LOCUS       NM_005053               1772 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens RAD23 homolog A, nucleotide excision repair protein
            (RAD23A), transcript variant 1, mRNA.
ACCESSION   NM_005053
VERSION     NM_005053.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1772)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1772)
  AUTHORS   Byeon,I.L., Calero,G., Wu,Y., Byeon,C.H., Jung,J., DeLucia,M.,
            Zhou,X., Weiss,S., Ahn,J., Hao,C., Skowronski,J. and
            Gronenborn,A.M.
  TITLE     Structure of HIV-1 Vpr in complex with the human nucleotide
            excision repair protein hHR23A
  JOURNAL   Nat Commun 12 (1), 6864 (2021)
   PUBMED   34824204
  REMARK    GeneRIF: Structure of HIV-1 Vpr in complex with the human
            nucleotide excision repair protein hHR23A.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1772)
  AUTHORS   Qin,L.Y., Gong,Z., Liu,K., Dong,X. and Tang,C.
  TITLE     Kinetic Constraints in the Specific Interaction between
            Phosphorylated Ubiquitin and Proteasomal Shuttle Factors
  JOURNAL   Biomolecules 11 (7), 1008 (2021)
   PUBMED   34356632
  REMARK    GeneRIF: Kinetic Constraints in the Specific Interaction between
            Phosphorylated Ubiquitin and Proteasomal Shuttle Factors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1772)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1772)
  AUTHORS   Withers-Ward,E.S., Jowett,J.B., Stewart,S.A., Xie,Y.M.,
            Garfinkel,A., Shibagaki,Y., Chow,S.A., Shah,N., Hanaoka,F.,
            Sawitz,D.G., Armstrong,R.W., Souza,L.M. and Chen,I.S.
  TITLE     Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a
            cellular protein implicated in nucleotide excision DNA repair
  JOURNAL   J Virol 71 (12), 9732-9742 (1997)
   PUBMED   9371639
REFERENCE   6  (bases 1 to 1772)
  AUTHORS   Li,L., Lu,X., Peterson,C. and Legerski,R.
  TITLE     XPC interacts with both HHR23B and HHR23A in vivo
  JOURNAL   Mutat Res 383 (3), 197-203 (1997)
   PUBMED   9164480
REFERENCE   7  (bases 1 to 1772)
  AUTHORS   van der Spek,P.J., Eker,A., Rademakers,S., Visser,C., Sugasawa,K.,
            Masutani,C., Hanaoka,F., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     XPC and human homologs of RAD23: intracellular localization and
            relationship to other nucleotide excision repair complexes
  JOURNAL   Nucleic Acids Res 24 (13), 2551-2559 (1996)
   PUBMED   8692695
REFERENCE   8  (bases 1 to 1772)
  AUTHORS   van der Spek,P.J., Visser,C.E., Hanaoka,F., Smit,B., Hagemeijer,A.,
            Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Cloning, comparative mapping, and RNA expression of the mouse
            homologues of the Saccharomyces cerevisiae nucleotide excision
            repair gene RAD23
  JOURNAL   Genomics 31 (1), 20-27 (1996)
   PUBMED   8808275
REFERENCE   9  (bases 1 to 1772)
  AUTHORS   van der Spek,P.J., Smit,E.M., Beverloo,H.B., Sugasawa,K.,
            Masutani,C., Hanaoka,F., Hoeijmakers,J.H. and Hagemeijer,A.
  TITLE     Chromosomal localization of three repair genes: the xeroderma
            pigmentosum group C gene and two human homologs of yeast RAD23
  JOURNAL   Genomics 23 (3), 651-658 (1994)
   PUBMED   7851894
REFERENCE   10 (bases 1 to 1772)
  AUTHORS   Masutani,C., Sugasawa,K., Yanagisawa,J., Sonoyama,T., Ui,M.,
            Enomoto,T., Takio,K., Tanaka,K., van der Spek,P.J., Bootsma,D. et
            al.
  TITLE     Purification and cloning of a nucleotide excision repair complex
            involving the xeroderma pigmentosum group C protein and a human
            homologue of yeast RAD23
  JOURNAL   EMBO J 13 (8), 1831-1843 (1994)
   PUBMED   8168482
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP213821.1 and BC014026.2.
            
            On Nov 22, 2018 this sequence version replaced NM_005053.3.
            
            Summary: The protein encoded by this gene is one of two human
            homologs of Saccharomyces cerevisiae Rad23, a protein involved in
            nucleotide excision repair. Proteins in this family have a modular
            domain structure consisting of an ubiquitin-like domain (UbL),
            ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2.
            The protein encoded by this gene plays an important role in
            nucleotide excision repair and also in delivery of
            polyubiquitinated proteins to the proteasome. Alternative splicing
            results in multiple transcript variants encoding multiple isoforms.
