LOCUS       NM_133510               1559 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens RAD51 paralog B (RAD51B), transcript variant 2, mRNA.
ACCESSION   NM_133510
VERSION     NM_133510.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Wei,X., Wang,C., Tang,S., Yang,Q., Shen,Z., Zhu,J., Cheng,X.,
            Wang,X., Xie,X., Xu,J. and Lu,W.
  TITLE     RAD51B-AS1 promotes the malignant biological behavior of ovarian
            cancer through upregulation of RAD51B
  JOURNAL   J Zhejiang Univ Sci B 25 (7), 581-593 (2024)
   PUBMED   39011678
  REMARK    GeneRIF: RAD51B-AS1 promotes the malignant biological behavior of
            ovarian cancer through upregulation of RAD51B.
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Slupianek,A., Jozwiakowski,S.K., Gurdek,E. and Skorski,T.
  TITLE     BCR/ABL kinase interacts with and phosphorylates the RAD51 paralog,
            RAD51B
  JOURNAL   Leukemia 23 (12), 2308-2310 (2009)
   PUBMED   19657362
  REMARK    GeneRIF: BCR/ABL fragments were used for identifying the sites of
            BCR/ABL interaction with RAD51B
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Thomas,G., Jacobs,K.B., Kraft,P., Yeager,M., Wacholder,S.,
            Cox,D.G., Hankinson,S.E., Hutchinson,A., Wang,Z., Yu,K.,
            Chatterjee,N., Garcia-Closas,M., Gonzalez-Bosquet,J.,
            Prokunina-Olsson,L., Orr,N., Willett,W.C., Colditz,G.A.,
            Ziegler,R.G., Berg,C.D., Buys,S.S., McCarty,C.A., Feigelson,H.S.,
            Calle,E.E., Thun,M.J., Diver,R., Prentice,R., Jackson,R.,
            Kooperberg,C., Chlebowski,R., Lissowska,J., Peplonska,B.,
            Brinton,L.A., Sigurdson,A., Doody,M., Bhatti,P., Alexander,B.H.,
            Buring,J., Lee,I.M., Vatten,L.J., Hveem,K., Kumle,M., Hayes,R.B.,
            Tucker,M., Gerhard,D.S., Fraumeni,J.F. Jr., Hoover,R.N.,
            Chanock,S.J. and Hunter,D.J.
  TITLE     A multistage genome-wide association study in breast cancer
            identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
  JOURNAL   Nat Genet 41 (5), 579-584 (2009)
   PUBMED   19330030
  REMARK    GeneRIF: A multistage genome-wide association study in breast
            cancer identifies two new risk alleles at 1p11.2 and 14q24.1
            (RAD51L1).
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   Quade,B.J., Weremowicz,S., Neskey,D.M., Vanni,R., Ladd,C., Dal
            Cin,P. and Morton,C.C.
  TITLE     Fusion transcripts involving HMGA2 are not a common molecular
            mechanism in uterine leiomyomata with rearrangements in 12q15
  JOURNAL   Cancer Res 63 (6), 1351-1358 (2003)
   PUBMED   12649198
REFERENCE   5  (bases 1 to 1559)
  AUTHORS   Lio,Y.C., Mazin,A.V., Kowalczykowski,S.C. and Chen,D.J.
  TITLE     Complex formation by the human Rad51B and Rad51C DNA repair
            proteins and their activities in vitro
  JOURNAL   J Biol Chem 278 (4), 2469-2478 (2003)
   PUBMED   12427746
  REMARK    GeneRIF: Rad51B and Rad51C function through interactions with the
            human Rad51 recombinase and play a crucial role in the homologous
            recombinational repair pathway
REFERENCE   6  (bases 1 to 1559)
  AUTHORS   Masson,J.Y., Tarsounas,M.C., Stasiak,A.Z., Stasiak,A., Shah,R.,
            McIlwraith,M.J., Benson,F.E. and West,S.C.
  TITLE     Identification and purification of two distinct complexes
            containing the five RAD51 paralogs
  JOURNAL   Genes Dev 15 (24), 3296-3307 (2001)
   PUBMED   11751635
REFERENCE   7  (bases 1 to 1559)
  AUTHORS   Takata,M., Sasaki,M.S., Sonoda,E., Fukushima,T., Morrison,C.,
            Albala,J.S., Swagemakers,S.M., Kanaar,R., Thompson,L.H. and
            Takeda,S.
  TITLE     The Rad51 paralog Rad51B promotes homologous recombinational repair
  JOURNAL   Mol Cell Biol 20 (17), 6476-6482 (2000)
   PUBMED   10938124
REFERENCE   8  (bases 1 to 1559)
  AUTHORS   Cartwright,R., Dunn,A.M., Simpson,P.J., Tambini,C.E. and Thacker,J.
  TITLE     Isolation of novel human and mouse genes of the recA/RAD51
            recombination-repair gene family
  JOURNAL   Nucleic Acids Res 26 (7), 1653-1659 (1998)
   PUBMED   9512535
REFERENCE   9  (bases 1 to 1559)
  AUTHORS   Albala,J.S., Thelen,M.P., Prange,C., Fan,W., Christensen,M.,
            Thompson,L.H. and Lennon,G.G.
  TITLE     Identification of a novel human RAD51 homolog, RAD51B
  JOURNAL   Genomics 46 (3), 476-479 (1997)
   PUBMED   9441753
  REMARK    Erratum:[Genomics 1998 Aug 1;51(3):480]
REFERENCE   10 (bases 1 to 1559)
  AUTHORS   Rice,M.C., Smith,S.T., Bullrich,F., Havre,P. and Kmiec,E.B.
