagg atgctggact tctgatcccg ctgctcagca caggccccag
     3961 agaaaggtct agacacccag gcgttggaaa gtggaccggc ctgatggtct ctgaggcgcc
     4021 gagcccaccc tgggccctgc ttcctctccc aggactcctg ctccctcctg agttcctctc
     4081 ccctactaaa gccaccagcg tggccctgat accaggctgg cggccccagg cccttaatcc
     4141 tcaccagcgt ccccctggcc accggcccta acccgggcag gaggccagcg tccctctcca
     4201 ccagctggct gaccatgcgc aggaccaggg cagggcactt gctgcctcgg ggtgacagcg
     4261 tgggtcgctg ggcatcctca gcagctccac caactgggtg tgggtggctt ccgcgccctc
     4321 ctggctgtgg tggaactggt ggcccagggt catctttgat agcaacagag aaaccctggg
     4381 gaagagggtc ccggcatcag ttgcagatgc acctctcact gggacagagg tctgtgcggg
     4441 gtccccagat cggtgtcctg ggtctgtccc aggccctggg cctcgtgcag ctccacgctg
     4501 ccccctggtg tgcgctacgg cgaggtgcag cgcgtccgcc ccgcgccctc tgccgacccg
     4561 cagttctgtg tgcggctccg cattgcgcct ggctcgaaac ggcgaccact gccaggttcc
     4621 caaaatactg gataaaatat atatatatat atagtgtttg tatatatatt taagatatgt
     4681 aaaatatatg aatatatata aatatataat tatatatgaa tatattacat attcatgtat
     4741 acgtaatata ttcgtatatt ttataaacat tttttatatt ttattatata aaatataaat
     4801 atttaatttt tttttatgag acggagtctc gctctgtgac ccaggctgga gtgcagtggt
     4861 gcaatctcag ctcactgcaa cctccacctc ccaggttcaa gcaattctcc tcagtctcct
     4921 gagtagctgg gattacaggc gcctgccacc acgcttggct aatttagtac ttttagtaga
     4981 gacagggttt caccacgttg gccaggctga tttcaaactg acatcaagtg atctgcccgc
     5041 cttgccctcc caaagtgctg ggattacagg cgtgggatta ccatgcctgg ccttgttctg
     5101 tttcttttcc taggagtccc acaacgtgtg tgttagcact gccgagaatg tctcacagct
     5161 ctggacggtc tgcatttctg gacctggtgc agatcccagg atcctggact ctgatttgat
     5221 gccttaacgg tggaaggggg ttgagtatat tttttatgtg ggaggggtgt ggactgtggc
     5281 cagaggaaag acagtggcaa ggcatttcca aaggtggcca ccaacagttc ctcccacaaa
     5341 gagaaggggg cttatctctt cttccctgca atattctccg gccttctgac ttgctccgaa
     5401 caacaggatg cagcataagt gatattctgg gaccttccaa gccagactga agggcctttg
     5461 gtttctattt tcatgctcct ggaactcagc atccatggaa agaagctctt ggcatcaccc
     5521 caaggaaggg aggccccgtg gagtcgggga ggcccagcta gcctctggcc gctgaagcac
     5581 ctagctgagg tgcgggactg gtgagggctg ccactggctg ttctggtctt gctgagcttc
     5641 caggcgaatg cagtcccacc agtgatcccg gggacaccac gtggagcaga acgacttccc
     5701 agccaggccc cagacaatct acaacactgt gaaagg
//
