LOCUS       NM_001384355            3216 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens RAD21 cohesin complex component like 1 (RAD21L1),
            transcript variant 2, mRNA.
ACCESSION   NM_001384355 XM_024451964
VERSION     NM_001384355.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Minase,G., Miyamoto,T., Miyagawa,Y., Iijima,M., Ueda,H., Saijo,Y.,
            Namiki,M. and Sengoku,K.
  TITLE     Single-nucleotide polymorphisms in the human RAD21L gene may be a
            genetic risk factor for Japanese patients with azoospermia caused
            by meiotic arrest and Sertoli cell-only syndrome
  JOURNAL   Hum Fertil (Camb) 20 (3), 217-220 (2017)
   PUBMED   28635411
  REMARK    GeneRIF: The association of three single-nucleotide polymorphisms
            with azoospermia, especially Sertoli cell-only syndrome, was
            studied in Japanese men.
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   Li,L., Fridley,B.L., Kalari,K., Niu,N., Jenkins,G., Batzler,A.,
            Abo,R.P., Schaid,D. and Wang,L.
  TITLE     Discovery of genetic biomarkers contributing to variation in drug
            response of cytidine analogues using human lymphoblastoid cell
            lines
  JOURNAL   BMC Genomics 15, 93 (2014)
   PUBMED   24483146
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3216)
  AUTHORS   Gutierrez-Caballero,C., Herran,Y., Sanchez-Martin,M., Suja,J.A.,
            Barbero,J.L., Llano,E. and Pendas,A.M.
  TITLE     Identification and molecular characterization of the mammalian
            alpha-kleisin RAD21L
  JOURNAL   Cell Cycle 10 (9), 1477-1487 (2011)
   PUBMED   21527826
  REMARK    GeneRIF: RAD21L is identified as a novel cohesin complex subunit
            homologous to mammalian RAD21/REC8/alpha-kleisin subfamily.
REFERENCE   4  (bases 1 to 3216)
  AUTHORS   Baranzini,S.E., Wang,J., Gibson,R.A., Galwey,N., Naegelin,Y.,
            Barkhof,F., Radue,E.W., Lindberg,R.L., Uitdehaag,B.M.,
            Johnson,M.R., Angelakopoulou,A., Hall,L., Richardson,J.C.,
            Prinjha,R.K., Gass,A., Geurts,J.J., Kragt,J., Sombekke,M.,
            Vrenken,H., Qualley,P., Lincoln,R.R., Gomez,R., Caillier,S.J.,
            George,M.F., Mousavi,H., Guerrero,R., Okuda,D.T., Cree,B.A.,
            Green,A.J., Waubant,E., Goodin,D.S., Pelletier,D., Matthews,P.M.,
            Hauser,S.L., Kappos,L., Polman,C.H. and Oksenberg,J.R.
  TITLE     Genome-wide association analysis of susceptibility and clinical
            phenotype in multiple sclerosis
  JOURNAL   Hum Mol Genet 18 (4), 767-778 (2009)
   PUBMED   19010793
REFERENCE   5  (bases 1 to 3216)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031665.19.
