LOCUS       NM_015106               9957 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens RAD54 like 2 (RAD54L2), transcript variant 2, mRNA.
ACCESSION   NM_015106 XM_011533524
VERSION     NM_015106.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9957)
  AUTHORS   He,Q., Hao,Q., Wu,Y., Vadgama,J.V. and Jiang,Y.
  TITLE     CircRAD54L2 promotes triple-negative breast cancer progression by
            regulating the miR-888 family/PDK1 axis
  JOURNAL   Life Sci 312, 121128 (2023)
   PUBMED   36334805
  REMARK    GeneRIF: CircRAD54L2 promotes triple-negative breast cancer
            progression by regulating the miR-888 family/PDK1 axis.
REFERENCE   2  (bases 1 to 9957)
  AUTHORS   Geng,T., Li,M., Chen,R., Yang,S., Jin,G., Jin,T. and Chen,F.
  TITLE     Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung
            cancer in the Chinese Han population
  JOURNAL   BMC Cancer 22 (1), 1181 (2022)
   PUBMED   36384536
  REMARK    GeneRIF: Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of
            lung cancer in the Chinese Han population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9957)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9957)
  AUTHORS   Tsuchiya,M., Isogai,S., Taniguchi,H., Tochio,H., Shirakawa,M.,
            Morohashi,K.I., Hiraoka,Y., Haraguchi,T. and Ogawa,H.
  TITLE     Selective autophagic receptor p62 regulates the abundance of
            transcriptional coregulator ARIP4 during nutrient starvation
  JOURNAL   Sci Rep 5, 14498 (2015)
   PUBMED   26412716
  REMARK    GeneRIF: p62 is a novel binding partner for ARIP4, and that its
            binding regulates the cellular protein level of ARIP4 under
            conditions of metabolic stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9957)
  AUTHORS   Ogawa,H., Komatsu,T., Hiraoka,Y. and Morohashi,K.
  TITLE     Transcriptional Suppression by Transient Recruitment of ARIP4 to
            Sumoylated nuclear receptor Ad4BP/SF-1
  JOURNAL   Mol Biol Cell 20 (19), 4235-4245 (2009)
   PUBMED   19692572
  REMARK    GeneRIF: The ATPase activity of ARIP4 was stimulated in the
            presence of sumoylated Ad4BP/SF-1 and the Ad4BP/SF-1-binding site
            containing double-stranded DNA.
REFERENCE   6  (bases 1 to 9957)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 9957)
  AUTHORS   Janne,O.A., Moilanen,A.M., Poukka,H., Rouleau,N., Karvonen,U.,
            Kotaja,N., Hakli,M. and Palvimo,J.J.
  TITLE     Androgen-receptor-interacting nuclear proteins
  JOURNAL   Biochem Soc Trans 28 (4), 401-405 (2000)
   PUBMED   10961928
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092037.2, AC113933.2 and AC099050.2.
            
            On Jun 2, 2019 this sequence version replaced NM_015106.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3599068.1,
                                           SRR11853559.23037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684192.1/ ENSP00000507587.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC092037.2         157179-157375
            198-259             AC092037.2         160049-160110
            260-452             AC113933.2         122351-122543
            453-654             AC113933.2         159537-159738
            655-794             AC113933.2         161318-161457
            795-911             AC113933.2         162256-162372
            912-1138            AC113933.2         162689-162915
            1139-1321           AC113933.2         165561-165743
            1322-1455           AC113933.2         165886-166019
            1456-1652           AC113933.2         167577-167773
            1653-1995           AC113933.2         169145-169487
