LOCUS       NM_002875               2436 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens RAD51 recombinase (RAD51), transcript variant 1, mRNA.
ACCESSION   NM_002875
VERSION     NM_002875.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2436)
  AUTHORS   Akita,M., Girvan,P., Spirek,M., Novacek,J., Rueda,D., Prokop,Z. and
            Krejci,L.
  TITLE     Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA
            stretches and fork DNA
  JOURNAL   Nucleic Acids Res 52 (19), 11738-11752 (2024)
   PUBMED   39268578
  REMARK    GeneRIF: Mechanism of BCDX2-mediated RAD51 nucleation on short
            ssDNA stretches and fork DNA.
REFERENCE   2  (bases 1 to 2436)
  AUTHORS   Gal,Z., Boukoura,S., Oxe,K.C., Badawi,S., Nieto,B., Korsholm,L.M.,
            Geisler,S.B., Dulina,E., Rasmussen,A.V., Dahl,C., Lv,W., Xu,H.,
            Pan,X., Arampatzis,S., Stratou,D.E., Galanos,P., Lin,L.,
            Guldberg,P., Bartek,J., Luo,Y. and Larsen,D.H.
  TITLE     Hyper-recombination in ribosomal DNA is driven by long-range
            resection-independent RAD51 accumulation
  JOURNAL   Nat Commun 15 (1), 7797 (2024)
   PUBMED   39242676
  REMARK    GeneRIF: Hyper-recombination in ribosomal DNA is driven by
            long-range resection-independent RAD51 accumulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2436)
  AUTHORS   Hsia,N.Y., Hu,P.S., Chuang,C.L., Mong,M.C., Chen,H.C., Tsai,C.W.,
            Wang,Y.C., Chen,J.C., Bau,D.T. and Chang,W.S.
  TITLE     Contribution of Radiation Sensitive Protein 51 Genotypes to
            Pterygium Risk in a Taiwanese Population
  JOURNAL   In Vivo 38 (5), 2197-2204 (2024)
   PUBMED   39187312
  REMARK    GeneRIF: Contribution of Radiation Sensitive Protein 51 Genotypes
            to Pterygium Risk in a Taiwanese Population.
REFERENCE   4  (bases 1 to 2436)
  AUTHORS   Hanthi,Y.W., Ramirez-Otero,M.A., Appleby,R., De Antoni,A.,
            Joudeh,L., Sannino,V., Waked,S., Ardizzoia,A., Barra,V.,
            Fachinetti,D., Pellegrini,L. and Costanzo,V.
  TITLE     RAD51 protects abasic sites to prevent replication fork breakage
  JOURNAL   Mol Cell 84 (16), 3026-3043 (2024)
   PUBMED   39178838
  REMARK    GeneRIF: RAD51 protects abasic sites to prevent replication fork
            breakage.
REFERENCE   5  (bases 1 to 2436)
  AUTHORS   Benson,F.E., Stasiak,A. and West,S.C.
  TITLE     Purification and characterization of the human Rad51 protein, an
            analogue of E. coli RecA
  JOURNAL   EMBO J 13 (23), 5764-5771 (1994)
   PUBMED   7988572
REFERENCE   6  (bases 1 to 2436)
  AUTHORS   Takahashi,E., Matsuda,Y., Hori,T., Yasuda,N., Tsuji,S., Mori,M.,
            Yoshimura,Y., Yamamoto,A., Morita,T. and Matsushiro,A.
  TITLE     Chromosome mapping of the human (RECA) and mouse (Reca) homologs of
            the yeast RAD51 and Escherichia coli recA genes to human (15q15.1)
            and mouse (2F1) chromosomes by direct R-banding fluorescence in
            situ hybridization
  JOURNAL   Genomics 19 (2), 376-378 (1994)
   PUBMED   8188269
REFERENCE   7  (bases 1 to 2436)
  AUTHORS   Shinohara,A., Ogawa,H., Matsuda,Y., Ushio,N., Ikeo,K. and Ogawa,T.