            [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1145533.1,
                                           SRR3476690.210220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000586534.6/ ENSP00000467024.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BP213821.1         33-58
            27-1772             BC014026.2         1-1746
FEATURES             Location/Qualifiers
     source          1..1772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1772
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /note="RAD23 homolog A, nucleotide excision repair
                     protein"
                     /db_xref="GeneID:5886"
                     /db_xref="HGNC:HGNC:9812"
                     /db_xref="MIM:600061"
     exon            1..159
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1179
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RAD23, yeast homolog, A; UV excision repair protein RAD23
                     homolog A"
                     /codon_start=1
                     /product="UV excision repair protein RAD23 homolog A
                     isoform 1"
                     /protein_id="NP_005044.1"
                     /db_xref="CCDS:CCDS12289.1"
                     /db_xref="GeneID:5886"
                     /db_xref="HGNC:HGNC:9812"
                     /db_xref="MIM:600061"
                     /translation="MAVTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGRDAFPVA
                     GQKLIYAGKILSDDVPIRDYRIDEKNFVVVMVTKTKAGQGTSAPPEASPTAAPESSTS
                     FPPAPTSGMSHPPPAAREDKSPSEESAPTTSPESVSGSVPSSGSSGREEDAASTLVTG
                     SEYETMLTEIMSMGYERERVVAALRASYNNPHRAVEYLLTGIPGSPEPEHGSVQESQV
                     SEQPATEAAGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRH
                     QEQFIQMLNEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPE
                     SLVIQAYFACEKNENLAANFLLSQNFDDE"
     exon            160..321
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            322..503
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            504..559
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            560..687
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            688..766
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            767..900
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1065
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1772
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1754..1759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /note="hexamer: AATAAA"
     polyA_site      1772
                     /gene="RAD23A"
                     /gene_synonym="HHR23A; HR23A"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgcgcc tgggcgctaa gatggcggcg gcgtgagttg catgttgtgt gaggatcccg
       61 gggccgccgc gtcgctcggg ccccgccatg gccgtcacca tcacgctcaa aacgctgcag
      121 cagcagacct tcaagatccg catggagcct gacgagacgg tgaaggtgct aaaggagaag
      181 atagaagctg agaagggtcg tgatgccttc cccgtggctg gacagaaact catctatgcc
      241 ggcaagatct tgagtgacga tgtccctatc agggactatc gcatcgatga gaagaacttt
      301 gtggtcgtca tggtgaccaa gaccaaagcc ggccagggta cctcagcacc cccagaggcc
      361 tcacccacag ctgccccaga gtcctctaca tccttcccgc ctgcccccac ctcaggcatg
      421 tcccatcccc cacctgccgc cagagaggac aagagcccat cagaggaatc cgcccccacg
      481 acgtccccag agtctgtgtc aggctctgtt ccctcttcag gtagcagcgg gcgagaggaa
      541 gacgcggcct ccacgctagt gacgggctct gagtatgaga cgatgctgac ggagatcatg
      601 tccatgggct atgagcgaga gcgggtcgtg gccgccctga gagccagcta caacaacccc
      661 caccgagccg tggagtatct gctcacggga attcctggga gccccgagcc ggaacacggt
      721 tctgtccagg agagccaggt atcggagcag ccggccacgg aagcagcagg agagaacccc
      781 ctggagttcc tgcgggacca gccccagttc cagaacatgc ggcaggtgat tcagcagaac
      841 cctgcgctgc tgcccgccct gctccagcag ctgggccagg agaaccctca gcttttacag
      901 caaatcagcc ggcaccagga gcagttcatc cagatgctga acgagccccc tggggagctg
      961 gcggacatct cagatgtgga gggggaggtg ggcgccatag gagaggaggc cccgcagatg
     1021 aactacatcc aggtgacgcc gcaggagaaa gaagctatag agaggttgaa ggccctgggc
     1081 ttcccagaga gcctggtcat ccaggcctat ttcgcgtgtg aaaaaaatga gaacttggct
     1141 gccaacttcc tcctgagtca gaactttgat gacgagtgat gccaggaagc caggccaccg
     1201 aagcccccac cctaccctta ttccatgaaa gttttataaa agaaaaaata tatatatatt
     1261 catgtttatt taagaaatgg aaaaaaaaat caaaaatctt aaaaaaacaa gcaaacagtc
     1321 cagcttcctg tcctcctaaa gtggcccctg ttcccatctc ccgggccaga cagctgtccc
     1381 cccgtcctcc tccccagccc agcctgctca gagaagctgg caggactggg aggcgacaga
     1441 tgggcccctc ttggcctctg tcccagctct ctgcagccag acggaaaggc ggctgcttgc
     1501 ctctccatcc tccgaaaaac ccctgaggac ccccccccat cctcttctag gatgagggga
     1561 agctggagcc ccaactttga tcctccattg gagtggccca aatctttcca tctagggcaa
     1621 gtcctgaaag gcccaaggcc ccctccccag tctggccttg gcctccagcc tggagaaggg
     1681 ctaacatcag ctcattgtca aggccacccc caccccagaa cagaaccgtg tctctgataa
     1741 aggttttgaa gtgaataaag ttttaaaaac ta
//