            1996-2173           AC113933.2         170128-170305
            2174-2425           AC113933.2         171403-171654
            2426-2544           AC113933.2         171865-171983
            2545-2581           AC113933.2         173733-173769
            2582-2663           AC099050.2         18370-18451
            2664-2763           AC099050.2         20459-20558
            2764-2969           AC099050.2         21608-21813
            2970-3142           AC099050.2         22175-22347
            3143-3339           AC099050.2         22869-23065
            3340-3539           AC099050.2         32555-32754
            3540-3629           AC099050.2         34164-34253
            3630-3722           AC099050.2         36610-36702
            3723-9957           AC099050.2         39010-45244
FEATURES             Location/Qualifiers
     source          1..9957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..9957
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /note="RAD54 like 2"
                     /db_xref="GeneID:23132"
                     /db_xref="HGNC:HGNC:29123"
                     /db_xref="MIM:620006"
     exon            1..197
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            198..259
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            260..452
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..4717
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /EC_number="3.6.4.12"
                     /note="isoform a is encoded by transcript variant 2;
                     helicase ARIP4; RAD54-like protein 2; androgen
                     receptor-interacting protein 4; AR interacting protein 4"
                     /codon_start=1
                     /product="helicase ARIP4 isoform a"
                     /protein_id="NP_055921.2"
                     /db_xref="CCDS:CCDS33765.2"
                     /db_xref="GeneID:23132"
                     /db_xref="HGNC:HGNC:29123"
                     /db_xref="MIM:620006"
                     /translation="MSDESASGSDPDLDPDVELEDAEEEEEEEEVAVEECDRDDEEDL
                     LDDPSLEGMCGTEHAQLGEDGQQPPRCTSTTSSQSEPSEQLRRHQGKNLASEDPKKKR
                     AQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKDYAAPIPTVPLEFLP
                     EEIALRASDGPQLPPRVLAQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSS
                     ESVSEDDEEEEKGGTHVNDVLNQRDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQI
                     GGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAI
                     VPVNTLQNWLAEFNMWLPPPEALPADNKPEEVQPRFFKVHILNDEHKTMASRAKVMAD
                     WVSEGGVLLMGYEMYRLLTLKKSFATGRPKKTKKRSHPVIIDLDEEDRQQEFRREFEK
                     ALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDF
                     VRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTV
                     LKIHLPAKEENVILVRLSKIQRDLYTQFMDRFRDCGSSGWLGLNPLKAFCVCCKIWNH
                     PDVLYEALQKESLANEQDLDVEELGSAGTSARCPPQGTKGKGEDSTLASSMGEATNSK
                     FLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKI
                     LVFSQSLSTLALIEEFLGKREVPCPPGTEGQGAQKWVRNISYFRLDGSTPAFERERLI
                     NQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQK
                     KPCYIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEP
                     APQVSLNVKGIKESVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSY
                     EEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKGDEKPVASVRPVQSTP
                     IPMMPRHVPLGGSVSSASSTNPSMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDV
