LOCUS       NM_012415               3074 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens RAD54 homolog B (RAD54B), transcript variant 1, mRNA.
ACCESSION   NM_012415 XM_001126364 XM_001126393
VERSION     NM_012415.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3074)
  AUTHORS   Li,J., Geng,H., Li,X., Zou,S. and Xu,X.
  TITLE     RAD54B promotes gastric cancer cell migration and angiogenesis via
            the Wnt/beta-catenin pathway
  JOURNAL   Radiol Oncol 58 (1), 67-77 (2024)
   PUBMED   38378037
  REMARK    GeneRIF: RAD54B promotes gastric cancer cell migration and
            angiogenesis via the Wnt/beta-catenin pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3074)
  AUTHORS   Huang,P., Wang,F., Wang,X., Meng,X., Qiao,W. and Meng,L.
  TITLE     RNA-sequencing analysis reveals the potential molecular mechanism
            of RAD54B in the proliferation of inflamed human dental pulp cells
  JOURNAL   Int Endod J 56 (1), 39-52 (2023)
   PUBMED   36196684
  REMARK    GeneRIF: RNA-sequencing analysis reveals the potential molecular
            mechanism of RAD54B in the proliferation of inflamed human dental
            pulp cells.
REFERENCE   3  (bases 1 to 3074)
  AUTHORS   Liu,P., Lin,C., Liu,L., Lu,Z., Tu,Z. and Liu,H.
  TITLE     RAD54B mutations enhance the sensitivity of ovarian cancer cells to
            poly(ADP-ribose) polymerase (PARP) inhibitors
  JOURNAL   J Biol Chem 298 (9), 102354 (2022)
   PUBMED   35952757
  REMARK    GeneRIF: RAD54B mutations enhance the sensitivity of ovarian cancer
            cells to poly(ADP-ribose) polymerase (PARP) inhibitors.
REFERENCE   4  (bases 1 to 3074)
  AUTHORS   Wang,M., Liao,J., Tan,C., Zhou,H., Wang,J., Wang,K., Li,Y. and
            Wu,W.
  TITLE     Integrated study of miR-215 promoting breast cancer cell apoptosis
            by targeting RAD54B
  JOURNAL   J Cell Mol Med 25 (7), 3327-3338 (2021)
   PUBMED   33635591
  REMARK    GeneRIF: Integrated study of miR-215 promoting breast cancer cell
            apoptosis by targeting RAD54B.
REFERENCE   5  (bases 1 to 3074)
  AUTHORS   Wesoly,J., Agarwal,S., Sigurdsson,S., Bussen,W., Van Komen,S.,
            Qin,J., van Steeg,H., van Benthem,J., Wassenaar,E., Baarends,W.M.,
            Ghazvini,M., Tafel,A.A., Heath,H., Galjart,N., Essers,J.,
            Grootegoed,J.A., Arnheim,N., Bezzubova,O., Buerstedde,J.M., Sung,P.
            and Kanaar,R.
  TITLE     Differential contributions of mammalian Rad54 paralogs to
            recombination, DNA damage repair, and meiosis
  JOURNAL   Mol Cell Biol 26 (3), 976-989 (2006)
   PUBMED   16428451
REFERENCE   6  (bases 1 to 3074)
  AUTHORS   Sarai,N., Kagawa,W., Kinebuchi,T., Kagawa,A., Tanaka,K.,
            Miyagawa,K., Ikawa,S., Shibata,T., Kurumizaka,H. and Yokoyama,S.
  TITLE     Stimulation of Dmc1-mediated DNA strand exchange by the human
            Rad54B protein
  JOURNAL   Nucleic Acids Res 34 (16), 4429-4437 (2006)
   PUBMED   16945962
  REMARK    GeneRIF: Rad54B enhanced the DNA strand-exchange activity of Dmc1
            by stabilizing the Dmc1-single-stranded DNA complex.