            
            On Jun 16, 2020 this sequence version replaced XM_024451964.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2897566.1,
                                           SRR5189667.243758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683101.1/ ENSP00000507397.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AL031665.19        113354-113450
            98-273              AL031665.19        115732-115907
            274-403             AL031665.19        117190-117319
            404-497             AL031665.19        118836-118929
            498-604             AL031665.19        121395-121501
            605-775             AL031665.19        125354-125524
            776-871             AL031665.19        126622-126717
            872-985             AL031665.19        127631-127744
            986-1212            AL031665.19        129929-130155
            1213-1312           AL031665.19        130407-130506
            1313-1437           AL031665.19        131356-131480
            1438-1530           AL031665.19        133523-133615
            1531-1608           AL031665.19        135936-136013
            1609-3216           AL031665.19        141579-143186
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3216
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /note="RAD21 cohesin complex component like 1"
                     /db_xref="GeneID:642636"
                     /db_xref="HGNC:HGNC:16271"
                     /db_xref="MIM:619533"
     exon            1..97
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            98..273
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1797
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /note="isoform 2 is encoded by transcript variant 2;
                     double-strand-break repair protein rad21-like protein 1;
                     RAD21-like 1"
                     /codon_start=1
                     /product="double-strand-break repair protein rad21-like
                     protein 1 isoform 2"
                     /protein_id="NP_001371284.1"
                     /db_xref="CCDS:CCDS92998.1"
                     /db_xref="GeneID:642636"
                     /db_xref="HGNC:HGNC:16271"
                     /db_xref="MIM:619533"
                     /translation="MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIEKI
                     LSPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFCPGLVDLPKENFE
                     ASYNAITLPEEFHDFDTQNMNAIDVSEHFTQNQSRPEEITLRENFDNDLIFQAESFGE
                     ESEILRRHSFFDDNILLNSSGPLIEHSSGSLTGERSLFYDSGDGFGDEGAAGEMIDNL
                     LQDDQNILLEDMHLNREISLPSEPPNSLAVEPDNSECICVPENEKMNETILLSTEEEG
                     FTLDPIDISDIAEKRKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRL
                     MMWKKRGGVHTLLSTAAQDLIHAELKMLFTKCFLSSGFKLGRKMIQKESVREEVGNQN
                     IVETSMMQEPNYQQELSKPQTWKDVIGGSQHSSHEDTNKNINSEDIVEMVSLAAEESS
                     LMNDLFAQEIEYSPVELESLSNEENIETERWNGRILQMLNRLRESNKMGMQSFSLMKL
                     CRNSDRKQAAAKFYSFLVLKKQLAIELSQSAPYADIIATMGPMFYNI"
     exon            274..403
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            404..497
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            498..604
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            605..775
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            776..871
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            872..985
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1212
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1312
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1437
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1530
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1608
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..3216
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3196..3201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /note="hexamer: CATAAA"
     polyA_site      3216
                     /gene="RAD21L1"
                     /gene_synonym="dJ545L17.2; RAD21L"