                     QARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKVPEDGRMAASGSQGPSCEST
                     SNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSTNAALPG
                     PPAQLMDSSAVPGTALGTEPRLGGHCLNSSLLVTGQPCGDRHPVLDLRGHKRKLATPP
                     AAQESSRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGENSLFM
                     GSTPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGI
                     LPSYSLPFSQPLLSEPRMFAPFPSPVLPSNLSRGMSIYPGYMSPHAGYPAGGLLRSQV
                     PPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK"
     exon            453..654
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            655..794
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            795..911
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1138
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1321
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1455
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1652
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1995
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2173
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2425
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2544
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2663
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2763
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2969
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3142
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3339
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3539
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3629
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3722
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..9957
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4886
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
     regulatory      9940..9945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /note="hexamer: AATAAA"
     polyA_site      9957
                     /gene="RAD54L2"
                     /gene_synonym="ARIP4; HSPC325; SRISNF2L"
                     /note="major polyA site"
ORIGIN      
        1 gctggcgagc gccgccgccg gtggagaccg acgcttggcc agagccagcc cgcggcgccc
       61 gggcctggcc ggctgcttcc cgcctcagcc gccgcccccg cctccgccgc cgcagacttt
      121 gcctaggcgg gcgaagctga acgtgaggtc cctcggccct gcgcggtccg gcgcggcccg
      181 gagccgcggc gcaggaggct gggagtgtct gctgatcact tggagtgctg tcccttggaa
      241 caggaggagt aagattgagc acccctgcag tggaccatga gtcggtaatg cccactgagg
      301 acctctggga gccatgtcag acgaatctgc ctcagggagc gatccagacc tggacccgga
      361 cgtggagctg gaggatgcgg aagaggagga ggaggaggag gaggtggcag tggaggagtg
      421 tgacagggat gatgaagaag acctgctgga tgacccatcc ctggaaggca tgtgtggcac
      481 tgagcatgcc cagttgggag aagatgggca gcagccgccg cggtgcactt caactacctc
      541 atctcagtct gagccttcag agcagcttag gcgccaccaa ggcaagaacc tagcctccga
      601 ggaccccaaa aagaagagag ctcagaagcc ctcccacatg agaagaaaca tacgaaagct
      661 actccgggag gatcaattgg agcctgttac caaagcagca cagcaagaag agttggaaag
      721 aaggaagcgc ctggagcagc agaggaaaga ttatgcagcc cctattccta ctgttccgct
      781 ggagttcctc cctgaggaaa ttgctttaag ggcaagtgac ggtccccaac tgcctcctcg
      841 ggtcttggcc caggaagtca tttgtttgga cagtagcagt ggcagtgagg atgaaaaaag
      901 cagtcgagat gaggtgattg aactgagctc tggagaggag gacactctgc acattgtgga
      961 cagcagtgaa tctgtcagtg aagatgatga ggaagaagag aagggtggca cccatgtcaa
     1021 tgatgtctta aaccagcgtg acgcccttgg gcgggtcctt gtcaacctaa accaccctcc
     1081 agaggaggaa aatgtcttcc ttgccccaca gttggcacgg gctgtgaaac ctcatcagat
     1141 tggcgggatc cggttccttt acgataacct agtggagtct ctggagaggt ttaagaccag
     1201 cagtggcttt ggctgtattc tggcccacag catgggtctg gggaaaactt tgcaagtgat