  TITLE     Cloning of human, mouse and fission yeast recombination genes
            homologous to RAD51 and recA
  JOURNAL   Nat Genet 4 (3), 239-243 (1993)
   PUBMED   8358431
  REMARK    Erratum:[Nat Genet 1993 Nov;5(3):312]
REFERENCE   8  (bases 1 to 2436)
  AUTHORS   Yoshimura,Y., Morita,T., Yamamoto,A. and Matsushiro,A.
  TITLE     Cloning and sequence of the human RecA-like gene cDNA
  JOURNAL   Nucleic Acids Res 21 (7), 1665 (1993)
   PUBMED   8479919
REFERENCE   9  (bases 1 to 2436)
  AUTHORS   Meneret,A., Trouillard,O., Dunoyer,M., Depienne,C. and Roze,E.
  TITLE     Congenital Mirror Movements
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25763452
REFERENCE   10 (bases 1 to 2436)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313503.1 and AC012476.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002875.4.
            
            Summary: The protein encoded by this gene is a member of the RAD51
            protein family. RAD51 family members are highly similar to
            bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to
            be involved in the homologous recombination and repair of DNA. This
            protein can interact with the ssDNA-binding protein RPA and RAD52,
            and it is thought to play roles in homologous pairing and strand
            transfer of DNA. This protein is also found to interact with BRCA1
            and BRCA2, which may be important for the cellular response to DNA
            damage. BRCA2 is shown to regulate both the intracellular
            localization and DNA-binding ability of this protein. Loss of these
            controls following BRCA2 inactivation may be a key event leading to
            genomic instability and tumorigenesis. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) uses an alternate exon in the
            5' coding region, compared to variant 2. The resulting isoform (1)
            contains a distinct segment near the N-terminus, compared to
            isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138512.575350.1, AK313503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267868.8/ ENSP00000267868.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1274              AK313503.1         1-1274
            1275-2436           AC012476.8         44527-45688
FEATURES             Location/Qualifiers
     source          1..2436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..2436
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /note="RAD51 recombinase"
                     /db_xref="GeneID:5888"
                     /db_xref="HGNC:HGNC:9817"
                     /db_xref="MIM:179617"
     exon            1..252
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     exon            253..341
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1274
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BRCA1/BRCA2-containing complex, subunit 5; recombination
                     protein A; RecA, E. coli, homolog of; RecA-like protein;
                     DNA repair protein RAD51 homolog 1; RAD51 homolog A"
                     /codon_start=1
                     /product="DNA repair protein RAD51 homolog 1 isoform 1"
                     /protein_id="NP_002866.2"
                     /db_xref="CCDS:CCDS10062.1"
                     /db_xref="GeneID:5888"
                     /db_xref="HGNC:HGNC:9817"
                     /db_xref="MIM:179617"
                     /translation="MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEA
                     GFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQI
                     TTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYI
                     DTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYAL
                     LIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGA
                     AMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGV
                     GDAKD"
     exon            342..479
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     exon            480..597
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     exon            598..689