                     /note="major polyA site"
ORIGIN      
        1 gcagacgccc agcggcgcca agaacccggc caagctgact tggcgactcc tcgcagcccc
       61 tgctctggca cgccacacct cagacgaggc tttgaaattt gttaaataca agtaaggaac
      121 acaggcaaca tgttctacac acatgtgctt atgagtaaac gagggccatt ggccaaaata
      181 tggcttgcag ctcactggga gaagaaactc acaaaggccc atgtatttga atgtaatcta
      241 gagataacca ttgaaaaaat tctttcaccc aaggtgaaaa tagcacttcg aacttcagga
      301 caccttcttt tgggagttgt tcgaatctat aacaggaagg caaaatatct tttggcagat
      361 tgcagtgaag catttcttaa aatgaagatg acattttgcc caggactggt tgaccttcca
      421 aaagagaatt ttgaagcatc ttacaatgct atcacattgc cagaagaatt tcatgatttt
      481 gacacccaaa atatgaatgc tattgatgtt tcagaacact ttactcagaa ccaaagcaga
      541 ccagaagaaa tcactcttag agaaaatttt gacaatgatc taattttcca agctgagagc
      601 tttggggagg aatctgaaat tctcagaaga catagcttct ttgatgacaa catattactg
      661 aattccagtg gtcctttaat tgaacatagt tctggaagcc tcactggaga acgatctcta
      721 ttctatgaca gtggagatgg gtttggagat gaaggagctg caggagaaat gattgacaat
      781 ctattgcaag atgatcagaa tatcctgtta gaagacatgc atttgaacag agaaatttcc
      841 ctgccttctg agcctcccaa tagtttagca gttgaaccag ataactcaga gtgtatatgt
      901 gtacctgaaa atgaaaaaat gaatgaaaca atattattat caactgaaga ggaaggattt
      961 acccttgatc caattgatat ttcagacatt gctgagaaaa ggaaaggcaa aaagaggaga
     1021 ttgctcatag atcctatcaa ggagctcagt agcaaagtta tacataaaca gcttacttcc
     1081 tttgcggaca cactcatggt tttggaactt gcacctccta cccaaagatt gatgatgtgg
     1141 aagaagaggg gaggagtgca tacacttctg tcaactgctg cccaggattt gattcatgct
     1201 gaactgaaaa tgttgtttac aaaatgcttt ctgtcctctg gctttaaact tggaagaaaa
     1261 atgatacaga aggagtcagt aagggaagaa gtgggaaacc aaaatatagt agagacatcc
     1321 atgatgcaag agccaaatta ccagcaagag ttaagtaaac cccaaacttg gaaggatgtg
     1381 attggtggat ctcagcatag ctctcatgag gataccaata aaaatattaa ctctgaggat
     1441 attgttgaaa tggtgtcttt agctgctgag gaatcatctt taatgaatga cttatttgca
     1501 caagaaattg aatatagtcc agttgaattg gagtcattga gcaatgaaga aaatattgag
     1561 acagagagat ggaatggaag aatacttcag atgttaaatc gtttacggga atctaacaag
     1621 atgggaatgc agtcctttag tctgatgaag ctctgtagaa atagtgaccg aaaacaagca
     1681 gctgccaaat tttatagctt tcttgtccta aagaaacagc tggctattga gctgagccag
     1741 agtgctccct atgcagatat tatagctacg atgggaccaa tgttttataa catatgaagg
     1801 aaacccagac atacagattt atggcatcac tggaatttct gtgtagattg ttcaatttaa
     1861 tgcagaagcc atctggaagc agctgaaggt ctgatccatt tcatagatag gctgacctac
     1921 ttcctctctg tagttcagaa taatcatagc tagaattgga aacctacatg cttacaaaga
     1981 aatactttaa attctgtttt gttttttttt gttgtttttt taaggacaaa ggtctcacta
     2041 tattgcccag gctggacttg aactctgggt tcaagtgatt ctcctgcctc agcctcctga
     2101 atagctggga ctacaggcac atgccaccat acctggctca gaaatactta attatagcta
     2161 agtaattatt tttaacttag ctgatttgaa tatatagcat ttatcatttc cctgatttga
     2221 atgttgcact tagcatacat ttagcatgca tttttaaaat gctgtatgtt tttgacagac
     2281 attcaaagat gtttcttaaa aggctatttt acattggagt atttacttga attttatggg
     2341 gttaatgaaa acatcattat ttctacacag actatttggt tgcaacgtat atcatacttg
     2401 atttgacata atgccatggt ttttaatcca atattttaat tgaagagtta caaagctcat
     2461 ctttgcttta aattgcctga gtgggtttta gtctatttat aggtcactta acttttttat
     2521 ttactattta atgattatta taatcaccat taatgtgtca gcaaaactaa atctgcttct
     2581 tatgtttaaa aaaattagca gacacttgtt cctcatgttg tttgcagcta cggtctgagt
     2641 aaagatcacc aaaataaatg ttcttttgtt tggtgtttac tgaacatttt tgacattaaa
     2701 actgttgttt tccttttttc ttaattgaag tttgagttag gacattttca tatgatgctc
     2761 tgtgagctcc atcatacact gtcaaatgaa gcctatggta ctcattaaaa tgttgttata
     2821 tctggaatta tgctgcaaac aacaaattct aaatagcctc tctaaatgtg ttaactataa
     2881 attttaaatg gcaaaattgc ctttttaaaa tttcttttat tttttaaatt aacatacaga
     2941 aaatttgact tcttaatttt ggtgcacagt tctgtgaatt ttaacatatt tgtagagtcc
     3001 tgtaaccatc tccacaatta ggattccagc agtaacatca ccctaaaaaa ttctgttatc
     3061 cctttgtagt aacccccttc ccccatataa catctggcaa ccactcttct ccatgactac
     3121 acttttgtct ttttgaaaat gtcacacaga tggaatcata tagcatgtaa gctttcgata
     3181 cgggcttctt tcactcataa atgtctttga gactta
//
