LOCUS       NM_001099218            3730 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens RAD51 associated protein 2 (RAD51AP2), transcript
            variant 1, mRNA.
ACCESSION   NM_001099218 XM_001130373 XM_001130559
VERSION     NM_001099218.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3730)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   2  (bases 1 to 3730)
  AUTHORS   Kovalenko,O.V., Wiese,C. and Schild,D.
  TITLE     RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares
            a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51
  JOURNAL   Nucleic Acids Res 34 (18), 5081-5092 (2006)
   PUBMED   16990250
  REMARK    GeneRIF: A novel protein, RAD51AP2, has been discovered that
            interacts with RAD51 through a C-terminal motif also present in
            RAD51AP1.
REFERENCE   3  (bases 1 to 3730)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104812.5 and DQ860102.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001099218.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ860102.1, SRR5189667.393897.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399080.3/ ENSP00000382030.2
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC104812.5         107177-107177       c
            2-3590              DQ860102.1         1-3589
            3591-3730           AC104812.5         99316-99455         c
FEATURES             Location/Qualifiers
     source          1..3730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.2"
     gene            1..3730
                     /gene="RAD51AP2"
                     /note="RAD51 associated protein 2"
                     /db_xref="GeneID:729475"
                     /db_xref="HGNC:HGNC:34417"
     exon            1..3272
                     /gene="RAD51AP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3505
                     /gene="RAD51AP2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="RAD51-associated protein 2 isoform 1"
                     /protein_id="NP_001092688.1"
                     /db_xref="CCDS:CCDS42656.1"
                     /db_xref="GeneID:729475"
                     /db_xref="HGNC:HGNC:34417"
                     /translation="MSLPQPTPRMAELRKPTSSLTPPEDPDSQPPSSKRLCLEEPGGV
                     FKAGWRLPLVPRLSEAEKVWELSPRPFKGLLVSTNAIFDNSTDSCVEKSVSGKQICNL
                     KCSNLKFQMSSCLQSPPSQSPDSDLRASGRSEAGLHDREAFSVHRSNSSKAGVSQLLP
                     STSIHDIHGIRNENRKQQFVQGRDNVHKENPFLDVTFYKETKSPFHEIKNRCKANSVV
                     PSNKRENNISSSVLKISKSQNQPSLEIAKPSYFRDSGTISVPQFPMDLNSKMSSVYLK
                     EIAKKKNDKKEAYVRDFTNIYWSQNRPDVKKQKLQNDKKTVEAENIFSKCYENDYPSL
                     SSQNTCKRKDLISSNYCNCSSIQCNVRDSRKNFAILENANWEEAECLDSYVLTRLEKS
                     QNWDCNVRHILRRNRGNCWIINNCKTKCENMKKTEEKWNWLLLLEIDLLSKEDYHCAK
                     VINAYEEQSKLLVREILGSQTALITTVWLNGKGENDNTLQLRYNTTQKVFHVNNPFES
                     FIIEIFYFHKSISGNKKDNSILTCCNILKCKKQIGIIGIQNLITRNMNTNIKNGILSI