     1261 ctctttcatc gacgtcctct tccgccacac gccagccaaa acagtccttg ccattgtgcc
     1321 ggttaatact cttcagaatt ggctggcaga gttcaacatg tggcttccac ctcctgaagc
     1381 cctcccggct gacaacaagc ctgaagaagt ccagcctcgg ttctttaaag ttcacatctt
     1441 gaatgatgag cacaagacga tggcatctcg tgctaaagtg atggctgatt gggtgtcaga
     1501 gggtggcgtg ctgctgatgg ggtacgagat gtacagactc ctcactctga agaaatcatt
     1561 tgccacaggt agaccgaaga aaaccaagaa gcgttctcac ccagtcatca ttgatctaga
     1621 tgaggaagat cggcagcagg agtttcggag agagtttgag aaggctttat gccgccctgg
     1681 ccctgatgta gtaatctgtg atgagggaca ccgcatcaaa aactgccagg ccagcacctc
     1741 acaggctctg aagaatatcc gctctcgccg ccgggtggtg ctgactgggt accctctgca
     1801 aaacaacctc attgagtact ggtgcatggt ggactttgtg cgcccagact tccttggcac
     1861 ccggcaggag ttcagcaaca tgtttgaacg ccctatcctg aatgggcaat gtattgacag
     1921 cacacctcag gacgtccgcc tcatgcggta ccggagccat gtcctgcaca gtcttctgga
     1981 gggctttgtg cagaggagag gccacactgt gctgaagatt catctccctg ccaaggaaga
     2041 aaatgtgatc cttgtgcggc tctccaagat ccagcgagat ttgtatacac agttcatgga
     2101 tcgcttccgg gactgtggta gcagcggttg gctggggctg aaccccctta aggcattctg
     2161 tgtgtgttgc aagatctgga atcaccctga tgtgctgtat gaagcccttc agaaggagag
     2221 cttggccaat gagcaggacc tagacgtgga agaacttggc tctgcaggga ccagtgcccg
     2281 ctgtccacca cagggaacaa aaggcaaggg agaggatagc accttggctt cctcgatggg
     2341 agaggcaacc aatagcaagt tcctacaggg cgttggcttc aaccctttcc aggagcgagg
     2401 caacaacatt gtcacatatg aatgggccaa ggaccttctg actaattacc agactggagt
     2461 cctagaaaac tctcccaaga tggtactgct tttccacctg attgaggaaa gtgtgaagct
     2521 tggggacaag atccttgtgt ttagccagag tctttccacc ttggctctca tcgaggaatt
     2581 ccttggaaaa cgagaagtac cctgtccacc tggtaccgag gggcaaggag cacagaagtg
     2641 ggttcgaaac atcagctact tccggctaga tggtagcacc cctgcctttg agagggagcg
     2701 gcttattaat cagttcaatg atcccagcaa cctcaccacc tggctgttcc ttctctctac
     2761 aagggccgga tgcttgggtg tgaatctgat tggtgccaac cgagtggtgg tgtttgatgc
     2821 ttcctggaac ccttgccatg atgcccaggc agtatgtcgg gtataccgtt atggccagaa
     2881 aaagccctgt tacatctatc gccttgtggc tgattacact ctagaaaaga agatctatga
     2941 ccgtcagatt tccaagcagg gcatgtcaga tcgggtggtg gatgatctaa atccaatgct
     3001 gaacttcaca cggaaagagg tggaaaacct actgcacttt gttgagaagg agccagctcc
     3061 ccaagtttcc ttgaacgtaa aggggatcaa ggagtcagtc ctgcaactgg cctgtctgaa
     3121 gtaccctcac ctcatcacca aggagccttt cgagcatgag tcattgctct tgaaccgaaa
     3181 ggatcacaag ctaaccaagg ctgagaaaaa agcagcaaag aaaagctatg aggaagacaa
     3241 acgcacatca gtcccctata cccgcccatc gtatgcgcag tattaccctg ccagcgatca
     3301 gagcctgacc agcatccccg ccttcagcca gagaaactgg cagccaactt tgaagggtga
     3361 tgaaaagcct gtggccagtg ttcgtcctgt gcagtccacc cccatcccca tgatgccccg
     3421 gcatgtccca ttgggaggaa gtgtaagctc tgcctccagc acaaatccat ccatgaactt
     3481 tcccatcaac tacttgcagc gtgcaggagt ccttgtgcag aaggtggtca ccacgacaga
     3541 tattgttatt cctggactca acagctccac agatgtacag gcaagaatta atgctggtga
     3601 gagcatccac atcatccgtg ggacaaaagg gacgtacatc cgtaccagtg atggacggat
     3661 ctttgctgtc cgggcaactg gcaaaccaaa ggttcctgaa gatggtcgga tggctgcctc
     3721 aggttcccag ggaccttctt gcgagtccac aagcaacggc agacacagtg cctcatcacc
     3781 caaagccccc gaccctgagg ggctggccag gcccgtctct cctgacagcc cagagatcat
     3841 cagtgagctt cagcagtatg cagatgtggc tgctgcccgg gaatcccgtc agagctcccc
     3901 aagcaccaat gccgccctgc ctggcccccc ggcccaactt atggacagca gtgctgttcc
     3961 cgggacagct ctcggaactg agcctcgact agggggtcat tgcctcaata gttccctctt
     4021 ggtgactggc cagccctgtg gtgacaggca cccagtgctg gacttaaggg gccacaagcg
     4081 aaagttggcc acaccacctg ctgcccagga gtcatcccgc cggcggtcca ggaagggtca