REFERENCE   7  (bases 1 to 3074)
  AUTHORS   Tanaka,K., Kagawa,W., Kinebuchi,T., Kurumizaka,H. and Miyagawa,K.
  TITLE     Human Rad54B is a double-stranded DNA-dependent ATPase and has
            biochemical properties different from its structural homolog in
            yeast, Tid1/Rdh54
  JOURNAL   Nucleic Acids Res 30 (6), 1346-1353 (2002)
   PUBMED   11884632
  REMARK    GeneRIF: Rad54B is a DNA-dependent ATPase and has biochemical
            properties different from its structural homolog in yeast,
            Tid1/Rdh54
REFERENCE   8  (bases 1 to 3074)
  AUTHORS   Miyagawa,K., Tsuruga,T., Kinomura,A., Usui,K., Katsura,M.,
            Tashiro,S., Mishima,H. and Tanaka,K.
  TITLE     A role for RAD54B in homologous recombination in human cells
  JOURNAL   EMBO J 21 (1-2), 175-180 (2002)
   PUBMED   11782437
REFERENCE   9  (bases 1 to 3074)
  AUTHORS   Tanaka,K., Hiramoto,T., Fukuda,T. and Miyagawa,K.
  TITLE     A novel human rad54 homologue, Rad54B, associates with Rad51
  JOURNAL   J Biol Chem 275 (34), 26316-26321 (2000)
   PUBMED   10851248
REFERENCE   10 (bases 1 to 3074)
  AUTHORS   Hiramoto,T., Nakanishi,T., Sumiyoshi,T., Fukuda,T., Matsuura,S.,
            Tauchi,H., Komatsu,K., Shibasaki,Y., Inui,H., Watatani,M.,
            Yasutomi,M., Sumii,K., Kajiyama,G., Kamada,N., Miyagawa,K. and
            Kamiya,K.
  TITLE     Mutations of a novel human RAD54 homologue, RAD54B, in primary
            cancer
  JOURNAL   Oncogene 18 (22), 3422-3426 (1999)
   PUBMED   10362364
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP872374.1 and BC001965.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 6, 2011 this sequence version replaced NM_012415.2.
            
            Summary: The protein encoded by this gene belongs to the DEAD-like
            helicase superfamily. It shares similarity with Saccharomyces
            cerevisiae RAD54 and RDH54, both of which are involved in
            homologous recombination and repair of DNA. This protein binds to
            double-stranded DNA, and displays ATPase activity in the presence
            of DNA. This gene is highly expressed in testis and spleen, which
            suggests active roles in meiotic and mitotic recombination.
            Homozygous mutations of this gene were observed in primary lymphoma
            and colon cancer. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001965.2, SRR1803614.22200.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336148.10/ ENSP00000336606.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BP872374.1         1-58
            59-3074             BC001965.2         1-3016
FEATURES             Location/Qualifiers
     source          1..3074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..3074
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /note="RAD54 homolog B"
                     /db_xref="GeneID:25788"
                     /db_xref="HGNC:HGNC:17228"
                     /db_xref="MIM:604289"
     exon            1..115
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            116..266
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..2864
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     repair and recombination protein RAD54B"
                     /codon_start=1