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     exon            690..784
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     exon            785..898
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1028
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1150
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..2436
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /note="hexamer: AATAAA"
     polyA_site      1691
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /note="major polyA site"
     regulatory      1721..1726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /note="hexamer: AGTAAA"
     polyA_site      1739
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
     regulatory      2231..2236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /note="hexamer: AATAAA"
     polyA_site      2254
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
     regulatory      2417..2422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /note="hexamer: AATAAA"
     polyA_site      2436
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
ORIGIN      
        1 aattctgaaa gccgctggcg gaccgcgcgc agcggccaga gaccgagccc taaggagagt
       61 gcggcgcttc ccgaggcgtg cagctgggaa ctgcaactca tctgggttgt gcgcagaagg
      121 ctggggcaag cgagtagaga agtggagcgt aagccagggg cgttgggggc cgtgcgggtc
      181 gggcgcgtgc cacgcccgcg gggtgaagtc ggagcgcggg gcctgctgga gagaggagcg
      241 ctgcggaccg agtaatggca atgcagatgc agcttgaagc aaatgcagat acttcagtgg
      301 aagaagaaag ctttggccca caacccattt cacggttaga gcagtgtggc ataaatgcca
      361 acgatgtgaa gaaattggaa gaagctggat tccatactgt ggaggctgtt gcctatgcgc
      421 caaagaagga gctaataaat attaagggaa ttagtgaagc caaagctgat aaaattctgg
      481 ctgaggcagc taaattagtt ccaatgggtt tcaccactgc aactgaattc caccaaaggc
      541 ggtcagagat catacagatt actactggct ccaaagagct tgacaaacta cttcaaggtg
      601 gaattgagac tggatctatc acagaaatgt ttggagaatt ccgaactggg aagacccaga
      661 tctgtcatac gctagctgtc acctgccagc ttcccattga ccggggtgga ggtgaaggaa
      721 aggccatgta cattgacact gagggtacct ttaggccaga acggctgctg gcagtggctg
      781 agaggtatgg tctctctggc agtgatgtcc tggataatgt agcatatgct cgagcgttca
      841 acacagacca ccagacccag ctcctttatc aagcatcagc catgatggta gaatctaggt
      901 atgcactgct tattgtagac agtgccaccg ccctttacag aacagactac tcgggtcgag
      961 gtgagctttc agccaggcag atgcacttgg ccaggtttct gcggatgctt ctgcgactcg
     1021 ctgatgagtt tggtgtagca gtggtaatca ctaatcaggt ggtagctcaa gtggatggag
     1081 cagcgatgtt tgctgctgat cccaaaaaac ctattggagg aaatatcatc gcccatgcat
     1141 caacaaccag attgtatctg aggaaaggaa gaggggaaac cagaatctgc aaaatctacg
     1201 actctccctg tcttcctgaa gctgaagcta tgttcgccat taatgcagat ggagtgggag
     1261 atgccaaaga ctgaatcatt gggtttttcc tctgttaaaa accttaagtg ctgcagccta
     1321 atgagagtgc actgctccct ggggttctct acaggcctct tcctgttgtg actgccagga
     1381 taaagcttcc gggaaaacag ctattatatc agcttttctg atggtataaa caggagacag
     1441 gtcagtagtc acaaactgat ctaaaatgtt tattccttct gtagtgtatt aatctctgtg
     1501 tgttttcttt ggttttggag gaggggtatg aagtatcttt gacatggtgc cttaggaatg
     1561 acttgggttt aacaagctgt ctactggaca atcttatgtt tccaagagaa ctaaagctgg
     1621 agagacctga cccttctctc acttctaaat taatggtaaa ataaaatgcc tcagctatgt
     1681 agcaaaggga atgggtctgc acagattctt tttttctgtc agtaaaactc tcaagcaggt
     1741 ttttaagttg tctgtctgaa tgatcttgtg taaggttttg gttatggagt cttgtgccaa
     1801 acctactagg ccattagccc ttcaccatct acctgcttgg tctttcattg ctaagactaa
     1861 ctcaagataa tcctagagtc ttaaagcatt tcaggccagt gtggtgtctt gcgcctgtac
     1921 tcccagcact ttgggaggcc gaggcaggtg gatcgcttga gcccaggagt tttaagtcca
     1981 gcttggccaa ggtggtgaaa tcccatctct acaaaaaatg cagaacttaa tctggacaca
     2041 ctgttacacg tgcctgtagt cccagctact cgatagcctg aggtgggaga atcacttaag
     2101 cctggaaggt ggaagttgca gtgagtcgag attgcactgc tgcattccag ccagggtgac
     2161 agagtgagac catgtttcaa acaagaaaca tttcagaggg taagtaaaca gatttgattg
     2221 tgaggcttct aataaagtag ttattagtag tgaatgtgct gtttatagca attattgcag
     2281 tgcaagctat ttcaagacag ggtttccata atctttttgg cactgtatag gggtgatcag
     2341 tttctgttgc ttcaagattt gaaaccagaa aggaaagtcc cacttgcaga tgattgtgct
     2401 taaaagctaa tggaaaaata aaagaaagac atacca
//
