LOCUS       NM_003579               3078 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens RAD54 like (RAD54L), transcript variant 1, mRNA.
ACCESSION   NM_003579
VERSION     NM_003579.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3078)
  AUTHORS   Li,Z., Xie,L., Zou,L., Xiao,S. and Tao,J.
  TITLE     Overexpression of RAD54L attenuates osteoarthritis by suppressing
            the HIF-1alpha/VEGF signaling pathway: Bioinformatics analysis and
            experimental validation
  JOURNAL   PLoS One 19 (4), e0298575 (2024)
   PUBMED   38593124
  REMARK    GeneRIF: Overexpression of RAD54L attenuates osteoarthritis by
            suppressing the HIF-1alpha/VEGF signaling pathway: Bioinformatics
            analysis and experimental validation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3078)
  AUTHORS   Liu,C., Ren,W., Zhang,Z. and Guan,J.
  TITLE     DNA repair/recombination protein 54L promotes the progression of
            lung adenocarcinoma by activating mTORC1 pathway
  JOURNAL   Hum Cell 36 (1), 421-433 (2023)
   PUBMED   36454390
  REMARK    GeneRIF: DNA repair/recombination protein 54L promotes the
            progression of lung adenocarcinoma by activating mTORC1 pathway.
REFERENCE   3  (bases 1 to 3078)
  AUTHORS   Wang,Y., Zhou,T., Chen,H., Wen,S., Dao,P. and Chen,M.
  TITLE     Rad54L promotes bladder cancer progression by regulating cell cycle
            and cell senescence
  JOURNAL   Med Oncol 39 (12), 185 (2022)
   PUBMED   36071250
  REMARK    GeneRIF: Rad54L promotes bladder cancer progression by regulating
            cell cycle and cell senescence.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3078)
  AUTHORS   Nathansen,J., Lukiyanchuk,V., Hein,L., Stolte,M.I., Borgmann,K.,
            Lock,S., Kurth,I., Baumann,M., Krause,M., Linge,A. and Dubrovska,A.
  TITLE     Oct4 confers stemness and radioresistance to head and neck squamous
            cell carcinoma by regulating the homologous recombination factors
            PSMC3IP and RAD54L
  JOURNAL   Oncogene 40 (24), 4214-4228 (2021)
   PUBMED   34079088
  REMARK    GeneRIF: Oct4 confers stemness and radioresistance to head and neck
            squamous cell carcinoma by regulating the homologous recombination
            factors PSMC3IP and RAD54L.
REFERENCE   5  (bases 1 to 3078)
  AUTHORS   Avsar,T., Mohiyuddin,R., Calis,S., Yapicier,O. and Kilic,T.
  TITLE     Association of MTHFR, MTRR and RAD54L Gene Variations with
            Meningioma and Correlation with Tumor's Histopathological
            Characteristics on Turkish Cohort
  JOURNAL   Turk Neurosurg 31 (4), 587-593 (2021)
   PUBMED   34169999
  REMARK    GeneRIF: Association of MTHFR, MTRR and RAD54L Gene Variations with
            Meningioma and Correlation with Tumor's Histopathological
            Characteristics on Turkish Cohort.
REFERENCE   6  (bases 1 to 3078)
  AUTHORS   Matsuda,M., Miyagawa,K., Takahashi,M., Fukuda,T., Kataoka,T.,
            Asahara,T., Inui,H., Watatani,M., Yasutomi,M., Kamada,N., Dohi,K.
            and Kamiya,K.
  TITLE     Mutations in the RAD54 recombination gene in primary cancers
  JOURNAL   Oncogene 18 (22), 3427-3430 (1999)
   PUBMED   10362365
REFERENCE   7  (bases 1 to 3078)
  AUTHORS   Swagemakers,S.M., Essers,J., de Wit,J., Hoeijmakers,J.H. and
            Kanaar,R.
  TITLE     The human RAD54 recombinational DNA repair protein is a
            double-stranded DNA-dependent ATPase
  JOURNAL   J Biol Chem 273 (43), 28292-28297 (1998)
   PUBMED   9774452
REFERENCE   8  (bases 1 to 3078)
  AUTHORS   Golub,E.I., Kovalenko,O.V., Gupta,R.C., Ward,D.C. and Radding,C.M.
  TITLE     Interaction of human recombination proteins Rad51 and Rad54
  JOURNAL   Nucleic Acids Res 25 (20), 4106-4110 (1997)
   PUBMED   9321665
REFERENCE   9  (bases 1 to 3078)
  AUTHORS   Rasio,D., Murakumo,Y., Robbins,D., Roth,T., Silver,A., Negrini,M.,
            Schmidt,C., Burczak,J., Fishel,R. and Croce,C.M.
