LOCUS       NM_002874               4114 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens RAD23 homolog B, nucleotide excision repair protein
            (RAD23B), transcript variant 1, mRNA.
ACCESSION   NM_002874
VERSION     NM_002874.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4114)
  AUTHORS   Rana,P.S., Ignatz-Hoover,J.J., Kim,B.G., Malek,E., Federov,Y.,
            Adams,D., Chan,T. and Driscoll,J.J.
  TITLE     HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the
            Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity
  JOURNAL   Cancer Res Commun 4 (6), 1517-1532 (2024)
   PUBMED   38747592
  REMARK    GeneRIF: HDAC6 Inhibition Releases HR23B to Activate Proteasomes,
            Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma
            Activity.
REFERENCE   2  (bases 1 to 4114)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 4114)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4114)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4114)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   6  (bases 1 to 4114)
  AUTHORS   Wood,R.D.
  TITLE     DNA damage recognition during nucleotide excision repair in
            mammalian cells
  JOURNAL   Biochimie 81 (1-2), 39-44 (1999)
   PUBMED   10214908
  REMARK    Review article
REFERENCE   7  (bases 1 to 4114)
  AUTHORS   Sugasawa,K., Ng,J.M., Masutani,C., Iwai,S., van der Spek,P.J.,
            Eker,A.P., Hanaoka,F., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Xeroderma pigmentosum group C protein complex is the initiator of
            global genome nucleotide excision repair
  JOURNAL   Mol Cell 2 (2), 223-232 (1998)
   PUBMED   9734359
REFERENCE   8  (bases 1 to 4114)
  AUTHORS   van der Spek,P.J., Eker,A., Rademakers,S., Visser,C., Sugasawa,K.,
            Masutani,C., Hanaoka,F., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     XPC and human homologs of RAD23: intracellular localization and
            relationship to other nucleotide excision repair complexes
  JOURNAL   Nucleic Acids Res 24 (13), 2551-2559 (1996)
   PUBMED   8692695
REFERENCE   9  (bases 1 to 4114)
  AUTHORS   van der Spek,P.J., Smit,E.M., Beverloo,H.B., Sugasawa,K.,
            Masutani,C., Hanaoka,F., Hoeijmakers,J.H. and Hagemeijer,A.
  TITLE     Chromosomal localization of three repair genes: the xeroderma
            pigmentosum group C gene and two human homologs of yeast RAD23
  JOURNAL   Genomics 23 (3), 651-658 (1994)
   PUBMED   7851894
REFERENCE   10 (bases 1 to 4114)
  AUTHORS   Masutani,C., Sugasawa,K., Yanagisawa,J., Sonoyama,T., Ui,M.,
            Enomoto,T., Takio,K., Tanaka,K., van der Spek,P.J., Bootsma,D. et
            al.
  TITLE     Purification and cloning of a nucleotide excision repair complex
            involving the xeroderma pigmentosum group C protein and a human
            homologue of yeast RAD23
  JOURNAL   EMBO J 13 (8), 1831-1843 (1994)
   PUBMED   8168482
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC404422.1, D21090.1 and
            AL137852.15.
            
            On Nov 22, 2018 this sequence version replaced NM_002874.4.
            
            Summary: The protein encoded by this gene is one of two human
            homologs of Saccharomyces cerevisiae Rad23, a protein involved in
            the nucleotide excision repair (NER). This protein was found to be
            a component of the protein complex that specifically complements
            the NER defect of xeroderma pigmentosum group C (XP-c) cell
            extracts in vitro. This protein was also shown to interact with,
            and elevate the nucleotide excision activity of 3-methyladenine-DNA
            glycosylase (MPG), which suggested a role in DNA damage recognition
            in base excision repair. This protein contains an N-terminal
            ubiquitin-like domain, which was reported to interact with 26S
            proteasome, and thus this protein may be involved in the ubiquitin
            mediated proteolytic pathway in cells. Alternative splicing results
            in multiple transcript variants encoding distinct isoforms.