                     /product="DNA repair and recombination protein RAD54B
                     isoform 1"
                     /protein_id="NP_036547.1"
                     /db_xref="CCDS:CCDS6262.1"
                     /db_xref="GeneID:25788"
                     /db_xref="HGNC:HGNC:17228"
                     /db_xref="MIM:604289"
                     /translation="MRRSAAPSQLQGNSFKKPKFIPPGRSNPGLNEEITKLNPDIKLF
                     EGVAINNTFLPSQNDLRICSLNLPSEESTREINNRDNCSGKYCFEAPTLATLDPPHTV
                     HSAPKEVAVSKEQEEKSDSLVKYFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILKNLE
                     GKDIGRGIGYKFKELEKIEEGQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAIS
                     HSSQVARKCFSNPFKSVCKPSSKENRQNDFQNCKPRHDPYTPNSLVMPRPDKNHQWVF
                     NKNCFPLVDVVIDPYLVYHLRPHQKEGIIFLYECVMGMRMNGRCGAILADEMGLGKTL
                     QCISLIWTLQCQGPYGGKPVIKKTLIVTPGSLVNNWKKEFQKWLGSERIKIFTVDQDH
                     KVEEFIKSIFYSVLIISYEMLLRSLDQIKNIKFDLLICDEGHRLKNSAIKTTTALISL
                     SCEKRIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREPSASEEE
                     KELGERRAAELTCLTGLFILRRTQEIINKYLPPKIENVVFCRPGALQIELYRKLLNSQ
                     VVRFCLQGLLENSPHLICIGALKKLCNHPCLLFNSIKEKECSSTCDKNEEKSLYKGLL
                     SVFPADYNPLLFTEKESGKLQVLSKLLAVIHELRPTEKVVLVSNYTQTLNILQEVCKR
                     HGYAYTRLDGQTPISQRQQIVDGFNSQHSSFFIFLLSSKAGGVGLNLIGGSHLILYDI
                     DWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIYQRQISKQGLCGAVVDLTKT
                     SEHIQFSVEELKNLFTLHESSDCVTHDLLDCECTGEEVHTGDSLEKFIVSRDCQLGPH
                     HQKSNSLKPLSMSQLKQWKHFSGDHLNLTDPFLERITENVSFIFQNITTQATGT"
     exon            267..435
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            436..630
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            631..912
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1075
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1301
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1509
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1649
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1940
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2116
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2378
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2445
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2646
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..3074
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3049..3054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /note="hexamer: AATAAA"
     polyA_site      3074
                     /gene="RAD54B"
                     /gene_synonym="RDH54"
                     /note="major polyA site"
ORIGIN      
        1 gtccgcgatt ggcttcgccg aggcgggatc cttgagcttc tccggcggcg aggggatagc
       61 tggttaccag aaggacttct ttgcagggcc agtggtttct gtcagatttt cgccggtcac
      121 gactgctgaa tatgagacga tctgcagcac caagtcagtt gcaggggaat tccttcaaaa
      181 aaccaaaatt tatacctcca ggaagaagta atccaggtct gaatgaagag attacaaaac
      241 tgaatccaga tataaaatta tttgagggtg ttgcaattaa taacaccttt ctcccgtcac
      301 aaaatgatct tagaatatgc agtttaaatc tgcctagtga agaaagtact agagaaatca
      361 ataacagaga taattgcagt ggaaaatatt gttttgaagc acctacactg gcaacattag
      421 atccacctca tacagttcat tcggctccta aagaagtagc agtgtccaag gaacaagaag