     4141 tctgccagcc cccgtgcagc cgtatgaaca cgggtatcca gtctctggcg ggtttgccat
     4201 gccacccgtc tccttaaacc ataacctcac cacccccttc acctcccagg ctggggagaa
     4261 ctccctgttt atgggcagta ccccctccta ctaccagctg tccaatttgc tggcagatgc
     4321 ccgcctggtg tttccagtga ctactgaccc tctggtgcca gcaggccccg tcagttcctc
     4381 ttccacggct acctcagtca ctgccagcaa cccctccttc atgctcaacc cttctgtgcc
     4441 agggatacta cccagctatt cactcccatt ctcacagcca ctcctgtccg agccgaggat
     4501 gtttgcgcct tttccttccc ctgtcttgcc cagcaacctt tcgcggggca tgtctatcta
     4561 tccaggctac atgtccccac atgcaggcta cccagctggt ggcctcctac ggtcccaggt
     4621 gcctccattt gactctcatg aggttgccga ggttgggttc agctccaatg atgatgagga
     4681 taaagacgat gatgtgatag aggtcactgg gaaatagcta gggagcccct ccccacctca
     4741 cttggggccc ccagcaggtt gcccaccaag ctgaaaggca gtgatttaga ccttttgaga
     4801 ataggacact tggcaggagg gaaaaggaag aggacaaagg agggtggttg gccaaagtgg
     4861 cagagctctg ttgctgttta acaaaagagg caaaaaaaaa aaaaaaaaaa aaaaagtcca
     4921 acacagcagc aatagcggga aatcagggac ccaaaacagg gatggagggg cagtgcagcc
     4981 tcttttcctt cctgccttgc ttatgctgtc tgcttgcttg ctcgcccatc tgagtgtaga
     5041 agcgcacatc ccatttctgt ctttgggaac attctttccc aagagagctg ccttactagg
     5101 tgacttagct tggcctgggg aggggagtga aggaagggag aatgagtgag agaaggaggg
     5161 tgggtagggg gagcagactg tgatcccatg tgaagtgggg tctttttagg gggtgggaag
     5221 gaagctgacc aggtatgtgt gtttgtgagt gtgtgtgtgt atgtttattt tgtatgtgta
     5281 tgtatggaac agagcagggg tgaaggtggg aggggaggga gggaagaact aagagggaaa
     5341 ctgaaaaatg aatttatctt tctttaaatg gaagtcagtt tggtggttca tggcacctag
     5401 tgtgaacatc agggtgagcc cagaagagcc atggaaataa caagtttcct tcgggatggg
     5461 tgaagagaag gcccagctaa ctcaagtccc tggtattcag agccacattt gtgtgagaat
     5521 ttggggaaat tcatgagaga aaatgggcat taccaatcta tgtctcttaa ccccggtggc
     5581 tatctctgag cagctctccc tttccagctt ggaaggttgt ctgtgtgcag aggctgggag
     5641 ggagaagcac tgcagtacgt gaatgaaagg tcgcagagtt gtggctggaa aatacatttt
     5701 tcaccagggt agaactgagc ccccagctgc ctatcctggt agtcttttct gttcctttcc
     5761 ttccccttta gagagctcca tgttaattta tttcttatgg gcaattattt attacttgga
     5821 cttttcatgt gtcttgttta tttgggggtg gggggaggtt aggggtaagg agggtaggtg
     5881 atagaaaggg aagttttaag atatcccaga ccctatagcc actggtgaaa aacaatcctg
     5941 gatggatggt aaattgacca ggggaagagt taggtttgac caaggtttgg attaaacaac
     6001 tatatttttg agagatggct tttcaggaag atcagggaat cctgagactg gatagttagt
     6061 ggagggtggg actcattcca cagaaatcga aagttgtgat catggagttt gcaattggga
     6121 agtaagagac cccagatttg gagctgtgtc ctcctgggat gatgttagat gttggctctc
     6181 tatgctgaat agtgaagctg tggataggcg gttgctgggt tgagggactg ttgatttcat
     6241 gttcgaaaat atcttcaggt ggtccatgta ggcctggtgt ctgctgcctc catctttgaa
     6301 ggaacatgga ggagcccttt ctctgtagga gccctaagtc tgggttttat cttaaaagaa
     6361 cacaccagtc attctgggtc tccccttatt gccattgcca ggggagggtc gtctagtcct
     6421 taagcataaa cactggctgt cttcctactg gtgtccccgc cccctctgta tcccccaccc
     6481 caacactttg ccagacagtt ctttatgatg aacaaacttt ggctttagag ctttaccact
     6541 tacccatggc tccctcctta ctgggcaggt ggtgtacctg cctcttccca gcccagaagg
     6601 cagcttagtc aggtcatccc agtagtagct cctacagctc ttctgaccag cccatttcca
     6661 tctttggagg gccttagcag actctggggt attgtcctca gagaagagac aaggagatga
     6721 tggatggggt gcatgtgtat atgtgtgttt gtctgctgtc caataacacc aaaagtggaa
     6781 cttaagaagc tttgtgtttt cataagcacc ctgccagaca cttaactctt ctactcatgg
     6841 aagccttaga tctacaattt agctatgcaa attattttaa taatttaaaa atagcagttc
     6901 caaccagtgc tttctctttc agatgcatcc caagaatgga tggtgaaggg actcagttgg
     6961 agtgagctct caggttgagg ctggtgcagt aggagtgagc tagactgaat ctccaattta
     7021 tgggacacac tcagaacctg ggttacactg atgcctctca ggccctggag cactgggatc