            [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D21090.1, SRR14038195.1383643.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358015.8/ ENSP00000350708.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DC404422.1         65-107
            44-1926             D21090.1           6-1888
            1927-4114           AL137852.15        91268-93455
FEATURES             Location/Qualifiers
     source          1..4114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.2"
     gene            1..4114
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /note="RAD23 homolog B, nucleotide excision repair
                     protein"
                     /db_xref="GeneID:5887"
                     /db_xref="HGNC:HGNC:9813"
                     /db_xref="MIM:600062"
     exon            1..417
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..1581
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /note="isoform 1 is encoded by transcript variant 1; XP-C
                     repair complementing protein; XP-C repair complementing
                     complex 58 kDa; RAD23, yeast homolog of, B; UV excision
                     repair protein RAD23 homolog B; XP-C repair-complementing
                     complex 58 kDa protein"
                     /codon_start=1
                     /product="UV excision repair protein RAD23 homolog B
                     isoform 1"
                     /protein_id="NP_002865.1"
                     /db_xref="CCDS:CCDS6769.1"
                     /db_xref="GeneID:5887"
                     /db_xref="HGNC:HGNC:9813"
                     /db_xref="MIM:600062"
                     /translation="MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQ
                     KLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPKAVSTPAPATTQQSAPASTTAVTSS
                     TTTTVAQAPTPVPALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATS
                     PTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNP
                     DRAVEYLLMGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPL
                     EFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQE
                     AGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEK
                     NENLAANFLLQQNFDED"
     exon            418..499
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            500..579
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            580..848
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            849..904
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1032
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1168
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1296
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1467
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..4114
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2354..2359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /note="hexamer: AGTAAA"
     polyA_site      2372
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /note="major polyA site"
     regulatory      2795..2800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /note="hexamer: ATTAAA"
     polyA_site      2818
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
     regulatory      2968..2973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /note="hexamer: AATAAT"
     polyA_site      2972
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
     regulatory      4095..4100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
                     /note="hexamer: TATAAA"
     polyA_site      4114
                     /gene="RAD23B"
                     /gene_synonym="HHR23B; HR23B; P58"
ORIGIN      
        1 gagtcacgat gatggcggcc accatcctgt ggtgagctag cggattccct gcttgtctcg
       61 ccgaccccct cgcgccttct gcagactccg tggctggcgc tcggcgcgtg aggaagcacg
      121 gcggcccgag ttcgcgggga aggccgcagt cgcggaggca gcggcgcggt ccggggcacg
      181 ggctggggga gaggccgctc cgctgggcga atgtgacaag cccccacccc caccgccttc
      241 ctccccagag cgcgaggagc gcgggcgacc ccggggcccc gccaggccac agaccccgcc
      301 cagcggccag cacccggcgc aggcccggca gccgagctgc gcggcggcac catgcaggtc
      361 accctgaaga ccctccagca gcagaccttc aagatagaca ttgaccccga ggagacggtg
      421 aaagcactga aagagaagat tgaatctgaa aaggggaaag atgcctttcc agtagcaggt
      481 caaaaattaa tttatgcagg caaaatcctc aatgatgata ctgctctcaa agaatataaa
      541 attgatgaga aaaactttgt ggtggttatg gtgaccaaac ccaaagcagt gtccacacca