                     YLQDSVSEPLDILLKTNIAFLLNNFDSLTRIENDFELEEECIFKCMLYLKYPKNIVEN
                     HTAYLVKILTSSRLLEDNMKPMLKKRKLFRTEQVFEKSKKKLINSFSMTTQNTGFPIF
                     ETYEKIPLLMDFDDMDEISLIREITCQNMSCPQQVVNVENWAHYNSSTVKAHGNSCPQ
                     FIQNNRGYINENFYEVNMHSQDLNMERKQGHNKISNFDCEHIFEDLCNVRQQAIPASH
                     NIIHNEETHTTSITQVLNFWNLLSEIEEKKYDLILKEEVKVTAESLTNSCQVHKDTKI
                     EKEEKDSFFPMDDMFSVQSVSLISKEVNVEENKYVNQNYVTNTNEYESILPEREIANS
                     KDFHRKNDSALYINHQFETGLSEGNDECFQDLAAKYLSTEALTIVKDFEMKRKFDLVL
                     EELRMFHEISRENELLSTVETNNGQENYFGENDAEKVKMEIEKDLKMVVVNKIRASSS
                     FHDTIAGPNMGKSHQSLFKWKTVPNNGEQEVPNESCYPSRSEEELLYSTSEKDCETPL
                     PKRPAFLPDECKEEFNYLLRGGSHFPHGISRVRPLKTCSRPIRIGLSRKARIKQLHPY
                     LKQMCYGNLKENF"
     exon            3273..3353
                     /gene="RAD51AP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3730
                     /gene="RAD51AP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3703..3708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD51AP2"
                     /note="hexamer: ATTAAA"
     polyA_site      3730
                     /gene="RAD51AP2"
                     /note="major polyA site"
ORIGIN      
        1 ggacagatcc tttccattcg ctgtcatgtc tctccctcag cccacgccgc ggatggccga
       61 gctcagaaag cctacctcct ctttaacgcc tcctgaggac ccggattccc aaccacctag
      121 tagcaagcgg ctctgtcttg aggagcctgg aggtgtcttt aaggcgggct ggcgactgcc
      181 tctggtgcct cgcttgtctg aggcggaaaa agtctgggag ttgtccccta gacccttcaa
      241 gggactcctt gtttcaacga atgctatttt cgataactcc acagactcgt gtgtggagaa
      301 atcagtcagt gggaagcaga tatgtaatct gaaatgctca aatctcaaat tccaaatgag
      361 tagctgtttg cagtctcccc cctcacaaag tcctgattct gatttgaggg cttcaggaag
      421 gtctgaggca ggcctgcatg acagagaggc tttcagtgtg caccgcagta atagctccaa
      481 agcaggggtt agtcaacttc tgcccagcac ctctatacac gatatacatg gaattagaaa
      541 tgagaatcga aaacaacagt ttgtccaagg aagagacaat gttcacaaag aaaatccatt
      601 tttagatgtt accttttaca aggaaactaa atcaccattt catgaaatta agaacagatg
      661 taaagctaac agtgttgtgc catcaaataa aagagaaaat aacatttcat catctgtact
      721 aaaaatatca aaatctcaaa accagcccag cttggaaatt gccaaaccta gctattttag
      781 agatagcggc acaataagtg tccctcagtt tccaatggac ttaaatagca aaatgtcctc
      841 tgtctattta aaggaaatag cgaagaaaaa gaatgacaaa aaagaggcat atgttaggga
      901 tttcacaaac atttactggt cccaaaatag acctgatgtt aagaagcaaa agttacagaa
      961 tgataaaaaa actgtagaag cggaaaacat tttttccaaa tgttatgaaa atgactaccc
     1021 atcactcagt agccaaaata cttgtaagag aaaagacttg atcagttcaa actactgtaa
     1081 ctgcagtagt atccagtgta atgtaagaga ctctagaaag aatttcgcta tactagaaaa
     1141 tgcaaattgg gaggaagcag aatgtctgga cagttacgta cttaccaggc tggaaaaatc
     1201 tcaaaactgg gactgtaacg ttagacatat tttgagaaga aatagaggaa attgttggat
     1261 tataaataat tgcaagacta aatgtgaaaa tatgaaaaaa actgaagaaa aatggaattg
     1321 gctattatta ttagaaatag accttttaag caaggaagat taccactgtg caaaagtcat