     7081 ccagagatgc atgtgtgcat gtgtatgtct gtgtgtgtgt gttgtcggga gaagggggta
     7141 gtatttctgt gttcacttct aggaaatcac tgtactagcc tccaagaatc cggaaacctt
     7201 cccagccggg aactgaaacc attccctgga gggatgggct tggcttttga agttgacaga
     7261 aagtaaatgg gtattctgag aggcagcaca tgcctactgt ctatccagtg ttccagggac
     7321 tgggtcttgc ttctactcag cagaggccat cattctggga ggctgacctg actagagaag
     7381 gctttctttt atatgtgcag tttctattgt gtagaggggt tgggggtggg atcatgggaa
     7441 attggagtgc taccaggtcc atggtttttg cttttttttt tttttttttt tttttttttt
     7501 ttttttaaag aaaataacct gaaaacactt ctgacttttc cactgtctct ttatatgtgc
     7561 tgataggcaa atgtgcatgc acaccaaaca taagcatgtt tgtgagggaa gcaggaagta
     7621 tctcagagcc taagaaccat gttttatagt ttctttgatc ataaacactt ggtggtgtct
     7681 tccacccatt atccaggcct gaggggggca gggtggctgg tgataagagg gagggcagaa
     7741 aatcaggcct aggcgttttc ccttaccatt gtcttccatg gaatgttttc aagggcctct
     7801 caagccccat tcatctggtt tagccaagtt ctcagcctgg ggaacacagt actacttaat
     7861 gattgaggtt taccatttat agtgatgctt gatttccttt tcttaatata tttgtagata
     7921 aaaattgaac agggacaaag tagctattta agaaaggaag tgaaccatgt tgggtcatat
     7981 cattttcttt agattggata tctatgaagt ccacacccct ttgagttatg ctttttaggc
     8041 atctatctca tcatctcctg atttaaggat aattctgtct ggtccttgga gctctcttcc
     8101 ctaggaatta gtgtgtggag tctctatatg cttgtgatcc ttggagctct cttccctagg
     8161 aattagtgtg tggagtctct atatgcttgt gattcacaac taaatatgaa atttctcaat
     8221 tcaggagcag gaagcaaagt gctggggtac agttttgcag attggttgaa acacttagcc
     8281 aaacttaagt ggcctgggta ggaccatcac tcccaaagtt gtcagcagag aagggccctc
     8341 tgtgtgagtc tattcaaacc tggcattgct ctgaaattga gtcctcatcc catggggaag
     8401 gtcttctggg ggctttacat tccttgttac tagtgttctg gatattacct tctgcttccc
     8461 acttcctttt tttttttttt gagacagagt cttgctctgt cacccaggct tgagtgcaat
     8521 ggtgtgatct tggctccgtg caacctccac tcccggtttc aagcgatcct cctgcctcag
     8581 cctcccaagt agctgggatt acaggtgcac accaccatgc ccagctaatt tgtatatttt
     8641 ttagtagaga cggggtttca ccacgttggc caggctggcc ttgaactcct gacctcaagt
     8701 gatccaccct cctcggcctc ccagtgatgg gattacaggc gtgagccact gctcctggcc
     8761 cccacttcct tttgatttct cagatcagtc tttcccttct gagccatggc cttctgtgca
     8821 cccagctcag tggctcttca cccctaaaac taagtgaagt catccttccc caaaaggacc
     8881 cctgggagat gttctggccc tctgctgact actcccagga atcagcacct caaggactat
     8941 ttgagaatgt tgtgctctct attggtcacc ttgagactcc gttcccctgc tgccaactct
     9001 tctcttctgc cctgtgtatt ctgctgtgat ccccttaacg gcttttctgt gctactagct
     9061 tagccctagg ccttttatga atacctgagt cttataacaa tgaacttctt gagcaggcag
     9121 tgtccaactt ctttgctctt cagggacctg agtgtgcacc tttccctttt gcaggtctat
     9181 ttgacatagt aatctagtgt gttggggagg ggtagccaag caggctgcag tgtctgcaat
     9241 gcagagggct tggggaggtt tgggtactct ctgctgccac tactgggatg atattcagaa
     9301 gagagaggac ctcatactgt gactggaccc aggaccctcc ctggaagaga gctcagccca
     9361 gctgtgtgtg tgtgtgtgtg tgagtgtgtg tgtgtgtgtt tgtgtgctgt gctcatgtgc
     9421 acctgggtgt aaaatgactg ttatctggtt gtgttactca gggtgggctg gggactcacc
     9481 agaagaatcc cccccagcct gcccaagaca ggtttttccc ttgtaccatc ttcagagagg
     9541 tcaggggaag agggtccagg tgggttaagg ggggtcgcta tggataacca ctaagaccag
     9601 actgctgcca ggaggagtgg gggataatga ggtggcccca gggtcctggc acctggcttt
     9661 ggttttccgt cttctttcct caggacgccc ctgaggcctg ggacctgtgc ctggcttcga
     9721 ggagcatctg tggctgggtg atccagctgc tggtgtgatc atgggcttcc ctcctctcag
     9781 cagggcaggc gctcctgccc cagagactgg gcaactggct gtttctatga cgtatttatt
     9841 tttacttgtg tttcatgtca cttttttaaa aaaaagcaaa cagaacaatt gtaagtcagt
     9901 ataactgcct atcagttttc tttatttctc tttttgtaaa ataaaattta aactcaa
//