      601 gcaccagcta caactcagca gtcagctcct gccagcacta cagcagttac ttcctccacc
      661 accacaactg tggctcaggc tccaacccct gtccctgcct tggcccccac ttccacacct
      721 gcatccatca ctccagcatc agcgacagca tcttctgaac ctgcacctgc tagtgcagct
      781 aaacaagaga agcctgcaga aaagccagca gagacaccag tggctactag cccaacagca
      841 actgacagta catcgggtga ttcttctcgg tcaaaccttt ttgaagatgc aacgagtgca
      901 cttgtgacgg gtcagtctta cgagaatatg gtaactgaga tcatgtcaat gggctatgaa
      961 cgagagcaag taattgcagc cctgagagcc agtttcaaca accctgacag agcagtggag
     1021 tatcttttaa tgggaatccc tggagataga gaaagtcagg ctgtggttga cccccctcaa
     1081 gcagctagta ctggggctcc tcagtcttca gcagtggctg cagctgcagc aactacgaca
     1141 gcaacaacta caacaacaag ttctggagga catccccttg aatttttacg gaatcagcct
     1201 cagtttcaac agatgagaca aattattcag cagaatcctt ccttgcttcc agcgttacta
     1261 cagcagatag gtcgagagaa tcctcaatta cttcagcaaa ttagccaaca ccaggagcat
     1321 tttattcaga tgttaaatga accagttcaa gaagctggtg gtcaaggagg aggaggtgga
     1381 ggtggcagtg gaggaattgc agaagctgga agtggtcata tgaactacat tcaagtaaca
     1441 cctcaggaaa aagaagctat agaaaggtta aaggcattag gatttcctga aggacttgtg
     1501 atacaagcgt attttgcttg tgagaagaat gagaatttgg ctgccaattt tcttctacag
     1561 cagaactttg atgaagattg aaagggactt ttttatatct cacacttcac accagtgcat
     1621 tacactaact tgttcactgg attgtctggg atgacttggg ctcatatcca caatacttgg
     1681 tataaggtag tagattgttg ggggtgggga gggagggatc taggatacag ggcagggata
     1741 aatacagtgc atgtctgctt caattagcag atgccgcaac tccacacagt gtgtaaaata
     1801 tatacaacca aaaatcagct tttgcaggtc tttatttctt ctgtaaaaca gtaggtaact
     1861 tttcctaggt ttcactcttt ttagtgtact agatccagaa acttagtgta atgccctgct
     1921 ttatatttct ttgacttaac attggtttca gaaagaatct tagctaccta gaatttacag
     1981 tctctgtttc atggcaacac tggataatgg ctttgtgaaa tttaaaaaat ttttgtagcg
     2041 actgtaaaca gaaatgccaa attgatggtt aattgttgct gcttcaaaaa taagtataaa
     2101 attaatatgt aaggaagccc attctttcat gttaaatact tggggtggga ggggagaaag
     2161 ggaacctttt cttaaaatga aaataattac tgctatttta aaatttcttg atcattgaat
     2221 gtgagaccct tctaacatga tttgagaagc tgtacaagta taggcagagt tattttcctg
     2281 tttacatttt ttttttgttt tggggaaaaa attggtaggt gtctaattac tgtttacttc
     2341 attgttatat tgcagtaaaa gttttaaaac aaccattgca tgtttgcttt tgatgtatcc
     2401 ctttgtgaaa ttagcacttt tggggccaat ggagaaatgc agcattcact ctccctgtct
     2461 tttccccttc cctcagcaga aacgtgttta tcagcaagtc gtgagtcaaa ctgctgcctt
     2521 ttaaaaaacc cacaaaatgc tgattcagtt caaaattaat gcaaatgttt caaaactggg
     2581 tttctgatat ttgtaaatgt gtttctttat tagataagag tgtattacca ttaaagtcat
     2641 tagtataata ttgctttcaa aaagaaatgg tagacaaaac tataatccag catcttttat
     2701 tgcattggaa agactggcaa agtcttttgg atgggttggg agatgtggct ggaaagtact
     2761 ttggaaaata tacaatcaag atatctcatg gcatattaaa agaaaaatct taatagcagt
     2821 gttggctttt atttggattt tttcatctca gttttttctg tggaatctcc ttcattggca
     2881 ttgttattta atcataaacg gggcagatgt ctacttgttc agtttttcaa atctgttttc
     2941 ctgagtataa ataagagtat ttaaagaaat aatttggatt gcttttgttt tttgtttcct
     3001 tttttttaac catctgatac taagaagatg aatttgcaca gatttctctg cataatttct
     3061 caatatcttt agcacagtat ggtgatgatg acttttaagc atttacatca cgtactcata
     3121 acctattatg aaaataaatg aaactggctg ggtatggtgg ctcatgccta taatcccagc
     3181 actttgggag gccgaggtgg gcagatcact tgaggccagg agattgagac cagcctgacc
     3241 gtcatggcga aaccccgtct atactaaaaa tacaaaaaat agccaggcat ggtggcgcac
     3301 gcctgtggtc ccagctactt gggaggctga ggcatgagaa ttgcttgaac ccgggaagtg
     3361 aaggttgccg tgagctgaga tcacaccact gccataaaca tgacaggctt ttggactttg
     3421 tattacctgt atgttttata atggatcatg cataatttct caggagaata aaatgagaat
     3481 tcatatatac gttcatcttt caagtcagag caatgagttg ggaaaagagg tggcatttct
     3541 gatcggataa tggaatactc tcatttattt tatgacattc tctgtctact cagatcatag
     3601 tgaaaactgg aaacaaaaaa aaaaaacagc ctcttcttgg aaagtgacag cagaaggtgg
     3661 catggagctt gtgtccttgg acaacaaatc tggatatact aggattaatt atcagaagac
     3721 agctcaggcc aagttttgat cgttccatac agtaccttgt ttatctgctt cttaaagaat
     3781 cagccgagac accataaaag aaataggctt tttgtgcctt ttgctgttaa tgtttaattt
     3841 acaaactgtt ttggtaaatc tcttaatgta agtagctatt tgactttgga attttgcatt
     3901 cgaggtatac tgtcatttct tgaaatcttt ttctcgttta gttgctctgt gggaaatgtg
     3961 aggaagccta agtttgtatt tgtaaatttc ttatgccatc ctctagtcaa attttttttc
     4021 attgtttaaa aatacggaag tgttccaata taattttttc ctgtactgga tggctaggat
     4081 tctagagaat tgattataaa atattttcaa taca
//