  TITLE     Isolation of human and mouse genes based on homology to REC2, a
            recombinational repair gene from the fungus Ustilago maydis
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7417-7422 (1997)
   PUBMED   9207106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL597484.1, BX161515.1 and
            Y15571.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_133510.3.
            
            Summary: The protein encoded by this gene is a member of the RAD51
            protein family. RAD51 family members are evolutionarily conserved
            proteins essential for DNA repair by homologous recombination. This
            protein has been shown to form a stable heterodimer with the family
            member RAD51C, which further interacts with the other family
            members, such as RAD51, XRCC2, and XRCC3. Overexpression of this
            gene was found to cause cell cycle G1 delay and cell apoptosis,
            which suggested a role of this protein in sensing DNA damage.
            Rearrangements between this locus and high mobility group AT-hook 2
            (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.
            [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (2) has an alternate exon at the
            3' end compared to the longest variant (3). The resulting isoform
            (2) has a distinct and shorter C-terminus, as compared to isoform
            3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y15571.1, ERR279856.1869.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000471583.6/ ENSP00000418859.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AL597484.1         1-392
            393-1517            BX161515.1         447-1571
            1518-1559           Y15571.1           1489-1530
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..1559
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /note="RAD51 paralog B"
                     /db_xref="GeneID:5890"
                     /db_xref="HGNC:HGNC:9822"
                     /db_xref="MIM:602948"
     exon            1..75
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     exon            76..161
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1130
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RecA-like protein; recombination repair protein; DNA
                     repair protein RAD51 homolog 2; RAD51 homolog B"
                     /codon_start=1
                     /product="DNA repair protein RAD51 homolog 2 isoform 2"
                     /protein_id="NP_598194.1"
                     /db_xref="CCDS:CCDS9790.1"
                     /db_xref="GeneID:5890"
                     /db_xref="HGNC:HGNC:9822"
                     /db_xref="MIM:602948"
                     /translation="MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGL
                     SYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGS
                     LTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRF
                     PRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRK
                     EFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSP
                     ADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFV
                     YTIKEEGLVLQGQEKP"
     exon            162..275
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..392
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..529
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..649
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..833
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..930
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1034
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1113
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1559
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /note="hexamer: AATAAA"
     polyA_site      1559
                     /gene="RAD51B"
                     /gene_synonym="R51H2; RAD51L1; REC2"
                     /note="major polyA site"
ORIGIN      
        1 gttgctttgc ggcgttttcc gcggggaaac tgtgtaaagg gtggggaaac ttgaaagttg
       61 gatgctgcag acccggcatg ggtagcaaga aactaaaacg agtgggttta tcacaagagc
      121 tgtgtgaccg tctgagtaga catcagatcc ttacctgtca ggacttttta tgtctttccc
      181 cactggagct tatgaaggtg actggtctga gttatcgagg tgtccatgaa cttctatgta
      241 tggtcagcag ggcctgtgcc ccaaagatgc aaacggctta tgggataaaa gcacaaaggt
      301 ctgctgattt ctcaccagca ttcttatcta ctaccctttc tgctttggac gaagccctgc
      361 atggtggtgt ggcttgtgga tccctcacag agattacagg tccaccaggt tgtggaaaaa
      421 ctcagttttg tataatgatg agcattttgg ctacattacc caccaacatg ggaggattag
      481 aaggagctgt ggtgtacatt gacacagagt ctgcatttag tgctgaaaga ctggttgaaa
      541 tagcagaatc ccgttttccc agatatttta acactgaaga aaagttactt ttgacaagta
      601 gtaaagttca tctttatcgg gaactcacct gtgatgaagt tctacaaagg attgaatctt
      661 tggaagaaga aattatctca aaaggaatta aacttgtgat tcttgactct gttgcttctg
      721 tggtcagaaa ggagtttgat gcacaacttc aaggcaatct caaagaaaga aacaagttct
      781 tggcaagaga ggcatcctcc ttgaagtatt tggctgagga gttttcaatc ccagttatct
      841 tgacgaatca gattacaacc catctgagtg gagccctggc ttctcaggca gacctggtgt
      901 ctccagctga tgatttgtcc ctgtctgaag gcacttctgg atccagctgt gtgatagccg
      961 cactaggaaa tacctggagt cacagtgtga atacccggct gatcctccag taccttgatt
     1021 cagagagaag acagattctt attgccaagt cccctctggc tcccttcacc tcatttgtct
     1081 acaccatcaa ggaggaaggc ctggttcttc aaggccaaga gaagccatag ggatactgtg
     1141 acctttgtct agagttgatg ggggtgtgat ttgtgaaata aaacaggacc gtactgcttg
     1201 gaagaaggaa acggaagctg acataatggg gattaattag ttgattgctg ttgagatggt
     1261 aacagatttg ctcctaaacc attgagctag cgatttcaga cctagcaggg aaggtgaaga
     1321 tgaagaagcc tttgttcagg tctctagatg tgtagggctg agggctttgc cgccatggga
     1381 tgtcaacagc cataataata atttgcactt atatagcacc tttcaaccag gcacctcaaa
     1441 gcggtttaac cacattaatt aattaaagcc cacaatcctc ctggggagag gaggaggatg
     1501 actaacaaga tttgtaatta caggagggaa catttccgaa taaagtattg tctaccaga
//