  TITLE     Characterization of the human homologue of RAD54: a gene located on
            chromosome 1p32 at a region of high loss of heterozygosity in
            breast tumors
  JOURNAL   Cancer Res 57 (12), 2378-2383 (1997)
   PUBMED   9192813
REFERENCE   10 (bases 1 to 3078)
  AUTHORS   Kanaar,R., Troelstra,C., Swagemakers,S.M., Essers,J., Smit,B.,
            Franssen,J.H., Pastink,A., Bezzubova,O.Y., Buerstedde,J.M.,
            Clever,B., Heyer,W.D. and Hoeijmakers,J.H.
  TITLE     Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA
            repair gene: evidence for functional conservation
  JOURNAL   Curr Biol 6 (7), 828-838 (1996)
   PUBMED   8805304
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB449264.2, BC121060.1 and
            BM678712.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003579.3.
            
            Summary: The protein encoded by this gene belongs to the DEAD-like
            helicase superfamily, and shares similarity with Saccharomyces
            cerevisiae Rad54, a protein known to be involved in the homologous
            recombination and repair of DNA. This protein has been shown to
            play a role in homologous recombination related repair of DNA
            double-strand breaks. The binding of this protein to double-strand
            DNA induces a DNA topological change, which is thought to
            facilitate homologous DNA paring, and stimulate DNA recombination.
            Alternative splicing results in multiple transcript variants
            encoding the same protein.[provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC121059.1, X97795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371975.9/ ENSP00000361043.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-424               DB449264.2         47-470
            425-2958            BC121060.1         1-2534
            2959-3078           BM678712.1         19-138              c
FEATURES             Location/Qualifiers
     source          1..3078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..3078
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /note="RAD54 like"
                     /db_xref="GeneID:8438"
                     /db_xref="HGNC:HGNC:9826"
                     /db_xref="MIM:603615"
     exon            1..646
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     CDS             644..2887
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1; RAD54
                     homolog"
                     /codon_start=1
                     /product="DNA repair and recombination protein RAD54-like
                     isoform 1"
                     /protein_id="NP_003570.2"
                     /db_xref="CCDS:CCDS532.1"
                     /db_xref="GeneID:8438"
                     /db_xref="HGNC:HGNC:9826"
                     /db_xref="MIM:603615"
                     /translation="MRRSLAPSQLAKRKPEGRSCDDEDWQPGLVTPRKRKSSSETQIQ
                     ECFLSPFRKPLSQLTNQPPCLDSSQHEAFIRSILSKPFKVPIPNYQGPLGSRALGLKR
                     AGVRRALHDPLEKDALVLYEPPPLSAHDQLKLDKEKLPVHVVVDPILSKVLRPHQREG
                     VKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPECKPEIDKAVVVS
                     PSSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMNQRGARVSSPILIISYE
                     TFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLE
                     YFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCL
                     IRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPAEELLEGKMSVSSLSSI
                     TSLKKLCNHPALIYDKCVEEEDGFVGALDLFPPGYSSKALEPQLSGKMLVLDYILAVT
                     RSRSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPD
                     FVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSA
                     GTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFILDEASLSDTHDRLHCR
                     RCVNSRQIRPPPDGSDCTSDLAGWNHCTDKWGLRDEVLQAAWDAASTAITFVFHQRSH
                     EEQRGLR"
     exon            647..733
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            734..853
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            854..914
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1050
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1120
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1409
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1534
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1685
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1812
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1887
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2018