      481 agaaatctga tagcctagtt aaatatttca gtgttgtttg gtgtaagcct tcaaagaaaa
      541 aacataaaaa gtgggaaggt gatgctgttc ttattgtaaa aggaaagtca tttatattaa
      601 agaatttgga aggcaaagac attggaagag gcattggtta taaattcaaa gagcttgaaa
      661 agattgaaga gggccaaaca ctgatgattt gtggaaaaga aatagaagtc atgggtgtaa
      721 tctctccaga tgacttcagc agtggcaggt gttttcagct tggaggagga agtactgcta
      781 tctcgcattc ttctcaggtt gccaggaaat gtttctctaa ccctttcaaa agtgtttgta
      841 aaccaagttc aaaggaaaat agacagaatg atttccaaaa ttgcaaacca cgccatgacc
      901 catatacgcc aaattccctc gttatgccac gaccagataa gaatcaccag tgggtattca
      961 ataagaactg tttccctctt gtggatgtag tgattgatcc ttaccttgta tatcatcttc
     1021 gaccacatca gaaagaagga atcatattcc tttatgaatg tgtaatggga atgagaatga
     1081 atggcagatg tggagctatt cttgctgatg aaatgggttt agggaagaca ttgcaatgta
     1141 tttcgctcat ctggaccctg cagtgtcagg gaccctatgg aggcaagcca gtaataaaga
     1201 agacactaat tgtcacacct ggaagcttgg tgaataattg gaagaaagaa tttcaaaaat
     1261 ggctaggaag tgaaaggatc aagatattta ctgttgatca ggaccacaaa gttgaagaat
     1321 tcatcaagtc tatattttat tctgttctta ttatcagtta tgaaatgtta cttcgttccc
     1381 tggatcaaat taagaatata aaatttgatc ttctaatctg tgacgagggg catcgtttga
     1441 agaacagtgc cattaagaca actacagccc tcattagcct ttcttgtgag aaaagaataa
     1501 ttctaactgg tactccaatt cagaatgatc tgcaagaatt ttttgcatta attgattttg
     1561 taaatccagg aatattaggc tctttgtcat cttataggaa aatatatgaa gaacccatca
     1621 ttttatcgag agaaccttct gcttctgagg aagaaaagga gttaggagaa agaagagcag
     1681 ctgaacttac ttgcctcact ggactcttta tccttagaag aacccaagaa attataaata
     1741 aatatctccc acctaaaata gagaatgttg tcttttgccg accaggagca ctacagattg
     1801 agctttatcg aaagctgtta aattctcagg ttgtcaggtt ctgccttcaa gggttgttgg
     1861 aaaatagtcc ccatctaata tgtataggag ctcttaaaaa actgtgcaat cacccctgcc
     1921 ttttgttcaa ctctataaag gaaaaggaat gtagctcaac ttgtgataaa aatgaagaaa
     1981 agagtctata caaaggcttg ctaagtgtgt ttcctgctga ctacaaccct ctcctgttta
     2041 ctgaaaagga gtcaggaaaa ctacaggtgt tgtccaagct cttagcggtt atccacgaac
     2101 ttcgacctac tgaaaaggtg gtgttggtat ccaactatac acaaaccttg aacattttac
     2161 aagaagtatg taagcgtcat ggatatgctt atacaagact tgatggacaa acaccaatct
     2221 ctcaaaggca gcagattgtt gatggcttta acagtcaaca ctcttctttt tttatttttt
     2281 tgttaagttc aaaagctggt ggtgtaggac ttaacctcat tggaggatct cacttaattc
     2341 tctatgacat tgattggaat ccagccactg acattcaggc aatgtctaga gtatggagag
     2401 atggtcagaa atatcctgta catatttaca gactcctaac tacaggtaca atagaagaaa
     2461 agatctatca aaggcagatc agtaagcaag gtctttgtgg ggcagttgtc gacctcacca
     2521 agacatctga acatattcag ttttcagtag aagaacttaa aaatttgttc acattacatg
     2581 aaagttcaga ttgtgttact catgatctgc ttgactgtga gtgtacagga gaagaagttc
     2641 atacaggtga ttcgttggaa aaattcattg tctctagaga ttgtcagctt ggtccacatc
     2701 accagaaatc taactccctg aaacctcttt ctatgtccca gctgaagcaa tggaaacatt
     2761 tttctggaga tcatttaaat cttacagatc cttttcttga aagaataaca gaaaatgtgt
     2821 cattcatttt tcagaatata accactcaag ctactggcac atagtgaaag attacttctg
     2881 acattccatt gctcttcttt tgaaaattag tatggtaatt aaatgtactt tttgaaaatt
     2941 aatagaatta tttaaattac agtatatgtt gcaaaatata tcacttttga tacaatagtc
     3001 aaaattgagt ggtttaatgt tttgtaaata ttaagtgttt aaatgaaaaa taaagatgtg
     3061 cttatatcat tgta
//