     1381 caatgcatat gaagaacaat caaagcttct cgtaagagaa atattaggta gtcagacagc
     1441 tttaataacg actgtttggc taaatggtaa aggagaaaat gataatactc tacagttgag
     1501 atacaatact acacaaaaag tctttcatgt gaacaaccct tttgaaagtt tcattataga
     1561 aattttttat ttccataaaa gtatttcagg aaataaaaaa gataatagta ttttaacctg
     1621 ctgtaacatt ttgaagtgta aaaagcaaat tggtataatt ggtattcaaa atctaataac
     1681 cagaaacatg aatacaaata taaagaatgg aattttaagc atatatttac aagatagtgt
     1741 ttcagaacct ttagatattc tattgaaaac taacatagct tttttgctca ataactttga
     1801 ctctttaaca agaattgaaa atgattttga attagaagag gaatgcattt tcaagtgcat
     1861 gctttatttg aagtatccaa aaaatatagt ggaaaatcat actgcatatc tagtaaagat
     1921 tttaacttct tcaagactat tagaagataa tatgaaacct atgttaaaga aaaggaagtt
     1981 atttagaact gaacaagttt ttgaaaagtc taagaaaaaa ctcattaatt ccttcagtat
     2041 gacaactcaa aatacaggtt ttccgatttt tgaaacatat gaaaaaattc cccttttaat
     2101 ggactttgat gacatggatg aaatttcttt aataagagaa attacttgtc agaatatgag
     2161 ttgtcctcaa caagttgtga atgtggaaaa ttgggctcac tataattcta gtactgttaa
     2221 agcacatggt aattcttgtc ctcaatttat acagaacaac cgaggataca ttaatgaaaa
     2281 tttttatgaa gtaaatatgc acagccaaga tttaaatatg gaaagaaaac agggacataa
     2341 taagatcagt aactttgact gtgagcacat atttgaagat ctctgcaatg ttaggcaaca
     2401 ggccatacca gcaagccaca acataataca taatgaagag acccatacca cttctataac
     2461 tcaagtacta aatttttgga acttgctaag tgaaatagaa gaaaaaaaat atgacttaat
     2521 tttgaaagag gaagtaaaag tcacagctga aagtttaaca aatagttgcc aagttcacaa
     2581 agatactaag atagaaaagg aagagaaaga tagttttttt ccaatggatg acatgttttc
     2641 tgtacagtca gtttcattaa taagtaagga agtaaatgtg gaagaaaata aatatgttaa
     2701 tcaaaattat gtaacaaata caaatgaata tgagagtatt ttgccagaaa gggagatagc
     2761 taattcaaag gattttcaca gaaagaatga ctctgcatta tatattaatc atcaatttga
     2821 aactggtctg agtgaaggga atgatgaatg ttttcaggac ttagctgcta aatatttatc
     2881 aacagaagct ctgacaatag taaaagattt tgagatgaag agaaaatttg acttagtact
     2941 tgaagaactt cgtatgtttc atgaaattag tagggaaaat gaacttctaa gcactgtgga
     3001 aacaaacaat gggcaagaaa attactttgg agaaaatgat gctgagaagg taaaaatgga
     3061 gatagaaaaa gatttgaaaa tggttgtggt caacaaaata cgtgcatctt cctcgttcca
     3121 tgatactata gcaggtccta atatgggcaa aagtcaccaa agtttattta aatggaaaac
     3181 tgtacccaat aatggagaac aggaagttcc taatgagagt tgttatccaa gtagatcaga
     3241 ggaagaatta ctttactcta cttctgagaa agattgtgaa acacctttac ctaaaagacc
     3301 tgcttttctc cctgatgaat gtaaagaaga atttaattat ttattgagag gaggtagtca
     3361 ctttccacat ggcatttcaa gagtacgacc gcttaagaca tgcagtaggc caatcaggat
     3421 tggtttgtca agaaaagcaa ggattaaaca acttcatcct tatctgaaac aaatgtgtta
     3481 cggaaactta aaagaaaatt tttgactttc atatttcaaa acattttaca acatctagaa
     3541 atgttttgtt ttctttggat atatgttctt ccagcttggg ggtttggggc ttgctttatt
     3601 ataaagtgga gaagtttttt tttttgagtg tataaattat ggtattacct ttcaaagtta
     3661 taaaatattt tatggatttt tatatgatat aaaaatgtac acattaaagc cgtttcatta
     3721 ttggataaaa
//