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2129
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2253
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2332
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2512
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2676
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..3078
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3059..3064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /note="hexamer: AATAAA"
     polyA_site      3078
                     /gene="RAD54L"
                     /gene_synonym="hHR54; HR54; hRAD54; RAD54A"
                     /note="major polyA site"
ORIGIN      
        1 gttaacgcgc gctttgggaa caggaaggtt gagagagagg tgctggggtc tgcgtctatc
       61 tctgtcgctc ttttcagccc ctcctggtat tcccctccta acctgggttt tttacacgcc
      121 cgcgtggctt cctgctcgac ctccctgagt ctgatcctgg tttccacctc cagccctggg
      181 aaatttcctt tctccagact cgccctcccc acccgggcct cggactttca ccccagcttc
      241 tctctcctgg ccagtgatta cccaccccca atcccacccc gccccgccgc gcaactacct
      301 cctcccttca cccggactgg gaccatcatc cccactccac tccgcccagt ctgggactcc
      361 acctgcctcc tccccaatcc cacactaatc tctgcttggt ctcttcctct ttggcctaat
      421 ctctcgtctc ggcttattgg ggacggccac tctcacagtt tggttccaaa caccagttcc
      481 tggatggatt cccgccatcc atgccccctc tttaattagc cggtcctctc aataatgtag
      541 cagccccctc tacagattag accctggtcc tacactctta gccgctgcct gcttttgacc
      601 tttggctcat gggtacttga cgttttaaac tcctaggccc aggatgagga ggagcttggc
      661 tcccagccag ctggccaaga gaaaacctga aggcaggtcc tgtgatgatg aagactggca
      721 acctggccta gtgactccta ggaaacggaa atccagcagt gagacccaga tccaggagtg
      781 tttcctgtct ccttttcgga aacctttgag tcagctaacc aatcaaccac cttgtctgga
      841 cagcagtcag catgaagcat ttattcgaag cattttgtca aagcctttca aagtccccat
      901 tccaaattat caaggtcctc tgggctctcg agcattgggc ctgaaaaggg ctggggtccg
      961 ccgggccctc catgaccccc tggaaaaaga tgccttggtt ctgtatgagc ctcccccgct
     1021 gagcgctcat gaccagctga agcttgacaa ggagaaactc cctgtccatg tggttgttga
     1081 ccctattctc agtaaggttt tgcggcctca tcagagagag ggagtgaaat tcctgtggga
     1141 gtgtgtcacc agtcggcgca tccctggcag ccatggctgc atcatggctg atgagatggg
     1201 cctaggaaag acgctgcagt gcatcacatt gatgtggaca cttttacgcc agagtccaga
     1261 gtgcaagcca gaaattgaca aggcagtggt ggtgtcgcct tccagcctgg tgaagaactg
     1321 gtacaatgag gttgggaaat ggctcggagg gaggatccaa cctctggcca tcgatggagg
     1381 atctaaggat gaaatagacc aaaagctgga aggattcatg aaccagcgtg gagccagggt
     1441 gtcttctccc atcctcatca tttcctatga gaccttccgc cttcatgttg gagtcctcca
     1501 gaaaggaagt gttggtctgg tcatatgtga cgagggacac aggctcaaga actctgagaa
     1561 tcagacttac caagccctgg acagcttgaa caccagccgg cgggtgctca tctccggaac
     1621 tcccatccag aatgatctgc ttgagtattt cagcttggta cattttgtta attccggcat
     1681 cctagggact gcccatgaat tcaagaagca ttttgaattg ccaattttga agggtcgaga
     1741 cgctgctgct agtgaggcag acaggcagct aggagaggag cggctgcggg agctcaccag
     1801 cattgtgaat agatgcctga tacggaggac ttctgatatc ctttctaaat atctgcctgt
     1861 gaagattgag caggtcgttt gttgtaggct gacacccctt cagactgagt tatacaagag
     1921 gtttctgaga caagccaaac cggcagaaga attgcttgag ggcaagatga gtgtgtcttc
     1981 cctttcttcc atcacctcgc taaagaagct ttgtaatcat ccagctctaa tctatgataa
     2041 gtgtgtggaa gaggaggatg gctttgtggg tgccttggac ctcttccctc ctggttacag
     2101 ctctaaggcc ctggagcccc agctgtcagg taagatgctg gtcctggatt atattctggc
     2161 ggtgacccga agccgtagca gtgacaaagt agtgctggtg tcgaattaca cccagacttt
     2221 ggatctcttt gagaagctgt gccgtgcccg aaggtactta tacgtccgcc tggatggcac
     2281 gatgtccatt aagaagcgag ccaaggttgt agaacgcttc aatagtccat cgagccctga
     2341 ctttgtcttc atgctgagca gcaaagctgg gggctgtggc ctcaatctca ttggggctaa
     2401 ccggctggtc atgtttgacc ctgactggaa cccagccaat gatgaacaag ccatggcccg
     2461 ggtctggcga gatggtcaaa agaagacttg ctatatctac cgcctgctgt ctgcagggac
     2521 cattgaggag aagatcttcc agcgtcagag ccacaagaag gcactgagca gctgtgtggt
     2581 ggatgaggag caggatgtag agcgccactt ctctctgggc gagttgaagg agctgtttat
     2641 cctggatgaa gctagcctca gtgacacaca tgacaggttg cactgccgac gttgtgtcaa
     2701 cagccgtcag atccggccac cccctgatgg ttctgactgc acttcagacc tggcagggtg
     2761 gaaccactgc actgataagt gggggctccg ggatgaggta ctccaggctg cctgggatgc
     2821 tgcctccact gccatcacct tcgtcttcca ccagcgttct catgaggagc agcggggcct
     2881 ccgctgataa ccagctggtc tgggtgtagc tcttagagga aggagatagg gaaaaggggc
     2941 tccttgctcc acagggccct gttgaatttt gttctctggg agaaaatcat caagaagggc
     3001 tgcatgatgt ttgcccaaaa tttattttat aagaaaaact tttttggtta aaaaaaagaa
     3061 taaaggtatg aaagggtt
//
